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Fig. 10 | Cancer Cell International

Fig. 10

From: RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid

Fig. 10

Schematic representation of proposed mechanism of action of RBP7 induced G0/G1 phase arrest and FFA reduction as well as inhibition of proliferation, migration and invasion in HR + BC cells. Upregulation of RBP7 decreased the levels of AKT, p-AKT and SREBP1, leading to FFA content reduction and G0/G1 phase arrest. Overexpression of RBP7 could suppress cell proliferation,migration and invasion. Furthermore, the correlation between RBP7 expression and tumor T-stage and Ki67 score has been validated through clinical sample validation

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Cancer Cell International

ISSN: 1475-2867

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