Fig. 5

VGF co-regulated genes and functions. (A) Dot plot of VGF co-regulated transcripts in our OSCC tumor cohort. X-axis, r value; Y-axis, -Log10(p value). The number of positively correlated transcripts is much more than those negatively correlated. Symbol ∟ separate r > 0.50 or r < -0.33 transcripts from the remaining transcripts. (B) The functions and diseases associated with VGF co-regulated transcripts analyzed with the IPA algorithm. (C) Enlisting of coding transcript highly co-regulated with VGF, as revealed in (A). The detailed parameters are organized in Table S7. (D) The correlation between VGF expression and smim14 expression (Lt panels), and IL23R expression (Rt panels) in our OSCC tumors (Upper panels, analyzed with TPM) and TCGA HNSCC tumors (Lower panels, analyzed with semi-log graph of TPM+0.01). (E) Kaplan-Meier survival analysis. Upper panels, TCGA HNSCC tumors. Lower panels, our OSCC tumors. Medium TPM values of SMIM14 or IL23R in tumor samples are used as cutoffs to designate high or low expression of these genes