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Fig. 5 | Cancer Cell International

Fig. 5

From: LncRNA RASAL2-AS1 promotes METTL14-mediated m6A methylation in the proliferation and progression of head and neck squamous cell carcinoma

Fig. 5

RASAL2-AS1 overexpression restored the LIS1 expression inhibition induced by METTL14 silencing. (A-B) LIS1 mRNA levels and protein expression in Cal-27 and SCC-25 cells cotransfected with the overexpressed RASAL2-AS1 vector and silenced METTL14 levels. (C) The level of m6A methylation modification by overexpression of RASAL2-AS1 vector and silencing of METTL14 in Cal-27 and SCC-25 cells. (D-E) The triple RASAL2-AS1-METTL14-LIS1 binding. (F) Representative images of IHC staining of the expression of METTL14 and LIS1 in HNSCC tissues are shown (Original magnification ×200 scale bars, 25 μm; ×400 scale bars,12.5 μm). *p < 0.05, **p < 0.01

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Cancer Cell International

ISSN: 1475-2867

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