Fig. 1

Landscape of genetic and expression variation of m6A regulators in hepatocellular carcinoma. (A) The mutation frequency of m6A regulators in 375 patients with hepatocellular carcinoma from TCGA-LIHC cohort. (B) The CNV variation frequency of m6A regulators in TCGA-LIHC cohort. The height of the column represented the alteration frequency. The deletion frequency, red dot; The amplification frequency, grey dot. (C) The differential expression of 23 m6A regulators between normal tissues and hepatocellular carcinoma tissues. Tumor, Grey; Normal, Red. The upper and lower ends of the boxes represented interquartile range of values. The lines in the boxes represented median value, and black dots showed outliers. The asterisks represented the statistical p value (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001). (D) Principal component analysis for the expression profiles of 23 m6A regulators to distinguish tumors from normal samples. The tumors and normal samples were well distinguished based on the expression profiles of m6A regulators. Tumors, red and normal, black. (E) HRs (boxes) and 95% confidence intervals (horizontal lines). Box size is inversely proportional to the width of the confidence interval