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Fig. 5 | Cancer Cell International

Fig. 5

From: Comprehensive analysis of m6A modification in immune infiltration, metabolism and drug resistance in hepatocellular carcinoma

Fig. 5

Differential immune characteristics in distinct m6A modification patterns. (A-B) The differential immune cell infiltration and the expression of 6 immune checkpoints between m6A-gene-cluster A and B. m6A-gene-cluster A, Grey; m6A-gene-cluster B, Red. The upper and lower ends of the boxes represented interquartile range of values. The lines in the boxes represented median value, and black dots showed outliers. The asterisks represented the statistical p value. (C) Comparison of the mRNA expression of the MHC molecules, co-stimulators and co-inhibitors for m6A-gene-clusters. (D-F) Comparison of the mRNA expression of TGFβ, ESTIMATE score and immune-score for m6A-gene-clusters. (G) Spearman correlation between SAA1 expression and immune score. (H-I) Comparison of ESTIMATE score, immune-score, stromal score and tumor purity between SAA1-High and SAA1-Low group. (J) Kaplan-Meier analysis for SAA1 expression in the TCGA cohort. (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001)

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Cancer Cell International

ISSN: 1475-2867

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