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Fig. 4 | Cancer Cell International

Fig. 4

From: The troglitazone derivative EP13 disrupts energy metabolism through respiratory chain complex I inhibition in breast cancer cells and potentiates the antiproliferative effect of glycolysis inhibitors

Fig. 4

EP13 shows a rotenone-like activity. MDA-MB-231 cells were grown in 2D conditions and treated with EP13 (1, 3, 6 or 12 µM) or the complex I inhibitor, rotenone (1 µM) during a time-course (every 5 min) of OCR measurement using XFe24 Seahorse. At the end of the experiment, addition of 6 µM rotenone in both conditions completely blocked the oxygen consumption. Data are the mean ± S.D. (at least n = 3 wells per group)

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Cancer Cell International

ISSN: 1475-2867

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