Fig. 1

The illustrates the frequency and functional enrichment analysis of MCU alterations in breast cancer. A Examination of diverse mutations in the MCU gene across various cancer types. B Utilizing cBioPortal cancer genomics analysis to determine the frequency of MCU gene alterations in different cancer types. C Fisher's exact test compared mutation frequencies between MCU-high and MCU-low groups, with the right panel displaying mutation types, driving mutation types, and respective groups. D Investigation into the relationship between MCU and the six highly mutated genes in BRCA, with mutation sites highlighted by red lines. E Significance of MCU dependency in 45 BRCA cell lines based on the CRISPR screen. F Violin plots depicting MCU gene expression from RNA-sequencing data. G Kaplan–Meier survival analysis illustrating overall survival (OS) based on low/high expression of MCU. ***p < 0.001