Fig. 9

Evaluation of drug sensitivity and cytotoxicity in breast cancer cells. A The scatter plot depicts cross-association scores of predictivity and descriptivity, employed to identify potent drugs with efficacy against BRCA cells. To unveil gene signatures and potential drugs, we queried the pharmacogenetics database for the MCU gene. Subsequently, we examined the drug sensitivity of the shMCU gene to various chemical drugs in BRCA cell lines. The boxplots B–E illustrate the logarithm of the half maximal inhibitory concentration (IC50) values for four drugs, namely NSC319126, RU-SKI 43, OSI-930, and MG-132, displaying altered potency. F Evaluation of drug responsiveness across various breast cancer cell lines. G Analysis of drug sensitivity following inactivation of the MCU gene. **P < 0.01, ***P < 0.001