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Fig. 1 | Cancer Cell International

Fig. 1

From: Sparassis latifolia and exercise training as complementary medicine mitigated the 5-fluorouracil potent side effects in mice with colorectal cancer: bioinformatics approaches, novel monitoring pathological metrics, screening signatures, and innovative management tactic

Fig. 1

TCGA-COAD analysis and enrichment assessment. A The visualization of significant DEG in colorectal cancer based on RNA-seq is depicted in the volcano plot, with consideration of a logFC ± 2. Volcano plots depicting differential expression of all transcripts in colorectal cancer (CRC) relative to normal tissue are discussed using The Cancer Genome Atlas (TCGA) data. Genes received acceptance based on criteria of logFC ± 1 and adj P.value < 0.01 to identify genes potentially involved in tumorigenesis processes. Variations in gene expression patterns have been correlated to the prognosis of individuals with CRC. B The protein–protein interactions (PPIs) network of 133 hub genes in colorectal cancer development and progression (TCGA-COAD) was presented based on network diameters (Degree = 10, betweenness centrality = 0.005, and closeness centrality = 0.2). C The enrichment analysis showed a higher abundance of hub genes related to adenoma/adenocarcinoma, malignancy, metastasis, extracellular structure organization, PI3K-Akt signaling pathway, IL-18, cancer pathway, GPCR downstream signaling, and B-cell activation

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Cancer Cell International

ISSN: 1475-2867

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