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Fig. 7 | Cancer Cell International

Fig. 7

From: Sparassis latifolia and exercise training as complementary medicine mitigated the 5-fluorouracil potent side effects in mice with colorectal cancer: bioinformatics approaches, novel monitoring pathological metrics, screening signatures, and innovative management tactic

Fig. 7

Virtual Screening & Pharmacophore Modeling. A-M The chemoinformatics analysis consequences designated the catalog of the binding affinity of bioactive components derived from sparassis latifolia, which targets FN1 macromolecules based on molecular docking analysis in the PyRx offline platform. Binding affinity elaborates the binding energy, and the RMSD score elaborates the stability of this binding energy. Further, the bond type is specified based on PyMOL and BIOVIA Discovery Studio Visualizer software. Different colors in the guidance characterize bond types. N The DHRRR pharmacophore model obtained the maximum survival score (5.530872) using 4 authorized ligands for FN1. Bioactive compounds derived from sparassis latifolia did not align with the pharmacophore model based on pharmacophore screening

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Cancer Cell International

ISSN: 1475-2867

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