Fig. 4

CDCA5 knockdown antagonizes ccRCC tumor growth in vivo. A, B ACHN cells (NC) or ACHN cells with CDCA5 knockdown (KD) were transplanted into nude mice. Tumor Growth was evaluated with the in vivo bioluminescence imaging system. C, D The representative photographs of ACHN tumor tissues in NC and KD groups (C), and tumor growth curves (D). N = 6 for each group. E WB analysis of P-S6, CDCA5 and β-actin levels in tumors (n = 3 in each group). The expression intensity was compared using arbitrary ratios normalized against β-actin. **P < 0.01 and ***P < 0.001