Table 1 T-cell subsets in TIME characterized by scRNA-seq
From: Unravelling immune microenvironment features underlying tumor progression in the single-cell era
Tumor type | Sample | T-cell sorted | Key findings | Refs. |
|---|---|---|---|---|
Colorectal cancer Ovarian cancer | Adjacent tissue and tumor Omental metastatic site | CD8+ CTL and TEx cells(XCL1/2) TRM and GNLY+CD4+ T-cell | XCL1+ T-cell clusters are associated with tumor mutational burden high status | [73] [117] |
Hepatocellular carcinoma | Tumor and adjacent tissues, and peripheral blood | TEM | High T-cell infiltration suggests an anti-tumor response | [68] |
Non-small cell lung cancer | Tumor and adjacent tissues, and peripheral blood | TEx | This group of T-cells is clonally expanded, with high migration potentials and state transition possibility | [155] |
Breast cancer | Tumor | TEx | TEx promotes intra-tumoral T-cell exhaustion | [156] |
Nasopharyngeal cancer | Tumor and adjacent tissues | CD8+ T-cell((LAG-3, TIGIT, PDCD-1 and HAVCR2) | PD-L1+ exhausted T-cells are abundant in tumors | [65] |
Hodgkin lymphoma | Tumor and reactive lymph nodes | Treg-like immunosuppressive subset of LAG3+ T-cells | These cell populations may become new therapeutic targets | [157] |
Clear cell renal cell carcinoma | Tumor and peripheral blood | MKI+ CD8+ T-cell | The group of LAG3+ T-cells contribute to the immune escape phenotype | [61] |
Oral squamous cell carcinoma | Tumor and adjacent tissues | TEx | MKI67+proliferative subpopulation is a potential culprit for tumor progression | [60] |
Cholangiocarcinoma | Tumor | Treg cells and partial GZMB+ CD8+ T-cells (LAIR2) | Enrichment of related T-cells is associated with tumor immunosuppression | [158] |
Melanoma | Tumor and adjacent tissues, and peripheral blood | TEx | LAIR2 is a potential marker for exhaustive T-cell populations, correlating with the worse survival of patients | [155] |
Gastric cancer | Tumor and adjacent tissues | TEM, TRM, native CD4+ T-cells, Th, Tfh, and Treg | TEx promotes intra- tumoral T-cell exhaustion | [62] |
Esophageal squamous cell carcinoma | Tumor and adjacent tissues | Tex(CCL5, STMN1, and TIGIT), Treg(IL1R2) | Treg significantly enriches an immunosuppressive microenvironment Tex and Treg lead to an immunosuppressive microenvironment | [63] |