From: Antitumor mechanisms and future clinical applications of the natural product triptolide
Cell Death | Target | Cancer Types | References |
---|---|---|---|
Apoptosis | NF-κB, p53 | Pancreatic Cancer, Gastric Cancer, Hepatoma, Lung Cancer | |
STAT3 | Multiple Myeloma, Non-small Cell Lung Cancer | ||
PUM1 | Pancreatic Cancer | [65] | |
Akt/Hdn2 | Prostate Cancer | [64] | |
MDM2, p85 | Breast Cancer | ||
CaMKKβ/Ampk | Lung Cancer | ||
P53, caspase3, caspase9 | Gastric Cancer | ||
CDKN1A, C-jun, NF-κB, p65 | Thyroid Cancer | [100] | |
HSP70 | Pancreatic Cancer | [101] | |
Sp1, HSP70 | Pancreatic Cancer | [102] | |
miR-142-3p, HSP70 | Pancreatic Cancer | [103] | |
DcR3 | Pancreatic Cancer | [104] | |
DcR3, MTA1 | Oral Cancer | [105] | |
E2F | Colon Cancer | [85] | |
Autophagy | CaMK1-AMPK, mTOR, ULK1, Beclin1 | Prostate Cancer, Neuroblastoma | |
JAK2/STAT3 | Ovarian Cancer | [62] | |
TRAIL, DR5, p27 | Prostate Cancer | ||
Pyroptosis | c-myc, HK-II, GSDME | Head and neck squamous cancer | [109] |
Ferroptosis | Nrf-2, GPX4, SLC7A11 | Leukemia |