Antitumor mechanisms and future clinical applications of the natural product triptolide

Table 3 Combination of TPL with other anticancer drugs

Medications	Dose	Pathway of Action	Cancer Types	References
Triptolide+ Cisplatin	Triptolide 10ng/ml-A549, 5ng/ml-HTB182 1ng/ml-CRL5810, CRL5922 Cisplatin 5μM	capase3 activation↑ ATM phosphorylation at Ser¹⁹⁸¹↑ CHK1 phosphorylation at Ser^317/345↓ Nucleotide excision repair↓	Lung Cancer	[164]
Triptolide+ Oxaliplatin	Triptolide 50nM Oxaliplatin 0–10μM	DNA damage repair↓	Pancreatic Cancer	[170]
Triptolide+ Enzalutamide	Triptolide 75 μg/kg Enzalutamide 25 mg/kg	TFIIH and RNA Pol II recruitment↓	Castration-resistant Prostate Cancer	[171]
Triptolide+ Doxorubicin	Doxorubicin was used after pretreatment with 20/40 nM of Triptolide for 3 h	ATM↓ DNA damage response↓	Breast Cancer	[174]
Triptolide+ Gefitinib	Triptolide 2ng/ml Gefitinib 1.25 μg/ml	Epithelial-Mesenchymal Transition↓	Lung Adenocarcinoma	[176]
Triptolide+ Erastin	Triptolide 0.1 mg/kg Erastin 10 mg/kg	NRF2/SLC7A11↓	Head and neck squamous cancer	[109]

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