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Table 1 P2X7R SNPs mutations in PDAC patients and controls

From: Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer

SNP

Genotype

Frequency (n and %)

Chi-square

Unadjusted OR

Adjusted (Age, Weight, Diabetes)

Control

PDAC

χ2

P

OR

CI (95%)

P

OR

CI (95%)

P

rs35933842

Null allele

GG

1479 (61.4)

889 (36.9)

        
 

GT

28 (1.2)

11 (0.5)

1.429

0.248

0.654

0.324–1.319

0.235

0.634

0.271–1.478

0.291

rs17525809

Val76Ala

TT

1327 (55.0)

771 (32.0)

        
 

TC

179 (7.4)

125 (5.2)

  

1.202

0.941–1.536

0.141

1.127

0.829–1.533

0.446

 

CC

6 (0.2)

5 (0.2)

  

1.434

0.436–4.715

0.553

1.727

0.475–6.285

0.407

 

TC + CC

  

2.392

0.134

1.209

0.950–1.539

0.122

1.149

0.851–1.553

0.364

rs28360447

Gly150Arg

GG

1458 (60.2)

876 (36.2)

        
 

GA

57 (2.4)

25 (1.0)

  

0.730

0.453–1.177

0.196

0.524

0.275–1.001

0.050

 

AA

4 (0.2)

0

        
 

GG + GA

  

2.542

0.114

0.682

0.425–1.095

0.113

0.49

0.259–0.928

0.029

rs7958311

Arg270His

GG

840 (35.1)

527 (22.1)

        
 

GA

543 (22.7)

329 (13.8)

  

0.966

0.811–1.150

0.696

1.059

0.854–1.313

0.599

 

AA

105 (4.4)

46 (1.9)

  

0.698

0.486–1.004

0.053

0.934

0.608–1.434

0.754

 

GA + AA

  

0.894

0.348

0.922

0.780–1.091

0.344

1.040

0.847–1.277

0.709

rs7958316

Arg276His

GG

1462 (60.6)

869 (36.0)

        
 

GA

48 (2.0)

32 (1.3)

0.244

0.639

1.122

0.712–1.768

0.621

1.791

1.033–3.103

0.038

rs28360457

Arg307Gln

GG

1489 (61.3)

882 (36.33)

        
 

GA

37 (1.5)

21 (0.9)

0.024

0.892

0.958

0.557–1.647

0.877

0.993

0.513–1.920

0.982

rs1718119

Ala348Thr

GG

542 (22.7)

299 (12.5)

        
 

GA

719 (30.1)

434 (18.2)

  

1.094

0.910–1.316

0.340

1.075

0.857–1.348

0.534

 

AA

235 (9.8)

160 (6.7)

  

1.234

0.965–1.578

0.093

1.141

0.842–1.546

0.396

 

GA + AA

  

1.850

0.184

1.129

0.948–1.344

0.174

1.091

0.880–1.352

0.426

rs2230911

Thr357Ser

CC

1273 (52.5)

761 (31.4)

        
 

CG

239 (9.90)

134 (5.5)

  

0.938

0.745–1.180

0.584

0.785

0.588–1.048

0.101

 

GG

12 (0.5)

5 (0.2)

  

0.697

0.245–1.986

0.499

0.672

0.193–2.336

0.531

 

CG + GG

  

0.441

0.529

0.926

0.739–1.161

0.507

0.78

0.587–1.035

0.085

rs2230912

Gln460Arg

AA

1057 (43.6)

631 (26.1)

        
 

AG

415 (17.1)

245 (10.1)

  

0.989

0.821–1.191

0.907

1.041

0.830–1.306

0.729

 

GG

46 (1.9)

28 (1.2)

  

1.020

0.631–1.648

0.937

0.744

0.394–1.407

0.364

 

AG + GG

  

0.008

0.964

0.992

0.829–1.187

0.93

1.010

0.811–1.258

0.931

rs3751143

Glu496Ala

AA

1051 (43.5)

621 (25.7)

        
 

AC

432 (17.9)

246 (10.2)

  

0.964

0.801–1.160

0.696

0.866

0.688–1.090

0.221

 

CC

38 (1.6)

29 (1.2)

  

1.292

0.789–2.115

0.309

1.716

0.970–3.037

0.064

 

AC + CC

  

0.012

0.927

0.990

0.828–1.184

0.915

0.929

0.745–1.158

0.513

rs1653624

Ile568Asn

TT

1419 (58.6)

848 (35.0)

        
 

TA

99 (4.1)

54 (2.2)

  

0.913

0.648–1.285

0.601

1.084

0.712–1.649

0.707

 

AA

2 (0.1)

0

        
 

TA + AA

  

0.409

0.549

0.895

0.636–1.258

0.523

1.064

0.700–1.616

0.773

  1. Genotype frequencies are shown as absolute numbers and in percentages. Analysis depicts chi-square (χ2) and P values (P), unadjusted and adjusted odds ratios (OR), confidence intervals (CI) and P value (P). PDAC refers to pancreatic ductal adenocarcinoma
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Cancer Cell International

ISSN: 1475-2867

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