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  1. Hypoxia, which affects the development, metastasis and prognosis of cancer, represents a key feature of cancer. This study describe a hypoxia risk factor model, with predicting the prognosis of cervical cancer.

    Authors: Yang Yang, Yaling Li, Ruiqun Qi and Lan Zhang
    Citation: Cancer Cell International 2021 21:345
    Content type: Primary research Published on:

  2. Although immunotherapy for colon cancer has made promising progress, only a few patients currently benefit from it. A recent study revealed that infiltrating immune cells are highly relevant to tumor prognosis...

    Authors: Hao Xu, Qianhui Xu and Lu Yin
    Citation: Cancer Cell International 2021 21:344
    Content type: Primary research Published on:

  3. Clear cell renal cell carcinoma (ccRCC), derived from renal tubular epithelial cells, is the most common malignant tumor of the kidney. The study of key genes related to the pathogenesis of ccRCC has become im...

    Authors: Chunxiu Yang, Jingjing Pang, Jian Xu, He Pan, Yueying Li, Huainian Zhang, Huan Liu and Shu-Yuan Xiao
    Citation: Cancer Cell International 2021 21:343
    Content type: Primary research Published on:

  4. Long non-coding RNAs (lncRNAs) are increasingly recognized as the crucial mediators in the regulation of ferroptosis and iron metabolism. A systematic understanding of ferroptosis and iron-metabolism related l...

    Authors: Jie Yao, Xiao Chen, Xiao Liu, Rui Li, Xijia Zhou and Yiqing Qu
    Citation: Cancer Cell International 2021 21:340
    Content type: Primary research Published on:

  5. Fatty acid oxidation (FAO) is the emerging hallmark of cancer metabolism because certain tumor cells preferentially utilize fatty acids for energy. Lymph node metastasis, the most common way of tumor metastasi...

    Authors: Mao Li, Hong-chun Xian, Ya-Jie Tang, Xin-hua Liang and Ya-ling Tang
    Citation: Cancer Cell International 2021 21:339
    Content type: Review Published on:

  6. Some driver oncogenes are still unknown in non-small-cell lung cancer (NSCLC). DNAJC19, a major component of the translocation machinery of mitochondrial membranes, is a disease-associated protein. Herein, we ...

    Authors: Ji Zhou, Yang Peng, Ying-chun Gao, Tai-yu Chen, Peng-cheng Li, Ke Xu, Tao Liu and Tao Ren
    Citation: Cancer Cell International 2021 21:338
    Content type: Primary research Published on:

  7. Osteosarcoma (OS) is a common type of bone malignancy that often occurs in children and adolescents. Chemoresistance is a huge barrier to cancer therapy. This study aimed to investigate the role and potential ...

    Authors: Huapeng Guan, Hao Xu, Jinshui Chen, Weishan Wu, Dongfeng Chen, Yungang Chen and Jianzhong Sun
    Citation: Cancer Cell International 2021 21:336
    Content type: Primary research Published on:

  8. Gastric cancer (GC) is one of the most common cancer worldwide. It is essential to identify non-invasive diagnostic and prognostic biomarkers of GC. The aim of the present study was to screen candidate biomark...

    Authors: Lei Liu, Honglin Pang, Qiao He, Biran Pan, Xiaobin Sun, Jing Shan, Liping Wu, Kaiwen Wu, Xue Yao and Yuanbiao Guo
    Citation: Cancer Cell International 2021 21:335
    Content type: Primary research Published on:

  10. Lung cancer is one of the most common malignant tumours worldwide. however, emerging immunotherapy and targeted therapies continue to show limited efficacy. In the search for new targets for lung cancer treatm...

    Authors: Runzhi Qi, Yuwei Zhao, Qiujun Guo, Xue Mi, Mengqi Cheng, Wei Hou, Honggang Zheng and Baojin Hua
    Citation: Cancer Cell International 2021 21:333
    Content type: Review Published on:

  11. BCL2L13 belongs to the BCL2 super family, with its protein product exhibits capacity of apoptosis-mediating in diversified cell lines. Previous studies have shown that BCL2L13 has functional consequence in severa...

    Authors: Fei Meng, Luojin Zhang, Mingjun Zhang, Kaiqin Ye, Wei Guo, Yu Liu, Wulin Yang, Zhimin Zhai, Hongzhi Wang, Jun Xiao and Haiming Dai
    Citation: Cancer Cell International 2021 21:332
    Content type: Primary research Published on:

  12. Emerging evidence shows that abnormal expression of long non-coding RNA is involved in the occurrence and development of various tumors. LncRNA MONC is abnormally expressed in head and neck squamous cell carci...

    Authors: Yibing Li, Jianing Huo, Junjian He and Xiaoxin Ma
    Citation: Cancer Cell International 2021 21:331
    Content type: Primary research Published on:

  13. Hepatocellular carcinoma (HCC) has a poor prognosis and has become the sixth most common malignancy worldwide due to its high incidence. Advanced approaches to therapy, including immunotherapeutic strategies, ...

    Authors: Qiuxian Zheng, Qin Yang, Jiaming Zhou, Xinyu Gu, Haibo Zhou, Xuejun Dong, Haihong Zhu and Zhi Chen
    Citation: Cancer Cell International 2021 21:330
    Content type: Primary research Published on:

  14. Patients with nasopharyngeal cancer (NPC) differ in prognosis, even at the same stage; therefore, new biomarkers are urgently required to identify early-stage NPC patients at high risk of poor prognosis. Altho...

    Authors: Tianhao Liang, Weixing Liu, Junyang Xie, Yiyan Wang, Gui Chen, Wenjing Liao, Lijuan Song and Xiaowen Zhang
    Citation: Cancer Cell International 2021 21:329
    Content type: Review Published on:

  15. Small non‐coding RNAs (sncRNAs) are a subgroup of non‐coding RNAs, with less than 200 nucleotides length and no potential for coding proteins. PiRNAs, a member of sncRNAs, were first discovered more than a dec...

    Authors: Fatemeh Sadoughi, Seyyed Mehdi Mirhashemi and Zatollah Asemi
    Citation: Cancer Cell International 2021 21:328
    Content type: Review Published on:

  16. CD58 has been demonstrated to be abnormally expressed in multiple hematopoietic malignancies and solid tumors and plays an essential role in tumorigenesis and progression; however, its clinical significance an...

    Authors: Yalu Zhang, Qiaofei Liu, Jingkai Liu and Quan Liao
    Citation: Cancer Cell International 2021 21:327
    Content type: Primary research Published on:

  18. RNA binding protein (RBP) is an active factor involved in the occurrence and development of colorectal cancer (CRC). Therefore, the potential mechanism of RBP in CRC needs to be clarified by dry-lab analyses o...

    Authors: Qinglian He, Ziqi Li, Xue Lei, Qian Zou, Haibing Yu, Yuanlin Ding, Guangxian Xu and Wei Zhu
    Citation: Cancer Cell International 2021 21:325
    Content type: Primary research Published on:

  19. Circular RNAs (circRNAs) have been reported to be important regulators of the development and progression of various carcinomas. However, the role of circRNA_100290 in gastric cancer (GC) is still unclear. Thi...

    Authors: Gang Wang, Dan Sun, Wenhui Li and Yan Xin
    Citation: Cancer Cell International 2021 21:324
    Content type: Primary research Published on:

  20. The dysfunction of myc-related zinc finger protein (MAZ) has been proven to contribute to tumorigenesis and development of multiple cancer types. However, the biological roles and clinical significance of MAZ ...

    Authors: Li-Xin Ren, Jin-Chun Qi, An-Ning Zhao, Bei Shi, Hong Zhang, Dan-Dan Wang and Zhan Yang
    Citation: Cancer Cell International 2021 21:323
    Content type: Primary research Published on:

  21. It have been proven that long non-coding RNAs (lncRNAs) serve as regulators in carcinogenesis. Interleukin enhancer binding factor 3 antisense RNA 1 (ILF3-AS1) has been illuminated as a prognostic factor in so...

    Authors: Zhaohui Zeng, Qiangfeng Teng and Jinhong Xiao
    Citation: Cancer Cell International 2021 21:322
    Content type: Primary research Published on:

  22. Long non-coding RNAs (lncRNAs), a class of non-coding RNAs (ncRNAs) associated with diverse biological processes of cells. Over the past decades, cumulating research evidences revealed that abnormal expression...

    Authors: Md Zahirul Islam Khan and Helen Ka Wai Law
    Citation: Cancer Cell International 2021 21:321
    Content type: Primary research Published on:

  23. Rho GTPase activating protein 10 (ARHGAP10) has been implicated as an essential element in multiple cellular process, including cell migration, adhesion and actin cytoskeleton dynamic reorganization. However, ...

    Authors: Lan-Lan Lin, Fan Yang, Dong-Huan Zhang, Cong Hu, Sheng Yang and Xiang-Qi Chen
    Citation: Cancer Cell International 2021 21:320
    Content type: Primary research Published on:

  24. Angiogenic switch is a hallmark feature of transition from low-grade to high-grade cervical intraepithelial neoplasia (CIN) in cervical cancer progression. Therefore, early events leading to locally-advanced c...

    Authors: Anjali Bhat, Joni Yadav, Kulbhushan Thakur, Nikita Aggarwal, Tanya Tripathi, Arun Chhokar, Tejveer Singh, Mohit Jadli and Alok Chandra Bharti
    Citation: Cancer Cell International 2021 21:319
    Content type: Primary research Published on:

  25. The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of ...

    Authors: Javad Sharifi-Rad, Cristina Quispe, Monica Butnariu, Lia Sanda Rotariu, Oksana Sytar, Simona Sestito, Simona Rapposelli, Muhammad Akram, Mehwish Iqbal, Akash Krishna, Nanjangud Venkatesh Anil Kumar, Susana S. Braga, Susana M. Cardoso, Karolina Jafernik, Halina Ekiert, Natália Cruz-Martins…
    Citation: Cancer Cell International 2021 21:318
    Content type: Review Published on:

  26. Circular RNAs (circRNAs) are RNAs that have an important role in various pathological processes, including cancer. After the usage of high-throughput RNA sequencing, many circRNAs were found to be differential...

    Authors: Pranavi Garlapati, Jinjie Ling, Paul J. Chiao and Jie Fu
    Citation: Cancer Cell International 2021 21:317
    Content type: Review Published on:

  27. Laryngeal carcinoma is a primary malignant tumor originating from the laryngeal mucosa, and its pathogenesis is not fully understood. It is a rare type of cancer that shows a downward trend in the 5-year survi...

    Authors: Yan Huang, Min Gu, Yiting Tang, Zhiqiang Sun, Judong Luo and Zhe Li
    Citation: Cancer Cell International 2021 21:316
    Content type: Review Published on:

  28. RSF1, remodelling and spacing factor 1, is an important interphase centromere protein and is overexpressed in many types of cancers and correlated with poor overall survival. RSF1 has functions mainly in maint...

    Authors: Guiyang Cai, Qing Yang and Wei Sun
    Citation: Cancer Cell International 2021 21:315
    Content type: Review Published on:

  29. Epithelial ovarian cancer remains one of the leading causes of cancer deaths among women worldwide, and advanced epithelial ovarian cancer frequently metastasizes to the omentum. The characteristics of metasta...

    Authors: Kosuke Yoshida, Nobuhisa Yoshikawa, Kazuhisa Kitami, Satoshi Tamauchi, Yoshiki Ikeda, Akira Yokoi, Kimihiro Nishino, Kaoru Niimi and Hiroaki Kajiyama
    Citation: Cancer Cell International 2021 21:314
    Content type: Primary research Published on:

  30. Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or...

    Authors: Jieyu He, Lin Ling, Zhongyue Liu, Xiaolei Ren, Lu Wan, Chao Tu and Zhihong Li
    Citation: Cancer Cell International 2021 21:313
    Content type: Review Published on:

  31. Circular RNAs (circRNAs) have been implicated in the initiation and development of breast cancer as functional non-coding RNAs (ncRNA). The roles of circRNAs as the competing endogenous RNAs (ceRNAs) to sponge...

    Authors: Farzaneh Darbeheshti, Elham Zokaei, Yaser Mansoori, Sima Emadi Allahyari, Zeeba Kamaliyan, Sepideh Kadkhoda, Javad Tavakkoly Bazzaz, Nima Rezaei and Abbas Shakoori
    Citation: Cancer Cell International 2021 21:312
    Content type: Primary research Published on:

  32. Myocardial damage is a mostly incurable complication of multiple myeloma (MM) that seriously affects the treatment outcome and quality of life of patients. Exosomal circular RNAs (exo-circRNAs) play an importa...

    Authors: Runjie Sun, Wei Liu, Yangang Zhao, Haoyu Chen, Zhenzhen Wang, Yanyu Zhang, Xiaoqi Sun and Xing Cui
    Citation: Cancer Cell International 2021 21:311
    Content type: Primary research Published on:

  33. Tumor-infiltrating B lymphocytes (TIL-Bs) is a heterogeneous population of lymphocytes. The prognostic value of TIL-Bs in patients with breast cancer remains controversial. Here we conducted this meta-analysis...

    Authors: You Qin, Fei Peng, Lisha Ai, Shidai Mu, Yuting Li, Chensu Yang and Yu Hu
    Citation: Cancer Cell International 2021 21:310
    Content type: Review Published on:

  35. High-risk human papillomaviruses (HPVs) are present and can cooperate with Epstein–Barr virus (EBV) to initiate and/or enhance the progression of several types of human carcinomas including cervical as well as...

    Authors: Karim Nagi, Ishita Gupta, Nawaf Jurdi, Ayesha Jabeen, Amber Yasmeen, Gerald Batist, Semir Vranic and Ala-Eddin Al-Moustafa
    Citation: Cancer Cell International 2021 21:308
    Content type: Primary research Published on:

  36. An increasing number of studies have shown that circular RNAs (circRNAs) play important roles in the regulation of tumor progression. Therefore, we explored the expression characteristics, function, and relate...

    Authors: Yi Liu, Simin Chen, Gang Peng, Yiwei Liao, Xuegong Fan, Zuping Zhang and Chenfu Shen
    Citation: Cancer Cell International 2021 21:307
    Content type: Primary research Published on:

  37. Drug resistance is always a great obstacle in any endocrine therapy of breast cancer. Although the combination of endocrine therapy and targeted therapy has been shown to significantly improve prognosis, refra...

    Authors: Jing Chen, Runlan Wan, Qinqin Li, Zhenghuan Rao, Yanlin Wang, Lei Zhang and Alexander Tobias Teichmann
    Citation: Cancer Cell International 2021 21:306
    Content type: Review Published on:

  38. This study incorporates fundamental research referring to considerable amounts of gene-sequencing data and bioinformatics tools to analyze the pathological mechanisms of diffuse large B-cell lymphoma (DLBCL).

    Authors: Yuying Cui, Hui Xu, Yu Yang, Dongmei Zhao, Yu Wen, Chao Lv, Hongbin Qiu and Chennan Wang
    Citation: Cancer Cell International 2021 21:305
    Content type: Primary research Published on:

  39. Echinacoside (ECH) is the main active ingredient of Cistanches Herba, which is known to have therapeutic effects on metastatic tumors. However, the effects of ECH on liver cancer are still unclear. This study was...

    Authors: Wen Li, Jing Zhou, Yajie Zhang, Jing Zhang, Xue Li, Qiao Yan, Jiabing Han and Fangdi Hu
    Citation: Cancer Cell International 2021 21:304
    Content type: Primary research Published on:

  40. Various diagnostic and prognostic tools exist in colorectal cancer (CRC) due to multiple genetic and epigenetic alterations causing the disease. Today, the expression of RNAs is being used as prognostic marker...

    Authors: Fahimeh Fattahi, Jafar Kiani, Mahdi Alemrajabi, Ahmadreza Soroush, Marzieh Naseri, Mohammad Najafi and Zahra Madjd
    Citation: Cancer Cell International 2021 21:303
    Content type: Primary research Published on:

  41. Malignant tumours of the female reproductive system threaten the lives and health of women worldwide, with ovarian cancer having the highest mortality rate. Based on previous work, this study analysed the expr...

    Authors: Xiao Li, Caixia Wang, Shuang Wang, Yuexin Hu, Shan Jin, Ouxuan Liu, Rui Gou, Xin Nie, Juanjuan Liu and Bei Lin
    Citation: Cancer Cell International 2021 21:302
    Content type: Primary research Published on:

  43. Osteosarcoma (OS) is a common malignant bone tumor with poor prognosis. We previously reviewed that CD146 is correlated with multiple cancer progression, while its impact on OS is currently not systematically ...

    Authors: Xing Lei, Kewei Wang, Wenbo Wang, Hao Jin, Wenguang Gu, Zhiguo Chen, Wei Wang, Kaituo Gao and Huan Wang
    Citation: Cancer Cell International 2021 21:300
    Content type: Primary research Published on:

  44. Colorectal cancer (CRC) is the leading cause of cancer deaths and most common malignant tumors worldwide. Immune-related genes (IRGs) can predict prognoses of patients and the effects of immunotherapy. A serie...

    Authors: Xuankun Yang, Jia Yan, Yahui Jiang and Yaxu Wang
    Citation: Cancer Cell International 2021 21:299
    Content type: Primary research Published on:

  45. The natural killer (NK) cells differentiated from umbilical cord blood (UCB) hematopoietic stem cells (HSCs) may be more suitable for cell-based immunotherapy compared to the NK cells from adult donors. This i...

    Authors: Alireza Shokouhifar, Gholamreza Anani Sarab, Mahboubeh Yazdanifar, Mohammad Fereidouni, Masoumeh Nouri and Marzieh Ebrahimi
    Citation: Cancer Cell International 2021 21:298
    Content type: Primary research Published on:

  46. Although many biomarkers have been reported for detecting glioma, the prognosis for the disease remains poor, and therefore, new biomarkers need to be identified. GNG5, which is part of the G-protein family, has ...

    Authors: Wang Zhang, Zhendong Liu, Binchao Liu, Miaomiao Jiang, Shi Yan, Xian Han, Hong Shen, Meng Na, Yanbiao Wang, Zhishuai Ren, Binfeng Liu, Zhenfeng Jiang, Yanzheng Gao and Zhiguo Lin
    Citation: Cancer Cell International 2021 21:297
    Content type: Primary research Published on:

  47. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Shiyi Liu, Feiyan Wang, Wei Tan, Li Zhang, Fangfang Dai, Yanqing Wang, Yaqi Fan, Mengqin Yuan, Dongyong Yang, Yajing Zheng, Zhimin Deng, Yeqiang Liu and Yanxiang Cheng
    Citation: Cancer Cell International 2021 21:296
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2020 20:519

  48. As the essential sexual hormone, estrogen and its receptor has been proved to participate in the regulation of autoimmunity diseases and anti-tumor immunity. The adjustment of tumor immunity is related to the ...

    Authors: Tiecheng Wang, Jiakang Jin, Chao Qian, Jianan Lou, Jinti Lin, Ankai Xu, Kaishun Xia, Libin Jin, Bing Liu, Huimin Tao, Zhengming Yang and Wei Yu
    Citation: Cancer Cell International 2021 21:295
    Content type: Review Published on:

  49. Lung adenocarcinoma (LUAD) is one of the most common types in the world with a high mortality rate. Despite advances in treatment strategies, the overall survival (OS) remains short. Our study aims to establis...

    Authors: Aisha Al-Dherasi, Qi-Tian Huang, Yuwei Liao, Sultan Al-Mosaib, Rulin Hua, Yichen Wang, Ying Yu, Yu Zhang, Xuehong Zhang, Chao Huang, Haithm Mousa, Dongcen Ge, Sufiyan Sufiyan, Wanting Bai, Ruimei Liu, Yanyan Shao…
    Citation: Cancer Cell International 2021 21:294
    Content type: Primary research Published on:

  50. Pancreatic cancer (PC) is a highly fatal and aggressive disease with its incidence and mortality quite discouraging. An effective prediction model is urgently needed for the accurate assessment of patients’ pr...

    Authors: Yuan Chen, Ruiyuan Xu, Rexiati Ruze, Jinshou Yang, Huanyu Wang, Jianlu Song, Lei You, Chengcheng Wang and Yupei Zhao
    Citation: Cancer Cell International 2021 21:291
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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