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  1. Although miR-190 has been reported to be related to human diseases, especially in the development and progression of cancer, its expression in human bladder cancer (BC) and potential contribution to BC remain ...

    Authors: Shirui Huang, Xiaohui Hua, Mengjiao Kuang, Junlan Zhu, Haiqi Mu, Zhongxian Tian, Xiaoqun Zheng and Qipeng Xie
    Citation: Cancer Cell International 2021 21:241
    Content type: Primary research Published on:

  2. Programmed death-1/programmed death ligand-1 (PD-1/PD-L1) based immunotherapy is a revolutionary cancer therapy with great clinical success. The majority of clinically used PD-1/PD-L1 inhibitors are monoclonal...

    Authors: Chang Liu, Navindra P. Seeram and Hang Ma
    Citation: Cancer Cell International 2021 21:239
    Content type: Review Published on:

  3. Colon cancer is a malignant gastrointestinal tumour with high incidence, mortality and metastasis rates worldwide. Aloe-emodin is a monomer compound derived from hydroxyanthraquinone. Aloe-emodin produces a wi...

    Authors: Dongxiao Jiang, Shufei Ding, Zhujun Mao, Liyan You and Yeping Ruan
    Citation: Cancer Cell International 2021 21:238
    Content type: Primary research Published on:

  4. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhenming Jiang, Yuxi Zhang, Xi Chen, Pingeng Wu and Dong Chen
    Citation: Cancer Cell International 2021 21:237
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2019 19:271

  6. Prostate cancer is the most common malignant tumor of male genitourinary system, molecular mechanism of which is still not clear. PSMC2 (proteasome 26S subunit ATPase 2) is a key member of the 19S regulatory s...

    Authors: Qingke Chen, Lingmin Fu, Jieping Hu, Guanghua Guo and An Xie
    Citation: Cancer Cell International 2021 21:235
    Content type: Primary research Published on:

  7. Non-small cell lung cancer (NSCLC) is a common malignancy around the globe. Increasing long non-coding RNAs (lncRNAs) have been confirmed to be associated with the progression of cancers, including NSCLC. Long...

    Authors: Yanchao Deng, Liwei Zhang and Ruiying Luo
    Citation: Cancer Cell International 2021 21:234
    Content type: Primary research Published on:

  8. Invasive bladder tumors cause a worse prognosis in patients and remain a clinical challenge. Epithelial–mesenchymal transition (EMT) is associated with bladder cancer metastasis. In the present research, we at...

    Authors: Yaoyao Xiong, Xiongbing Zu, Long Wang, Yuan Li, Minfeng Chen, Wei He and Lin Qi
    Citation: Cancer Cell International 2021 21:233
    Content type: Primary research Published on:

  9. Anoikis resistance plays a critical role in the tumor metastasis by allowing survival of cancer cells in the systemic circulation. We previously showed that long non-coding RNAs APOC1P1-3 (lncRNA APOC1P1-3) in...

    Authors: Qi Lu, Li Wang, Yabiao Gao, Ping Zhu, Luying Li, Xue Wang, Youping Jin, Xiuling Zhi, Jerry Yu, Xin Li, Xingjun Qin and Ping Zhou
    Citation: Cancer Cell International 2021 21:232
    Content type: Primary research Published on:

  10. Immune cells account for a large proportion of the tumour microenvironment in anaplastic thyroid carcinomas (ATCs). However, the expression pattern of immune-related genes (IRGs) in ATCs is unclear. Our study ...

    Authors: Xuemin Wang, Wen Peng, Chunyan Li, Rujia Qin, Zhaoming Zhong and Chuanzheng Sun
    Citation: Cancer Cell International 2021 21:231
    Content type: Primary research Published on:

  11. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a high risk of induction failure and poor outcomes, with relapse due to drug resistance. Recent studies show that bromodomains and extr...

    Authors: Shuiyan Wu, You Jiang, Yi Hong, Xinran Chu, Zimu Zhang, Yanfang Tao, Ziwei Fan, Zhenjiang Bai, Xiaolu Li, Yanling Chen, Zhiheng Li, Xin Ding, Haitao Lv, Xiaoli Du, Su Lin Lim, Yongping Zhang…
    Citation: Cancer Cell International 2021 21:230
    Content type: Primary research Published on:

  13. Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death. This study aimed to develop and validate reliable prognostic biomarkers and signature.

    Authors: Cui Zhao, Jian Liu, Haomiao Zhou, Xin Qian, Hui Sun, Xuewen Chen, Miaosen Zheng, Tingting Bian, Lei Liu, Yifei Liu and Jianguo Zhang
    Citation: Cancer Cell International 2021 21:228
    Content type: Primary research Published on:

  14. The purpose of this study is to explore the effect of miRNA-539 on osteosarcoma (OS) and the underlying mechanism, so as to find a new method for early diagnosis and treatment of osteosarcoma.

    Authors: Huowen Liu, Min Yang, Yufeng Zhang, Zhiqiang Yang, Zhe Chen, Yuanlong Xie, Binglong Peng and Lin Cai
    Citation: Cancer Cell International 2021 21:227
    Content type: Primary research Published on:

  15. Urothelial carcinoma (UC) is the second most common malignancy of the urinary system with high rate of recurrence, UC patients therefore needed to be treated with surgery followed by chemotherapy. Development ...

    Authors: Yeong-Chin Jou, Guan-Ling Lin, Hon-Yi Lin, Wan-Hong Huang, Yu-Ming Chuang, Ru-Inn Lin, Pie-Che Chen, Shu-Fen Wu, Cheng-Huang Shen and Michael W. Y. Chan
    Citation: Cancer Cell International 2021 21:226
    Content type: Primary research Published on:

  16. Intrahepatic cholangiocarcinoma (iCCA) is the second most common malignant hepatic tumor and has a high postoperative recurrence rate and a poor prognosis. The key roles of most tumor recurrence-associated mol...

    Authors: Fengwei Li, Qinjunjie Chen, Yang Yang, Meihui Li, Lei Zhang, Zhenlin Yan, Junjie Zhang and Kui Wang
    Citation: Cancer Cell International 2021 21:225
    Content type: Primary research Published on:

  17. We aimed to understand the clinical characteristics and better predict the prognosis of patients with mucosal melanoma of the head and neck (MMHN) using a nomogram.

    Authors: Qing-Qing Xu, Qing-Jie Li, Liu Chen, Xin-Yi Su, Jing-Xia Song, Juan Du, Lei Chen and Li-Xia Lu
    Citation: Cancer Cell International 2021 21:224
    Content type: Primary research Published on:

  19. Clear cell renal cell carcinoma (ccRCC) has been the commonest renal cell carcinoma (RCC). Although the disease classification, diagnosis and targeted therapy of RCC has been increasingly evolving attributing ...

    Authors: Xiaoqin Zhang, Ziyue Wang, Zixin Zeng, Ningning Shen, Bin Wang, Yaping Zhang, Honghong Shen, Wei Lu, Rong Wei, Wenxia Ma and Chen Wang
    Citation: Cancer Cell International 2021 21:222
    Content type: Primary research Published on:

  20. MicroRNAs (miRNAs) are a class of small noncoding RNA molecules containing only 20–22 nucleotides. MiRNAs play a role in gene silencing and translation suppression by targeting and binding to mRNA. Proper cont...

    Authors: Yufei Tang, Shaoqi Zong, Hailun Zeng, Xiaofeng Ruan, Liting Yao, Susu Han and Fenggang Hou
    Citation: Cancer Cell International 2021 21:221
    Content type: Review Published on:

  21. Serine hydroxymethyltransferase 2 (SHMT2) is a vital metabolic enzyme in one carbon metabolism catalyzing the conversion of serine to glycine, which has been reported to play a crucial role in the progression ...

    Authors: Yan Liao, Fang Wang, Yadong Zhang, Hongshi Cai, Fan Song and Jinsong Hou
    Citation: Cancer Cell International 2021 21:220
    Content type: Primary research Published on:

  22. Given that dysregulated metabolism has been recently identified as a hallmark of cancer biology, this study aims to establish and validate a prognostic signature of lung adenocarcinoma (LUAD) based on metaboli...

    Authors: Zhihao Wang, Kidane Siele Embaye, Qing Yang, Lingzhi Qin, Chao Zhang, Liwei Liu, Xiaoqian Zhan, Fengdi Zhang, Xi Wang and Shenghui Qin
    Citation: Cancer Cell International 2021 21:219
    Content type: Primary research Published on:

  24. Lung adenocarcinoma (LUAD) metastasis significantly reduces patient survival; hence inhibiting the metastatic ability of lung cancer cells will greatly prolong patient survival. Alkaline phosphatase (ALPL), a ...

    Authors: Zhefeng Lou, Weiwei Lin, Huirong Zhao, Xueli Jiao, Cong Wang, He Zhao, Lu Liu, Yu Liu, Qipeng Xie, Xing Huang, Haishan Huang and Lingling Zhao
    Citation: Cancer Cell International 2021 21:217
    Content type: Primary research Published on:

  25. The third-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have shown significant therapeutic effects on patients with non-small cell lung carcinoma (NSCLC) who carry active ...

    Authors: Yuting Meng, Xixi Qian, Li Zhao, Nan Li, Shengjie Wu, Baoan Chen, Tong Sun and Xuerong Wang
    Citation: Cancer Cell International 2021 21:216
    Content type: Primary research Published on:

  26. MicroRNAs (miRNAs) are involved in the oncogenesis, development and transformation of lung squamous cell carcinoma (LUSC). miR-665 is clinically significant and acts as a pivotal function in some cancers. Neve...

    Authors: Tian-Jun Chen, Qi Zheng, Fei Gao, Tian Yang, Hui Ren, Yang Li and Ming-Wei Chen
    Citation: Cancer Cell International 2021 21:215
    Content type: Primary research Published on:

  27. Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as wel...

    Authors: Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh, Jesus Simal-Gandara, Dalia M. Kopustinskiene, Jurga Bernatoniene and Saeed Samarghandian
    Citation: Cancer Cell International 2021 21:214
    Content type: Review Published on:

  29. Epithelial-mesenchymal transition (EMT) has been associated with wound healing, tumorigenesis, and metastasis. Circular RNAs (circRNAs) are functional non-coding RNAs involved in multiple human cancers. Howeve...

    Authors: Guili Xu, Peng Zhang, Hansi Liang, Yunhua Xu, Jian Shen, Wansheng Wang, Mingming Li, Jintao Huang, Caifang Ni, Xueguang Zhang and Xiaoli Zhu
    Citation: Cancer Cell International 2021 21:212
    Content type: Primary research Published on:

  30. Cancers located on the right and left sides of the colon have distinct clinical and molecular characteristics. This study aimed to explore the regulatory mechanisms of location-specific long noncoding RNAs (ln...

    Authors: Ke-zhi Li, Yi-xin Yin, Yan-ping Tang, Long Long, Ming-zhi Xie, Ji-lin Li, Ke Ding and Bang-li Hu
    Citation: Cancer Cell International 2021 21:211
    Content type: Primary research Published on:

  31. Emerging evidences have revealed that long non-coding RNAs (lncRNAs) have played critical roles in tumor occurrence and progression. LINC00641 has been reported to be involved in the initiation and development...

    Authors: Jianping Zhang, Shengming Jin, Wenjun Xiao, Xuchao Zhu, Chengyou Jia and Zongming Lin
    Citation: Cancer Cell International 2021 21:210
    Content type: Primary research Published on:

  32. The metabolic change of tumor cells is an extremely complicated process that involves the intersection and integration of various signal pathways. Compared with normal tissues, cancer cells show distinguished ...

    Authors: Yuhong Guo, Bin Lv, Renfeng Liu, Zhengzai Dai, Feifei Zhang, Yiping Liang, Bo Yu, Duo Zeng, Xiao-Bin Lv and Zhiping Zhang
    Citation: Cancer Cell International 2021 21:209
    Content type: Review Published on:

  33. Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer. Although there are different treatment options, these strategies are not efficient in terms of restricting the tumor cell’s pr...

    Authors: Zahra Farzaneh, Massoud Vosough, Tarun Agarwal and Maryam Farzaneh
    Citation: Cancer Cell International 2021 21:208
    Content type: Review Published on:

  35. Cervical cancer is a type of the most common gynecology tumor in women of the whole world. Accumulating data have shown that icariin (ICA), a natural compound, has anti-cancer activity in different cancers, in...

    Authors: Chunyang Li, Shuangqing Yang, Huaqing Ma, Mengjia Ruan, Luyan Fang and Jing Cheng
    Citation: Cancer Cell International 2021 21:206
    Content type: Primary research Published on:

  36. Preoperative tumor markers, inflammation, and nutritional status are considered important predictors of prognosis and tumor response in locally advanced rectal cancer (LARC) patients. This study aims to explor...

    Authors: Siyi Lu, Zhenzhen Liu, Bingyan Wang, Fei Li, Yan Meng, Junwei Wang, Yuxia Wang, Hao Wang, Xin Zhou and Wei Fu
    Citation: Cancer Cell International 2021 21:205
    Content type: Primary research Published on:

  37. Relapse and metastasis in colorectal cancer (CRC) are often attributed to cancer stem-like cells (CSCs), as small sub-population of tumor cells with ability of drug resistance. Accordingly, development of appr...

    Authors: Elmira Gheytanchi, Marzieh Naseri, Feridoun Karimi-Busheri, Fatemeh Atyabi, Ensie Sadat Mirsharif, Mahmood Bozorgmehr, Roya Ghods and Zahra Madjd
    Citation: Cancer Cell International 2021 21:204
    Content type: Primary research Published on:

  38. Long non-coding RNA is considered to be essential to modulate the development and progression of human malignant cancers. And long non-coding RNA can act as crucial modulators by sponging the corresponding mic...

    Authors: Qingyun Pan, Ying Huang, Yirui Wang, Deke Li and Changjiang Lei
    Citation: Cancer Cell International 2021 21:203
    Content type: Primary research Published on:

  39. Microarray profiles of hepatocellular carcinoma (HCC) identified that long intergenic noncoding RNA 00221 (LINC00221) was upregulated. Herein, we aimed to identify the functional significance and underlying me...

    Authors: Lin Yang, Hailong Si, Meng Ma, Yu Fang, Yina Jiang, Jintao Wang, Cheng Zhang and Haijuan Xiao
    Citation: Cancer Cell International 2021 21:202
    Content type: Primary research Published on:

  40. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-021-01905-z

    Authors: Hongwang Song, Xiaojun Fu, Chenxing Wu and Shouwei Li
    Citation: Cancer Cell International 2021 21:201
    Content type: Retraction Note Published on:

    The original article was published in Cancer Cell International 2020 20:489

  41. VEGF and its receptor family (VEGFR) members have unique signaling transduction system that play significant roles in most pathological processes, such as angiogenesis in tumor growth and metastasis. VEGF-VEGF...

    Authors: Farnaz Khodabakhsh, Parnaz Merikhian, Mohammad Reza Eisavand and Leila Farahmand
    Citation: Cancer Cell International 2021 21:200
    Content type: Review Published on:

  42. Breast cancer (BC) is one of the commonest female cancers, which is characterized with high incidence. Although treatments have been improved, the prognosis of BC patients in advanced stages remains unsatisfac...

    Authors: Dilihumaer Tuluhong, Tao Chen, Jingjie Wang, Huijuan Zeng, Hanjun Li, Wangmu Dunzhu, Qiurong Li and Shaohua Wang
    Citation: Cancer Cell International 2021 21:199
    Content type: Primary research Published on:

  43. Acute myeloid leukaemia (AML) is an aggressive blood cancer. In approximately 30% of the cases, driver mutations in the FLT3 gene are identified. FLT3 inhibitors are used in treatment of such patients together...

    Authors: Jingmei Yang, H. Jonathan G. Lindström and Ran Friedman
    Citation: Cancer Cell International 2021 21:198
    Content type: Primary research Published on:

  44. Osteosarcoma is an aggressive malignant tumor which has attracted worldwide attention. MEX3A may be associated with tumors while has not yet seen its coverage on osteosarcoma. Herein, this study was to investi...

    Authors: Bangmin Wang, Zheping Hong, Chen Zhao, Qing Bi, Junhui Yuan, Jihang Chen and Yi Shen
    Citation: Cancer Cell International 2021 21:197
    Content type: Primary research Published on:

  45. High tumor mutation burden (TMB) has gradually become a sensitive biomarker for predicting the response to immunotherapy in many cancers, including lung, bladder and head and neck cancers. However, whether hig...

    Authors: Rong Tang, Xiaomeng Liu, Wei Wang, Jie Hua, Jin Xu, Chen Liang, Qingcai Meng, Jiang Liu, Bo Zhang, Xianjun Yu and Si Shi
    Citation: Cancer Cell International 2021 21:196
    Content type: Primary research Published on:

  46. Non-germinal center B-cell-like diffuse large B-cell lymphoma (non-GCB-DLBCL) has worse clinical outcome than GCB-DLBCL, and some relapsed/refractory non-GCB-DLBCL (R/R non-GCB-DLBCL) are even resistant to CD2...

    Authors: Xin Xu, Ting Wei, Weijie Zhong, Rosalind Ang, Ye Lei, Hui Zhang and Qingshan Li
    Citation: Cancer Cell International 2021 21:195
    Content type: Primary research Published on:

  47. Colorectal cancer (CRC) is the third most common cause of cancer globally and the fourth attributable cause of mortality and morbidity due to cancer. An emerging factor contributing to CRC is the gut microbiot...

    Authors: Maryam Ranjbar, Rasoul Salehi, Shaghayegh Haghjooy Javanmard, Laleh Rafiee, Habibollah Faraji, Sima jafarpor, Gordon A. Ferns, Majid Ghayour-Mobarhan, Mostafa Manian and Reza Nedaeinia
    Citation: Cancer Cell International 2021 21:194
    Content type: Review Published on:

    The Correction to this article has been published in Cancer Cell International 2022 22:134

  48. Ovarian epithelial cancer is one of the leading malignant tumors in gynecology and lacks effective diagnostic and prognostic markers. Our study aims to screen and verify ovarian epithelial cancer biomarkers.

    Authors: Xiaoying Chang, Dan Li, Chang Liu, Zhe Zhang and Tao Wang
    Citation: Cancer Cell International 2021 21:193
    Content type: Primary research Published on:

  49. Prostate cancer (PCa) is the most common malignant tumor in developed countries, which has seriously threatened men’s lifestyle and quality of life. The up-regulation of EZH2 is associated with advanced PCa an...

    Authors: Mengyuan Jin, Jiachen Duan, Wei Liu, Jing Ji, Bin Liu and Mingzhi Zhang
    Citation: Cancer Cell International 2021 21:191
    Content type: Primary research Published on:

  50. Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In recent years, there has been a keen interest towards the development of natural extracts-based cancer therapeutics with ...

    Authors: Zeeshan Javed, Haleema Sadia, Muhammad Javed Iqbal, Shazia Shamas, Kausar Malik, Rais Ahmed, Shahid Raza, Monica Butnariu, Natalia Cruz-Martins and Javad Sharifi-Rad
    Citation: Cancer Cell International 2021 21:189
    Content type: Review Published on:
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Cancer Cell International

ISSN: 1475-2867

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