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  1. Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with stem cell property. Increased evidence suggest that CSCs could be responsible for chemoresistance and recurrence in colorectal can...

    Authors: Zhao-liang Yu, Yu-feng Chen, Bin Zheng, Ze-rong Cai, Yi-feng Zou, Jia Ke, Ping Lan, Feng Gao and Xiao-jian Wu
    Citation: Cancer Cell International 2021 21:94
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:176

  2. Epstein-Barr virus (EBV) is closely associated with multiple human cancers. EBV-associated cancers are mainly lymphomas derived from B cells and T cells (Hodgkin lymphoma, Burkitt lymphoma, NK/T-cell lymphoma,...

    Authors: Yin Luo, Yitong Liu, Chengkun Wang and Runliang Gan
    Citation: Cancer Cell International 2021 21:93
    Content type: Review Published on:

  3. For patients with hepatocellular carcinoma (HCC) with microvascular invasion (MVI) after curative resection, the effects of various postoperative adjuvant therapies are not summarized in detail, and the compar...

    Authors: Jiarui Yang, Hao Liang, Kunpeng Hu, Zhiyong Xiong, Mingbo Cao, Zhaozhong Zhong, Zhicheng Yao and Meihai Deng
    Citation: Cancer Cell International 2021 21:92
    Content type: Review Published on:

  4. Exosomes are known to transmit microRNAs (miRNAs) to affect cancer progression, while the role of M2 macrophages-derived exosomes (M2 exosomes) conveying miR-501-3p in lung cancer (LC) remains unknown. We aim ...

    Authors: Jie Lei, Peng Chen, Feng Zhang, Na Zhang, Jianfei Zhu, Xiaoping Wang and Tao Jiang
    Citation: Cancer Cell International 2021 21:91
    Content type: Primary research Published on:

  5. Osteosarcoma is one of the most prevalent primary bone tumours in adolescents. Accumulating evidence shows that aberrant expression of the long non-coding RNA (lncRNA) NEAT1 and microRNA-483 (miR-483) contribu...

    Authors: Yan Chen, Jun Li, Jia-Kun Xiao, Lei Xiao, Bin-Wu Xu and Chen Li
    Citation: Cancer Cell International 2021 21:90
    Content type: Primary research Published on:

  6. MicroRNAs are a class of non-coding RNAs that regulate gene expression through binding to mRNAs and preventing their translation. One family of microRNAs known as the miR-200 family is an important regulator o...

    Authors: K. Simpson, G. Conquer-van Heumen, K. L. Watson, M. Roth, C. J. Martin and R. A. Moorehead
    Citation: Cancer Cell International 2021 21:89
    Content type: Primary research Published on:

  7. Utrophin (UTRN), as a tumor suppressor gene, is involved in various cancer progression. The function of UTRN in the melanoma process and the related molecular mechanisms are still unclear. Herein, we studied the ...

    Authors: Sitong Zhou, Wen Ouyang, Xi Zhang, Lexi Liao, Xiaobing Pi, Ronghua Yang, Baiqiang Mei, Huaiyuan Xu, Shijian Xiang and Jiehua Li
    Citation: Cancer Cell International 2021 21:88
    Content type: Primary research Published on:

  9. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Lianghai Wang, Lisha Zhou, Jun Hou, Jin Meng, Ke Lin, Xiangwei Wu and Xueling Chen
    Citation: Cancer Cell International 2021 21:86
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2021 21:72

  12. Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer deaths worldwide. Besides common therapeutic approaches, such as surgery, chemotherapy, and radiotherapy, novel th...

    Authors: Ke-Tao Jin, Bo Chen, Yu-Yao Liu, H uan-Rong Lan and Jie-Ping Yan
    Citation: Cancer Cell International 2021 21:83
    Content type: Review Published on:

  13. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-021-01786-2

    Authors: Kaushik Kumar Dey, Siddik Sarkar, Ipsita Pal, Subhasis Das, Goutam Dey, Rashmi Bharti, Payel Banik, Joygopal Roy, Sukumar Maity, Indranil Kulavi and Mahitosh Mandal
    Citation: Cancer Cell International 2021 21:82
    Content type: Retraction Note Published on:

    The original article was published in Cancer Cell International 2015 15:74

  14. Liver cancer (LC) is one of the most fatal cancers throughout the world. More efficient and sensitive gene signatures that could accurately predict survival in LC patients are vitally needed to promote a bette...

    Authors: Wenjing Zhu, Qiliang Zhang, Min Liu, Meixing Yan, Xiao Chu and Yongchun Li
    Citation: Cancer Cell International 2021 21:81
    Content type: Primary research Published on:

  15. UCEC is the most common gynecological malignancy in many countries, and its mechanism of occurrence and development is related to tumor mutation burden (TMB) and immune cell infiltration. Therefore, it is nece...

    Authors: Ling Zhao, Xueshu Fu, Xiling Han, Yanjun Yu, Yaping Ye and Jun Gao
    Citation: Cancer Cell International 2021 21:80
    Content type: Primary research Published on:

  18. Prostate cancer (PC) is a multifactorial disease characterized by the abrogation of androgen receptor signaling. Advancement in microbiology techniques has highlighted the significant role of microRNAs (miRNAs...

    Authors: Zeeshan Javed, Khushbukhat Khan, Amna Rasheed, Haleema Sadia, Muhammad Naeem Shahwani, Asma Irshad, Shahid Raza, Bahare Salehi, Javad Sharifi-Rad, Hafiz A. R. Suleria, Natália Cruz-Martins and Cristina Quispe
    Citation: Cancer Cell International 2021 21:77
    Content type: Review Published on:

  19. Glioblastoma (GBM) is the most common and malignant Grade IV primary craniocerebral tumor caused by glial cell carcinogenesis with an extremely poor median survival of 12–18 months. The current standard treatm...

    Authors: Xin Xu, Wenli Chen, Wenjun Zhu, Jing Chen, Bin Ma, Jianxia Ding, Zaichuan Wang, Yifei Li, Yeming Wang and Xiaochun Zhang
    Citation: Cancer Cell International 2021 21:76
    Content type: Review Published on:

  20. The regulator of cullins-1 (ROC1) is an essential subunit in the cullin-RING ligase (CRL) protein complex and has been shown to be critical in bladder cancer cell survival and progression. This study aimed to ...

    Authors: W. Wang, J. Qiu, P. Qu, H. Chen, J. Lan, H. Chen, L. Li and M. Gu
    Citation: Cancer Cell International 2021 21:75
    Content type: Primary research Published on:

  21. Lung cancer is one of the important health threats worldwide, of which 5-year survival rate is less than 15%. Non-small-cell lung cancer (NSCLC) accounts for about 80% of all lung cancer with high metastasis a...

    Authors: Yuxin Qi, Wenping Yang, Shuang Liu, Fanjie Han, Haibin Wang, Yonghong Zhao, Yufa Zhou and Daijun Zhou
    Citation: Cancer Cell International 2021 21:74
    Content type: Primary research Published on:

  22. Non-small cell lung cancer (NSCLC) is a threat to human health. Circular RNAs (circRNAs) have been proved to function in NSCLC development. In this study, the role of circRNA hsa_circ_0010235 in NSCLC progress...

    Authors: Furui Zhang, Ruirui Cheng, Ping Li, Chunya Lu and Guojun Zhang
    Citation: Cancer Cell International 2021 21:73
    Content type: Primary research Published on:

  23. The regulatory roles of circular RNAs (circRNAs) in tumorigenesis have attracted increasing attention. However, novel circRNAs with the potential to be used as serum/plasma biomarkers and their regulatory mech...

    Authors: Lianghai Wang, Lisha Zhou, Jun Hou, Jin Meng, Ke Lin, Xiangwei Wu and Xueling Chen
    Citation: Cancer Cell International 2021 21:72
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:86

  24. Recent studies have established the roles of microRNAs (miRNAs) in cancer progression. The aberrant expression of miR-335-5p has been reported in many cancers, including gastric cancer (GC). In this study, the...

    Authors: Yi Gao, Yanfeng Wang, Xiaofei Wang, Changan Zhao, Fenghui Wang, Juan Du, Huahua Zhang, Haiyan Shi, Yun Feng, Dan Li, Jing Yan, Yan Yao, Weihong Hu, Ruxin Ding, Mengjie Zhang, Lumin Wang…
    Citation: Cancer Cell International 2021 21:71
    Content type: Primary research Published on:

  25. Gastric cancer is one of the most prevalent and deadly malignancies without efficient treatment option. This study aimed to investigate the effect of hydrogen gas on the behavior of gastric cancer cells.

    Authors: Baocheng Zhu, Hengguan Cui and Weiqiang Xu
    Citation: Cancer Cell International 2021 21:70
    Content type: Primary research Published on:

  26. Colorectal cancer (CRC) is among the deadliest cancers, wherein early dissemination of tumor cells, and consequently, metastasis formation, are the main causes of mortality and poor prognosis. Cofilin-1 (CFL-1...

    Authors: Annie Cristhine Moraes Sousa-Squiavinato, Renata Ivo Vasconcelos, Adriana Sartorio Gehren, Priscila Valverde Fernandes, Ivanir Martins de Oliveira, Mariana Boroni and Jose Andrés Morgado-Díaz
    Citation: Cancer Cell International 2021 21:69
    Content type: Primary research Published on:

  27. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) could interact with each other to play a vital role in the pathogenesis of cancers. We aimed to examine the expression profile, clinical significance and r...

    Authors: Jingjing Jing, Xu Zhao, Jiannan Wang and Tan Li
    Citation: Cancer Cell International 2021 21:68
    Content type: Primary research Published on:

  28. Bladder cancer (BCa) is a malignant tumor that occurs on the mucosa of the bladder, in which dysregulated long non-coding RNAs (lncRNAs) are involved. This study investigated the effect of lncRNA small nucleol...

    Authors: Rui Feng, Zhongxing Li, Xing Wang, Guangcheng Ge, Yuejun Jia, Dan Wu, Yali Ji and Chenghao Wang
    Citation: Cancer Cell International 2021 21:67
    Content type: Primary research Published on:

  29. Gastric cancer (GC) is one of the most common cancers with high malignancy. In spite of the great development in diagnostic tools and application of anti-tumor drugs, we have not witnessed a significant increa...

    Authors: Milad Ashrafizadeh, Hossein Rafiei, Reza Mohammadinejad, Tahereh Farkhondeh and Saeed Samarghandian
    Citation: Cancer Cell International 2021 21:66
    Content type: Review Published on:

  30. Lung cancer is the most common malignant tumor. Identification of novel diagnostic and prognostic biomarkers for lung cancer is a key research imperative. The role of centromere protein K (CENPK) in cancer is ...

    Authors: Jiayu Ma, Xiaochuan Chen, Mingqiang Lin, Zhiping Wang, Yahua Wu and Jiancheng Li
    Citation: Cancer Cell International 2021 21:65
    Content type: Primary research Published on:

  31. Hedgehog (Hh) signaling pathway, which is essential for cell proliferation and differentiation, is noted to be aberrantly activated in tumor from increasing studies in recent years. MicroRNAs (miRNAs) as an im...

    Authors: Jiong Ma, Chunxia Zhou and Xuejun Chen
    Citation: Cancer Cell International 2021 21:64
    Content type: Primary research Published on:

  32. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce substantial cytotoxicity in tumor cells but rarely exert cytotoxic activity on non-transformed cells. In the present study, we therefo...

    Authors: Shihai Liu, Jing Qiu, Guifang He, Weitai He, Changchang Liu, Duo Cai and Huazheng Pan
    Citation: Cancer Cell International 2021 21:63
    Content type: Primary research Published on:

  33. Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels suppl...

    Authors: Asieh Emami Nejad, Simin Najafgholian, Alireza Rostami, Alireza Sistani, Samaneh Shojaeifar, Mojgan Esparvarinha, Reza Nedaeinia, Shaghayegh Haghjooy Javanmard, Marjan Taherian, Mojtaba Ahmadlou, Rasoul Salehi, Bahman Sadeghi and Mostafa Manian
    Citation: Cancer Cell International 2021 21:62
    Content type: Review Published on:

  34. Studies have shown the value of subtypes and distribution of gastric intestinal metaplasia (GIM) for prediction of gastric cancer. We aim to combine GIM subtypes and distribution to form a new scoring system f...

    Authors: Ning Wei, Zhiheng Zhong and Ruihua Shi
    Citation: Cancer Cell International 2021 21:61
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:132

  37. Interferon regulatory factor 4 (IRF4) is a transcription factor from the IRF factor family that exerts regulatory functions in the immune system and oncogenesis. However, the biological role of IRF4 in colon c...

    Authors: Jiwei Wang, Song Li, Honglang Li, Xiaoshuang Zhou, Huabin Wen and Bin Lai
    Citation: Cancer Cell International 2021 21:58
    Content type: Primary research Published on:

  38. Drug resistance and metastasis involving hypoxic tumor environments and persistent stem cell populations are detrimental to the survival of patients with non-small cell lung carcinoma (NSCLC). Tie1 is upregula...

    Authors: Chaojie Li, Nannan Yang, Zhijin Chen, Ning Xia, Qungang Shan, Ziyin Wang, Jian Lu, Mingyi Shang and Zhongmin Wang
    Citation: Cancer Cell International 2021 21:57
    Content type: Primary research Published on:

  39. Increasing evidence has demonstrated that snoRNAs play crucial roles in tumorigenesis of various cancer types. However, researches on snoRNAs in ccRCC were very little. This study mainly aimed to validate the ...

    Authors: Xiaoling Shang, Xingguo Song, Kangyu Wang, Miao Yu, Shanshan Ding, Xiaohan Dong, Li Xie and Xianrang Song
    Citation: Cancer Cell International 2021 21:56
    Content type: Primary research Published on:

  40. Resistance to drug therapy is a major impediment for successful treatment of patients suffering from breast cancer (BC). Tamoxifen (TAM) is an extensively used therapeutic agent, which substantially reduces th...

    Authors: Jianhui Liu, Shaoliang Zhu, Wei Tang, Qinghua Huang, Yan Mei and Huawei Yang
    Citation: Cancer Cell International 2021 21:55
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:673

    The Correction to this article has been published in Cancer Cell International 2021 21:240

  41. Increasing evidence manifested that circular RNAs (circRNAs) acted as crucial regulators in human cancers by targeting the miRNA/mRNA axis, including cervical cancer (CC). Circ_0007534 was reported to promote ...

    Authors: Qiang Sun, Xiangying Qi, Wenyan Zhang and Xiaoyu Li
    Citation: Cancer Cell International 2021 21:54
    Content type: Primary research Published on:

  42. Acute myeloid leukemia (AML) remains a devastating disease with a 5-year survival rate of less than 30%. AML treatment has undergone significant changes in recent years, incorporating novel targeted therapies ...

    Authors: May Levin, Michal Stark, Yishai Ofran and Yehuda G. Assaraf
    Citation: Cancer Cell International 2021 21:53
    Content type: Primary research Published on:

  43. Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hin...

    Authors: Heena Saini, Harshita Sharma, Sudeshna Mukherjee, Shibasish Chowdhury and Rajdeep Chowdhury
    Citation: Cancer Cell International 2021 21:52
    Content type: Primary research Published on:

  44. It has been reported that the lncRNA SNHG16 has significantly increased expression in pancreatic adenocarcinoma (PC). However, the functions and mechanisms of SNHG16 are not clear. The aim of this study was to...

    Authors: Hao Xu, Xin Miao, Xin Li, Haofei Chen, Bo Zhang and Wence Zhou
    Citation: Cancer Cell International 2021 21:51
    Content type: Primary research Published on:

  45. The exosomal nucleic acid (exoNA) from the plasma and pleural fluid can potentially provide means to identify genomic changes in non-small cell lung cancer (NSCLC) patients who develop resistance to targeted e...

    Authors: Yoonjung Kim, Saeam Shin and Kyung-A Lee
    Citation: Cancer Cell International 2021 21:50
    Content type: Primary research Published on:

  46. Serum Deprivation Protein Response (SDPR) plays an important role in formation of pulmonary alveoli. However, the functions and values of SDPR in lung cancer remain unknown. We explored prognostic value, expre...

    Authors: Xiaoqing Luo, Shunli Peng, Sijie Ding, Qin Zeng, Rong Wang, Yueyun Ma, ShiYu Chen, Yanxia Wang and Wei Wang
    Citation: Cancer Cell International 2021 21:49
    Content type: Primary research Published on:

  47. Cell division cycle associated 4 (CDCA4) has been reported to be engaged into the progression of several cancers. The function of CDCA4 in Non-small cell lung cancer (NSCLC) was unknown. We aimed to explore th...

    Authors: Chenxin Xu, Haixia Cao, Ying Sui, Hui Zhang, Chen Shi, Jianzhong Wu, Rong Ma and Jifeng Feng
    Citation: Cancer Cell International 2021 21:48
    Content type: Primary research Published on:

  48. The incidence of multiple primary malignant tumors (MPMTs) is rising due to the development of screening technologies, significant treatment advances and increased aging of the population. For patients with a ...

    Authors: Yu Zheng, Yifeng Sun, Yue Kuai, Guoxiang Fu, Huimin An, Jinyun Chen, Jinying Chen, Jiajun Zhu, Yixin Wo, Yiwang Wu, Kaibin Song, Qinghua Xu, Di Wu, Deshuang Huang, Qifeng Wang and Hongming Pan
    Citation: Cancer Cell International 2021 21:47
    Content type: Primary research Published on:

  49. Castration-resistant prostate cancer (CRPC) remains prostate cancer research and treatment bottleneck. Abnormal androgen receptor (AR) activation still has a pivotal role in CRPC. Multiple mechanisms involve t...

    Authors: Dali Tong
    Citation: Cancer Cell International 2021 21:45
    Content type: Hypothesis Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:301

  50. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-021-01759-5.

    Authors: Jin Gao, Yuan Yuan, Lili Zhang, Shaorong Yu, Jianwei Lu, Jifeng Feng and Sainan Hu
    Citation: Cancer Cell International 2021 21:40
    Content type: Retraction Note Published on:

    The original article was published in Cancer Cell International 2020 20:90

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Cancer Cell International

ISSN: 1475-2867

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