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  1. Exosomes, emerging mediators of intercellular communication, are reported to transfer certain non-coding RNAs, such as microRNAs (miRNAs), which play a crucial role in cancer progression. The objective of this...

    Authors: Mingjun Li, Qianqian Wang, Xiaofei Zhang, Ningning Yan and Xingya Li
    Citation: Cancer Cell International 2020 20:574
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:289

  2. Ovarian cancer greatly threatens the general health of women worldwide. Implementation of predictive prognostic biomarkers aids in ovarian cancer management.

    Authors: Jiahong Tan, Kangjia Tao, Xu Zheng, Dan Liu, Ding Ma and Qinglei Gao
    Citation: Cancer Cell International 2020 20:598
    Content type: Primary research Published on:

  3. Glioblastoma (GBM) is the most lethal brain tumor characterized by high morbidity and limited treatment options. Tumor malignancy is usually associated with the epigenetic marks, which coordinate gene expressi...

    Authors: Aliaksandr A. Yarmishyn, Yi-Ping Yang, Kai-Hsi Lu, Yi-Chen Chen, Yueh Chien, Shih-Jie Chou, Ping-Hsing Tsai, Hsin-I. Ma, Chian-Shiu Chien, Ming-Teh Chen and Mong-Lien Wang
    Citation: Cancer Cell International 2020 20:597
    Content type: Primary research Published on:

  4. Glutathione Peroxidase 8 (GPX8) as a member of the glutathione peroxidase (GPx) family plays an important role in anti-oxidation. Besides, dysregulation of GPX8 has been found in gastric cancer, but its detail...

    Authors: Hong Chen, Lu Xu, Zhi-li Shan, Shu Chen and Hao Hu
    Citation: Cancer Cell International 2020 20:596
    Content type: Primary research Published on:

  5. In terms of biological behavior, gene regulation, or signaling pathways, there is a certain similarity between tumorigenesis and embryonic development of humans. Three germ layer structure exhibits the distinc...

    Authors: Xingjie Gao, Xiaoteng Cui, Xinxin Zhang, Chunyan Zhao, Nan Zhang, Yan Zhao, Yuanyuan Ren, Chao Su, Lin Ge, Shaoyuan Wu and Jie Yang
    Citation: Cancer Cell International 2020 20:595
    Content type: Primary research Published on:

  6. Recent studies suggest that long noncoding RNAs (lncRNAs) play an important role in tumorigenesis. As a newly identified lncRNA, the role of XIST in colorectal cancer (CRC) has not been established. Here, we s...

    Authors: Nan Wang, Jia-Xing He, Guo-Zhan Jia, Ke Wang, Shuai Zhou, Tao Wu and Xian-Li He
    Citation: Cancer Cell International 2020 20:553
    Content type: Primary research Published on:

  7. Activating transcription factor 2 (ATF2), a member of the activator protein 1 (AP-1) transcription factor family, has been shown to be involved in the pathobiology of numerous cancers. However, the biological ...

    Authors: Jian Liu, Kai Li, Rui Wang, Sisi Chen, Jie Wu, Xiang Li, Qian Ning, Ganghua Yang and Yamei Pang
    Citation: Cancer Cell International 2020 20:594
    Content type: Primary research Published on:

  8. Circular RNAs (circRNAs) can regulate gene expression in different malignancies. However, the biological functions of circRNA polo-like kinase-1 (circPLK1) in the tumorigenesis of breast cancer (BC) and its po...

    Authors: Guanhong Lin, Shenyu Wang, Xinyu Zhang and Dan Wang
    Citation: Cancer Cell International 2020 20:593
    Content type: Primary research Published on:

  9. The ability to treat glioblastoma (GBM) using the chemotherapeutic agent temozolomide (TMZ) has been hampered by the development of therapeutic resistance. In this study, we assessed the ability of the isoquin...

    Authors: Huiling Qu, Xiaofu Song, Zhuyin Song, Xin Jiang, Xin Gao, Lijuan Bai, Jiao Wu, Li Na and Zhicheng Yao
    Citation: Cancer Cell International 2020 20:592
    Content type: Primary research Published on:

  10. A host of researches have demonstrated the regulation of long non-coding RNAs (lncRNAs) in the progression of pancreatic cancers (PC). In this study, our main task was to analyze the function of MAF bZIP trans...

    Authors: Liqing Ye, Weijian Feng, Hanqin Weng, Chongde Yuan, Jia Liu and Zaiguo Wang
    Citation: Cancer Cell International 2020 20:591
    Content type: Primary research Published on:

  11. Although advanced non-squamous non-small cell lung cancer (NSCLC) patients have significantly better survival outcomes after pemetrexed based treatment, a subset of patients still show intrinsic resistance and...

    Authors: Bo Jia, Zhi Dong, Di Wu, Jun Zhao, Meina Wu, Tongtong An, Yuyan Wang, Minglei Zhuo, Jianjie Li, Yang Wang, Jie Zhang, Xinghui Zhao, Sheng Li, Junfeng Li, Menglei Ma, Chen Chen…
    Citation: Cancer Cell International 2020 20:590
    Content type: Primary research Published on:

  12. In past few years, long non-coding RNAs (lncRNAs) have been reported to play regulatory roles during cancer progression. LncRNA SNHG10 has been explored in several sorts of cancers. However, its detailed role ...

    Authors: Lide Jin, Shengquan Huang, Congjin Guan and Shun Chang
    Citation: Cancer Cell International 2020 20:589
    Content type: Primary research Published on:

  13. It is increasingly evidenced that long non-coding RNAs (lncRNAs) play an important role in various diseases. LncRNA LINC01194 acts as an oncogene in several cancer types. Nevertheless, the role of LINC01194 in...

    Authors: Fanmei Meng, Yijing Zhou, Baohua Dong, Aiqin Dong and Jingtao Zhang
    Citation: Cancer Cell International 2020 20:588
    Content type: Primary research Published on:

  14. Ferroptosis is the process of cell death triggered by lipid peroxides, and inhibition of glutathione (GSH) synthesis leads to ferroptosis. Liver cancer progression is closely linked to ferroptosis suppression....

    Authors: Yueyue Yang, Jiafei Lin, Susu Guo, Xiangfei Xue, Yikun Wang, Shiyu Qiu, Jiangtao Cui, Lifang Ma, Xiao Zhang and Jiayi Wang
    Citation: Cancer Cell International 2020 20:587
    Content type: Primary research Published on:

  15. M2-polarized tumor-associated macrophages (M2-TAMs) have been shown to correlate with the progression of various cancers, including intrahepatic cholangiocarcinoma (ICC). However, the interactions and mechanis...

    Authors: Hui Yuan, Zelong Lin, Yingjun Liu, Yuchuan Jiang, Ke Liu, Mengxian Tu, Nan Yao, Chen Qu and Jian Hong
    Citation: Cancer Cell International 2020 20:586
    Content type: Primary research Published on:

  16. RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associat...

    Authors: Shanshan Xie, Wenwen Chen, Kanghua Chen, Yongxia Chang, Feng Yang, Aifu Lin, Qiang Shu, Tianhua Zhou and Xiaoyi Yan
    Citation: Cancer Cell International 2020 20:585
    Content type: Review Published on:

  17. VHL mutation is the most common mutation in clear cell renal cell carcinoma (ccRCC). Here, we developed and validated an immune-related signature to predict the prognosis of ccRCC with VHL mutations.

    Authors: Jin Zhang, Aiting Yan, Wei Cao, Honglei Shi, Kai Cao and Xiaowu Liu
    Citation: Cancer Cell International 2020 20:584
    Content type: Primary research Published on:

  18. PD-L1 inhibitors is widely applied in lung adenocarcinoma patients. Tumor cells with high PD-L1 expression could trigger immune evasion. Cancer stem cells (CSCs) can evade from immunesurveillance due to their ...

    Authors: Chenyue Zhang, Hui Wang, Xia Wang, Chenglong Zhao and Haiyong Wang
    Citation: Cancer Cell International 2020 20:583
    Content type: Primary research Published on:

  19. Plasmacytoid dendritic cells (pDCs) are present in various primary and metastatic human neoplasms; however, their clinical significance in intrahepatic cholangiocarcinoma is not clear.

    Authors: Zhi-Qiang Hu, Zheng-Jun Zhou, Chu-Bin Luo, Hao-Yang Xin, Jia Li, Song-Yang Yu and Shao-Lai Zhou
    Citation: Cancer Cell International 2020 20:582
    Content type: Primary research Published on:

  20. Long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) exhibits an oncogenic role in multiple cancers, including gastric cancer (GC). But, the functions of NEAT1 in modulating radio-sensitivity of G...

    Authors: Ying Jiang, Shan Jin, Shisheng Tan, Yingbo Xue and Xue Cao
    Citation: Cancer Cell International 2020 20:581
    Content type: Primary research Published on:

  21. Despite an enormous research effort, patients diagnosed with advanced colorectal cancer (CRC) still have low prognosis after surgical resection and chemotherapy. The major obstacle for CRC treatment is chemore...

    Authors: Xianjun Sun, Wenhou Hou, Xin Liu, Jie Chai, Hongliang Guo and Jinming Yu
    Citation: Cancer Cell International 2020 20:580
    Content type: Primary research Published on:

  22. Cancer stem cells (CSCs) have been recognized as an important drug target, however, the underlying mechanisms have not been fully understood. SKP1 is a traditional drug target for cancer therapy, while, whethe...

    Authors: Cong Tian, Tingyuan Lang, Jiangfeng Qiu, Kun Han, Lei Zhou, Daliu Min, Zhiqi Zhang and Dachuan Qi
    Citation: Cancer Cell International 2020 20:579
    Content type: Primary research Published on:

  23. Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. In colorectal cancer, an early mut...

    Authors: Ronja S. Adam, Sanne M. van Neerven, Cayetano Pleguezuelos-Manzano, Salvatore Simmini, Nicolas Léveillé, Nina E. de Groot, Andrew N. Holding, Florian Markowetz and Louis Vermeulen
    Citation: Cancer Cell International 2020 20:578
    Content type: Primary research Published on:

  25. Radiation resistance is a major obstacle to the prognosis of cervical cancer (CC) patients. Many studies have confirmed that long non-coding RNAs (lncRNAs) are involved in the regulation of radiosensitivity of...

    Authors: Chen Wang, Shiqing Shao, Li Deng, Shelian Wang and Yongyan Zhang
    Citation: Cancer Cell International 2020 20:554
    Content type: Primary research Published on:

  26. Autophagy plays an essential role in metastasis of malignancies. Although our studies showed that Aurora-B facilitate pulmonary metastasis in OS, the mechanism of Aurora-B kinase on autophagy and metastasis in...

    Authors: Xin Wu, Jia-ming Liu, Hong-hai Song, Qi-kun Yang, Hui Ying, Wei-lai Tong, Yang Zhou and Zhi-li Liu
    Citation: Cancer Cell International 2020 20:575
    Content type: Primary research Published on:

  27. Gliomas are one of the most common primary tumors of the central nervous system, and have an unfavorable prognosis. SLC39A1 is a zinc ion transport protein which inhibits the progression of prostate cancer. By...

    Authors: Peng Wang, Jingjing Zhang, Shuai He, Boan Xiao and Xiaobin Peng
    Citation: Cancer Cell International 2020 20:573
    Content type: Primary research Published on:

  29. Prostate cancer (PC) is common male cancer with high mortality worldwide. Emerging evidence demonstrated that long noncoding RNAs (lncRNAs) play critical roles in various type of cancers including PC by servin...

    Authors: Yunxia Zhang and Yang Li
    Citation: Cancer Cell International 2020 20:571
    Content type: Primary research Published on:

  31. Expression of the long non-coding mRNA LINC00152 has been reported to correlate with cancer cell resistance to oxaliplatin (L-OHP). However, little is known regarding the molecular mechanism of LINC00152 in es...

    Authors: Shuyao Zhang, Wei Liao, Qinshui Wu, Xiaoshan Huang, Zhen Pan, Wang Chen, Shuyi Gu, Zuojun Huang, Yiwen Wang, Xu Tang, Shanshan Liang, Xiaoyan Zhang, Yun Chen, Shuang Chen, Wanying Chen, Yi Jiang…
    Citation: Cancer Cell International 2020 20:569
    Content type: Primary research Published on:

  32. Colorectal adenocarcinoma (CRA) is one of the leading causes of cancer-related deaths in the world. Long non-coding RNAs (lncRNAs) have been implicated to be effective regulators in the disease course of human...

    Authors: Yang Liu, Qinshan Li, Dongxin Tang, Mengxing Li, Peng Zhao, Wenxiu Yang, Liping Shu, Jishi Wang, Zhixu He, Yanju Li and Feiqing Wang
    Citation: Cancer Cell International 2020 20:566
    Content type: Primary research Published on:

  33. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qiao Zhang, Zhe Yang, Yueli Ni, Honggang Bai, Qiaoqiao Han, Zihan Yi, Xiaojia Yi, Yannick Luther Agbana, Yingmin Kuang and Yuechun Zhu
    Citation: Cancer Cell International 2020 20:565
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2020 20:483

  35. CD44 is highly expressed in most cancer cells and its cross-linking pattern is closely related to tumor migration and invasion. However, the underlying molecular mechanism regarding CD44 cross-linking during c...

    Authors: Song Hu, Xiaoxing Shi, Yiwen Liu, Yiqing He, Yan Du, Guoliang Zhang, Cuixia Yang and Feng Gao
    Citation: Cancer Cell International 2020 20:563
    Content type: Primary research Published on:

  36. Early prediction of response to neoadjuvant chemotherapy (NAC) is critical in choosing appropriate chemotherapeutic regimen for patients with locally advanced breast cancer. Herein, we sought to identify poten...

    Authors: Qin Xie, Ying-sheng Xiao, Shi-cheng Jia, Jie-xuan Zheng, Zhen-chao Du, Yi-chun Chen, Mu-tong Chen, Yuan-ke Liang, Hao-yu Lin and De Zeng
    Citation: Cancer Cell International 2020 20:562
    Content type: Primary research Published on:

  37. EGFR tyrosine kinase inhibitors (TKIs) have been developed for the treatment of EGFR mutated NSCLC. Parthenolide, a natural product of parthenolide, which belongs to the sesquiterpene lactone family and has a ...

    Authors: Xiaoling Li, Riming Huang, Mingyue Li, Zheng Zhu, Zhiyan Chen, Liao Cui, Hui Luo and Lianxiang Luo
    Citation: Cancer Cell International 2020 20:561
    Content type: Primary research Published on:

  38. Bladder cancer (BC) is a leading cause of death among urothelial malignancies that more commonly affect male population. Poor prognosis and resistance to chemotherapy are the two most important characteristics...

    Authors: Khushbukhat Khan, Cristina Quispe, Zeeshan Javed, Muhammad Javed Iqbal, Haleema Sadia, Shahid Raza, Asma Irshad, Bahare Salehi, Željko Reiner and Javad Sharifi-Rad
    Citation: Cancer Cell International 2020 20:560
    Content type: Review Published on:

  39. Beast cancer is the most common women cancer worldwide, while two third of them are ER alpha positive breast cancer. Among the ER alpha positive breast cancer, about 80% are P53 wild type, indicating the poten...

    Authors: Xinxing Wang, Yujie Zhang, Xinhong Pei, Guangcheng Guo, Bingjian Xue, Xin Duan and Dongwei Dou
    Citation: Cancer Cell International 2020 20:559
    Content type: Primary research Published on:

  40. Extracellular vesicles (EVs) secreted by tumours, including exosomes, are important factors that regulate cell–cell interactions in oncogenesis. Although EV studies are ongoing, the biological understanding of...

    Authors: Seung Ah Choi, Eun Jung Koh, Ryong Nam Kim, Jung Woo Byun, Ji Hoon Phi, Jeyul Yang, Kyu-Chang Wang, Ae Kyung Park, Do Won Hwang, Ji Yeoun Lee and Seung-Ki Kim
    Citation: Cancer Cell International 2020 20:558
    Content type: Primary research Published on:

  41. Colorectal cancer (CRC) is a common malignant tumor with unsatisfactory overall prognosis. CircRNAs could be promising prognostic biomarkers in cancers, and play important role in the process of tumorigenesis ...

    Authors: Linlin Xing, Mengyan Xia, Xin Jiao and Ling Fan
    Citation: Cancer Cell International 2020 20:557
    Content type: Primary research Published on:

  42. There is evidence that circSMYD4 is differentially expressed in hepatocellular carcinoma (HCC), but its mechanism of action remains unclear. Therefore, this study aimed to explore the role of circSMYD4 in the ...

    Authors: Yanhe Zhang, Hui Wang, Chao Li, Linlin Gao, Yayun Zheng, Wenjuan Chang, Chao Lu and Xiaoguang Zhao
    Citation: Cancer Cell International 2020 20:556
    Content type: Primary research Published on:

  43. To establish and validate a multi-parametric prognostic model based on clinical features and serological markers to estimate the overall survival (OS) in non-small cell lung cancer (NSCLC) patients with chroni...

    Authors: Shulin Chen, Hanqing Huang, Yijun Liu, Changchun Lai, Songguo Peng, Lei Zhou, Hao Chen, Yiwei Xu and Xia He
    Citation: Cancer Cell International 2020 20:555
    Content type: Primary research Published on:

  44. Circular RNAs (circRNAs) play crucial roles in the development and progression of human cancers, including non-small cell lung cancer (NSCLC). However, most of these circRNAs, such as hsa_circ_0014235, are not...

    Authors: Xueliang Xu, Rong Tao, Liying Sun and Xia Ji
    Citation: Cancer Cell International 2020 20:552
    Content type: Primary research Published on:

  45. It has been known that ovarian cancer (OC) is a leading cause for women mortality globally. We aimed to analyze the underlying mechanism supporting that enhancer of zeste homolog 2 (EZH2) affected the developm...

    Authors: Dongbo Wu, Fanglan Wu, Birong Li, Wei Huang and Donglian Wang
    Citation: Cancer Cell International 2020 20:551
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:551

  46. A systematic review and meta-analysis was performed to compare the clinicopathological features and survival outcomes between sarcomatoid variant (SV)-urothelial carcinoma of the bladder (UCB) and conventional...

    Authors: Liangyou Gu, Qing Ai, Qiang Cheng, Xin Ma, Baojun Wang, Qingbo Huang, Xintao Li, Peng Zhang, Kan Liu, Xupeng Zhao, Hongzhao Li and Xu Zhang
    Citation: Cancer Cell International 2020 20:550
    Content type: Review Published on:

  47. Gastric carcinoma (GC) is currently one of the most common malignant tumors of the digestive system, and gastric precancerous lesions play a vital role in studying the mechanism of GC. Multiple microRNAs (miRN...

    Authors: Tianqi Zhang, Kunpeng Zhang, Kaiyue Ji, Cuiping Zhang, Yueping Jiang, Qi Zhang, Zibin Tian, Xinyu Wang, Mengyuan Zhang and Xiaoyu Li
    Citation: Cancer Cell International 2020 20:549
    Content type: Primary research Published on:

  48. RAS association domain family protein 1A (RASSF1A) promoter hypermethylation is suggested to be linked to hepatocellular carcinoma (HCC), but the results remained controversial.

    Authors: Gang Xu, Xiaoxiang Zhou, Jiali Xing, Yao Xiao, Bao Jin, Lejia Sun, Huayu Yang, Shunda Du, Haifeng Xu and Yilei Mao
    Citation: Cancer Cell International 2020 20:547
    Content type: Primary research Published on:

  49. Pathogenesis of colorectal cancer (CRC) is connected to deregulation of apoptosis while the effect of lncRNAs, as critical regulatory molecules, on this pathway is not clear well. The present study aimed to id...

    Authors: Fatemeh Akbari, Maryam Peymani, Ali Salehzadeh and Kamran Ghaedi
    Citation: Cancer Cell International 2020 20:546
    Content type: Primary research Published on:

  50. Long noncoding RNAs (lncRNAs) are important functional regulators of many biological processes of cancers. However, the mechanisms by which lncRNAs modulate androgen-independent prostate cancer (AIPC) developm...

    Authors: Weiyuan Li, Ganggang Yang, Dengke Yang, Dong Li and Qian Sun
    Citation: Cancer Cell International 2020 20:543
    Content type: Primary research Published on:
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Cancer Cell International

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