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  1. Chemotherapy for advanced cholangiocarcinoma (CCA) is largely ineffective, but innovative combinations of chemotherapeutic agents and natural compounds represent a promising strategy. In our previous studies, ...

    Authors: Chariya Hahnvajanawong, Wareeporn Wattanawongdon, Chariya Chomvarin, Natthinee Anantachoke, Sakawrat Kanthawong, Banchob Sripa and Vichai Reutrakul
    Citation: Cancer Cell International 2014 14:68
    Content type: Primary research Published on:

  2. Interleukin (IL)-23 is one of the newly identified inflammatory cytokines, and inflammation is also known to be related to the development of gastric cancer (GC). The role of IL-23 in gastric cancer, however, ...

    Authors: Changming Liu, Ying Zhang, Jie Zhan, Yuanyuan Zhao, Qijun Wan, Huiping Peng and Wei Zhu
    Citation: Cancer Cell International 2014 14:104
    Content type: Primary research Published on:

  3. Mechanical loads can regulate cell proliferation and differentiation at various stages of development and homeostasis. However, the extension of this regulatory effect of mechanical loads on cancer cells is la...

    Authors: Melis Olcum and Engin Ozcivici
    Citation: Cancer Cell International 2014 14:102
    Content type: Primary research Published on:

  4. Chemotherapy either before or after surgery is a common breast cancer treatment. Long-term, high dose treatments with chemotherapeutic drugs often result in undesirable side effects, frequent recurrences and r...

    Authors: Shan Wu, Jinsong Guo, Wendong Wei, Jue Zhang, Jing Fang and Stephen J Beebe
    Citation: Cancer Cell International 2014 14:98
    Content type: Primary research Published on:

  5. Hepatocellular carcinoma (HCC) is a highly aggressive and heterogeneous disease. HCC cell lines established from different patients would be useful in elucidating the molecular pathogenesis. However, success o...

    Authors: Phyllis Fung-Yi Cheung, Chi Wai Yip, Linda Wing-Chi Ng, Kwok Wai Lo, Nathalie Wong, Kwong Wai Choy, Chit Chow, Kui Fat Chan, Tan To Cheung, Ronnie Tung-Ping Poon, Sheung Tat Fan and Siu Tim Cheung
    Citation: Cancer Cell International 2014 14:103
    Content type: Primary research Published on:

  6. Side population (SP) assay identifies cells with dye/drug extrusion ability, a characteristic of stem cells. Here, we determined if SP cells exist in a verified cell line originating from recurrent nasopharyng...

    Authors: Susan Ling Ling Hoe, Lu Ping Tan, Juliana Jamal, Suat Cheng Peh, Ching Ching Ng, Wen Cai Zhang, Munirah Ahmad and Alan Soo Beng Khoo
    Citation: Cancer Cell International 2014 14:101
    Content type: Primary research Published on:

  7. Matrix metalloproteinase-2 (MMP-2) is an endopeptidase that facilitates extracellular matrix remodeling and molecular regulation, and is implicated in tumor metastasis. Type I collagen (Col I) regulates the ac...

    Authors: Kulrut Borrirukwanit, Prasit Pavasant, Tony Blick, Marc A Lafleur and Erik W Thompson
    Citation: Cancer Cell International 2014 14:99
    Content type: Primary research Published on:

  8. Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-γ), which indu...

    Authors: Paulina Gómez-Lomelí, Alejandro Bravo-Cuellar, Georgina Hernández-Flores, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy, José Manuel Lerma-Díaz, Jorge Ramiro Domínguez-Rodríguez, Karina Sánchez-Reyes and Pablo Cesar Ortiz-Lazareno
    Citation: Cancer Cell International 2014 14:100
    Content type: Primary research Published on:

  10. Hypoxia inducible factor 1α (HIF-1α) is a stress-responsive transcription factor to hypoxia and its expression is correlated to tumor progression and angiogenesis. Several single nucleotide polymorphisms (SNPs...

    Authors: Chih-Jen Huang, Shi-Long Lian, Ming-Feng Hou, Chee-Yin Chai, Yi-Hsing Yang, Sheng-Fung Lin and Hsueh-Wei Chang
    Citation: Cancer Cell International 2014 14:87
    Content type: Primary research Published on:

  11. In response to antigen naive CD8+, T cells differentiate into effector cells, which express Natural killer (NK) receptors, lose CD28 expression, and die by apoptosis. However, in smaller quantities, the cells ...

    Authors: Maria Luisa Pita-Lopez, Pablo Cesar Ortiz-Lazareno, Monica Navarro-Meza, Felipe Santoyo-Telles and Oscar Peralta-Zaragoza
    Citation: Cancer Cell International 2014 14:97
    Content type: Primary research Published on:

  12. Human umbilical cord blood derived-mesenchymal stem cells (hUCMSCs) offer an attractive alternative to bone marrow-derived MSCs (BMMSCs) for cell-based therapy as it is a less invasive source of biological mat...

    Authors: Xiaoya Yang, Zhu Li, Yintu Ma, Jun Gao, Surui Liu, Yuhua Gao and Gengyin Wang
    Citation: Cancer Cell International 2014 14:93
    Content type: Primary research Published on:

  13. Up-regulation of the PI3K/mTOR (phosphatidylinositol-3′ kinase/mammalian target of rapamycin) signaling is common in carcinoma. Consistently, targeting these molecules has been shown to halt the growth of many...

    Authors: Alia Albawardi, Muna Al Ayyan, Mohamed Al Bashir, Abdul-Kader Souid and Saeeda Almarzooqi
    Citation: Cancer Cell International 2014 14:90
    Content type: Primary research Published on:

  14. Many studies support that chemokine (C-X-C motif) ligand 1 (CXCL1) regulate tumor epithelial-stromal interactions involving in tumor growth and invasion. However, limited studies have been conducted on the exp...

    Authors: Zhongwei Cao, Biao Fu, Biao Deng, Yue Zeng, Xinjian Wan and Lei Qu
    Citation: Cancer Cell International 2014 14:86
    Content type: Primary research Published on:

  15. Aberrant microRNA (miRNA) expression plays an essential role in the pathogenesis of Hepatocellular Carcinoma (HCC). However, specific involvement of miRNAs in HCC remains incompletely understood. The aim of th...

    Authors: Jianxin Jiang, Yi Zhang, Chao Yu, Zhipeng Li, Yaozheng Pan and Chengyi Sun
    Citation: Cancer Cell International 2014 14:95
    Content type: Primary research Published on:

  16. Five cell lines were established from a Singaporean patient of Chinese origin with breast ductal carcinoma in situ (DCIS). These five cell lines express exogenous human telomerase reverse transcriptase (hTERT)...

    Authors: Jacklyn WY Yong, Meng Ling Choong, SiFang Wang, Yu Wang, Shermaine QY Lim and May Ann Lee
    Citation: Cancer Cell International 2014 14:94
    Content type: Primary research Published on:

  17. Oncolytic herpes simplex virus (HSV) can replicate in and kill cancer cells while sparing the adjacent normal tissue. Hepatocellular carcinoma (HCC) is amongst the most common and lethal cancers, especially in...

    Authors: Jiani Wang, Lihua Xu, Weigen Zeng, Pan Hu, Musheng Zeng, Samuel D Rabkin and Renbin Liu
    Citation: Cancer Cell International 2014 14:83
    Content type: Primary research Published on:

  18. Transforming growth factor beta (TGF-β) plays major roles in tumorigenesis by regulating cell growth, epithelial-to-mesenchymal transition (EMT), migration/invasion and metastasis. The epithelial markers E-cad...

    Authors: Jingfang Gao, Yihong Zhu, Mikael Nilsson and Karin Sundfeldt
    Citation: Cancer Cell International 2014 14:72
    Content type: Primary research Published on:

  19. Published data on the association between AURKA polymorphisms and breast cancer (BC) risk are inconclusive. This meta-analysis was performed to derive a more precise estimation on the relationship between AURK...

    Authors: Zhi-Jun Dai, Hua-Feng Kang, Xi-Jing Wang, Yong-Ping Shao, Shuai Lin, Yang Zhao, Hong-Tao Ren, Wei-Li Min, Meng Wang and Xiao-Xu Liu
    Citation: Cancer Cell International 2014 14:91
    Content type: Primary research Published on:

  20. Platelet-derived growth factors (PDGFs) bind to two receptors, PDGFRα and PDGFRα to mediate cell proliferation, migration and survival. Although epithelial cells typically do not express high levels of PDGFRs,...

    Authors: Leanne Stalker, James Pemberton and Roger A Moorehead
    Citation: Cancer Cell International 2014 14:89
    Content type: Primary research Published on:

  21. Ribavirin is an anti-viral drug; however, recent data suggest that it may also be effective in cancer therapy. This study investigated the effect of ribavirin alone or in combination with IFN-α on biological p...

    Authors: Lichen Teng, Dexin Ding, Yongsheng Chen, Hongshuang Dai, Guobin Liu, Zhongjie Qiao and Ruihua An
    Citation: Cancer Cell International 2014 14:63
    Content type: Primary research Published on:

  22. Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive loco-regional invasion. Sphingosine kinase1 (SphK1), an enzyme in sphingolipid metabolism, is emerging as a key player in HNSCC path...

    Authors: Paulette M Tamashiro, Hideki Furuya, Yoshiko Shimizu and Toshihiko Kawamori
    Citation: Cancer Cell International 2014 14:76
    Content type: Primary research Published on:

  23. There is a strong interest in the investigation of extremely low frequency Electromagnetic Fields (EMF) in the clinic. While evidence about anticancer effects exists, the mechanism explaining this effect is st...

    Authors: Nenad Filipovic, Tijana Djukic, Milos Radovic, Danijela Cvetkovic, Milena Curcic, Snezana Markovic, Aleksandar Peulic and Branislav Jeremic
    Citation: Cancer Cell International 2014 14:84
    Content type: Primary research Published on:

  24. The molecular heterogeneity of high-grade astrocytomas underlies the difficulties in the development of representative and valuable in vitro experimental models for their studies.

    Authors: Monika Witusik-Perkowska, Magdalena Zakrzewska, Malgorzata Szybka, Wielislaw Papierz, Dariusz J Jaskolski, Pawel P Liberski and Beata Sikorska
    Citation: Cancer Cell International 2014 14:82
    Content type: Primary research Published on:

  25. Serum microRNAs (miRNAs) are a novel class of diagnostic and prognostic biomarkers for numerous cancers. However, the level and clinical relevance of circulating miR-205 transcripts in human serum of cervical ...

    Authors: Quanhui Ma, Guiping Wan, Shuxia Wang, Wanwei Yang, Jiaming Zhang and Xiaoming Yao
    Citation: Cancer Cell International 2014 14:81
    Content type: Primary research Published on:

  26. Aberrant DNA methylation is an acquired epigenetic alteration that serves as an alternative to genetic defects in the inactivation of tumor suppressor genes and other genes in diverse human cancers. Gastric ca...

    Authors: Yinguo Bai, Na Fang, Tingxun Gu, Yuhua Kang, Jiang Wu, Desheng Yang, Hui Zhang, Zhimin Suo and Shaoping Ji
    Citation: Cancer Cell International 2014 14:79
    Content type: Primary research Published on:

  27. Survivin is a protein that is normally present only in G2 and M-phases in somatic cells, however, in cancer cells, it is expressed throughout the cell cycle. A prosurvival factor, survivin is both an inhibitor...

    Authors: Aysha M Aljaberi, Jamie RM Webster and Sally P Wheatley
    Citation: Cancer Cell International 2014 14:78
    Content type: Primary research Published on:

  29. Bone destruction and abnormal immunity always occur in patients with multiple myeloma (MM), which manifested by impaired osteoblasts and immune system. In this study, we investigated the quantity and function ...

    Authors: Rong Fu, Shan Gao, Fengping Peng, Jing Li, Hui Liu, Huaquan Wang, Linmin Xing and Zonghong Shao
    Citation: Cancer Cell International 2014 14:62
    Content type: Primary research Published on:

  30. Therapeutic options for patients with non-small cell lung cancer (NSCLC) are often restricted to systemic chemotherapy. However, the molecular and cellular processes during chemotherapy of advanced NSCLC patie...

    Authors: Zengguang Xu, Fengying Wu, Chunhong Wang, Xiyu Liu, Baoli Kang, Shan Shan, Xia Gu, Kailing Wang and Tao Ren
    Citation: Cancer Cell International 2014 14:80
    Content type: Primary research Published on:

  31. Cancer cells, even in the presence of available oxygen, have a glycolysis enhancement. The “aerobic glycolysis” is known as the Warburg effect and it is considered one of the fundamental hallmarks of metabolic...

    Authors: Luca Bruni, Adesola A Babarinde, Ida Ortalli and Simonetta Croci
    Citation: Cancer Cell International 2014 14:77
    Content type: Primary research Published on:

  32. The small molecule NSC676914A was previously identified as an NF-κB inhibitor in TPA-stimulated HEK293 cells (Mol Can Ther 8:571-581, 2009). We hypothesized that this effect would also be seen in ovarian cance...

    Authors: Ethan Sagher, Lidia Hernandez, Callee Heywood, Gary T Pauly, Matthew R Young, Joel Schneider, Nancy H Colburn and Christina M Annunziata
    Citation: Cancer Cell International 2014 14:75
    Content type: Primary research Published on:

  33. For treatment and prevention of metastatic disease, one of the premier challenges is the identification of pathways and proteins to target for clinical intervention. Micro RNAs (miRNAs) are short, non-coding R...

    Authors: Jason R Dobson, Hanna Taipaleenmäki, Yu-Jie Hu, Deli Hong, Andre J van Wijnen, Janet L Stein, Gary S Stein, Jane B Lian and Jitesh Pratap
    Citation: Cancer Cell International 2014 14:73
    Content type: Primary research Published on:

  34. The involvement of NF-κB signaling in prostate cancer (PCa) has largely been established through the study of the classical p65 subunit. Nuclear localization of p65 in PCa patient tissues has been shown to cor...

    Authors: Ingrid Labouba, Alexis Poisson, Julie Lafontaine, Nathalie Delvoye, Philippe O Gannon, Cécile Le Page, Fred Saad and Anne-Marie Mes-Masson
    Citation: Cancer Cell International 2014 14:67
    Content type: Primary research Published on:

  35. Hepatocellular carcinoma (HCC) is the most prevalent hepatic cancer worldwide. Currently, a targeted therapy via monoclonal antibodies (mAbs) specific to tumor-associated antigen is undergoing continual develo...

    Authors: Panadda Rojpibulstit, Suthathip Kittisenachai, Songchan Puthong, Sirikul Manochantr, Pornpen Gamnarai, Sarawut Jitrapakdee and Sittiruk Roytrakul
    Citation: Cancer Cell International 2014 14:69
    Content type: Primary research Published on:

  36. MiR-133b is a muscle-specific microRNA; it has a role in the formation of cardiocytes and the expression of myocardium ion channels by regulating target genes. Many human malignant tumors demonstrate a low exp...

    Authors: Xiao-nan Chen, Ke-feng Wang, Zhen-qun Xu, Shi-jie Li, Qiang Liu, Dong-hui Fu, Xia Wang and Bin Wu
    Citation: Cancer Cell International 2014 14:70
    Content type: Primary research Published on:

  37. Flavonoids are structurally heterogeneous, polyphenolic compounds present in high concentrations in fruits, vegetables, and other plant-derived foods. Currently, there is growing interest in the therapeutic ap...

    Authors: Lei Wang, Jianfang Feng, Xiaonan Chen, Wei Guo, Yuwen Du, Yuanyuan Wang, Wenqiao Zang, Shijie Zhang and Guoqiang Zhao
    Citation: Cancer Cell International 2014 14:71
    Content type: Primary research Published on:

  38. Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migratio...

    Authors: Diego Pinheiro Aguiar, Gabriel Correa de Farias, Eduardo Branco de Sousa, Juliana de Mattos Coelho-Aguiar, Julie Calixto Lobo, Priscila Ladeira Casado, Maria Eugênia Leite Duarte and José Garcia Ribeiro Abreu Jr
    Citation: Cancer Cell International 2014 14:61
    Content type: Review Published on:

  39. Considerable progress has been made to understand the association between lifestyle and diet in cancer initiation and promotion. Because excessive glucose consumption is a key metabolic hallmark of cancer cell...

    Authors: Layal Wardi, Nada Alaaeddine, Issam Raad, Riad Sarkis, Rim Serhal, Charbel Khalil and George Hilal
    Citation: Cancer Cell International 2014 14:60
    Content type: Primary research Published on:

  40. Metformin is a widely used oral hypoglycemizing agent recently proposed as potential anti-cancer drug. In this study we report the antiproliferative effect of metformin treatment in a high risk neuroblastoma c...

    Authors: Delfina Costa, Arianna Gigoni, Roberto Würth, Ranieri Cancedda, Tullio Florio and Aldo Pagano
    Citation: Cancer Cell International 2014 14:59
    Content type: Primary research Published on:

  41. MicroRNAs (miRNAs) are a large group of post-transcriptional gene regulators that potentially play a critical role in tumorigenesis. Increasing evidences indicate that miR-744 deregulated in numerous human can...

    Authors: Feng Lin, Ruliang Ding, Shuang Zheng, Dongyi Xing, Weiwen Hong, Zhijun Zhou and Jie Shen
    Citation: Cancer Cell International 2014 14:58
    Content type: Primary research Published on:

  42. The stem cell-associated intermediate filament nestin has recently been linked with neoplastic transformation, but the specific mechanism by which nestin positive tumor cells leads to malignant invasion and me...

    Authors: Beilong Zhong, Tao Wang, Xueping Lun, Jinli Zhang, Sannv Zheng, Weilin Yang, Weiqiang Li, Andy Peng Xiang and Zhenguang Chen
    Citation: Cancer Cell International 2014 14:57
    Content type: Primary research Published on:

  43. In general, growth and differentiation are mutually exclusive but are cooperatively regulated throughout development. Thus, the process of a cell’s switching from growth to differentiation is of great importan...

    Authors: Junji Chida, Hikaru Araki and Yasuo Maeda
    Citation: Cancer Cell International 2014 14:56
    Content type: Primary research Published on:

  44. Bone morphogenetic protein receptor II (BMPR-II) plays an important role in tumor’s invasion and proliferation. In this study, we observed the effects of small interfering RNA (siRNA) targeting bone morphogene...

    Authors: Peng Zeng, Sheng Cai, Jia-na Zhang, Feng-ming Yi, Wei-min Jiang and Jian-bing Wu
    Citation: Cancer Cell International 2014 14:55
    Content type: Primary research Published on:

  45. Many types of tumors are organized in a hierarchy of heterogeneous cell populations with different molecular signature. Such heterogeneity may be associated with different responsiveness to microenvironment st...

    Authors: Simin Rezania, Noor Amirmozaffari, Nesa Rashidi, Ebrahim Mirzadegan, Saeed Zarei, Jamileh Ghasemi, Omid Zarei, Leila Katouzian and Amir-Hassan Zarnani
    Citation: Cancer Cell International 2014 14:54
    Content type: Primary research Published on:

  46. Effective therapies for early endometrial cancer usually involve surgical excision and consequent infertility Therefore, new treatment approaches that preserve fertility should be developed. Metformin, a well-...

    Authors: Akimasa Takahashi, Fuminori Kimura, Akiyoshi Yamanaka, Akie Takebayashi, Nobuyuki Kita, Kentaro Takahashi and Takashi Murakami
    Citation: Cancer Cell International 2014 14:53
    Content type: Primary research Published on:

  48. A detailed analysis of the expression of 440 cancer-related genes was performed after the combined treatment of medulloblastoma cells with all-trans retinoic acid (ATRA) and inhibitors of lipoxygenases (LOX) and ...

    Authors: Petr Chlapek, Jakub Neradil, Martina Redova, Karel Zitterbart, Jaroslav Sterba and Renata Veselska
    Citation: Cancer Cell International 2014 14:51
    Content type: Primary research Published on:

  49. Recent findings indicated that Derlin-1 has an important function in tumour progression. In this study, we aimed to determine whether Derlin-1 has an oncogene function as a cross-talk molecule with autophagy.

    Authors: Li Xu, Zan-Hong Wang, Dong Xu, Gang Lin, Dai-Rong Li, Tao Wan and Shu-Liang Guo
    Citation: Cancer Cell International 2014 14:50
    Content type: Primary research Published on:

  50. Hepatocellular carcinoma (HCC), the primary liver cancer, is one of the most malignant human tumors with extremely poor prognosis. The aim of this study was to investigate the anti-cancer effect of berberine i...

    Authors: Rong Yu, Zhi-qing Zhang, Bin Wang, Hong-xin Jiang, Lei Cheng and Li-ming Shen
    Citation: Cancer Cell International 2014 14:49
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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