Skip to main content

Articles

Page 30 of 41

  1. For treatment and prevention of metastatic disease, one of the premier challenges is the identification of pathways and proteins to target for clinical intervention. Micro RNAs (miRNAs) are short, non-coding R...

    Authors: Jason R Dobson, Hanna Taipaleenmäki, Yu-Jie Hu, Deli Hong, Andre J van Wijnen, Janet L Stein, Gary S Stein, Jane B Lian and Jitesh Pratap

    Citation: Cancer Cell International 2014 14:73

    Content type: Primary research

    Published on:

  2. The involvement of NF-κB signaling in prostate cancer (PCa) has largely been established through the study of the classical p65 subunit. Nuclear localization of p65 in PCa patient tissues has been shown to cor...

    Authors: Ingrid Labouba, Alexis Poisson, Julie Lafontaine, Nathalie Delvoye, Philippe O Gannon, Cécile Le Page, Fred Saad and Anne-Marie Mes-Masson

    Citation: Cancer Cell International 2014 14:67

    Content type: Primary research

    Published on:

  3. Hepatocellular carcinoma (HCC) is the most prevalent hepatic cancer worldwide. Currently, a targeted therapy via monoclonal antibodies (mAbs) specific to tumor-associated antigen is undergoing continual develo...

    Authors: Panadda Rojpibulstit, Suthathip Kittisenachai, Songchan Puthong, Sirikul Manochantr, Pornpen Gamnarai, Sarawut Jitrapakdee and Sittiruk Roytrakul

    Citation: Cancer Cell International 2014 14:69

    Content type: Primary research

    Published on:

  4. MiR-133b is a muscle-specific microRNA; it has a role in the formation of cardiocytes and the expression of myocardium ion channels by regulating target genes. Many human malignant tumors demonstrate a low exp...

    Authors: Xiao-nan Chen, Ke-feng Wang, Zhen-qun Xu, Shi-jie Li, Qiang Liu, Dong-hui Fu, Xia Wang and Bin Wu

    Citation: Cancer Cell International 2014 14:70

    Content type: Primary research

    Published on:

  5. Flavonoids are structurally heterogeneous, polyphenolic compounds present in high concentrations in fruits, vegetables, and other plant-derived foods. Currently, there is growing interest in the therapeutic ap...

    Authors: Lei Wang, Jianfang Feng, Xiaonan Chen, Wei Guo, Yuwen Du, Yuanyuan Wang, Wenqiao Zang, Shijie Zhang and Guoqiang Zhao

    Citation: Cancer Cell International 2014 14:71

    Content type: Primary research

    Published on:

  6. Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migratio...

    Authors: Diego Pinheiro Aguiar, Gabriel Correa de Farias, Eduardo Branco de Sousa, Juliana de Mattos Coelho-Aguiar, Julie Calixto Lobo, Priscila Ladeira Casado, Maria Eugênia Leite Duarte and José Garcia Ribeiro Abreu Jr

    Citation: Cancer Cell International 2014 14:61

    Content type: Review

    Published on:

  7. Considerable progress has been made to understand the association between lifestyle and diet in cancer initiation and promotion. Because excessive glucose consumption is a key metabolic hallmark of cancer cell...

    Authors: Layal Wardi, Nada Alaaeddine, Issam Raad, Riad Sarkis, Rim Serhal, Charbel Khalil and George Hilal

    Citation: Cancer Cell International 2014 14:60

    Content type: Primary research

    Published on:

  8. Metformin is a widely used oral hypoglycemizing agent recently proposed as potential anti-cancer drug. In this study we report the antiproliferative effect of metformin treatment in a high risk neuroblastoma c...

    Authors: Delfina Costa, Arianna Gigoni, Roberto Würth, Ranieri Cancedda, Tullio Florio and Aldo Pagano

    Citation: Cancer Cell International 2014 14:59

    Content type: Primary research

    Published on:

  9. MicroRNAs (miRNAs) are a large group of post-transcriptional gene regulators that potentially play a critical role in tumorigenesis. Increasing evidences indicate that miR-744 deregulated in numerous human can...

    Authors: Feng Lin, Ruliang Ding, Shuang Zheng, Dongyi Xing, Weiwen Hong, Zhijun Zhou and Jie Shen

    Citation: Cancer Cell International 2014 14:58

    Content type: Primary research

    Published on:

  10. The stem cell-associated intermediate filament nestin has recently been linked with neoplastic transformation, but the specific mechanism by which nestin positive tumor cells leads to malignant invasion and me...

    Authors: Beilong Zhong, Tao Wang, Xueping Lun, Jinli Zhang, Sannv Zheng, Weilin Yang, Weiqiang Li, Andy Peng Xiang and Zhenguang Chen

    Citation: Cancer Cell International 2014 14:57

    Content type: Primary research

    Published on:

  11. In general, growth and differentiation are mutually exclusive but are cooperatively regulated throughout development. Thus, the process of a cell’s switching from growth to differentiation is of great importan...

    Authors: Junji Chida, Hikaru Araki and Yasuo Maeda

    Citation: Cancer Cell International 2014 14:56

    Content type: Primary research

    Published on:

  12. Bone morphogenetic protein receptor II (BMPR-II) plays an important role in tumor’s invasion and proliferation. In this study, we observed the effects of small interfering RNA (siRNA) targeting bone morphogene...

    Authors: Peng Zeng, Sheng Cai, Jia-na Zhang, Feng-ming Yi, Wei-min Jiang and Jian-bing Wu

    Citation: Cancer Cell International 2014 14:55

    Content type: Primary research

    Published on:

  13. Many types of tumors are organized in a hierarchy of heterogeneous cell populations with different molecular signature. Such heterogeneity may be associated with different responsiveness to microenvironment st...

    Authors: Simin Rezania, Noor Amirmozaffari, Nesa Rashidi, Ebrahim Mirzadegan, Saeed Zarei, Jamileh Ghasemi, Omid Zarei, Leila Katouzian and Amir-Hassan Zarnani

    Citation: Cancer Cell International 2014 14:54

    Content type: Primary research

    Published on:

  14. Effective therapies for early endometrial cancer usually involve surgical excision and consequent infertility Therefore, new treatment approaches that preserve fertility should be developed. Metformin, a well-...

    Authors: Akimasa Takahashi, Fuminori Kimura, Akiyoshi Yamanaka, Akie Takebayashi, Nobuyuki Kita, Kentaro Takahashi and Takashi Murakami

    Citation: Cancer Cell International 2014 14:53

    Content type: Primary research

    Published on:

  15. A detailed analysis of the expression of 440 cancer-related genes was performed after the combined treatment of medulloblastoma cells with all-trans retinoic acid (ATRA) and inhibitors of lipoxygenases (LOX) and ...

    Authors: Petr Chlapek, Jakub Neradil, Martina Redova, Karel Zitterbart, Jaroslav Sterba and Renata Veselska

    Citation: Cancer Cell International 2014 14:51

    Content type: Primary research

    Published on:

  16. Recent findings indicated that Derlin-1 has an important function in tumour progression. In this study, we aimed to determine whether Derlin-1 has an oncogene function as a cross-talk molecule with autophagy.

    Authors: Li Xu, Zan-Hong Wang, Dong Xu, Gang Lin, Dai-Rong Li, Tao Wan and Shu-Liang Guo

    Citation: Cancer Cell International 2014 14:50

    Content type: Primary research

    Published on:

  17. Hepatocellular carcinoma (HCC), the primary liver cancer, is one of the most malignant human tumors with extremely poor prognosis. The aim of this study was to investigate the anti-cancer effect of berberine i...

    Authors: Rong Yu, Zhi-qing Zhang, Bin Wang, Hong-xin Jiang, Lei Cheng and Li-ming Shen

    Citation: Cancer Cell International 2014 14:49

    Content type: Primary research

    Published on:

  18. 2-Methoxyestradiol is known to have antitumour and antiproliferative action in vitro and in vivo. However, when 2-methoxyestradiol is orally administered, it is rapidly oxidized by the enzyme 17β-hydroxysteriod ...

    Authors: Lisa Repsold, Etheresia Pretorius and Annie Margaretha Joubert

    Citation: Cancer Cell International 2014 14:48

    Content type: Primary research

    Published on:

  19. Pin2/TRF1 binding protein X1 (PinX1) has been identified as an endogenous telomerase inhibitor and a major haploinsufficient tumor suppressor gene. Increasing evidence suggests that reduced expression of PinX1...

    Authors: Rong Shi, Zhen Zhao, Hui Zhou, Min Wei, Wen-Li Ma, Jue-Yu Zhou and Wan-Long Tan

    Citation: Cancer Cell International 2014 14:46

    Content type: Primary research

    Published on:

  20. Tumors are not merely masses of neoplastic cells but complex tissues composed of cellular and noncellular elements. This review provides recent data on the main components of a dynamic system, such as carcinom...

    Authors: Gvantsa Kharaishvili, Dana Simkova, Katerina Bouchalova, Mariam Gachechiladze, Nato Narsia and Jan Bouchal

    Citation: Cancer Cell International 2014 14:41

    Content type: Review

    Published on:

  21. The role of the microenvironment during the initiation and progression of carcinogenesis is thought to be of critical importance, both for the enhanced understanding of fundamental cancer biology as well as fo...

    Authors: Viviana Salvatore, Gabriella Teti, Silvia Bolzani, Stefano Focaroli, Sandra Durante, Maria Carla Mazzotti and Mirella Falconi

    Citation: Cancer Cell International 2014 14:40

    Content type: Primary research

    Published on:

  22. Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandins synthesis which exists in two isoforms, COX-1 and COX-2. Over-expression of COX-2 was considered to increase the proliferation and enhance the inva...

    Authors: Jie Gao, Hua-Feng Kang, Xiao-Bin Ma, Wei Tang, Di Liu, Yang Zhao, Shu-Qun Zhang, Hai-Tao Guan, Shuai Lin, Hong-Tao Ren, Xi-Jing Wang and Zhi-Jun Dai

    Citation: Cancer Cell International 2014 14:38

    Content type: Primary research

    Published on:

  23. Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates the cellular adaptation to hypoxia. HIF-1α gene single nucleotide polymorphisms (SNPs) are implicated to be associated with cance...

    Authors: Yuqiao Zhou, Lin Lin, Yun Wang, Xin Jin, Xin Zhao, Dongjuan Liu, Ting Hu, Lu Jiang, Hongxia Dan, Xin Zeng, Jing Li, Jiayi Wang and Qianming Chen

    Citation: Cancer Cell International 2014 14:37

    Content type: Primary research

    Published on:

  24. Cell-mediated immunity is often suppressed in patients with hematological malignancies. Recently, we found that low T cell receptor (TCR)-CD3 signaling was related to abnormal expression of the negative regula...

    Authors: Xu Wang, Yan Xu, Lichan Liang, Yi Xu, Chunyan Wang, Liang Wang, Shaohua Chen, Lijian Yang, Xiuli Wu, Bo Li, Gengxin Luo, Huo Tan, Wenyu Li and Yangqiu Li

    Citation: Cancer Cell International 2014 14:36

    Content type: Primary research

    Published on:

  25. Glucocorticoids (GCs) are often included in the therapy of lymphoid malignancies because they kill several types of malignant lymphoid cells. GCs activate the glucocorticoid receptor (GR), to regulate a comple...

    Authors: Aaron L Miller, Chuandong Geng, Georgiy Golovko, Meenakshi Sharma, Jason R Schwartz, Jiabin Yan, Lawrence Sowers, William R Widger, Yuriy Fofanov, Wayne V Vedeckis and E Brad Thompson

    Citation: Cancer Cell International 2014 14:35

    Content type: Primary research

    Published on:

  26. Prostate cancer is a gland tumor in the male reproductive system. It is a multifaceted and genomically complex disease. Transmembrane protease, serine 2 and v-ets erythroblastosis virus E26 homolog (TMPRSS2-ER...

    Authors: Ammad Ahmad Farooqi, Ming-Feng Hou, Chien-Chi Chen, Chun-Lin Wang and Hsueh-Wei Chang

    Citation: Cancer Cell International 2014 14:34

    Content type: Review

    Published on:

  27. PRO2000/ANCCA may be an important candidate gene which located within a region of chromosome 8q in hepatocellular carcinoma (HCC). However, its significance remains unclear. The aim of this study was to explor...

    Authors: Jie Yang, Jie Huang, Luqiao Luo, Zhenzhu Chen, Ying Guo and Linlang Guo

    Citation: Cancer Cell International 2014 14:33

    Content type: Primary research

    Published on:

  28. Although rituximab in the combination of CHOP chemotherapy has been widely used as the standard treatment for several kinds of B-cell non-Hodgkin lymphoma (B-NHL), a great number of B-NHL patients treated with...

    Authors: Xiaohui Zheng, Ning Ding, Yuqin Song, Lixia Feng and Jun Zhu

    Citation: Cancer Cell International 2014 14:32

    Content type: Primary research

    Published on:

  29. Previously, we found that treatment of LM8 murine osteosarcoma cells with genistein, an isoflavone found in soy, increased the cellular level of β-catenin and decreased its invasive and motile potential. The p...

    Authors: Teruki Kidani, Atsushi Nakamura, Setsuya Kamei, Yoshiaki Norimatsu, Hiromasa Miura and Hiroshi Masuno

    Citation: Cancer Cell International 2014 14:31

    Content type: Primary research

    Published on:

  30. Phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, is a chemopreventive agent. It blocks initiation and post-initiation progression of carcinogenesis. Mechanism study in human prost...

    Authors: Chengsen Xue, Hilda A Pasolli, Irene Piscopo, Daniel J Gros, Christina Liu, Yamei Chen and Jen Wei Chiao

    Citation: Cancer Cell International 2014 14:30

    Content type: Primary research

    Published on:

  31. ORAI1 channels play an important role for breast cancer progression and metastasis. Previous studies indicated the strong correlation between breast cancer and individual single nucleotide polymorphisms (SNPs) of...

    Authors: Wei-Chiao Chang, Yong-Yuan Fang, Hsueh-Wei Chang, Li-Yeh Chuang, Yu-Da Lin, Ming-Feng Hou and Cheng-Hong Yang

    Citation: Cancer Cell International 2014 14:29

    Content type: Primary research

    Published on:

  32. Nkx2.8 (Nk2 homeobox 8) is a novel NK-2 gene family member that has been implicated in the progression of human cancer. Its role in the progression of HCC remains unknown. In this study, we investigated the ex...

    Authors: Lei Qu, Biao Deng, Yue Zeng and Zhongwei Cao

    Citation: Cancer Cell International 2014 14:28

    Content type: Primary research

    Published on:

  33. Primary and secondary brain cancers are highly treatment resistant, and their marked angiogenesis attracts interest as a potential therapeutic target. Recent observations reveal that the microvascular endothel...

    Authors: Natsuko Nomura, Sandra Pastorino, Pengfei Jiang, Gage Lambert, John R Crawford, Marco Gymnopoulos, David Piccioni, Tiffany Juarez, Sandeep C Pingle, Milan Makale and Santosh Kesari

    Citation: Cancer Cell International 2014 14:26

    Content type: Primary research

    Published on:

  34. Rituximab in the combination of CHOP chemotherapy has been widely used as the standard treatment for several kinds of B-cell non-Hodgkin lymphoma (B-NHL). Inactivation of phosphorylation of STAT3 plays an essenti...

    Authors: Yunfei Hu, Ning Ding, Xuan Jin, Lixia Feng, Lingyan Ping, Yuqin Song and Jun Zhu

    Citation: Cancer Cell International 2014 14:25

    Content type: Primary research

    Published on:

  35. Nasopharyngeal carcinoma (NPC) is a common malignancy in China and Southeast Asia. Radiotherapy is the major treatment modality for patients with NPC, but does not always achieve fully satisfactory outcomes. S...

    Authors: Yanyang Liu, Zhixi Li, Lu Wu, Zi Wang, Xia Wang, Yang Yu, Qian Zhao and Feng Luo

    Citation: Cancer Cell International 2014 14:24

    Content type: Primary research

    Published on:

  36. The enumeration and characterization of circulating tumor cells (CTCs) in the blood of cancer patients is useful for cancer prognostic and treatment monitoring purposes. The number of CTCs present in patient b...

    Authors: Jianbing Qin, Jodi R Alt, Bradford A Hunsley, Thomas L Williams and M Rohan Fernando

    Citation: Cancer Cell International 2014 14:23

    Content type: Primary research

    Published on:

  37. Breast cancer is the most common malignancy in women throughout the world. Mitochondria play important roles in cellular energy production, free radical generation and apoptosis. Identification of mitochondria...

    Authors: Massoud Ghaffarpour, Reza Mahdian, Forouzandeh Fereidooni, Behnam Kamalidehghan, Nasrin Moazami and Massoud Houshmand

    Citation: Cancer Cell International 2014 14:21

    Content type: Primary research

    Published on:

  38. In vivo, the transforming growth factor-beta1 (TGF-β1)-induced epithelial to mesenchymal transition (EMT) occurs in seconds during cancer cells intravasation and extravasation. Although it has been established th...

    Authors: Tsung-Hsien Wu, Yu-Wei Chou, Pei-Hung Chiu, Ming-Jer Tang, Chun-Wen Hu and Ming-Long Yeh

    Citation: Cancer Cell International 2014 14:20

    Content type: Primary research

    Published on:

  39. We previously observed that the TGFbeta-Par6 pathway mediates loss of polarity and apoptosis in NMuMG cells. Here we investigate the contribution of Par6 versus TGFbeta receptor I activation to TGFbeta-induced...

    Authors: Geordon Avery-Cooper, Meghan Doerr, Richard WD Gilbert, Mahmoud Youssef, Amy Richard, Patricia Huether and Alicia M Viloria-Petit

    Citation: Cancer Cell International 2014 14:19

    Content type: Primary research

    Published on:

  40. General transcription is required for the growth and survival of all living cells. However, tumor cells require extraordinary levels of transcription, including the transcription of ribosomal RNA genes by RNA ...

    Authors: Claudia Villicaña, Grisel Cruz and Mario Zurita

    Citation: Cancer Cell International 2014 14:18

    Content type: Review

    Published on:

  41. The oncogene PTI-1 was originally isolated from a prostate cancer cell line by its capability to transform rat fibroblasts. The PTI-1 mRNA has a very eccentric structure as the 5′UTR is similar to prokaryotic 23S...

    Authors: Louise D Dahl, Thomas J Corydon, Liina Ränkel, Karen Margrethe Nielsen, Ernst-Martin Füchtbauer and Charlotte R Knudsen

    Citation: Cancer Cell International 2014 14:17

    Content type: Primary research

    Published on:

Annual Journal Metrics

Institutional membership

Visit the membership page to check if your institution is a member and learn how you could save on article-processing charges (APCs).

Funding your APC

​​​​​​​Open access funding and policy support by SpringerOpen​​

​​​​We offer a free open access support service to make it easier for you to discover and apply for article-processing charge (APC) funding. Learn more here