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  1. The tachykinin receptor 2 (TACR2) is encoded by the tachykinin receptor correlation gene. Recent microarray analysis for prostate cancer suggests that TACR2 expression is associated with clinical phenotype and...

    Authors: Wang Jianfeng, Wang Yutao and Bi Jianbin
    Citation: Cancer Cell International 2021 21:415
    Content type: Primary research Published on:

  2. Ferroptosis, a novel form of regulated cell death, has been implicated in the pathogenesis of cancers. Nevertheless, the potential function and prognostic values of ferroptosis in bladder urothelial carcinoma ...

    Authors: Jiao-chen Luan, Teng-yue Zeng, Qi-jie Zhang, De-run Xia, Rong Cong, Liang-yu Yao, Le-bin Song, Xiang Zhou, Xuan Zhou, Xiang Chen, Jia-dong Xia and Ning-hong Song
    Citation: Cancer Cell International 2021 21:414
    Content type: Primary research Published on:

  3. Increasing evidence has demonstrated the critical roles of mRNA modification regulators on multiple types of cancers. However, it is still poorly known about the prognostic and therapeutic value of mRNA modifi...

    Authors: Wenjie Tao, Guocai Tian, Shengming Xu, Jiayi Li, Zhiyuan Zhang and Jiang Li
    Citation: Cancer Cell International 2021 21:413
    Content type: Primary research Published on:

  4. Circular RNAs (circRNAs) could participate in cis-dichlorodiammineplatinum (DDP) resistance of human cancers. However, circRNAs role in DDP resistance of oral squamous cell carcinoma (OSCC) progression remains la...

    Authors: Feng Qiu, Bin Qiao, Nan Zhang, Zheng Fang, Lu Feng, Shanfeng Zhang and Weiliu Qiu
    Citation: Cancer Cell International 2021 21:412
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2022 22:63

  5. Altered Plastin-3 (PLS3; an actin-binding protein) expression was associated with human carcinogenesis, including pancreatic ductal adenocarcinoma (PDA). This study first assessed differentially expressed gene...

    Authors: Fei Xiong, Guan-Hua Wu, Bing Wang and Yong-Jun Chen
    Citation: Cancer Cell International 2021 21:411
    Content type: Primary research Published on:

  6. Most of the biological functions of circular RNAs (circRNAs) and the potential underlying mechanisms in hepatocellular carcinoma (HCC) have not yet been discovered.

    Authors: Ying Xie, Xiaofeng Hang, Wensheng Xu, Jing Gu, Yuanjing Zhang, Jianrong Wang, Xiucui Zhang, Xinghao Cao, Junjie Zhan, Junxue Wang and Jianhe Gan
    Citation: Cancer Cell International 2021 21:410
    Content type: Primary research Published on:

  7. Cumulating evidence reveals the key role of aberrant lipogenesis and immunogenomic features in hepatocellular carcinoma (HCC). However, there are still obstacles in our understanding of the complicated interac...

    Authors: Yunfeng Xu, Ze Zhang, Da Xu, Xin Yang, Lina Zhou and Ying Zhu
    Citation: Cancer Cell International 2021 21:409
    Content type: Primary research Published on:

  8. Epigenetic modulation by noncoding RNAs substantially contributes to human cancer development, but noncoding RNAs involvement in bladder cancer remains poorly understood. This study investigated the role of lo...

    Authors: Ranran Dai, Qingping Jiang, You Zhou, Ruifeng Lin, Hai Lin, Yumin Zhang, Jinhu Zhang and Xingcheng Gao
    Citation: Cancer Cell International 2021 21:408
    Content type: Primary research Published on:

  9. Gastrointestinal stromal tumor (GIST) is a common tumor that originates from the alimentary system mesenchyme. Compared to typical gastrointestinal carcinomas, GISTs exhibit unique malignant behaviors. Bioinfo...

    Authors: Xiaobin Cheng, Jinhai Wang, Sen Lu, Weina Fan and Weilin Wang
    Citation: Cancer Cell International 2021 21:407
    Content type: Primary research Published on:

  10. Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide. Due to the interaction of tumor cells...

    Authors: Gang Cheng, Hui Dong, Chen Yang, Yang Liu, Yi Wu, Lifen Zhu, Xiangmin Tong and Shibing Wang
    Citation: Cancer Cell International 2021 21:406
    Content type: Review Published on:

  11. WNT1-inducible signaling pathway protein 1 (WISP1) is a member of the CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression may be involved in carcinogenesis. To date, no studies h...

    Authors: Yanqiong Liu, Weijuan Qin, Fuyong Zhang, Jian Wang, Xi Li, Shan Li, Xue Qin and Yuefeng Lu
    Citation: Cancer Cell International 2021 21:405
    Content type: Primary research Published on:

  12. Authors: Hua‑fu Zhao, Chang‑peng Wu, Xiu‑ming Zhou, Peng‑yu Diao, Yan‑wen Xu, Jing Liu, Jing Wang, Xian‑jian Huang, Wen‑lan Liu, Zhong‑ping Chen, Guo‑dong Huang and Wei‑ping Li
    Citation: Cancer Cell International 2021 21:403
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2021 21:24

  13. The Chromobox (CBX) domain protein family, a core component of polycomb repressive complexes 1, is involved in transcriptional repression, cell differentiation, and program development by binding to methylated...

    Authors: He Zhou, Yongfu Xiong, Zuoliang Liu, Songlin Hou and Tong Zhou
    Citation: Cancer Cell International 2021 21:402
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:449

  14. As previously reported, midazolam anesthesia exerts tumor-suppressing effects in non-small cell lung cancer (NSCLC), but the regulating effects of this drug on cisplatin-resistance in NSCLC have not been studi...

    Authors: Tingting Sun, Jing Chen, Xuechao Sun and Guonian Wang
    Citation: Cancer Cell International 2021 21:401
    Content type: Primary research Published on:

  15. Cervical cancer (CC) is one of the most common gynaecological malignancies all around the world. The mechanisms of cervical carcinoma formation remain under close scrutiny. The long non-coding RNAs (lncRNA) an...

    Authors: Yu Zhou, Yuqing Wang, Mingying Lin, Daiqian Wu and Min Zhao
    Citation: Cancer Cell International 2021 21:400
    Content type: Primary research Published on:

  16. The tumor microenvironment (TME) has received an increasing amount of attention. CXC chemokines can regulate immune cell transport and tumor cell activity to exert anti-tumor immunity. However, studies on the ...

    Authors: Weina Kong, Gang Zhao, Haixia Chen, Weina Wang, Xiaoqian Shang, Qiannan Sun, Fan Guo and Xiumin Ma
    Citation: Cancer Cell International 2021 21:399
    Content type: Primary research Published on:

  17. Pancreatic ductal adenocarcinoma (PDAC) one of the deadliest malignant tumor. Despite considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality has shown no appreciable change, ...

    Authors: Jia Yao, Man Yang, Lawrence Atteh, Pinyan Liu, Yongcui Mao, Wenbo Meng and Xun Li
    Citation: Cancer Cell International 2021 21:398
    Content type: Review Published on:

  18. Despite current advances in gastric cancer treatment, disease metastasis and chemo-resistance remain as major hurdles against better overall prognosis. Previous studies indicated that IGHG1 as well as -Catenin...

    Authors: Xinyu Li, Wen Chen, Chunkang Yang, Yisen Huang, Jing Jia, Rongyu Xu, Shen Guan, Ruijun Ma, Haitao Yang and Lifeng Xie
    Citation: Cancer Cell International 2021 21:397
    Content type: Primary research Published on:

  19. Protopine is an isoquinoline alkaloid that possesses various biological activities including the anti-tumour activity. However, the effects of protopine on liver carcinoma cells are still elusive. The aim of t...

    Authors: Chunhui Nie, Bei Wang, Baoquan Wang, Ning Lv, Rui Yu and Enfan Zhang
    Citation: Cancer Cell International 2021 21:396
    Content type: Primary research Published on:

  20. Bladder cancer is one of the most commonly diagnosed urological malignant tumor. The Hippo tumor suppressor pathway is highly conserved in mammals and plays an important role in carcinogenesis. YAP is one of m...

    Authors: Yongwen Luo, Jun Zhou, Jianing Tang, Fengfang Zhou, Zhiwen He, Tongzu Liu and Tao Liu
    Citation: Cancer Cell International 2021 21:395
    Content type: Primary research Published on:

  21. Histological transformation (HT) of follicular lymphoma to a more aggressive lymphoma is a serious event affecting patients’ outcomes. To date, no strong clinical HT predictors present at diagnosis have yet be...

    Authors: Mixue Xie, Lulu Wang, Qi Jiang, Xuxia Luo, Xin Zhao, Xueying Li, Jie Jin, Xiujin Ye and Kui Zhao
    Citation: Cancer Cell International 2021 21:394
    Content type: Primary research Published on:

  22. The homeobox gene Homeobox B7 (HOXB7) is overexpressed across a range of cancers and promotes tumorigenesis through varying effects on proliferation, survival, migration and invasion. However, its expression p...

    Authors: Xiang Wu, Jin Li, Tingyuan Yan, Xueping Ke, Xin Li, Yumin Zhu, Jianrong Yang and Zhongwu Li
    Citation: Cancer Cell International 2021 21:393
    Content type: Primary research Published on:

  23. Long noncoding RNAs (lncRNAs) have emerged as crucial regulators in various cancers. However, the functional roles of most lncRNA in papillary thyroid cancer (PTC) are not detailly understood. This study aims ...

    Authors: Luyao Wu, Yu Ding, Houchao Tong, Xi Zhuang, Jingsheng Cai, Yan Si, Hao Zhang, Xiaoting Wang and Meiping Shen
    Citation: Cancer Cell International 2021 21:392
    Content type: Primary research Published on:

  24. Glioblastoma, WHO grade IV astrocytoma, is the most aggressive type of brain tumors. These cancerous cells have a rapid growth rate, tendency to penetrate vital brain structures, molecular heterogeneity, etc. ...

    Authors: AmirAhmad Arabzadeh, Tohid Mortezazadeh, Tayebeh Aryafar, Esmaeil Gharepapagh, Mehrsa Majdaeen and Bagher Farhood
    Citation: Cancer Cell International 2021 21:391
    Content type: Review Published on:

  25. miR-198 is involved in the formation, migration, invasion, and metastasis of various malignant cancers. However, the function and mechanism of action of miR-198 in the tumorigenesis of renal cell carcinoma (RC...

    Authors: Chao Yuan, Zhenhong Su, Shengjie Liao, Duanzhuo Li, Zhiwen Zhou, Yawen Wang, Mingchun Quan, Lingling Zeng, Cai Lv, Chenyi Shen, Weida Gong, Jianfeng Wu, Xiaogang Chen, Wenbing Hu, Xu Lv, Wenxia Si…
    Citation: Cancer Cell International 2021 21:390
    Content type: Primary research Published on:

  27. Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsibl...

    Authors: Zeeshan Javed, Khushbukhat Khan, Jesús Herrera-Bravo, Sajid Naeem, Muhammad Javed Iqbal, Haleema Sadia, Qamar Raza Qadri, Shahid Raza, Asma Irshad, Ali Akbar, Željko Reiner, Ahmed Al-Harrasi, Ahmed Al-Rawahi, Dinara Satmbekova, Monica Butnariu, Iulia Cristina Bagiu…
    Citation: Cancer Cell International 2021 21:388
    Content type: Review Published on:

    The Correction to this article has been published in Cancer Cell International 2022 22:256

  28. We have read with great interest the article entitled “Identification of an immune-related signature indicating the dedifferentiation of thyroid cells” by Wang et al. Their data reinforce our own previous resu...

    Authors: Lucas Leite Cunha, Guilherme Augusto Barcelos Domingues, Elaine Cristina Morari, Fernando Augusto Soares, José Vassallo and Laura Sterian Ward
    Citation: Cancer Cell International 2021 21:387
    Content type: Commentary Published on:

  29. Malignant tumor has become one of the major diseases that seriously endangers human health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely associated with patient prognosis. Tu...

    Authors: Yanming Luo, Shuangshuang Yin, Jia Lu, Shiyue Zhou, Yingying Shao, Xiaomei Bao, Tao Wang, Yuling Qiu and Haiyang Yu
    Citation: Cancer Cell International 2021 21:386
    Content type: Review Published on:

  30. N6-Methyladenosine (m6A) is the most common RNA modification and regulates RNA splicing, translation, translocation, and stability. Aberrant expression of m6A has been reported in various types of human cancers.....

    Authors: Zhi-Hao Yu, Shao-Ting Feng, Di Zhang, Xu-Chen Cao, Yue Yu and Xin Wang
    Citation: Cancer Cell International 2021 21:385
    Content type: Primary research Published on:

  31. Circular RNAs (circRNAs) have been confirmed to be relevant to the 5-fluorouracil (5-FU) resistance of breast cancer. Nevertheless, how and whether circRNA F-box and leucine-rich repeat protein 5 (circFBXL5) r...

    Authors: Mingzhi Zhu, Yanyan Wang, Fang Wang, Lin Li and Xinguang Qiu
    Citation: Cancer Cell International 2021 21:384
    Content type: Primary research Published on:

  32. Methyltransferase-like 7B (METTL7B) is a member of the methyltransferase-like protein family that plays an important role in the development and progression of tumors. However, its prognostic value and the cor...

    Authors: Zhipeng Jiang, Wen Yin, Hecheng Zhu, Jun Tan, Youwei Guo, Zhaoqi Xin, Quanwei Zhou, Yudong Cao, Zhaoping Wu, Yirui Kuang, Can Li, Dongcheng Xie, Hailong Huang, Ming Zhao, Xingjun Jiang, Lei Wang…
    Citation: Cancer Cell International 2021 21:383
    Content type: Primary research Published on:

  33. Ginsenosides have been reported to possess a variety of biological activities. Synthesized from the ginsenoside protopanaxadiol (PPD), the octanone pseudoginsengenin DQ (PDQ) may have robust pharmacological ef...

    Authors: Sanchun Wang, Yu Cai, Qingjie Feng, Jing Gao and Bo Teng
    Citation: Cancer Cell International 2021 21:382
    Content type: Primary research Published on:

  34. Osteosarcoma was the most common primary bone malignancy in children and adolescents. It was imperative to identify effective prognostic biomarkers for this cancer. This study was aimed to identify potential ...

    Authors: Feng Yao, Zhao Feng Zhu, Jun Wen, Fu Yong Zhang, Zheng Zhang, Lun Qing Zhu, Guang Hao Su, Quan Wen Yuan, Yun Fang Zhen and Xiao Dong Wang
    Citation: Cancer Cell International 2021 21:381
    Content type: Review Published on:

  35. Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating the miR-376c-3p/DNM3 axis. However, the regulation mechanism o...

    Authors: Shaojian Lin, Weiwei Zhang, Ziwen Shi, Langping Tan, Yue Zhu, Honghao Li and Xinzhi Peng
    Citation: Cancer Cell International 2021 21:380
    Content type: Primary research Published on:

  36. Recently, more and more studies have highlighted the critical regulatory roles of circular RNAs (circRNAs), a class of non-coding RNAs, in the progression of many human cancers, including prostate cancer (PCa)...

    Authors: Deping Yang, Bo Yang, Yanjun Zhu, Qianlin Xia, Yan Zhang, Xin Zhu, Jianming Guo, Tao Ding and Jianghua Zheng
    Citation: Cancer Cell International 2021 21:379
    Content type: Primary research Published on:

  37. Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid cancer. The effect of traditional anti-tumor therapy is not ideal for the patients with recurrence, metastasis and radioiodine ...

    Authors: Rujia Qin, Chunyan Li, Xuemin Wang, Zhaoming Zhong and Chuanzheng Sun
    Citation: Cancer Cell International 2021 21:378
    Content type: Primary research Published on:

  38. This study aimed to identify novel targets in the carcinogenesis, therapy and prognosis of osteosarcoma from genomic level, together with screening ideal lead compounds with potential inhibition regarding MMP-9.

    Authors: Weihang Li, Ziyi Ding, Dong Wang, Chengfei Li, Yikai Pan, Yingjing Zhao, Hongzhe Zhao, Tianxing Lu, Rui Xu, Shilei Zhang, Bin Yuan, Yunlong Zhao, Yanjiang Yin, Yuan Gao, Jing Li and Ming Yan
    Citation: Cancer Cell International 2021 21:377
    Content type: Primary research Published on:

  39. Gastric cancer (GC) remains an important cancer worldwide. Further understanding of the molecular mechanisms of gastric carcinogenesis will enhance the diagnosis and treatment of GC.

    Authors: Shuyi Han, Yan Qi, Yihui Xu, Min Wang, Jun Wang, Jing Wang, Mingjie Yuan, Yanfei Jia, Xiaoli Ma, Yunshan Wang and Xiangdong Liu
    Citation: Cancer Cell International 2021 21:376
    Content type: Primary research Published on:

  40. Deubiquitinating enzymes (DUBs) play critical roles in various cancers by modulating functional proteins post-translationally. Previous studies have demonstrated that DUB Josephin Domain Containing 1 (JOSD1) i...

    Authors: Chao Jing, Dandan Liu, Qingchuan Lai, Linqi Li, Mengqian Zhou, Beibei Ye, Yue Wu, Hong Li, Kai Yue, Yansheng Wu, Yuansheng Duan and Xudong Wang
    Citation: Cancer Cell International 2021 21:375
    Content type: Primary research Published on:

  41. Hepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an essential role in the development of various cancers. Gi...

    Authors: Zhibo Shen, Wenhua Xue, Yuanyuan Zheng, Qishun Geng, Le Wang, Zhirui Fan, Wenbin Wang, Ying Yue, Yunkai Zhai, Lifeng Li and Jie Zhao
    Citation: Cancer Cell International 2021 21:374
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:672

  43. Bone is the most common site of metastatic breast cancer, and it is a leading cause of breast cancer-related death. This study aimed to explore bone metastasis-related long non-coding RNAs (lncRNAs) in breast ...

    Authors: Yu Zhang, Xiaofeng Huang, Jin Liu, Guo Chen, Chengjun Liu, Sen Zhang and Jiaxin Li
    Citation: Cancer Cell International 2021 21:372
    Content type: Primary research Published on:

  44. Programmed death- ligand 1 (PD-L1) seems to be associated with the immune escape of tumors, and immunotherapy may be a favorable treatment for PD-L1-positive patients. We evaluated intrahepatic cholangiocarcin...

    Authors: Min Deng, Shao-Hua Li, Xu Fu, Xiao-Peng Yan, Jun Chen, Yu-Dong Qiu and Rong-Ping Guo
    Citation: Cancer Cell International 2021 21:371
    Content type: Primary research Published on:

  45. LncRNA prostate cancer-associated transcript 6 (PCAT6) has been reported to be dysregulated in several cancers and is associated with tumor progression. Here, we have performed a meta-analysis to assess the ge...

    Authors: Song-bo Shi, Qing-hao Cheng, Shi-yi Gong, Ting-ting Lu, Shi-fang Guo, Shao-ming Song, Yu-ping Yang, Qi Cui, Ke-hu Yang and Yao-wen Qian
    Citation: Cancer Cell International 2021 21:370
    Content type: Review Published on:

  47. Epstein-Barr virus-associated gastric cancer (EBVaGC) is the most common EBV-related malignancy. A comprehensive research for the protein expression patterns in EBVaGC established by high-throughput assay rema...

    Authors: Zeyang Wang, Zhi Lv, Qian Xu, Liping Sun and Yuan Yuan
    Citation: Cancer Cell International 2021 21:368
    Content type: Primary research Published on:

  48. Long non-coding RNAs (lncRNAs) are vital regulators of gene expression and cellular processes in multiple cancers, including melanoma. Nevertheless, the function of lncRNA NCK1-antisense 1 (NCK1-AS1) in melano...

    Authors: Quan Lin, Yan Jia, Duo Zhang and Hongjuan Jin
    Citation: Cancer Cell International 2021 21:367
    Content type: Primary research Published on:

  49. Peroxiredoxins (PRDXs) are an antioxidant enzymes protein family involved in several biological functions such as differentiation, cell growth. In addition, previous studies report that PRDXs play critical rol...

    Authors: Lei Gao, Jialin Meng, Chuang Yue, Xingyu Wu, Quanxin Su, Hao Wu, Ze Zhang, Qinzhou Yu, Shenglin Gao, Song Fan and Li Zuo
    Citation: Cancer Cell International 2021 21:366
    Content type: Primary research Published on:

  50. Uterus corpus endometrial cancer (UCEC) is the main malignant tumor in gynecology, with a high degree of heterogeneity, especially in terms of prognosis and immunotherapy efficacy. DNA methylation is one of th...

    Authors: JinHui Liu, ChengJian Ji, Yichun Wang, Cheng Zhang and HongJun Zhu
    Citation: Cancer Cell International 2021 21:365
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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