Figure 4
From: Translesion DNA synthesis in the context of cancer research
Two-polymerase mechanisms for bypassing BaP-G (top) or cisplatin (cisPt) (bottom) DNA adducts. The insertion step is performed by one or a combination of several TLS polymerases incorporating nucleotides in an error-free or error-prone manner opposite the adduct whereas the extension step is mainly carried out by TLS Pol ζ (adapted from [247]). See text for details.