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Table 3 Multivariate Cox-regression analysis for RFS and EFS in patients with BCP-ALL (N = 164)

From: FPGS rs1544105 polymorphism is associated with treatment outcome in pediatric B-cell precursor acute lymphoblastic leukemia

Variable

Multivariable analysis for RFS

Multivariable analysis for EFS

HR

95% CI

p*

HR

95% CI

p*

Age

      

<10

1

Reference

-

1

Reference

-

≥10

0.239

0.023-2.518

0.847

0.300

0.036-2.466

0.244

WBC (109/L)

      

<50

1

Reference

-

1

Reference

-

≥50

4.677

1.715-12.760

0.003

3.745

1.062-13.204

0.072

BCR-ABL

      

Negative

1

Reference

-

1

Reference

-

Positive

7.190

2.022-25.567

0.118

2.701

0.497-14.681

0.250

TEL-AML1

      

Negative

1

Reference

-

1

Reference

-

Positive

0.508

0.057-4.550

0.104

0.316

0.038-2.629

0.059

E2A-PBX1

      

Negative

      

Positive

1

Reference

-

1

Reference

-

7.557

1.416-40.334

0.257

3.890

0.877-17.248

0.222

CNS involvement

      

Absent

1

Reference

-

1

Reference

-

Present

25.259

5.124-124.504

0.001

11.375

1.487-86.991

0.019

rs1544105

      

CT + TT

1

Reference

-

1

Reference

-

CC

4.992

1.550-16.078

0.007

2.723

0.766-9.674

0.059

  1. *Data were calculated by Cox-regression analysis. BCP-ALL, B-cell precursor ALL; RFS, relapse free survival; EFS, event free survival; WBC, white blood cell count; CNS, central nervous system; HR, hazard ratio; 95% CI, 95% confidence interval.
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Cancer Cell International

ISSN: 1475-2867

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