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Table 3 Multivariate Cox-regression analysis for RFS and EFS in patients with BCP-ALL (N = 164)

From: FPGS rs1544105 polymorphism is associated with treatment outcome in pediatric B-cell precursor acute lymphoblastic leukemia

Variable Multivariable analysis for RFS Multivariable analysis for EFS
HR 95% CI p* HR 95% CI p*
Age       
<10 1 Reference - 1 Reference -
≥10 0.239 0.023-2.518 0.847 0.300 0.036-2.466 0.244
WBC (109/L)       
<50 1 Reference - 1 Reference -
≥50 4.677 1.715-12.760 0.003 3.745 1.062-13.204 0.072
BCR-ABL       
Negative 1 Reference - 1 Reference -
Positive 7.190 2.022-25.567 0.118 2.701 0.497-14.681 0.250
TEL-AML1       
Negative 1 Reference - 1 Reference -
Positive 0.508 0.057-4.550 0.104 0.316 0.038-2.629 0.059
E2A-PBX1       
Negative       
Positive 1 Reference - 1 Reference -
7.557 1.416-40.334 0.257 3.890 0.877-17.248 0.222
CNS involvement       
Absent 1 Reference - 1 Reference -
Present 25.259 5.124-124.504 0.001 11.375 1.487-86.991 0.019
rs1544105       
CT + TT 1 Reference - 1 Reference -
CC 4.992 1.550-16.078 0.007 2.723 0.766-9.674 0.059
  1. *Data were calculated by Cox-regression analysis. BCP-ALL, B-cell precursor ALL; RFS, relapse free survival; EFS, event free survival; WBC, white blood cell count; CNS, central nervous system; HR, hazard ratio; 95% CI, 95% confidence interval.
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