Hunter T, Pines J: Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age [see comments]. Cell. 1994, 79: 573-582.
Article
CAS
PubMed
Google Scholar
Sherr CJ: G1 phase progression: cycling on cue [see comments]. Cell. 1994, 79: 551-555.
Article
CAS
PubMed
Google Scholar
Sherr CJ: Mammalian G1 cyclins and cell cycle progression. Proc Assoc Am Physicians. 1995, 107: 181-186.
CAS
PubMed
Google Scholar
Grana X, Reddy EP: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene. 1995, 11: 211-219.
CAS
PubMed
Google Scholar
Biernat W, Tohma Y, Yonekawa Y, Kleihues P, Ohgaki H: Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas. Acta Neuropathol (Berl). 1997, 94: 303-309. 10.1007/s004010050711.
Article
CAS
Google Scholar
Schmidt EE, Ichimura K, Reifenberger G, Collins VP: CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res. 1994, 54: 6321-6324.
CAS
PubMed
Google Scholar
Burns KL, Ueki K, Jhung SL, Koh J, Louis DN: Molecular genetic correlates of p1 6, cdk4, and pRb immunohistochemistry in glioblastomas. J Neuropathol Exp Neurol. 1998, 57: 122-130.
Article
CAS
PubMed
Google Scholar
Nishikawa R, Furnari FB, Lin H, Arap W, Berger MS, Cavenee WK, Su Huang HJ: Loss of P16INK4 expression is frequent in high grade gliomas. Cancer Res. 1995, 55: 1941-1945.
CAS
PubMed
Google Scholar
Hayashi Y, Ueki K, Waha A, Wiestler OD, Louis DN, von Deimling A: Association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme. Brain Pathol. 1997, 7: 871-875.
Article
CAS
PubMed
Google Scholar
Sure U, Ruedi D, Tachibana O, Yonekawa Y, Ohgaki H, Kleihues P, Hegi ME: Determination of p53 mutations, EGFR overexpression, and loss of p1 6 expression in pediatric glioblastomas. J Neuropathol Exp Neurol. 1997, 56: 782-789.
Article
CAS
PubMed
Google Scholar
Costello JF, Berger MS, Huang HS, Cavenee WK: Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res. 1996, 56: 2405-2410.
CAS
PubMed
Google Scholar
Fischer U, Meltzer P, Meese E: Twelve amplified and expressed genes localized in a single domain in glioma. Hum Genet. 1996, 98: 625-628. 10.1007/s004390050271.
Article
CAS
PubMed
Google Scholar
Rollbrocker B, Waha A, Louis DN, Wiestler OD, von Deimling A: Amplification of the cyclin-dependent kinase 4 (CDK4) gene is associated with high cdk4 protein levels in glioblastoma multiforme. Acta Neuropathol (Berl). 1996, 92: 70-74. 10.1007/s004010050491.
Article
CAS
Google Scholar
Ueki K, Ono Y, Henson JW, Efird JT, von Deimling A, Louis DN: CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res. 1996, 56: 150-153.
CAS
PubMed
Google Scholar
Costanzi-Strauss E, Strauss BE, Naviaux RK, Haas M: Restoration of growth arrest by p16INK4, p21WAF1, pRB, and p53 is dependent on the integrity of the endogenous cell-cycle control pathways in human glioblastoma cell lines. Exp Cell Res. 1998, 238: 51-62. 10.1006/excr.1997.3810.
Article
CAS
PubMed
Google Scholar
Serrano M, Gomez-Lahoz E, DePinho RA, Beach D, Bar-Sagi D: Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science. 1995, 267: 249-252.
Article
CAS
PubMed
Google Scholar
Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J: Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature. 1995, 375: 503-506. 10.1038/375503a0.
Article
CAS
PubMed
Google Scholar
Koh J, Enders GH, Dynlacht BD, Harlow E: Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature. 1995, 375: 506-510. 10.1038/375506a0.
Article
CAS
PubMed
Google Scholar
Nazzaro JM, Neuwelt EA: The role of surgery in the management of supratentorial intermediate and high-grade astrocytomas in adults [see comments]. J Neurosurg. 1990, 73: 331-344.
Article
CAS
PubMed
Google Scholar
Wilson CB: Glioblastoma: the past, the present, and the future. Clin Neurosurg. 1992, 38: 32-48.
CAS
PubMed
Google Scholar
Ammirati M, Galicich JH, Arbit E, Liao Y: Reoperation in the treatment of recurrent intracranial malignant gliomas. Neurosurgery. 1987, 21: 607-614.
Article
CAS
PubMed
Google Scholar
Harsh GRt, Levin VA, Gutin PH, Seager M, Silver P, Wilson CB: Reoperation for recurrent glioblastoma and anaplastic astrocytoma. Neurosurgery. 1987, 21: 615-621.
Article
PubMed
Google Scholar
Naviaux RK, Costanzi E, Haas M, Verma IM: The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. Journal of Virology. 1996, 70: 5701-5705.
PubMed Central
CAS
PubMed
Google Scholar
Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Campisi J: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 1995, 92: 9363-9367.
Article
PubMed Central
CAS
PubMed
Google Scholar
Schlegel J, Piontek G, Kersting M, Schuermann M, Kappler R, Scherthan H, Weghorst C, Buzard G, Mennel H: The p16/Cdkn2a/Ink4a gene is frequently deleted in nitrosourea-induced rat glial tumors. Pathobiology. 1999, 67: 202-206. 10.1159/000028073.
Article
CAS
PubMed
Google Scholar
Sherr CJ: Tumor surveillance via the ARF-p53 pathway. Genes Dev. 1998, 12: 2984-2991.
Article
CAS
PubMed
Google Scholar
Momand J, Zambetti GP, Olson DC, George D, Levine AJ: The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell. 1992, 69: 1237-1245.
Article
CAS
PubMed
Google Scholar
Uhrbom L, Nister M, Westermark B: Induction of senescence in human malignant glioma cells by p16INK4A. Oncogene. 1997, 15: 505-514. 10.1038/sj/onc/1201227.
Article
CAS
PubMed
Google Scholar
Hung KS, Hong CY, Lee J, Lin SK, Huang SC, Wang TM, Tse V, Sliverberg GD, Weng SC, Hsiao M: Expression of p16(INK4A) induces dominant suppression of glioblastoma growth in situ through necrosis and cell cycle arrest. Biochemical & Biophysical Research Communications. 2000, 269: 718-725. 10.1006/bbrc.2000.2339.
Article
CAS
Google Scholar
Chintala SK, Fueyo J, Gomez-Manzano C, Venkaiah B, Bjerkvig R, Yung WK, Sawaya R, Kyritsis AP, Rao JS: Adeno virus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro. Oncogene. 1997, 15: 2049-2057. 10.1038/sj/onc/1201382.
Article
CAS
PubMed
Google Scholar
Fuxe J, Akusjarvi G, Goike HM, Roos G, Collins VP, Pettersson RF: Adeno virus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A [In Process Citation]. Cell Growth Differ. 2000, 11: 373-384.
CAS
PubMed
Google Scholar
Lee SH, Kim MS, Kwon HC, Park IC, Park MJ, Lee CT, Kim YW, Kim CM, Hong SI: Growth inhibitory effect on glioma cells of adeno virus-mediated p16/INK4a gene transfer in vitro and in vivo [In Process Citation]. Int J Mol Med. 2000, 6: 559-563.
CAS
PubMed
Google Scholar
Engelhard HH, Duncan HA, Kim S, Criswell PS, Van Eldik L: Therapeutic effects of sodium butyrate on glioma cells in vitro and in the rat C6 glioma model. Neurosurgery. 2001, 48: 616-624.
Article
CAS
PubMed
Google Scholar
Saleh M, Jonas NK, Wiegmans A, Stylli SS: The treatment of established intracranial tumors by in situ retro viral IFN-gamma transfer. Gene Ther. 2000, 7: 1715-1724. 10.1038/sj/gt/3301273.
Article
CAS
PubMed
Google Scholar
Asai A, Miyagi Y, Sugiyama A, Gamanuma M, Hong SH, Takamoto S, Nomura K, Matsutani M, Takakura K, Kuchino Y: Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy. J Neurooncol. 1994, 19: 259-268.
Article
CAS
PubMed
Google Scholar
Dorigo O, Turla ST, Lebedeva S, Gjerset RA: Sensitization of rat glioblastoma multiforme to cisplatin in vivo following restoration of wild-type p53 function. J Neurosurg. 1998, 88: 535-540.
Article
CAS
PubMed
Google Scholar
Lotfi CF, Todorovic Z, Armelin HA, Schimmer BP: Unmasking a growth-promoting effect of the adrenocorticotropic hormone in Y1 mouse adrenocortical tumor cells. J Biol Chem. 1997, 272: 29886-29891. 10.1074/jbc.272.47.29886.
Article
CAS
PubMed
Google Scholar
Paxinos G, Watson C: The rat brain in stereotaxic coordinates. 1996, San Diego: Academic Press
Google Scholar