Introduction
Certain autonomous parvoviruses and their derivates are currently under evaluation as antitumor vectors since they preferentially replicate and kill in vitro-transformed cells and may reduce the incidence of spontaneous and implanted tumors in animals. However, their oncolytic properties are not yet fully understood and seem to involve more than tumor cell killing. H1-mediated tumor cell lysates may trigger antigen presenting cells to augment host immune responses. Therefore, we analysed maturation, activation and crosspresentation of dendritic cells (DC) after phagocytosis of H1-induced tumor cell lysates using the known human SK29-Mel melanoma cell model.