Fig. 5

Subgroup analysis of TCGA data by human system. In combination with Table 3, lower miR-146a-5p expression was associated with poorer prognosis for patients with reproductive system cancers (HR 0.791, 95% CI 0.661–0.947, I² = 0.00%) and digestive system cancers (HR 0.844, 95% CI 0.738–0.965, I² = 49.00%). The final heterogeneity could be considered slight (I² = 21.6%); Thus, a fixed-effect model was used