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Table 6 Association between vitamin B2, B12 with the MTHFR C677T genotype and the risk of EPL and ESCC

From: MTHFR C677T genetic polymorphism in combination with serum vitamin B2, B12 and aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and esophageal precancerous lesions: a case–control study

VariablesEPL [OR (95% CI)a, p for interaction]ESCC [OR (95% CI)a, p for interaction]
CCCTTTCCCTTT
Vitamin B2 (μg/l)
 Q1 (< 2074.39)1.00 (reference)2.05 (0.85–4.99)
0.112
4.91 (1.31–18.35)
0.018
1.00 (reference)1.13 (0.47–2.68)
0.790
1.25 (0.28–5.63)
0.771
 Q2 (2074.39–2592.69)1.16 (0.45–3.02)
0.760
0.85 (0.32–2.26)
0.750
1.56 (0.47–5.22)
0.469
2.13 (0.95–4.76)
0.067
2.45 (1.13–5.30) 0.0230.78 (0.22–2.76)
0.702
 Q3 (2592.69–3019.57)0.60 (0.23–1.57)
0.294
1.79 (0.70–4.56)
0.226
2.98 (0.62–14.36)
0.174
0.54 (0.23–1.30)
0.171
1.10 (0.44–2.74) 0.8331.67 (0.33–8.32)
0.534
 Q4 (> 3019.57)0.07 (0.01–0.61)
0.016
0.49 (0.16–1.49)
0.206
2.23 (0.51–9.69)
0.284
0.16 (0.04–0.60)
0.006
0.23 (0.07–0.77) 0.0170.31 (0.03–3.02)
0.315
Vitamin B12 (ng/l)
 Q1 (< 375.09)1.00 (reference)2.03 (0.70–5.87)
0.193
6.88 (1.10–42.80)
0.039
1.00 (reference)0.93 (0.38–2.28)
0.868
1.65 (0.25–10.91)
0.603
 Q2 (375.09–499.07)1.18 (0.41–3.38)
0.760
2.06 (0.75–5.69)
0.162
3.30 (0.79–13.88)
0.103
1.49 (0.69–3.25)
0.313
2.38 (1.10–5.17)
0.028
1.10 (0.28–4.37)
0.892
 Q3 (499.07–570.88)0.74 (0.23–2.37)
0.612
0.73 (0.19–2.88)
0.657
1.83 (0.49–6.81)
0.365
0.42 (0.16–1.09)
0.075
0.73 (0.27–2.00)
0.545
0.49 (0.13–1.84)
0.290
 Q4 (> 570.88)1.32 (0.45–3.88)
0.620
2.41 (0.89–6.53)
0.085
10.08 (2.22–45.71)
0.003
0.10 (0.02–0.46)
0.003
0.18 (0.05–0.62)
0.006
0.73 (0.11–4.85)
0.748
  1. aAdjusted for gender, age, tobacco smoking and alcoholic drinking