Table 6 Association between vitamin B₂, B₁₂ with the MTHFR C677T genotype and the risk of EPL and ESCC

Vitamin B₂ (μg/l)

 Q1 (< 2074.39)

1.00 (reference)

2.05 (0.85–4.99)

0.112

4.91 (1.31–18.35)

0.018

1.00 (reference)

1.13 (0.47–2.68)

0.790

1.25 (0.28–5.63)

0.771

 Q2 (2074.39–2592.69)

1.16 (0.45–3.02)

0.760

0.85 (0.32–2.26)

0.750

1.56 (0.47–5.22)

0.469

2.13 (0.95–4.76)

0.067

2.45 (1.13–5.30) 0.023

0.78 (0.22–2.76)

0.702

 Q3 (2592.69–3019.57)

0.60 (0.23–1.57)

0.294

1.79 (0.70–4.56)

0.226

2.98 (0.62–14.36)

0.174

0.54 (0.23–1.30)

0.171

1.10 (0.44–2.74) 0.833

1.67 (0.33–8.32)

0.534

 Q4 (> 3019.57)

0.07 (0.01–0.61)

0.016

0.49 (0.16–1.49)

0.206

2.23 (0.51–9.69)

0.284

0.16 (0.04–0.60)

0.006

0.23 (0.07–0.77) 0.017

0.31 (0.03–3.02)

0.315

Vitamin B₁₂ (ng/l)

 Q1 (< 375.09)

1.00 (reference)

2.03 (0.70–5.87)

0.193

6.88 (1.10–42.80)

0.039

1.00 (reference)

0.93 (0.38–2.28)

0.868

1.65 (0.25–10.91)

0.603

 Q2 (375.09–499.07)

1.18 (0.41–3.38)

0.760

2.06 (0.75–5.69)

0.162

3.30 (0.79–13.88)

0.103

1.49 (0.69–3.25)

0.313

2.38 (1.10–5.17)

0.028

1.10 (0.28–4.37)

0.892

 Q3 (499.07–570.88)

0.74 (0.23–2.37)

0.612

0.73 (0.19–2.88)

0.657

1.83 (0.49–6.81)

0.365

0.42 (0.16–1.09)

0.075

0.73 (0.27–2.00)

0.545

0.49 (0.13–1.84)

0.290

 Q4 (> 570.88)

1.32 (0.45–3.88)

0.620

2.41 (0.89–6.53)

0.085

10.08 (2.22–45.71)

0.003

0.10 (0.02–0.46)

0.003

0.18 (0.05–0.62)

0.006

0.73 (0.11–4.85)

0.748