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Correction to: The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells

Correction to: Cancer Cell Int (2019) 19:321 https://doi.org/10.1186/s12935-019-1045-1

Following publication of the original article [1] the authors have notified us of a few errors in Figures 2, 3 and 6. The corrected Figs. 2, 3, and 6 are presented below.

Fig. 2
figure2

FTO regulates cervical cancer cells’ proliferation and migration. a Immunoblot analysis of FTO expression in control and knocking down Hela cells using two different shRNAs; b m6A dot blot assays of Hela cells with or without knocking down of FTO. MB, methylene blue staining (as loading control); c effects of knocking down FTO on Hela cells growth/proliferation. ***P < 0.001. (Student’s t test); d Western blot analysis of FTO expression in control and knocking down SiHa cells using same shRNAs as described in a; e m6A dot blot assays of SiHa cells with or without knocking down of FTO. MB, methylene blue staining (as loading control); f effects of knocking down FTO on SiHa cells growth/proliferation. ***P < 0.001. (Student’s t test); g, h analysis of cell migration capacity using competent or deficient Hela and SiHa cells

Fig. 3
figure3

The m6A demethylase activity is required for FTO to play its oncogenic function. a Enforced FTO or FTO-mut expression in Hela cells. FTO-mut carries two point- mutations, H231A and D233A, which disrupt the enzymatic activity of FTO. GAPDH was used as a loading control; b m6A dot blot assays of Hela cells with enforced FTO or FTO-mut expression. MB, methylene blue staining (as loading control); c effects of FTO or mutant FTO overexpression on Hela cells’ growth/proliferation, ***P < 0.001. (Student’s t test); d enforced FTO or FTO-mut expression in SiHa cells. GAPDH was used as a loading control; e m6A dot blot assays of SiHa cells with enforced FTO or FTO-mut expression. MB, methylene blue staining (as loading control); f effects of FTO or mutant FTO overexpression on SiHa cells’ growth/proliferation, ***P < 0.001. (Student’s t test); g, h analysis of cell migration capacity in FTO or mutant FTO overexpressed Hela and SiHa cells

Fig. 6
figure6

Overexpression of E2F1 or Myc compensates FTO knocking down effect. a The protein level determination of overexpressed E2F1 or Myc in FTO control and knockdown Hela and SiHa cells, **P < 0.01 (unpaired two-sided t test); b cell proliferation analysis of Hela (upper panel) and SiHa cells (lower panel) in different genetic background as described (a). *P < 0.05, **P < 0.01, ***P < 0.001 (Student’s t test). c, d The migration analysis of Hela cells (c) and SiHa cells (d) in different genetic background as described in a

Reference

  1. 1.

    Zou D, Dong L, Li C, Yin Z, Rao S, Zhou Q. The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells. Cancer Cell Int. 2019;19:321. https://doi.org/10.1186/s12935-019-1045-1.

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Correspondence to Dongling Zou or Shuan Rao or Qi Zhou.

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Zou, D., Dong, L., Li, C. et al. Correction to: The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells. Cancer Cell Int 20, 423 (2020). https://doi.org/10.1186/s12935-020-01473-8

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