Fig. 3
From: The Ibr-7 derivative of ibrutinib radiosensitizes pancreatic cancer cells by downregulating p-EGFR
Ibr-7 promoted radiation-induced G2/M phase arrest in pancreatic cancer cells. a Representative histograms showing the cell cycles of PANC-1 and Capan2 cells in the Ctrl, Ibr-7, radiation and combination groups. Cells were treated with Ibr-7 (2 μmol/L) for 24 h, exposed to 6 Gy of radiation and stained with PI after another 24 h. b The percentages of the cell cycle phases in each group were quantified. The results shown are the mean ± SD of 3 independent experiments. Significance was determined by Student’s t-test (*p < 0.05 compared with the combination group)