Fig. 3
From: MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer
miRNA-mediated regulation of BCSCs via targeting the Notch signaling pathway. The Notch signaling pathway is activated when Notch ligands on one cell interact with Notch receptors on an adjacent cell, resulting in the two consecutive cleavages of Notch receptors by ADAMs and γ-secretase, and the release of Notch receptor intracellular domain NICD into the cytoplasm. The released NICD is translocated into the nucleus and binds to CSL to initiate the Notch target genes’ expression. The immediate targets of related miRNAs are marked