Table 3 miRNA acts as oncomiR in breast cancer
From: MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer
miRNA | Target | Result on BCSCs |
|---|---|---|
miR-155 | CD44 | Enhances BCSCs’ chemoresistance to doxorubicin |
CD90 | Â | |
ABCG2 | Promotes BCSCs’ formation | |
miR-181 | BRCA1 | Increases stemness, colony formation and phenotypes of BCSCs |
miR-22 | TET family | Increases stemness and metastasis of BCSCs |
miR-29a | H4K20 | Promotes metastasis and invasion of BCSCs |
miR-9 and miR221 | CD133 | Enhances stemness, proportion and tumor sphere formation of BCSCs |
Nanog | Â | |
Oct4 | Â | |
miR-203 | SOCS3 | Promotes proliferation, growth and self-renewal of BCSCs |