A review on the role of cyclin dependent kinases in cancers

Ghafouri-Fard, Soudeh; Khoshbakht, Tayyebeh; Hussen, Bashdar Mahmud; Dong, Peixin; Gassler, Nikolaus; Taheri, Mohammad; Baniahmad, Aria; Dilmaghani, Nader Akbari

doi:10.1186/s12935-022-02747-z

Cancer Cell International

Table 2 Function of CDK1 in animal models of cancer

From: A review on the role of cyclin dependent kinases in cancers

Tumor Type	Animal models	Results	References
Bladder cancer	female BALB/c nude mice	∆ PVT1: ↓ tumor volume and tumor weight	[7]
Breast cancer	4–6-week-old female nude BALB/C mice	↑↑ RBM7 (which up-regulates CDK1): ↑ proliferation, tumor growth	[19]
Breast cancer	6-week-old nude mice	∆ KIAA1429 + CDK1: ↓ tumor weight	[10]
Cervical cancer	4–6-week-old BALB/c nude mice	↑↑ miR-143-3p or miR-495-3p: ↓ tumorigenicity	[20]
Cervical cancer	4–6-week-old BALB/c nude mice	∆ NCK1-AS1: ↓ tumor growth and tumor weight	[21]
Cholangiocarcinoma	5-week-old male BALB/cAnNCrj-nu/nu nude mice	∆ CDK1: ↓ tumor growth	[56]
Colorectal cancer	5-week-old male BALB/c mice	dinaciclib and cobimetinib combination: ↓ tumor growth	[15]
	4-week-old male nude mice	↑↑ miR-378a-5p: ↓ tumor growth by targeting CDK1	[24]
	4-week-old female BALB/c nude mice	∆ DPP3: ↓ tumor growth	[25]
	7-week-old BALB/c nude mice	∆ SNHG4 (which regulated CDK1): ↓ tumor growth	[26]
	female BALB/c nude mice	∆ SNRPA1: ↓ tumor formation	[28]
Gastric cancer	4-week-old male nude mice	∆ ESRRA: ↓ tumor growth	[32]
Hepatocellular carcinoma	NOD-SCID mice	Combination of RO3306 (CDK1 inhibitory substance) and sorafenib: ↓ tumor growth and ↓ sorafenib resistance	[37]
	BALB/c nude mice	∆ DEPDC1B: ↓ tumor growth	[38]
	nude mice	↑↑ miR-1271-5p: ↓ tumor growth via targeting CDK1	[39]
	male nude mice	∆ SNORD52: ↓ tumor growth and mass	[41]
Nasopharyngeal carcinoma	5-week-old immunodeficient BALB/c nu/nu female mice	Tetrandrine treatment: ↑ radiosensitivity and ↓ tumor growth	[57]
Ovarian cancer	ovarian xenograft mice	∆ UBE2C: ↓ tumor growth	[59]
Ovarian cancer	4-week-old female BALB/c mice	↑↑ DLEU1: ↑ tumor growth	[62]
Pancreatic cancer	NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice	AT7519 treatment: ↓ phosphorylation of CDK1, 2, 7, and 9 substrates and ↓ tumor growth	[63]
Pancreatic ductal adenocarcinoma cancer	female C57BL/6 (KPC) or BALB/c (CT26) mic	FNG/dinaciclib combination therapy: ↑ CD8 + T cell-dependent antitumour activity	[65]
Prostate cancer	nude mice	∆ TPX2: ↓ tumor weight	[66]
Prostate cancer	4-week-old male BALB/c immunodeficient nude mice	↑↑ ABCC5: ↑ tumor volume and tumor weight	[67]

∆: knock-down or deletion, GIST Gastrointestinal stromal tumor

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