Table 3 Dysregulation of CDK1 in clinical samples

Adrenocortical carcinoma

GEO and TCGA databases

Up-regulation of CENPF (which interacts with CDK1)

Shorter OS

different immune cell populations, and high TMB/MSI score

[6]

Bladder cancer

GEO database

5 bladder cancer tissues and 35 normal tissues

Up-regulation of PVT1 (which regulated CDK1)

Up-regulation of CDK1

_

_

[7]

TCGA dataset

Up-regulation of TFCP2L1

Shorter OS

tumor grade, lymphovascular and muscularis propria invasion, and distant metastasis

[8]

GEO database (GSE71576)

TCGA database: 412 BC patients

GEO database (GSE13507: 165 primary bladder cancer samples, 58 ANCTs, 23 recurrent bladder tumor tissues and 10 normal bladder mucosae)

Up-regulation of CDK1

_

tumor grade and recurrence

[70]

Breast cancer

46 PTANCT

Up-regulation of RBM7 (which regulates up-regulation of CDK1)

Shorter OS

_

[19]

TCGA dataset

72 PTANCT

Up-regulation of KIAA1429

_

advanced clinical stages

[10]

Oncomine database and GEPIA dataset

Up-regulation of CDK1

Shorter OS, RFP, and PPS

advanced tumor stage

[69]

GSE42568, GSE45827, and GSE124646 (244 BC tissues and 28 normal breast tissues)

Up-regulation of CDK1

_

_

[11]

8 PTANCT

Up-regulation of UBAP2L

_

_

[12]

17 PTANCT

Down-regulation of miR-424

_

_

[17]

GEO database

(GSE21422 and GSE21974)

Up-regulation of NUSAP1 (which regulates CDK1)

_

_

[18]

GEO database (GSE21422, GSE42568 and GSE45827)

Up-regulation of CDK1

Shorter OS

_

[71]

Cervical cancer

GEO database

60 PTANCT

Up-regulation of CDK1

_

_

[20]

TCGA dataset (two courts 100 and 120 patients)

31 PTANCT

Up-regulation of NCK1-AS1 (which regulates CDK1)

Shorter OS

_

[21]

Cholangiocarcinoma

54 cholangiocarcinoma patients

Up-regulation of CDK1

Shorter OS

lymph node metastasis and the clinical stage

[22]

74 CCA tissues and 5 normal tissues

Up-regulation of PSMC2 (which regulates CDK1)

_

advanced tumor grades

[23]

Colorectal cancer

TCGA dataset

Up-regulation of CDK1

_

_

[15]

TCGA database

22 PTANCT

108 CRC patients

Down-regulation of miR-378a-5p (which targets CDK1)

Up-regulation of CDK1

_

tumors in the right colon, lymph node metastasis, and TNM stage

[24]

99 cancerous tissues and 76 normal tissues

Up-regulation of DPP3

Shorter OS

lymphatic metastases, stage, positive numbers of lymph nodes

[25]

GSE8671, GSE74602, and TCGA datasets

12 tumor tissues and 12 normal tissues

Up-regulation of SNHG4 (which regulated CDK1)

_

lymphatic or distal metastatic stage

[26]

GEO database (GSE126092)

Up-regulation of CDK1

Shorter OS

_

[72]

TCGA database (459 colon cancer samples and

41 normal samples)

5 PTANCT

Up-regulation of NFE2L3

_

_

[27]

GEO database

(GSE21815, GSE106582, and GSE41657)

Up-regulation of CDK1

Shorter OS

gender, tumor type, TNM stage, and KRAS gene mutation

[73]

Endometrial carcinoma

42 PTANCT

Up-regulation of CDK1

_

_

[29]

Esophageal squamous cell carcinoma

151 ESCC tissues and 138 normal esophageal tissues

8 PTANCT

664 ESCC patients and 1733 control tissues

Up-regulation of CDK1

_

_

[74]

Gastric cancer

80 PTANCT

GEO database (GSE99416 (6 PTANCT))

Up-regulation of CASC11 (which regulated CDK1)

_

_

[75]

GEPIA2 database

50 PTANCT

246 patients

Up-regulation of ESRRA

Shorter OS

tumor invasion extent, lymph node/distant metastases and TNM stage

[32]

Oncomine database, TCGA database and GTEx project (9736 tumor samples and 8726 normal samples)

Up-regulation of CDK1 and CDCA5

_

_

[33]

Glioma

TCGA database (511 low‐grade glioma cases and 156 glioblastoma cases)

30 glioma tissues and 7 normal tissues

Up-regulation of FOXD2-AS1 (which regulated CDK1)

Shorter OS

_

[36]

Hepatocellular carcinoma

3 HCC patients

Up-regulation of CDK1

Shorter OS

_

[37]

ONCOMINE database AND TCGA, ICGC, and GEO databases

Up-regulation of CDK1

_

immune cell infiltration

[76]

GEO database (GSE121248, GSE45267 and GSE84402 (132 tumor tissues and 90 normal tissues))

Up-regulation of CDK1

Shorter OS

_

[77]

178 PTANCT

TCGA database

Up-regulation of DEPDC1B (which plays its role via CDK1)

_

pathologic T/N, tumor stage, and gender

[38]

GEO database (GSE55092, GSE84044 and GSE121248 (119 HBV-related HCC samples and 252 HBV-related non-tumor samples))

Up-regulation of CDK1

_

clinical grading of HCC

[78]

GEO database (GSE113850)

14 PTANCT

Up-regulation of CDK1

Shorter OS and DFS

HCC occurrence, pathological stages, and survivorship curve

[40]

GEO database (GSE14520: 225 HCC tissues and 220 normal tissues)

TCGA database: 365 patients

59 PTANCT

Up-regulation of CDK1

Shorter OS

_

[79]

80 PTANCT

Up-regulation of SNORD52 (which regulated CDK1)

Shorter OS and RFS

microvascular invasion and TNM stage

[41]

Hepatocellular carcinoma

GEO database (GSE27635 and GSE28248)

Up-regulation of CDK1

Shorter OS

_

[80]

GEO database (GSE84402, GSE101685, and GSE112791)

TCGA dataset

Up-regulation of CDK1

_

tumor-infiltrate lymphocytes

[81]

Lung cancer

lung tissues

Up-regulation of CDK1

Shorter OS

_

[43]

GEPIA database

(9,736 tumor samples and 8,587 normal controls)

8 PTANC

Up-regulation of CDK1

Shorter OS

advanced tumor stages

[82]

30 PTANC

Up-regulation of CASC11 (which regulated CDK1)

_

_

[44]

TCGA database (991 tumor tissues and 91 normal tissues)

14 pairs of KRASmut tumor tissues and ANCTs

Down-regulation of miR-34c-3p (which targets CDK1)

_

_

[45]

64 PTANC

Up-regulation of NCK1-AS1 (which regulated CDK1)

_

tumor size, TNM stage and lymph node metastasis

[46]

GEO database (GSE6044 and

GSE118370)

Up-regulation of CDK1

Shorter OS and DFS

tumor stages and relative abundance of tumor infiltrating immune cells

[83]

50 PTANC

Up-regulation of TMPO-AS1 (which regulated CDK1)

Shorter OS

_

[49]

78 PTANC

Down-regulation of miR-181a

_

histological grade, N status and TNM stage

[50]

GEO database (5 different microarray datasets: 330 samples)

Up-regulation of CDK1

Shorter OS

_

[84]

Nasopharyngeal carcinoma

99 NPC patients and 46 normal tissues

Down-regulation of miR-195-3p (which sponged CDK1)

_

tumor grade, lymph node metastasis, clinical stage, and radioresistance

[58]

Ovarian cancer

20 tumor tissues and 12 normal tissues

Up-regulation of UBE2C

Shorter OS and PFS

_

[59]

GEO database (GSE14407, GSE29450, and GSE54388)

Up-regulation of CDK1

Shorter OS

_

[85]

TCGA dataset

62 PTANC

Up-regulation of TONSL-AS1 (which regulates CDK1)

Shorter OS

_

[61]

11 benign ovarian tumors, 8 borderline ovarian tumors, 99 ovarian cancer tissues and 15 normal ovary tissues

Up-regulation of DLEU1 (which regulated CDK1) in ovarian cancer tissues

_

differentiation and FIGO staging

[62]

Pancreatic ductal adenocarcinoma

99 PDAC tissues and 71 normal pancreatic tissues

Up-regulation of CDK1

Shorter OS

tumor size and histological grade

[86]

GEO database (GSE46234, GSE71989, and GSE107610)

Up-regulation of CDK1

Shorter OS and DFS

advanced tumor stage

[87]

Prostate cancer

TCGA database (499 prostate cancer and 52 adjacent tissues)

Up-regulation of TPX2

Shorter OS

high Gleason grade

[66]

TCGA and GEO databases

149 prostate cancer patients

Up-regulation of ABCC5

Shorter OS and PFS

tumor stage

[67]

Prostate cancer

1,461 patients and 510 normal samples

Down-regulation of miR-205 (which targeted CDK1)

_

bone metastasis

[88]

Rhabdomyosarcoma

GEO database

66 samples (GSE16382 [N = 8] and GSE66533 [N = 58)) and 16 normal striated muscle tissues (GSE39454 [N = 5], GSE17674 [N = 5] and GSE38417 [N = 6])

Up-regulation of CDK1

_

_

[89]

Sebaceous gland carcinoma of the eyelid

3 SGC patients and 1 sebaceous adenoma case

Up-regulation of CDK1 in SGC patients

_

_

[90]

Thyroid cancer

Two tissue microarrays (THC961 and THC1021) (125 cancerous thyroid tissues and 23 non-cancerous thyroid tissues)

46 cancerous thyroid tissues and 64 non-cancerous thyroid tissues

171 cancerous thyroid tissues and 87 non-cancerous thyroid tissues

16 gene microarrays (419 cancerous thyroid tissues and 269 non-cancerous thyroid tissues)

Up-regulation of CDK1

_

_

[91]