Table 8 Function of CDK3 in animal models of cancer
From: A review on the role of cyclin dependent kinases in cancers
Tumor Type | Animal models | Results | References |
|---|---|---|---|
Breast cancer | 5 – 7-week-old female BALB/c nude mice | ↑↑ CDK3: ↓ metastasis | [181] |
6-week-old female nude mice | NCTD treatment: ↓ tumor growth via miR-873/CDK3 axis | [182] | |
4-week-old female BALB/c nude mice | ↑↑ miR-125a-3p: ↓ tumor growth | [183] | |
6- week-old female nude mice | ↑↑ miR-873: ↓ tumor growth via targeting CDK3 | [184] | |
Colorectal cancer | 5– 6-week-old female nude BABL/c mice | ↑↑ CDK3: ↑ metastasis | [185] |
Hepatocellular carcinoma | 4–5-week-old Male BALB/c-nu mice | ↑↑ miR-214: ↓ tumor growth via targeting E2F2, CDK3 and CDK6 | [189] |
Skin cancer | 6-week-old male BALB/c nu/nu mice | ↑↑ NFAT3: ↑ tumor growth | [193] |