Retraction Note: Mst1 overexpression combined with Yap knockdown augments thyroid carcinoma apoptosis via promoting MIEF1-related mitochondrial fission and activating the JNK pathway
Cancer Cell International volume 23, Article number: 75 (2023)
Retraction Note: Cancer Cell Int (2019) 19:143
The Editors-in-Chief have retracted this article. After publication, concerns were raised regarding image similarities between this article and several other articles. Specifically:
Figure 1a GAPDH blot appears highly similar to Fig. 7a t-JNK in , which was under consideration within a similar time frame as this article.
Figure 2a Cyclin D1 blot appears highly similar to Fig. 3e CIV-II in .
In Fig. 2g, the Ctrl and Ad-Mst1 images appear to share some highly similar features; the Ad-Mst1 image also appears to contain some repetitive elements.
Figure 3 h Bcl2 blot appears highly similar to Fig. 3b CIII-core2 in .
Figure 3 g has very unusual shapes for flow cytometry plots.
Figure 4a Ctrl and Ad-Mst1 + sh-Yap images appear highly similar to Fig. 4a Melatonin and TNFα images (rotated), respectively, in .
Figure 4c Mff blot appears highly similar to Fig. 3b CII-30 (flipped horizontally) in .
The same Caspase-9 western blots appear to be presented in Fig. 3 h and S1e.
Figure 4c Drp1 blot appears highly similar to Fig. 2d CyclinD1 (flipped horizontally) in .
The Editors-in-Chief therefore no longer have confidence in the presented data.
None of the authors have responded to any correspondence from the editor or publisher about this retraction.
Yao W, Zhu S, Li P, et al. Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway. Cancer Cell Int. 2019;19:97. https://doi.org/10.1186/s12935-019-0812-3.
Zhao Q, Wang W, Cui J. Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death via suppressing CaMKII/Parkin/mitophagy axis. Cancer Cell Int. 2019;19:58. https://doi.org/10.1186/s12935-019-0777-2.
Zhang J, Sun L, Li W, et al. Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy. Biomed Pharmacother. 2019;114:108844. https://doi.org/10.1016/j.biopha.2019.108844.
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The online version of the original article can be found at https://doi.org/10.1186/s12935-019-0860-8.
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Zhang, X., Li, F., Cui, Y. et al. Retraction Note: Mst1 overexpression combined with Yap knockdown augments thyroid carcinoma apoptosis via promoting MIEF1-related mitochondrial fission and activating the JNK pathway. Cancer Cell Int 23, 75 (2023). https://doi.org/10.1186/s12935-023-02921-x