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Fig. 1 | Cancer Cell International

Fig. 1

From: ROS impairs tumor vasculature normalization through an endocytosis effect of caveolae on extracellular SPARC

Fig. 1

In comparison with the control group, the density of vessels with normal structure was significantly reduced in LLC (A&B) and B16F10 (C&D) tumor tissues after H2O2 treatments (α-SMA+ vascular smooth muscle cell, green; CD31+ endothelial cells, red). Data presented were mean ± SD. By DPI treatment, a higher proportion of normal structured blood vessels could be observed. Differences among two H2O2-treated and DPI-treated groups were tested by ANOVA, with the * representing p values less than 0.05 and the *** representing p values less than 0.01

LLC: Lewis lung carcinoma cell line; B16F10: murine melanoma cell line; DPI: diphenyleneiodonium; ANOVA: analysis of variance

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Cancer Cell International

ISSN: 1475-2867

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