Fig. 8From: ROS impairs tumor vasculature normalization through an endocytosis effect of caveolae on extracellular SPARCIn response to oxidative stress, SPARC outside the endothelium enters intracellularly via endocytosis of caveolin-1, triggering defective recruitment of pericytes, structural aberrations followed by inadequate perfusion, hypoxic microenvironment, and hyperpermeability (Created with BioRender.com). SPARC: secreted acidic and cysteine-rich proteinBack to article page