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  1. Osteosarcoma (OS) is the most common primary malignant bone tumor in young people. Tumor-associated macrophages (TAMs) have been reported to play an important role in the development of osteosarcoma. However, ...

    Authors: Hongliang Zhang, Yiyang Yu, Jun Wang, Yu Han, Tingting Ren, Yi Huang, Chenglong Chen, Qingshan Huang, Wei Wang, Jianfang Niu, Jingbing Lou and Wei Guo
    Citation: Cancer Cell International 2021 21:192
    Content type: Primary research Published on:

  2. Prostate cancer (PCa) is the most common malignant tumor in developed countries, which has seriously threatened men’s lifestyle and quality of life. The up-regulation of EZH2 is associated with advanced PCa an...

    Authors: Mengyuan Jin, Jiachen Duan, Wei Liu, Jing Ji, Bin Liu and Mingzhi Zhang
    Citation: Cancer Cell International 2021 21:191
    Content type: Primary research Published on:

  3. Hepatocellular carcinoma (HCC) ranks the sixth prevalent tumors with high mortality globally. Alternative splicing (AS) drives protein diversity, the imbalance of which might act an important factor in tumorig...

    Authors: Qianhui Xu, Hao Xu, Rongshan Deng, Nanjun Li, Ruiqi Mu, Zhixuan Qi, Yunuo Shen, Zijie Wang, Jingchao Wen, Jiaxin Zhao, Di Weng and Wen Huang
    Citation: Cancer Cell International 2021 21:190
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:448

  4. Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In recent years, there has been a keen interest towards the development of natural extracts-based cancer therapeutics with ...

    Authors: Zeeshan Javed, Haleema Sadia, Muhammad Javed Iqbal, Shazia Shamas, Kausar Malik, Rais Ahmed, Shahid Raza, Monica Butnariu, Natalia Cruz-Martins and Javad Sharifi-Rad
    Citation: Cancer Cell International 2021 21:189
    Content type: Review Published on:

  5. Cancers are serious life-threatening diseases which annually are responsible for millions of deaths across the world. Despite many developments in therapeutic approaches for affected individuals, the rate of m...

    Authors: Saeed Mehrzadi, Mohammad Hossein Pourhanifeh, Alireza Mirzaei, Farid Moradian and Azam Hosseinzadeh
    Citation: Cancer Cell International 2021 21:188
    Content type: Review Published on:

  6. Myeloma bone disease (MBD) is a severe complication of multiple myeloma (MM) mainly due to an imbalance between enhanced osteoclast activity and reduced osteoblast function. Previous studies have demonstrated ...

    Authors: Zheyu Wu, Yufeng Zhang, Zhiqiang Yang, Yufan Zhu, Yuanlong Xie, Fuling Zhou and Lin Cai
    Citation: Cancer Cell International 2021 21:187
    Content type: Primary research Published on:

  7. To our knowledge, LncRNA SNHG15 exerted its tumor-promoting effects to facilitate the development of breast cancer (BC), but there still needed more data to elucidate the potential underlying mechanisms.

    Authors: Jiang Du, Hong Zhong and Binlin Ma
    Citation: Cancer Cell International 2021 21:186
    Content type: Primary research Published on:

  8. Early diagnosis of nasopharyngeal carcinoma (NPC) is vital to improve the prognosis of these patients. However, early diagnosis of NPC is typically challenging. Therefore, we explored the pathogenetic roles an...

    Authors: Wei Zheng, Wangzhong Ye, Zijie Wu, Xinyi Huang, Yuanji Xu, Qinyan Chen, Zhizhong Lin, Yanyu Chen, Penggang Bai and Chuanben Chen
    Citation: Cancer Cell International 2021 21:185
    Content type: Primary research Published on:

  9. Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which repres...

    Authors: Li Dai, Mao Li, Wei-long Zhang, Ya-Jie Tang, Ya-ling Tang and Xin-hua Liang
    Citation: Cancer Cell International 2021 21:184
    Content type: Review Published on:

  10. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jihui Chen, Zhipeng Wang, Shouhong Gao, Kejin Wu, Fang Bai, Qiqiang Zhang, Hongyu Wang, Qin Ye, Fengjing Xu, Hong Sun, Yunshu Lu and Yan Liu
    Citation: Cancer Cell International 2021 21:183
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2021 21:136

  11. Previous studies have found that the microenvironment of cervical cancer (CESC) affects the progression and treatment of this disease. Thus, we constructed a multigene model to assess the survival of patients ...

    Authors: Qian Chen, Bingqing Qiu, Xiaoyun Zeng, Lang Hu, Dongping Huang, Kaihua Chen and Xiaoqiang Qiu
    Citation: Cancer Cell International 2021 21:182
    Content type: Primary research Published on:

  12. Lung adenocarcinoma (LUAD) is one of the most common malignancies worldwide. However, the molecular mechanism of LUAD tumorigenesis and development remains unclear. The purpose of this study was to comprehensi...

    Authors: Guoshu Bi, Donglin Zhu, Yunyi Bian, Yiwei Huang, Cheng Zhan, Yong Yang and Qun Wang
    Citation: Cancer Cell International 2021 21:181
    Content type: Primary research Published on:

  13. Long noncoding RNAs (lncRNAs) have recently identified as essential gene modulators in numerous cancers. Previous studies have confirmed the oncogenic role of long intergenic nonprotein-coding RNA 00514 (LINC0...

    Authors: Xiao Luo and Hui Wang
    Citation: Cancer Cell International 2021 21:180
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:561

  14. Studies have discussed long noncoding RNA DDX11-AS1 (DDX11-AS1)-mediated downstream mechanism in hepatocellular carcinoma (HCC). The goal of this study was to investigate the regulatory mechanism of DDX11-AS1-...

    Authors: Gangqiang Ding, Yanli Zeng, Dongqiang Yang, Can Zhang, Chongshan Mao, Erhui Xiao, Yi Kang and Jia Shang
    Citation: Cancer Cell International 2021 21:179
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:659

  15. Aberrantly expressed microRNAs play important roles in gastric tumorigenesis. However, use of miRNAs as a therapeutic option in gastric cancer still remains as a challenging problem.

    Authors: Narjes Jafari, Saeid Abediankenari and Hadi Hossein-Nataj
    Citation: Cancer Cell International 2021 21:178
    Content type: Primary research Published on:

  16. Chemo-resistance is still a major obstacle in leukemia treatment. Accumulating evidence indicates that cancer-associated fibroblasts (CAFs), the most abundant stromal cells in tumor microenvironment (TME), pla...

    Authors: Yuanyuan Li and Ling Gu
    Citation: Cancer Cell International 2021 21:177
    Content type: Primary research Published on:

  17. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhao‑liang Yu, Yu‑feng Chen, Bin Zheng, Ze-rong Cai, Yi‑feng Zou, Jia Ke, Ping Lan, Feng Gao and Xiao‑jian Wu
    Citation: Cancer Cell International 2021 21:176
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2021 21:94

  18. Transcription factors (TFs) may be engaged in reciprocal regulatory circuits with certain miRNAs to maintain cellular homeostasis. Disequilibrium of the reciprocities by certain tumor-related stimuli may give ...

    Authors: Wenjing Zhang, Haitao Yang, Zhongqiu Wang, Yanting Wu, Jingzhai Wang, Guihua Duan, Qiang Guo and Yu Zhang
    Citation: Cancer Cell International 2021 21:175
    Content type: Primary research Published on:

  19. The incidence and mortality rates of hepatocellular carcinoma are among the highest of all cancers all over the world. However the survival rates are relatively low due to lack of effective treatments. Efforts...

    Authors: Fan Zhang, Mengjuan Xue, Xin Jiang, Huiyuan Yu, Yixuan Qiu, Jiaming Yu, Fan Yang and Zhijun Bao
    Citation: Cancer Cell International 2021 21:174
    Content type: Primary research Published on:

  20. Gastric intestinal metaplasia (GIM) is a significant risk factor for gastric cancer. Risk of gastric cancer/dysplasia between complete intestinal metaplasia (CIM) and incomplete intestinal metaplasia (IIM) was...

    Authors: Ning Wei, Mengyue Zhou, Siyu Lei, Zhiheng Zhong and Ruihua Shi
    Citation: Cancer Cell International 2021 21:173
    Content type: Review Published on:

  22. As a tissue-specific proangiogenic or antiangiogenic agent, angiopoietin-like 4 (ANGPTL4) has recently gained attention in many diseases, such as metabolic syndrome, cardiovascular disease and cancer. However,...

    Authors: Yuxian Wu, Jinghai Gao and Xiaojun Liu
    Citation: Cancer Cell International 2021 21:171
    Content type: Primary research Published on:

  23. Neuroblastoma is a childhood neural crest tumor showing large clinical and genetic heterogeneity, one form displaying 11q-deletion is very aggressive. It has been shown that 11q-deletion results in decreased e...

    Authors: Simon Keane, Tommy Martinsson, Per Kogner and Katarina Ejeskär
    Citation: Cancer Cell International 2021 21:170
    Content type: Primary research Published on:

  24. Nowadays, colorectal cancer (CRC) is one of the most commonly diagnosed malignant tumors worldwide, the incidence rate of which is still increasing year by year. Herein, the objective of this study is to inves...

    Authors: Qiang Feng, Dongkui Xu, Mingyao Zhou, Zijian Wu, Zhiyuan Wu, Zheng Wang, Jianjun Bi and Wei Pei
    Citation: Cancer Cell International 2021 21:169
    Content type: Primary research Published on:

  25. Long non-coding RNA (lncRNA) has been confirmed to exert a critical effect on the progression of tumors, including prostate cancer. Previous literature has demonstrated LINC01116 involves in activities of mult...

    Authors: Shengjie Yu, Huihong Yu, Yuanfeng Zhang, Chuan Liu, Weili Zhang and Yunyun Zhang
    Citation: Cancer Cell International 2021 21:168
    Content type: Primary research Published on:

  26. Head and neck squamous cell carcinoma (HNSCC) is a common tumor worldwide with poor prognosis. The pathogenesis of human papillomavirus (HPV)-positive and HPV-negative HNSCCs differs. However, few studies have...

    Authors: Guocai Tian, You Fu, Dahe Zhang, Jiang Li, Zhiyuan Zhang and Xi Yang
    Citation: Cancer Cell International 2021 21:167
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:248

  27. Tumor metastasis is one of the leading reasons of the dismal prognosis of hepatocellular carcinoma (HCC). Epithelial-mesenchymal transition (EMT) is closely associated with tumor metastasis including HCC. The ...

    Authors: Gongmin Zhu, Hongwei Xia, Qiulin Tang and Feng Bi
    Citation: Cancer Cell International 2021 21:166
    Content type: Primary research Published on:

  28. Radiotherapy is a major treatment for esophageal squamous cell carcinoma (ESCC). However, HPV infection related radioresistance caused poor prognosis of ESCC. The function of SOCS6, which has been shown to be ...

    Authors: Xuanzi Sun, Yuchen Sun, Jing Li, Xu Zhao, Xiaobo Shi, Tuotuo Gong, Shupei Pan, Zhongqiang Zheng and Xiaozhi Zhang
    Citation: Cancer Cell International 2021 21:165
    Content type: Primary research Published on:

  29. Numerous individual studies have investigated the diagnostic value of EBV-DNA, EA-IgA, VCA-IgA, EBNA1-IgA and Rta-IgG detection for nasopharyngeal carcinoma (NPC), but the conclusions remain controversial. Thi...

    Authors: Weixing Liu, Gui Chen, Xin Gong, Yingqi Wang, Yaoming Zheng, Xiao Liao, Wenjing Liao, Lijuan Song, Jun Xu and Xiaowen Zhang
    Citation: Cancer Cell International 2021 21:164
    Content type: Review Published on:

  30. Slug (Snai2) is a pivotal player in initiating epithelial-mesenchymal transition (EMT) through its trans-suppression effect on E-cadherin in various normal and malignant cells. In this study, the positive effe...

    Authors: Xian Liu, Qian Feng, Yanru Zhang, PengSheng Zheng and Nan Cui
    Citation: Cancer Cell International 2021 21:163
    Content type: Primary research Published on:

  31. Patients with type 2 diabetes mellitus (T2DM) have an increased risk of suffering from various malignancies. This study aimed to identify specific biomarkers that can detect lung adenocarcinoma (LAC) in T2DM p...

    Authors: Jiayue Yang, Cheng Yang, Hong Shen, Wenjun Wu, Zhen Tian, Qinghua Xu, Cuiping Cao, Shugao Ye, Le Ban, Xin Tong and Jie Mei
    Citation: Cancer Cell International 2021 21:162
    Content type: Primary research Published on:

  32. Cholangiocarcinoma (CCA) is the second most common primary liver malignancy worldwide. Several microRNAs (miRNAs) have been implicated as potential tumor suppressors in CCA. This study aims to explore the pote...

    Authors: Xin Pan, Gang Wang and Baoming Wang
    Citation: Cancer Cell International 2021 21:161
    Content type: Primary research Published on:

  33. CDC27 is one of the core components of Anaphase Promoting complex/cyclosome. The main role of this protein is defined at cellular division to control cell cycle transitions. Here we review the molecular aspect...

    Authors: Golnaz Ensieh Kazemi-Sefat, Mohammad Keramatipour, Saeed Talebi, Kaveh Kavousi, Roya Sajed, Nazanin Atieh Kazemi-Sefat and Kazem Mousavizadeh
    Citation: Cancer Cell International 2021 21:160
    Content type: Review Published on:

  34. Human cell division cycle associated 8 (CDCA8) a key regulator of mitosis, has been described as a potential prognostic biomarker for a variety of cancers, such as breast, colon and lung cancers. We aimed to eval...

    Authors: Yu Shuai, Erxi Fan, Qiuyue Zhong, Qiying Chen, Guangyong Feng, Xiaoxia Gou and Guihai Zhang
    Citation: Cancer Cell International 2021 21:159
    Content type: Primary research Published on:

  35. A crosstalk established between tumor microenvironment and tumor cells leads to contribution or inhibition of tumor progression. Mesenchymal stem cells (MSCs) are critical cells that fundamentally participate ...

    Authors: Surendar Aravindhan, Sura Salman Ejam, Methaq Hadi Lafta, Alexander Markov, Alexei Valerievich Yumashev and Majid Ahmadi
    Citation: Cancer Cell International 2021 21:158
    Content type: Review Published on:

  36. Uterine leiomyosarcoma (ULMS) is a malignant tumor found in the smooth muscle lining the walls of the uterus. Cancer stem cells (CSCs) are responsible for metastasis, drug resistance, and relapse of cancer, re...

    Authors: Jiuping Gao, Ting Yang, Xu Wang, Yi Zhang, Jing Wang, Beilei Zhang, Dihong Tang, Yanqiong Liu, Ting Gao, Qiuhui Lin, Jun Tang and Jingting Cai
    Citation: Cancer Cell International 2021 21:157
    Content type: Primary research Published on:

  38. Esophageal squamous cell carcinoma (ESCC) is one of the most malignant tumors in gastrointestinal system. MicroRNAs (miRNAs) have been reported to be implicated in cancer development. However, the role of miR-...

    Authors: Shuwen Xu, Xiaofeng Li, Longfei Li, Yufeng Wang, Chong Geng, Feng Guo, Tao Zhang, Aonan Du, Zhiwei Lu, Hua Hui and Qiang Wang
    Citation: Cancer Cell International 2021 21:155
    Content type: Primary research Published on:

  39. Globally, gastrointestinal (GI) cancer is one of the most prevalent malignant tumors. However, studies have not established glycolysis-related gene signatures that can be used to construct accurate prognostic ...

    Authors: Rong Xia, Hua Tang, Jiemiao Shen, Shuyu Xu, Yinyin Liang, Yuxin Zhang, Xing Gong, Yue Min, Di Zhang, Chenzhe Tao, Shoulin Wang, Yi Zhang, Jinyou Yang and Chao Wang
    Citation: Cancer Cell International 2021 21:154
    Content type: Primary research Published on:

  40. Circular RNAs (circRNAs) have been reported to play vital roles in colorectal cancer (CRC). However, only a few circRNAs have been experimentally validated and functionally described. In this research, we aime...

    Authors: Lanlan Xi, Quanlin Liu, Wei Zhang, Linshan Luo, Jingfeng Song, Ruitao Liu, Shue Wei and Yong Wang
    Citation: Cancer Cell International 2021 21:153
    Content type: Primary research Published on:

  42. CircRNAs with tissue-specific expression and stable structure may be good tumor prognostic markers. However, the expression of circRNAs in esophageal squamous cell carcinoma (ESCC) remain unknown. We aim to id...

    Authors: Weiwei Wang, Di Zhu, Zhihua Zhao, Miaomiao Sun, Feng Wang, Wencai Li, Jianying Zhang and Guozhong Jiang
    Citation: Cancer Cell International 2021 21:151
    Content type: Primary research Published on:

  43. Accumulating evidences have been reported that long noncoding RNAs play crucial roles in the progression of hepatocellular carcinoma (HCC). SnoRNA host gene 6 (SNHG6) is believed to be involved in several huma...

    Authors: Xiaoxi Fan, Zhongwei Zhao, Jingjing Song, Dengke Zhang, Fazong Wu, Jianfei Tu, Min Xu and Jiansong Ji
    Citation: Cancer Cell International 2021 21:150
    Content type: Primary research Published on:

  45. Transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2) is a transmembrane protein in the tomoregulin family. Little research has been performed to determine whether TMEFF2 methylation ...

    Authors: Sidi Xie, Yunxiao Zhang, Tao Peng, Jinglin Guo, Yongfu Cao, Jing Guo, Xiaofeng Shi, Yaqin Li, Yawei Liu, Songtao Qi and Hai Wang
    Citation: Cancer Cell International 2021 21:148
    Content type: Primary research Published on:

  46. Tongue squamous cell carcinoma (TSCC) is one of the most common oral tumors. Recently, long intergenic noncoding RNA 00958 (LINC00958) has been identified as an oncogene in human cancers. Nevertheless, the rol...

    Authors: Bo Jia, Junfeng Dao, Jiusong Han, Zhijie Huang, Xiang Sun, Xianghuai Zheng, Shijian Xiang, Huixi Zhou and Shuguang Liu
    Citation: Cancer Cell International 2021 21:147
    Content type: Primary research Published on:

  47. Pien Tze Huang (PZH) is a well-known Traditional Chinese Medicine (TCM), characterized by a multitude of pharmacological effects, such as hepatoprotection and inhibition of inflammation and cell proliferative ...

    Authors: Zhiliang Chen
    Citation: Cancer Cell International 2021 21:146
    Content type: Review Published on:

  48. TUBA1C is a microtubule component that is involved in a variety of cancers. Our main objective was to investigate TUBA1C expression, its prognostic value, its potential biological functions, and its impact on ...

    Authors: Tingting Bian, Miaosen Zheng, Daishan Jiang, Jian Liu, Hui Sun, Xiaoli Li, Lei Liu, Jianguo Zhang and Yifei Liu
    Citation: Cancer Cell International 2021 21:144
    Content type: Primary research Published on:

  49. Long non-coding RNAs (lncRNAs) have been reported to exert crucial functions in regulating the progression of human cancers. However, the function and mechanism of long intergenic non-protein coding RNA 01089 ...

    Authors: Huixian Zhang, Hao Zhang, Xingya Li, Siyuan Huang, Qianqian Guo and Di Geng
    Citation: Cancer Cell International 2021 21:143
    Content type: Primary research Published on:

  50. Invasive malignant pleomorphic adenoma (IMPA) is a highly invasive parotid gland tumor and lacks effective therapy. N6-Methyladenosine (m6A) is the most prevalent post-transcriptional modification of mRNAs in euk...

    Authors: Zhenyuan Han, Biao Yang, Qin Wang, Yuhua Hu, Yuqiong Wu and Zhen Tian
    Citation: Cancer Cell International 2021 21:142
    Content type: Primary research Published on:
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Cancer Cell International

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