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  1. Long non-coding RNAs (lncRNAs) are a class of endogenous non-coding RNAs of longer than 200 bp that play crucial roles in cancer biology. Here, we assessed the tumorigenic properties of a long noncoding RNA, M...

    Authors: Zhi Zhou, Shan Zhang and Yaqiong Xiong
    Citation: Cancer Cell International 2020 20:348
    Content type: Primary research Published on:

  2. Colorectal cancer (CRC) is one of the most common digestive malignant tumors in the world. Ubiquitin-specific peptidase 18 (USP18) plays a regulatory role in tumorigenesis, and abnormal expression of Snail1 is...

    Authors: Fakun Huang, Chengying Zheng, Longkai Huang, Changqing Lin and Jiaxing Wang
    Citation: Cancer Cell International 2020 20:346
    Content type: Primary research Published on:

  3. Meningiomas are the second most common primary tumors of the central nervous system. However, there is a paucity of data on meningioma biology due to the lack of suitable preclinical in vitro and in vivo model...

    Authors: Eunhye Kim, Mirae Kim, Kyungha So, Young Seok Park, Chang Gok Woo and Sang-Hwan Hyun
    Citation: Cancer Cell International 2020 20:345
    Content type: Primary research Published on:

  4. Concurrent chemoradiotherapy is the common first-line treatment for patients with advanced cervical cancer. However, radioresistance remains a major clinical challenge, which results in recurrence and poor sur...

    Authors: Shan-Shan Yang, De-Yang Yu, Yu-Ting Du, Le Wang, Lina Gu, Yun-Yan Zhang and Min Xiao
    Citation: Cancer Cell International 2020 20:344
    Content type: Primary research Published on:

  5. Long non-coding RNAs (lncRNAs) play significant roles in tumorigenesis and can contribute to identification of novel therapeutic targets for cancers. This paper was aimed at exploring the role of CTBP1 diverge...

    Authors: Shanshan Yang, Feng Shi, Yuting Du, Zhao Wang, Yue Feng, Jiayu Song, Yunduo Liu and Min Xiao
    Citation: Cancer Cell International 2020 20:343
    Content type: Primary research Published on:

  6. Aberrant methylation and miRNA-target-gene regulation function as important mechanisms for gene inactivation in colon carcinogenesis. Although a serious of molecular events (such as aberrant alterations of gen...

    Authors: Jiaxin Liu, Zhao Liu, Xiaozhi Zhang, Yanli Yan, Shuai Shao, Demao Yao and Tuotuo Gong
    Citation: Cancer Cell International 2020 20:342
    Content type: Primary research Published on:

  7. Cervical cancer (CC) is the second leading cause of cancer deaths in women worldwide, still lacking effective biomarkers and therapies for diagnosis and treatment. CircRNAs are a class of endogenous RNAs that ...

    Authors: Shuaisai Zhang, Zhengli Chen, Jinxue Sun, Na An and Qinghua Xi
    Citation: Cancer Cell International 2020 20:287
    Content type: Primary research Published on:

  8. As one of the most lethal cancers, pancreatic cancer has been characterized by abundant supportive tumor-stromal cell microenvironment. Although the advent of tumor-targeted immune checkpoint blockers has brou...

    Authors: Tong Li, Qiaofei Liu, Ronghua Zhang, Quan Liao and Yupei Zhao
    Citation: Cancer Cell International 2020 20:341
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:397

  9. Long non-coding RNAs (lncRNAs) have been certified to be involved in the occurrence and growth of diverse cancers, including CRC. The purpose of the research was to explore the effects of lncRNA KCNQ1 overlapp...

    Authors: Xing Liu, Yexiang Zhang, Yan Wang, Chao Bian and Fengji Wang
    Citation: Cancer Cell International 2020 20:340
    Content type: Primary research Published on:

  10. GATA binding protein 3 (GATA3) and miR-29b are related to colorectal cancer (CRC). The current study explored the regulatory relationship between GATA3 and miR-29b, and the mechanism of the two in the drug res...

    Authors: Wei Wang, Mei Wang, Jing Xu, Fei Long and Xianbao Zhan
    Citation: Cancer Cell International 2020 20:339
    Content type: Primary research Published on:

  11. Cell autophagy has been proposed to be involved in drug resistance therapy. However, how the long non-coding RNA (lncRNA) reduces risks of drug resistance in renal cancer (RC) cells needs a thorough inquiry. T...

    Authors: Dechao Li, Changfu Li, Yongsheng Chen, Lichen Teng, Yan Cao, Wentao Wang, Hongxin Pan, Yongpeng Xu and Dan Yang
    Citation: Cancer Cell International 2020 20:338
    Content type: Primary research Published on:

  12. Glioblastoma multiforme (GBM) is the most common and lethal type of primary brain tumor. More than half of GBMs contain mutation(s) of PTEN/PI3K/AKT, making inhibitors targeting the PI3K pathway very attractiv...

    Authors: Zhen Chen, Chao Chen, Tingting Zhou, Chao Duan, Qianqian Wang, Xiaohui Zhou, Xia Zhang, Fangrong Wu, Yunfen Hua and Fan Lin
    Citation: Cancer Cell International 2020 20:337
    Content type: Primary research Published on:

  13. Accumulating data suggested that circular RNAs (circRNAs) played important roles in the development of human cancer. However, the potential mechanism of circRNAs in ovarian cancer remains unclear.

    Authors: Chunli Lin, Xiaofeng Xu, Qiumin Yang, Lu Liang and Shulin Qiao
    Citation: Cancer Cell International 2020 20:336
    Content type: Primary research Published on:

  14. Antisense non-coding RNA in the INK4 locus (ANRIL) is of great importance in cell biological behaviors, and ANRIL functions in many kinds of cancers including leukemia. However, the mechanism of ANRIL in the p...

    Authors: Gang Li, Lan Gao, Jing Zhao, Dejun Liu, Hui Li and Min Hu
    Citation: Cancer Cell International 2020 20:335
    Content type: Primary research Published on:

  15. One of the main reasons for the failure of prostate cancer (PCa) treatment is the generation of chemoresistance. Circular RNA hsa_circ_0000735 (hsa_circ_0000735) is connected with the progression of cancer. Ne...

    Authors: Yisheng Gao, Jie Liu, Jing Huan and Fengyuan Che
    Citation: Cancer Cell International 2020 20:334
    Content type: Primary research Published on:

  16. Cervical cancer (CC) is a malignant tumor found in the lowermost part of the womb. Evolving studies on CC have reported that circRNA plays a crucial role in CC progression. In this study, we investigated the m...

    Authors: Xinhua Qu, Liumei Zhu, Linlin Song and Shaohua Liu
    Citation: Cancer Cell International 2020 20:333
    Content type: Primary research Published on:

  17. Fatty acid synthase (FASN) is highly expressed in various types of cancer and has an important role in carcinogenesis and metastasis. To clarify the mechanisms of FASN in liver cancer invasion and metastasis, ...

    Authors: Juan Huang, Yao Tang, Xiaoqin Zou, Yi Lu, Sha She, Wenyue Zhang, Hong Ren, Yixuan Yang and Huaidong Hu
    Citation: Cancer Cell International 2020 20:332
    Content type: Primary research Published on:

  18. Although major driver gene have been identified, the complex molecular heterogeneity of renal cell cancer (RCC) remains unclear. Therefore, more relevant genes need to be identified to explain the pathogenesis...

    Authors: Yeda Chen, Di Gu, Yaoan Wen, Shuxin Yang, Xiaolu Duan, Yongchang Lai, Jianan Yang, Daozhang Yuan, Aisha Khan, Wenqi Wu and Guohua Zeng
    Citation: Cancer Cell International 2020 20:331
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2022 22:302

  19. The incidence of lung squamous cell carcinoma (LUSC) increased substantially in recent years. Systematical investigation of the immunogenomic pattern is critical to improve the prognosis of LUSC.

    Authors: Jianguo Zhang, Jianzhong Zhang, Cheng Yuan, Yuan Luo, Yangyi Li, Panpan Dai, Wenjie Sun, Nannan Zhang, Jiangbo Ren, Junhong Zhang, Yan Gong and Conghua Xie
    Citation: Cancer Cell International 2020 20:330
    Content type: Primary research Published on:

  20. Endometrial cancer (EnCa) ranks fourth in menace within women’s malignant tumors. Large numbers of studies have proven that functional genes can change the process of tumors by regulating the cell cycle, there...

    Authors: Jinhui Liu, Jie Mei, Siyue Li, Zhipeng Wu and Yan Zhang
    Citation: Cancer Cell International 2020 20:329
    Content type: Primary research Published on:

  21. Despite decades of therapeutic trials, effective diagnosis, many drugs available and numerous studies on breast cancer, it remains the deadliest cancer in women. In order to choose the most appropriate treatme...

    Authors: Augustin Le Naour, Yvonne Koffi, Mariane Diab, Delphine Le Guennec, Stéphanie Rougé, Sahar Aldekwer, Nicolas Goncalves-Mendes, Jérémie Talvas, Marie-Chantal Farges, Florence Caldefie-Chezet, Marie-Paule Vasson and Adrien Rossary
    Citation: Cancer Cell International 2020 20:328
    Content type: Primary research Published on:

  22. Long non-coding RNAs (lncRNAs) has been extensively reported play important roles in regulating the development and progression of cancers, including Glioblastoma (GBM). LINC01426 is a novel lncRNA that has be...

    Authors: Jingwei Cao, Zhanbin Tang and Zhiqiang Su
    Citation: Cancer Cell International 2020 20:327
    Content type: Primary research Published on:

  23. The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs (lncRNAs) are tiny molecules that have begun emerging as vital mol...

    Authors: Zeeshan Javed, Khushbukhat Khan, Haleema Sadia, Shahid Raza, Bahare Salehi, Javad Sharifi-Rad and William C. Cho
    Citation: Cancer Cell International 2020 20:326
    Content type: Review Published on:

  24. Methylation of histone 3 at lysine 9 (H3K9) and DNA methylation are epigenetic marks correlated with genes silencing. The tumor microenvironment significantly influences therapeutic responses and clinical outc...

    Authors: Li Zhang, Sijuan Tian, Minyi Zhao, Ting Yang, Shimin Quan, Qing Yang, Lihua Song and Xiaofeng Yang
    Citation: Cancer Cell International 2020 20:325
    Content type: Primary research Published on:

  25. Cholangiocarcinoma (CCA) is a mortal cancer with high mortality, whereas the function and mechanism of occurrence and progression of CCA are still mysterious. Long non-coding RNAs (lncRNAs) could function as i...

    Authors: Lining Huang, Xingming Jiang, Zhenglong Li, Jinglin Li, Xuan Lin, Zengtao Hu and Yunfu Cui
    Citation: Cancer Cell International 2020 20:324
    Content type: Primary research Published on:

  26. Prostate cancer (PCa) is a malignant heterogeneous tumor that threatens men’s health. Long non-coding RNA activated by DNA damage (NORAD) and microRNA-495-3p (miR-495-3p) have been revealed to be concerned wit...

    Authors: Fengling Chen, Ling Liu and Shuya Wang
    Citation: Cancer Cell International 2020 20:323
    Content type: Primary research Published on:

  27. Long non-coding RNAs (lncRNAs) have been defined as vital regulators in the progression of human cancers, including colorectal cancer (CRC). Long intergenic non-protein coding RNA 667 (LINC00667) is a tumor pr...

    Authors: Juan Yu, Furang Wang, Jun Zhang, Jing Li, Xiaoguang Chen and Guangsen Han
    Citation: Cancer Cell International 2020 20:322
    Content type: Primary research Published on:

  28. Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play vital roles in human cancers. Nevertheless, the effects of lncRNAs and miRNAs on breast cancer (BC) remain to be further investigated. This study was d...

    Authors: Shaoqiang Cheng, Bingshu Xia, Hongbin Li, Yuying Li, Xinxin Lv, Yue Zhang and Yuanxi Huang
    Citation: Cancer Cell International 2020 20:321
    Content type: Primary research Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2021 21:104

  29. Breast cancer (BC) is a common malignancy worldwide. It has been reported that long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) is abnormally expressed in BC. However, the role of HOTAIR in t...

    Authors: Yuanyuan Wang, Guoliang Gong, Jingyun Xu, Yuanxin Zhang, Shenggui Wu and Shaohong Wang
    Citation: Cancer Cell International 2020 20:320
    Content type: Primary research Published on:

  30. Long noncoding RNA (lncRNA) is generally identified as competing endogenous RNA (ceRNA) that plays a vital role in the pathogenesis of kidney renal clear cell carcinoma (KIRC), the most common subtype of renal...

    Authors: Di Zhang, Song Zeng and Xiaopeng Hu
    Citation: Cancer Cell International 2020 20:319
    Content type: Primary research Published on:

  31. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yang Hu, Hong Xie, Yankun Liu, Weiying Liu, Min Liu and Hua Tang
    Citation: Cancer Cell International 2020 20:318
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2017 17:36

  32. Papillary renal cell carcinoma (pRCC) accounting for near 20% of renal cell carcinoma is the second most common histological subtype. MiRNAs have been demonstrated to played significant roles on predicting pro...

    Authors: Ge Li, Haifan Yang, Yong Cheng, Xin Zhao, Xu Li and Rui Jiang
    Citation: Cancer Cell International 2020 20:317
    Content type: Primary research Published on:

  33. Cell cycle dysregulation plays a key role in the pathogenesis of malignant tumors. As a part of the CDK-activating kinase (CAK) trimeric complex, cyclin H is necessary to regulate the cell cycle and proliferat...

    Authors: Chen Peng, Yansong Yang, Li Ji, Panpan Yang, Xiaoqing Yang and Yuquan Zhang
    Citation: Cancer Cell International 2020 20:316
    Content type: Primary research Published on:

  34. Accumulating amount of evidence has highlighted the important roles of long non-coding RNAs (lncRNAs) acting as competing endogenous RNAs (ceRNAs) in tumor pathogenesis. However, the roles of long non coding R...

    Authors: Zhichen Kang, Lixin Guo, Zhuo Zhu and Rongfeng Qu
    Citation: Cancer Cell International 2020 20:315
    Content type: Primary research Published on:

  35. Although the medical level is constantly improving, cancer is still a major disease that threatens human health, and very effective treatments have not been found. In recent years, studies have found that four...

    Authors: Yaoyue Qi, Hui Li, Jing Lv, Weiwei Qi, Liwei Shen, Shihai Liu, Aiping Ding, Gongjun Wang, Libin Sun and Wensheng Qiu
    Citation: Cancer Cell International 2020 20:314
    Content type: Primary research Published on:

  36. The aim of this study was to investigate the association between telomerase reverse transcriptase (TERT) gene polymorphisms and acute myeloid leukemia (AML) susceptibility in a Chinese Han population.

    Authors: Yong Tong, Yinzhou Xiang, Bao Li, Shijie Bao, Ying Zhou, Wen Yuan, Yu Ling, Dan Hao, Huamin Zhu and Zhiqiang Sun
    Citation: Cancer Cell International 2020 20:313
    Content type: Primary research Published on:

  37. Prostate cancer (PCa) is the second cause of cancer related death in North American men. Androgens play an important role in its progression by regulating the expression of several genes including fusion ones ...

    Authors: Carlos D. Cruz-Hernández, Marian Cruz-Burgos, Sergio A. Cortés-Ramírez, Alberto Losada-García, Ignacio Camacho-Arroyo, Patricia García-López, Elizabeth Langley, Vanessa González-Covarrubias, Monserrat Llaguno-Munive, Martha E. Albino-Sánchez, José L. Cruz-Colín, Carlos Pérez-Plasencia, Fredy O. Beltrán-Anaya and Mauricio Rodríguez-Dorantes
    Citation: Cancer Cell International 2020 20:312
    Content type: Primary research Published on:

  38. Long noncoding ribonucleic acid (lncRNA) promoter methylation is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Thus, we aim to screen and verify the lncRNA promoter methy...

    Authors: Zhuo Lin, Xiaofeng Ni, Shengjie Dai, Hao Chen, Jianhui Chen, Boda Wu, Jianyang Ao, Keqing Shi and Hongwei Sun
    Citation: Cancer Cell International 2020 20:311
    Content type: Primary research Published on:

  39. Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a poor prognosis. DEPDC1B (DEP domain-containing protein 1B) has been shown to be associated with some types of malignancies. ...

    Authors: Xu Chen, Zheng-Qian Guo, Dan Cao, Yong Chen and Jian Chen
    Citation: Cancer Cell International 2020 20:310
    Content type: Primary research Published on:

  40. Ovarian serous cystadenocarcinoma (OSC) is the most common and lethal gynecological cancer in women worldwide; however, biomarkers to diagnose and predict prognosis of OSC remain limited. Therefore, the presen...

    Authors: Wei Huang, Yongjian Zhang, Ye Xu, Shaoyou Yang, Bing Li, Lan Huang and Ge Lou
    Citation: Cancer Cell International 2020 20:309
    Content type: Primary research Published on:

  41. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Rustelle Janse van Vuuren, Mandie Botes, Tamarin Jurgens, Anna Margaretha Joubert and Iman van den Bout
    Citation: Cancer Cell International 2020 20:308
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2019 19:1

  42. Although the fact that long non-coding RNA MCM3AP antisense RNA 1 (MCM3AP-AS1) is oncogenic in several cancers is well documented, very few researchers investigate its expression and function in prostate cancer.

    Authors: Jie Wu, Yalin Lv, Yujun Li, Yanxia Jiang, Lili Wang, Xiangyan Zhang, Mengqi Sun, Yuwei Zou, Jin Xu and Li Zhang
    Citation: Cancer Cell International 2020 20:307
    Content type: Primary research Published on:

  43. Autophagy is associated with cancer development. Autophagy-related genes play significant roles in endometrial cancer (EC), a major gynecological malignancy worldwide, but little was known about their value as...

    Authors: Hui Wang, Xiaoling Ma, Jinhui Liu, Yicong Wan, Yi Jiang, Yankai Xia and Wenjun Cheng
    Citation: Cancer Cell International 2020 20:306
    Content type: Primary research Published on:

  44. Osteosarcoma (OS) is the most common bone malignant tumor in children, youth, and adolescents. Circular RNA hsa_circ_0005909 (circ_0005909) is involved in the progression of OS. Nevertheless, there are few rep...

    Authors: Shuai Ding, Guangquan Zhang, Yanzheng Gao, Shulian Chen and Chen Cao
    Citation: Cancer Cell International 2020 20:305
    Content type: Primary research Published on:

  45. It has been widely reported that the expression levels of SNHG20 are elevated in diverse types of cancers, indicating that SNHG20 may participate in cancer initiation and development. Besides, accumulating evi...

    Authors: Hanlong Zhu, Si Zhao, Ruonan Jiao, Huishan Wang, Ruiyi Tang, Xiaochao Wu, Fei Wang, Xianxiu Ge, Quanpeng Li and Lin Miao
    Citation: Cancer Cell International 2020 20:304
    Content type: Review Published on:

  46. Gastric cancer (GC) is the leading cause of death worldwide and is closely related to metastasis. MRTF-A is one of the most well-characterized genetic markers in cancer. However, the mechanism whereby MRTF-A m...

    Authors: Libin Yin, Tao Liu, Chenyao Li, Guoqiang Yan, Chao Li, Jiantao Zhang and Lei Wang
    Citation: Cancer Cell International 2020 20:303
    Content type: Primary research Published on:

  47. Bladder cancer (BCa) is one of the important tumors that have been proven to be treatable with immunotherapy. This study aims to identify and validate a molecular prognostic index of BCa based on immunogenomic...

    Authors: Ning Xu, Zhi-Bin Ke, Xiao-Dan Lin, Ye-Hui Chen, Yu-Peng Wu, Yu Chen, Ru-Nan Dong, Shao-Hao Chen, Xiao-Dong Li, Yong Wei, Qing-Shui Zheng, Yun-Zhi Lin and Xue-Yi Xue
    Citation: Cancer Cell International 2020 20:302
    Content type: Primary research Published on:

  48. Researches validate that circular RNAs (circRNAs) are dysregulated in a variety of malignancies and play an important role in regulating the malignant phenotype of tumor cells. Nevertheless, the role of circ_0...

    Authors: Li Zhang, Jie Wu, Yujun Li, Yanxia Jiang, Lili Wang, Yunqing Chen, Yalin Lv, Yuwei Zou and Xiaoyan Ding
    Citation: Cancer Cell International 2020 20:301
    Content type: Primary research Published on:

  49. Small nucleolar RNAs (snoRNAs) are a new non-coding RNAs (ncRNAs), which have not been widely investigated and are identified to be involved in tumorigenesis. But the function of snoRNAs in BLCA has not been r...

    Authors: Rui Cao, Bo Ma, Lushun Yuan, Gang Wang and Ye Tian
    Citation: Cancer Cell International 2020 20:299
    Content type: Primary research Published on:

  50. Cancer remains one of the major culprits causing disease-related deaths and leads to a high morbidity and similar mortality. Insidious onset, difficult early detection and a lack of broad-spectrum and effectiv...

    Authors: Yizhi Wang, Li Zhou, Jun Lu, Bolun Jiang, Chengxi Liu and Junchao Guo
    Citation: Cancer Cell International 2020 20:298
    Content type: Review Published on:
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Cancer Cell International

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