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  1. Osteosarcoma (OS) is one of the most aggressive malignancies with mortality rate worldwide. Accumulating evidence has revealed that long noncoding RNAs (lncRNAs) exert important functions in regulation of canc...

    Authors: Zhiqian Gu, Shaokun Wu, Jingnan Wang and Shoujun Zhao
    Citation: Cancer Cell International 2020 20:147
    Content type: Primary research Published on:

  2. We used bioinformatic tools to dichotomize 157 non-M3 AML patients from the TCGA dataset based on the presence or absence of TP53 mutations, and screened out a key gene related to TP53 mutation for future analysi...

    Authors: Siyu Gu, Jie Zi, Qi Han, Chunhua Song and Zheng Ge
    Citation: Cancer Cell International 2020 20:146
    Content type: Primary research Published on:

  3. Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function ...

    Authors: Lijuan Zhu, Aihua Wang, Mei Gao, Xiaoyan Duan and Zehua Li
    Citation: Cancer Cell International 2020 20:145
    Content type: Primary research Published on:

  4. Non-small cell lung cancer (NSCLC) is the most deadly cancer worldwide. LncRNA KCNQ1OT1 has been reported to be involved in the progression of various tumors, including NSCLC. However, the precise mechanism of...

    Authors: Yan Wang, Lei Zhang, Jiasheng Yang and Ruilin Sun
    Citation: Cancer Cell International 2020 20:144
    Content type: Primary research Published on:

  5. Genetic biomarkers of lung cancer (LC) susceptibility may provide a basis for treatment and prevention. This study analyzed an association between SNPs (single nucleotide polymorphisms) in the complementary re...

    Authors: Shimin Yang, Fanglin Yu, Mingyan Lin, Linyi Sun, Junjie Wei, Cheng Lai, Lin Cai, Zhijian Hu and Fei He
    Citation: Cancer Cell International 2020 20:143
    Content type: Primary research Published on:

  6. The eukaryotic translation initiation factor 5A1 (eIF5A1) and its homolog eIF5A2 are the only two human proteins containing the unique post-translational modification–hypusination, which is essential for the f...

    Authors: Gao-Qi Wu, Yan-Ming Xu and Andy T. Y. Lau
    Citation: Cancer Cell International 2020 20:142
    Content type: Review Published on:

  7. Without targets, triple negative breast cancer (TNBC) has the worst prognosis in all subtypes of breast cancer (BC). Recently, eukaryotic translation initiation factor 3 m (eIF3m) has been declared to be invol...

    Authors: Wei Han, Cong Zhang, Chun-tao Shi, Xiao-jiao Gao, Ming-hui Zhou, Qi-xiang Shao, Xiao-jun Shen, Cheng-jiang Wu, Fang Cao, Yong-wei Hu, Jian-liang Yuan, Hou-zhong Ding, Qing-hua Wang and Hao-nan Wang
    Citation: Cancer Cell International 2020 20:141
    Content type: Primary research Published on:

  8. The primary tumor, regional lymph nodes and distant metastasis (TNM) stage is an independent risk factor for 1-year hepatocellular carcinoma (HCC) recurrence but has insufficient predictive efficiency. We atte...

    Authors: Haohan Liu, Yongcong Yan, Ruibing Chen, Mengdi Zhu, Jianhong Lin, Chuanchao He, Bingchao Shi, Kai Wen, Kai Mao and Zhiyu Xiao
    Citation: Cancer Cell International 2020 20:140
    Content type: Primary research Published on:

  9. Canine prostate cancer represents a unique model for human prostate cancer. In vitro systems offer various possibilities but Xenograft in vivo imaging allows studying complex tasks as tumor progression and dru...

    Authors: Wen Liu, Sina Sender, Weibo Kong, Julia Beck, Anett Sekora, Kirsten Bornemann-Kolatzki, Ekkehart Schuetz, Christian Junghanss, Bertram Brenig, Ingo Nolte and Hugo Murua Escobar
    Citation: Cancer Cell International 2020 20:139
    Content type: Primary research Published on:

  10. Nasopharyngeal carcinoma (NPC) is a subtype of head and neck cancer with dismal prognosis and high relapse rate. The role of long non-coding RNAs (lncRNAs) in NPC has become a research hotspot in recent years....

    Authors: Hongchao Yao, Like Yang, Linli Tian, Yan Guo and Yushan Li
    Citation: Cancer Cell International 2020 20:138
    Content type: Primary research Published on:

  11. The purpose of this study was to explore the regulatory mechanism of the long non-coding RNA (lncRNA) LINC00461 underlying the breast cancer invasion and migration via the miR-144-3p/KPNA2 axis.

    Authors: Qiang Zhang, Xiaoyan Jin, Wenbiao Shi, Xin Chen, Wenyang Pang, Xiaodong Yu and Linjun Yang
    Citation: Cancer Cell International 2020 20:137
    Content type: Primary research Published on:

  12. The crucial role of long non-coding RNAs (lncRNAs) has been certified in human cancers. The lncRNAs with abnormal expressions could act as tumor inhibitors or oncogenes in the advancement of tumors. LBX2-AS1 w...

    Authors: Gang Xu, Yan Zhang, Na Li, Yanling Wu, Jinbiao Zhang, Rui Xu and Hui Ming
    Citation: Cancer Cell International 2020 20:136
    Content type: Primary research Published on:

  13. The primary bone tumor is usually observed in adolescence age group which has been shown to be part of nearly 20% of the sarcomas known today. Giant cell tumor of bone (GCTB) can be benign as well as malignant...

    Authors: Abdul Rouf War, Kai Dang, Shanfen Jiang, Zhongwei Xiao, Zhiping Miao, Tuanmin Yang, Yu Li and Airong Qian
    Citation: Cancer Cell International 2020 20:135
    Content type: Review Published on:

  14. Recent studies have emphasized determining the ability of microRNAs (miRNAs) as crucial regulators in the occurrence and development of pancreatic cancer (PC), which continues to be one of the deadliest malign...

    Authors: Jingyang Zhou, Haihong Wang, Jinhui Che, Lu Xu, Weizhong Yang, Yunjiu Li and Wuyuan Zhou
    Citation: Cancer Cell International 2020 20:134
    Content type: Primary research Published on:

  15. Spinal osteosarcoma (OS) is a rare and aggressive malignancy. Long noncoding RNA (lncRNA) BSN-AS2 has been shown to be an oncogenic gene in several cancers. However, the role and function of BSN-AS2 in spinal ...

    Authors: Xianwei Zhou, Jitian Li, Junyan Teng, Yufeng Liu, Di Zhang, Linyun Liu and Wenming Zhang
    Citation: Cancer Cell International 2020 20:133
    Content type: Primary research Published on:

  16. Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are being found to play crucial roles in ATC progression. Herein, we focused on the role...

    Authors: Xiangrong Tan, Peng Wang, Jianlin Lou and Jiazheng Zhao
    Citation: Cancer Cell International 2020 20:132
    Content type: Primary research Published on:

  17. Compared with conventional cancer treatments, the main advantage of oncolytic virotherapy is its tumor-selective replication followed by the destruction of malignant cells without damaging healthy cells. Accor...

    Authors: Mohsen Keshavarz, Ailar Sabbaghi, Seyed Mohammad Miri, Abolhasan Rezaeyan, Yaser Arjeini and Amir Ghaemi
    Citation: Cancer Cell International 2020 20:131
    Content type: Review Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:527

  18. Cholangiocarcinoma (CCA) is an invasive malignancy arising from biliary epithelial cells; it is the most common primary tumour of the bile tract and has a poor prognosis. The aim of this study was to screen pr...

    Authors: Zijian Da, Long Gao, Gang Su, Jia Yao, Wenkang Fu, Jinduo Zhang, Xu Zhang, Zhaoji Pei, Ping Yue, Bing Bai, Yanyan Lin, Wenbo Meng and Xun Li
    Citation: Cancer Cell International 2020 20:130
    Content type: Primary research Published on:

  19. Recent evidence of clinical trials highlights that the combination of two noncompetitive anti-EGFR antibodies can benefit patients with several cancers. Previous studies propose that a lattice complex assemble...

    Authors: Dianshuai Huang, Tianqi Lu, Xingyu Du, Xi Xi, Xin Zhang, Xitian Zhang, Haoran Zhang and Fei Sun
    Citation: Cancer Cell International 2020 20:129
    Content type: Primary research Published on:

  20. Cisplatin is a platinum-based first-line drug for treating ovarian cancer. However, chemotherapy tolerance has limited the efficacy of cisplatin for ovarian cancer patients. Research has demonstrated that cisp...

    Authors: Xiao-Yu Yan, Xian-Zhi Qu, Long Xu, Si-Hang Yu, Rui Tian, Xin-Ru Zhong, Lian-Kun Sun and Jing Su
    Citation: Cancer Cell International 2020 20:128
    Content type: Review Published on:

  21. Thymidine kinase 1 (TK1) is a pyrimidine salvage pathway enzyme that is up-regulated in malignant tissues and elevated in the serum of cancer patients. While TK1 has been well established as a tumor biomarker,...

    Authors: Edwin J. Velazquez, Taylor D. Brindley, Gajendra Shrestha, Eliza E. Bitter, Jordan D. Cress, Michelle H. Townsend, Bradford K. Berges, Richard A. Robison, K. Scott Weber and Kim L. O’Neill
    Citation: Cancer Cell International 2020 20:127
    Content type: Primary research Published on:

  22. Colorectal carcinoma is one of the most deadly cancers that requests effective and safe chemotherapy. Evaluation of natural product-based anticancer drugs as adjuvant treatment with fewer side effects is large...

    Authors: Omar Al-Obeed, Adila Salih El-Obeid, Sabine Matou-Nasri, Mansoor-Ali Vaali-Mohammed, Yazeid AlHaidan, Mohammed Elwatidy, Hamad Al Dosary, Zeyad Alehaideb, Khayal Alkhayal, Adil Haseeb, James McKerrow, Rehan Ahmad and Maha-Hamadien Abdulla
    Citation: Cancer Cell International 2020 20:126
    Content type: Primary research Published on:

  23. Kinesin superfamily proteins (KIFs) can transport membranous organelles and protein complexes in an ATP-dependent manner. Kinesin family member 15 (KIF15) is overexpressed in various cancers. However, the func...

    Authors: Lixian Ding, Bin Li, Xiaotong Yu, Zhongsheng Li, Xinglong Li, Shuwei Dang, Qiang Lv, Jiufeng Wei, Haixia Sun, Hongsheng Chen, Ming Liu and Guodong Li
    Citation: Cancer Cell International 2020 20:125
    Content type: Primary research Published on:

  24. LNK adaptor protein is a crucial regulator of normal hematopoiesis, which down-regulates activated tyrosine kinases at the cell surface resulting in an antitumor effect. To date, little studies have examined a...

    Authors: Jianxin Lv, Wei Yu, Yanan Zhang, Xinhua Cao, Lifei Han, Haolin Hu and Chenfei Wang
    Citation: Cancer Cell International 2020 20:124
    Content type: Primary research Published on:

  25. Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, the prognostic value of whole family members was poorly done. Our st...

    Authors: Tian-Fu Li, Hui-Juan Zeng, Zhen Shan, Run-Yi Ye, Tuck-Yun Cheang, Yun-Jian Zhang, Si-Hong Lu, Qi Zhang, Nan Shao and Ying Lin
    Citation: Cancer Cell International 2020 20:123
    Content type: Primary research Published on:

  26. Tenascin-C (TNC) is an extracellular matrix protein that is widely expressed in the stromal fibroblasts of various cancers. However, the roles of TNC in colorectal cancer (CRC) cells remain unclear.

    Authors: Zhaoting Yang, Chengye Zhang, Ying Feng, Mingji Quan, Yan Cui and Yanhua Xuan
    Citation: Cancer Cell International 2020 20:122
    Content type: Primary research Published on:

  27. As one of the many breast cancer subtypes, human epidermal growth factor receptor 2 (Her2)-positive breast cancer has higher invasiveness and poor prognosis, although the advent of anti-Her2 drugs has brought ...

    Authors: Chundi Gao, Jing Zhuang, Huayao Li, Cun Liu, Chao Zhou, Lijuan Liu, Fubin Feng, Changgang Sun and Jibiao Wu
    Citation: Cancer Cell International 2020 20:121
    Content type: Primary research Published on:

  28. Splicing factor SRSF3 is an oncogene and overexpressed in various kinds of cancers, however, the function and mechanism involved in colorectal cancer (CRC) remained unclear. The aim of this study was to explor...

    Authors: Ji-Lin Wang, Chun-Rong Guo, Tian-Tian Sun, Wen-Yu Su, Qiang Hu, Fang-Fang Guo, Lun-Xi Liang, Jie Xu, Hua Xiong and Jing-Yuan Fang
    Citation: Cancer Cell International 2020 20:120
    Content type: Primary research Published on:

  30. Circular RNAs (circRNAs) are identified to play an important role in many human cancers, such as glioblastoma. However, the potential mechanisms underlying the relationship between circRNAs and glioblastoma pa...

    Authors: Fei Zhu, Cheng Cheng, Hong qin, Hongsheng Wang and Hailong Yu
    Citation: Cancer Cell International 2020 20:118
    Content type: Primary research Published on:

  31. The carcinogenesis and progression of cervical cancer is a complex process in which numerous microRNAs are involved. The purpose of this study is to investigate the role of miR-125a-5p in progression of cervic...

    Authors: Qinxue Cao, Ning Wang, Lu Ren, Jun Tian, Shaoqin Yang and Hailing Cheng
    Citation: Cancer Cell International 2020 20:117
    Content type: Primary research Published on:

  32. The significance of long non-coding RNAs (lncRNAs) in mediating oxidative stress of cancers has been implicated recently. This study proposed a potential therapeutic target lncRNA growth arrest-specific transc...

    Authors: Wei Xu, Zeqiang Yan, Fen Hu, Wei Wei, Chao Yang and Zhihua Sun
    Citation: Cancer Cell International 2020 20:116
    Content type: Primary research Published on:

  33. Emerging studies have explored the prognostic value of MIR31HG in cancers, but its role remains elusive. Herein, we aimed to summarize the prognostic potential of MIR31HG in this study.

    Authors: Chao Tu, Xiaolei Ren, Jieyu He, Shuangqing Li, Lin Qi, Zhixi Duan, Wanchun Wang and Zhihong Li
    Citation: Cancer Cell International 2020 20:115
    Content type: Primary research Published on:

  36. Acute myeloid leukemia (AML) is a heterogeneous hematological disease. Our purpose of the research was to investigate the regulatory influence of long non-coding RNA (lncRNA) nuclear enriched abundant transcri...

    Authors: Song Feng, Na Liu, Xiaoguang Chen, Yufeng Liu and Jindou An
    Citation: Cancer Cell International 2020 20:112
    Content type: Primary research Published on:

  37. Glioblastoma (GBM) is a subclass of brain malignancy with unsatisfactory prognosis. MicroRNAs (miRNAs) are a group of non-coding RNAs (ncRNAs) that exert key function on tumorigenesis and tumor development.

    Authors: Xinli Zhao, Fazheng Shen, Jiwei Ma, Shupeng Zhao, Lei Meng, Xiangyang Wang, Shufeng Liang, Jianing Liang, Chaoshuai Hu and Xinzhong Zhang
    Citation: Cancer Cell International 2020 20:111
    Content type: Primary research Published on:

  39. A number of studies have demonstrated the critical role of long non-coding RNA gastric cancer high expressed transcript 1 (GHET1) in many cancers. This meta-analysis provides an evidence-based evaluation of th...

    Authors: Dingding Wang, Hong Zhang, Xiaolian Fang, Xue Zhang and Honggang Liu
    Citation: Cancer Cell International 2020 20:109
    Content type: Review Published on:

  40. Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is identified as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) is poorly compre...

    Authors: Zhijun Yan, Qilian Yang, Min Xue, Sheng Wang, Weijun Hong and Xiwen Gao
    Citation: Cancer Cell International 2020 20:108
    Content type: Primary research Published on:

  41. Infections by both human oncoviruses, human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) are very common in the adult human population and are associated with various malignancies. While HPV is generall...

    Authors: Ishita Gupta, Gheyath K. Nasrallah, Anju Sharma, Ayesha Jabeen, Maria K. Smatti, Hamda A. Al-Thawadi, Ali A. Sultan, Moussa Alkhalaf, Semir Vranic and Ala-Eddin Al Moustafa
    Citation: Cancer Cell International 2020 20:107
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2022 22:45

  42. Lung cancer is the leading cause of cancer-related mortality globally. Discovering effective biomarkers for early diagnosis and prognosis is important to reduce the mortality rate and ensure efficient therapy ...

    Authors: Jiaxing Sun, Tian Xie, Muhammad Jamal, Zhenbo Tu, Xinran Li, Yingjie Wu, Jingyuan Li, Qiuping Zhang and Xiaoxing Huang
    Citation: Cancer Cell International 2020 20:106
    Content type: Primary research Published on:

  43. Tumor progression and distant metastasis are the main causes of deaths in colorectal cancer (CRC) patients, and the molecular mechanisms in CRC metastasis have not been completely discovered.

    Authors: Wenping Lian, Huifang Jin, Jingjing Cao, Xinyu Zhang, Tao Zhu, Shuai Zhao, Sujun Wu, Kailu Zou, Xinyun Zhang, Mingliang Zhang, Xiaoyong Zheng and Mengle Peng
    Citation: Cancer Cell International 2020 20:105
    Content type: Primary research Published on:

  45. Colorectal cancer (CRC) is a malignant tumor, and the overall prognosis of patients with advanced CRC is still unsatisfactory. Circular RNAs (circRNAs) vesicle-associated membrane protein-associated protein A ...

    Authors: Xiaoyu Zhang, Yingying Xu, Kenji Yamaguchi, Jinping Hu, Lianbo Zhang, Jianfeng Wang, Jifeng Tian and Wanying Chen
    Citation: Cancer Cell International 2020 20:103
    Content type: Primary research Published on:

  46. This study aimed to screen osteosarcoma (OS) prognosis relevant genes for methylation dysregulation, and the functional mechanisms of FES overexpression in OS cells were investigated.

    Authors: Yang Zhao, Zhimeng Wang, Qian Wang, Liang Sun, Ming Li, Cheng Ren, Hanzhong Xue, Zhong Li, Kun Zhang, Dingjun Hao, Na Yang, Zhe Song, Teng Ma and Yao Lu
    Citation: Cancer Cell International 2020 20:102
    Content type: Primary research Published on:

  47. Osteosarcoma (OS) is one of the most common types of primary bone tumors which poses negative effects on the bones of both young children and adolescents. LncRNA LINC00472 has been reported to be involved with...

    Authors: Jingwei Zhang, Jieyuan Zhang, Dong Zhang, Weifeng Ni, Haijun Xiao and Bizeng Zhao
    Citation: Cancer Cell International 2020 20:100
    Content type: Primary research Published on:

  48. Osteosarcoma is a malignant bone tumor. Increasing evidences have revealed that a disintegrin and metalloproteinase 10 (ADAM10) is implicated in tumor development. The main purpose of this study is to explore ...

    Authors: Quan Yuan, Honghao Yu, Jianhua Chen, Xiaoyu Song and Li Sun
    Citation: Cancer Cell International 2020 20:99
    Content type: Primary research Published on:

  49. Pancreatic ductal adenocarcinoma (PDAC) is a lethal human malignancy, and previous researches support the contribution of microRNA (miRNA) to cancer progression. MiR-122-5p is reported to participate in the re...

    Authors: Chen Dai, Yan Zhang, Zhihua Xu and Mengxian Jin
    Citation: Cancer Cell International 2020 20:98
    Content type: Primary research Published on:

  50. Activation of nuclear factor-kappa B (NF-κΒ) through DNA damage is one of the causes of tumor cell resistance to radiotherapy. Chromosome region 1 (CRM1) regulates tumor cell proliferation, drug resistance, an...

    Authors: Xuejiao Liu, Yiming Tu, Yifeng Wang, Di Zhou, Yulong Chong, Lin Shi, Guanzheng Liu, Xu Zhang, Sijin Wu, Huan Li, Shangfeng Gao, Mingshan Niu and Rutong Yu
    Citation: Cancer Cell International 2020 20:97
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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