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  1. Recent studies showed that long non-coding RNA (lncRNA) plays an important role in many life activities. RPPH1 is one of the lncRNA genes that are expressed differently between breast cancer and normal tissues by...

    Authors: Yi Zhang and Lili Tang

    Citation: Cancer Cell International 2017 17:109

    Content type: Primary Research

    Published on:

  2. Gastric cancer ranks 4th among the most common cancers worldwide, and the mortality caused by gastric cancer is 2nd only to lung cancer. Gastric cancer shows a lack of specific symptoms in its early stages. In...

    Authors: Hongshuang Tong, Yue Wang, Yue Li, Shujuan Liu, Chunjie Chi, Desheng Liu, Lei Guo, Enyou Li and Changsong Wang

    Citation: Cancer Cell International 2017 17:108

    Content type: Primary Research

    Published on:

  3. Bmi1 (B lymphoma Mo-MLV insertion region 1 homolog) contributes to human tumorigenesis via epigenetic transcriptional silencing and represents a novel therapeutic target with great potentials. Here we sought t...

    Authors: Qiong Wang, Zhongwu Li, Yaping Wu, Rong Huang, Yumin Zhu, Wei Zhang, Yanling Wang and Jie Cheng

    Citation: Cancer Cell International 2017 17:107

    Content type: Primary Research

    Published on:

  4. Human mucoepidermoid carcinoma (MEC) is regarded as the most common primary salivary malignancy. High-grade MEC has a high risk of recurrence and poor prognosis. Tumor angiogenesis, induced by poorly different...

    Authors: Sen Yang and Li-Juan Guo

    Citation: Cancer Cell International 2017 17:106

    Content type: Primary Research

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  5. MiRNAs are vital in functioning as either oncogenes or tumor suppressors in the cell cycle. Target transcripts for immune checkpoint molecules such as PD-1/PD-L1 and (programmed cell death-1/its ligand and cyt...

    Authors: Laura Boldrini, Mirella Giordano, Cristina Niccoli, Franca Melfi, Marco Lucchi, Alfredo Mussi and Gabriella Fontanini

    Citation: Cancer Cell International 2017 17:105

    Content type: Primary Research

    Published on:

  6. Glioblastoma multiforme (GBM) is known as one of the most fatal forms of cancer. MicroRNAs have been widely implicated in the regulation of mammalian development and pathogenesis. The brain-enriched miR-29 sub...

    Authors: Jaekyung Shin, Hyun Geun Shim, Taeyoung Hwang, Hyungsin Kim, Shin-Hyuk Kang, Yun-Sik Dho, Sung-Hye Park, Sang Jeong Kim and Chul-Kee Park

    Citation: Cancer Cell International 2017 17:104

    Content type: Primary Research

    Published on:

  7. Renal cell carcinoma (RCC) is the most common kidney cancer, accounting for approximately 80–90% of all primary kidney cancer. Treatment for patients with advanced RCC remains unsatisfactory. Rare cancer stem ...

    Authors: Du-Chu Chen, You-De Liang, Liang Peng, Yi-Ze Wang, Chun-Zhi Ai, Xin-Xing Zhu, Ya-Wei Yan, Yasmeen Saeed, Bin Yu, Jingying Huang, Yuxin Gao, Jiaqi Liu, Yi-Zhou Jiang, Min Liu and Demeng Chen

    Citation: Cancer Cell International 2017 17:103

    Content type: Primary research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2018 18:73

  8. MicroRNAs are considered as potential regulators in various biological pathways and contribute to the diagnosis and prognosis of cancers. MicroRNA-214-3p (miR-214-3p) was proved to be correlated with various c...

    Authors: Yue Li, You Li, Yao Chen, Qian Xie, Ningning Dong, Yanjun Gao, Huan Deng, Chunhua Lu and Suihai Wang

    Citation: Cancer Cell International 2017 17:102

    Content type: Primary Research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2018 18:55

  9. Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential...

    Authors: Hu Lei, Huizhuang Shan and Yingli Wu

    Citation: Cancer Cell International 2017 17:101

    Content type: Review

    Published on:

  10. As one of the hallmarks of cancer, chemoresistance hinders curative cancer chemotherapy in osteosarcoma (OS). MicroRNAs (miRNAs) act as key regulators of gene expression in diverse biological processes includi...

    Authors: Fangfang Zhao, Youguang Pu, Mingda Cui, Haiyan Wang and Shanbao Cai

    Citation: Cancer Cell International 2017 17:100

    Content type: Primary Research

    Published on:

  11. Upon publication of the original article [1], it was noticed that corresponding author status has been erroneously attributed to José Antonio Fagundes Assumpção. The corresponding author of this manuscript should...

    Authors: José Antonio Fagundes Assumpção, Kelly Grace Magalhães and José Raimundo Corrêa

    Citation: Cancer Cell International 2017 17:99

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2017 17:82

  12. More than 400,000 patients die from esophageal cancer annually. Considerable efforts have been made to develop new and effective treatments, one of which is directed toward herbal medication. Crocetin is a nat...

    Authors: Sheng Li, Xiu-Yin Shen, Ting Ouyang, Yuhua Qu, Tao Luo and Hua-Qiao Wang

    Citation: Cancer Cell International 2017 17:98

    Content type: Primary Research

    Published on:

  13. Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-re...

    Authors: Lisa Repsold, Roger Pool, Mohammed Karodia, Gregory Tintinger and Annie Margaretha Joubert

    Citation: Cancer Cell International 2017 17:89

    Content type: Review

    Published on:

  14. miRNAs are regarded as molecular biomarkers and therapeutic targets for colorectal cancer (CRC), a series of miRNAs have been proven to involve into CRC carcinogenesis, invasion and metastasis. Aberrant miR-42...

    Authors: Wen-Ting Wei, Xin-Xin Nian, Shu-Yang Wang, Hong-Li Jiao, Yong-Xia Wang, Zhi-Yuan Xiao, Run-Wei Yang, Yan-Qing Ding, Ya-Ping Ye and Wen-Ting Liao

    Citation: Cancer Cell International 2017 17:91

    Content type: Primary Research

    Published on:

  15. The aim of this study was to determine whether brain abundant membrane attached signal protein 1 (BASP1) is a valuable prognostic biomarker for cervical cancer and whether BASP1 regulates the progression of ce...

    Authors: Huiru Tang, Yan Wang, Bing Zhang, Shiqiu Xiong, Liangshuai Liu, Wei Chen, Guosheng Tan and Heping Li

    Citation: Cancer Cell International 2017 17:97

    Content type: Primary Research

    Published on:

  16. Cellular based therapeutic approaches for cancer rely on careful consideration of finding the optimal cell to execute the cellular goal of cancer treatment. Cell lines and primary cell cultures have been used ...

    Authors: Jehad Zweiri and Stephen E. Christmas

    Citation: Cancer Cell International 2017 17:96

    Content type: Primary Research

    Published on:

  17. The tumor suppressive role of miR-1296 is observed in triple negative breast cancer (TNBC). However, the effect of miR-1296-5p in ERBB2-positive breast cancers remains obscure.

    Authors: Gang Chen, Mingfeng He, Yin Yin, Ting Yan, Wenfang Cheng, Zebo Huang, Lan Zhang, Huo Zhang, Ping Liu, Wei Zhu and Yichao Zhu

    Citation: Cancer Cell International 2017 17:95

    Content type: Primary Research

    Published on:

  18. The relationship between specific genome alterations and hepatocellular carcinoma (HCC) cancer stem cells (CSCs) remains unclear. In this study, we evaluated the relationship between somatic mutations and epit...

    Authors: Takehiro Hayashi, Taro Yamashita, Hikari Okada, Kouki Nio, Yasumasa Hara, Yoshimoto Nomura, Tomoyuki Hayashi, Yoshiro Asahina, Mariko Yoshida, Naoki Oishi, Hajime Sunagozaka, Hajime Takatori, Masao Honda and Shuichi Kaneko

    Citation: Cancer Cell International 2017 17:94

    Content type: Primary Research

    Published on:

  19. Cancers can survive the oxidative conditions by upregulating nucleoside diphosphate linked moiety X-type motif 1 (NUDT1). However, the mechanisms underlying gastric carcinogenesis and the dys-regulation of NUD...

    Authors: Jingjing Duan, Haiyang Zhang, Shuang Li, Xinyi Wang, Haiou Yang, Shunchang Jiao and Yi Ba

    Citation: Cancer Cell International 2017 17:92

    Content type: Primary Research

    Published on:

  20. Cancers are caused by the acquisition of somatic mutations. Numerous efforts have been made to characterize the key driver genes and pathways in glioma, however, the etiology of glioma is still not completely ...

    Authors: Aijun Liang, Bin Zhou and Wei Sun

    Citation: Cancer Cell International 2017 17:90

    Content type: Primary Research

    Published on:

  21. Cervical cancer is a major cause of death in women worldwide. Interferon-induced transmembrane protein 1 (IFITM1) is involved in antivirus defense, cell adhesion, and carcinogenesis in different tissues. Howev...

    Authors: Weinan Zheng, Zhimin Zhao, Xinan Yi, Qiangqiang Zuo, Hongtao Li, Xiaoqing Guo, Dongmei Li, Hongchang He, Zemin Pan, Peiwen Fan, Feng Li, Yanhong Liao and Renfu Shao

    Citation: Cancer Cell International 2017 17:88

    Content type: Primary Research

    Published on:

  22. Glioblastoma is the most common and aggressive brain tumor associated with a poor prognosis. Plant homeodomain finger protein 20 (PHF20) is highly expressed in primary human gliomas and its expression is assoc...

    Authors: Tianlong Liu, Tiejun Zhang, Feng Zhou, Jitao Wang, Xiaohu Zhai, Nan Mu, Jongsun Park, Minna Liu, Wenxing Liu, Peijin Shang, Yi Ding, Aidong Wen and Yuwen Li

    Citation: Cancer Cell International 2017 17:87

    Content type: Primary Research

    Published on:

  23. BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V...

    Authors: Tiziana Notarangelo, Lorenza Sisinni, Valentina Condelli and Matteo Landriscina

    Citation: Cancer Cell International 2017 17:86

    Content type: Primary Research

    Published on:

  24. Transforming growth factor-β (TGF-β) plays a paradoxical role in cancer: it suppresses proliferation at early stages but promotes metastasis at late stages. This cytokine is upregulated in cholangiocarcinoma a...

    Authors: Phaijit Sritananuwat, Natthaporn Sueangoen, Parichut Thummarati, Kittiya Islam and Tuangporn Suthiphongchai

    Citation: Cancer Cell International 2017 17:85

    Content type: Primary Research

    Published on:

  25. Curcumin, a natural compound derived from the turmeric rhizome Curcuma longa Linn, has anticancer and chemoresistance reduction biological activities. We evaluated the efficacy of curcumin in sensitizing chemothe...

    Authors: Qian-Mei Zhou, Yang Sun, Yi-Yu Lu, Hui Zhang, Qi-Long Chen and Shi-Bing Su

    Citation: Cancer Cell International 2017 17:84

    Content type: Primary Research

    Published on:

  26. Ubiquitin-conjugating enzyme E2C (UBE2C) has been previously reported to correlate with the malignant progression of various human cancers, however, the exact molecular function of UBE2C in breast carcinoma (B...

    Authors: Chao-hua Mo, Li Gao, Xiao-fei Zhu, Kang-lai Wei, Jing-jing Zeng, Gang Chen and Zhen-bo Feng

    Citation: Cancer Cell International 2017 17:83

    Content type: Primary Research

    Published on:

  27. In cancer cells, autophagy can act as both tumor suppressor, when autophagic event eliminates cellular contends which exceeds the cellular capacity of regenerate promoting cell death, and as a pro-survival age...

    Authors: José Antonio Fagundes Assumpção, Kelly Grace Magalhães and José Raimundo Corrêa

    Citation: Cancer Cell International 2017 17:82

    Content type: Primary Research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2017 17:99

  28. ErbB3 is an oncogene which has proliferation and metastasis promotion effects by several signaling pathways. However, the individual expression difference regulated by miRNA was almost still unknown. We focuse...

    Authors: Yaxiang Shi, Xuan Chen, Biao Xi, Xiaowen Yu, Jun Ouyang, Chunxia Han, Yucheng Qin, Defeng Wu and Hong Shen

    Citation: Cancer Cell International 2017 17:81

    Content type: Primary Research

    Published on:

  29. Epithelial–mesenchymal transition (EMT), TP53, and Podoplanin have been implicated in the tumorigenesis and metastasis of human cancers. Nevertheless, the clinical significance of these markers in cancer patie...

    Authors: Jiaying Lin, Jiaqi Lu, Chao Wang and Xiaohong Xue

    Citation: Cancer Cell International 2017 17:80

    Content type: Primary Research

    Published on:

  30. Cisplatin has been used in the treatment of many cancers, including laryngeal cancer; however, its efficacy can be reduced due to the development of drug resistance. This study aimed to investigate whether int...

    Authors: Qiang Fu, Pengruofeng Liu, Xiumei Sun, Shanshan Huang, Fengchan Han, Lili Zhang, Yannan Xu and Tingyan Liu

    Citation: Cancer Cell International 2017 17:79

    Content type: Primary Research

    Published on:

  31. Methylation plays an important role in the etiology and pathogenesis of colorectal cancer (CRC). This study aimed to identify aberrantly methylated-differentially expressed genes (DEGs) and pathways in CRC by ...

    Authors: Jingwei Liu, Hao Li, Liping Sun, Zhenning Wang, Chengzhong Xing and Yuan Yuan

    Citation: Cancer Cell International 2017 17:75

    Content type: Primary Research

    Published on:

  32. Increased expression of voltage-gated sodium channels (VGSCs) have been implicated with strong metastatic potential of human breast cancer in vitro and in vivo where the main culprits are cardiac isoform Nav1....

    Authors: Nur Sabrina Kamarulzaman, Hemaniswarri Dewi Dewadas, Chiuan Yee Leow, Nik Soriani Yaacob and Noor Fatmawati Mokhtar

    Citation: Cancer Cell International 2017 17:74

    Content type: Primary Research

    Published on:

  33. Meningioma tumors arise in arachnoid membranes, and are the most reported central nervous system (CNS) tumors worldwide. Up to 20% of grade I meningioma tumors reoccur and currently predictive cancer stem cell...

    Authors: Ishaq Khan, Saleh Baeesa, Mohammed Bangash, Hans-Juergen Schulten, Fahad Alghamdi, Hanadi Qashqari, Nawal Madkhali, Angel Carracedo, Mohamad Saka, Awatif Jamal, Jaudah Al-Maghrabi, Mohammed AlQahtani, Saleh Al-Karim, Ghazi Damanhouri, Kulvinder Saini, Adeel Chaudhary…

    Citation: Cancer Cell International 2017 17:72

    Content type: Research

    Published on:

  34. Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related death. Growing evidence from recent studies have shown indicated that microRNA-126 (miR-126) played an important role in the progression ...

    Authors: Wen Zheng, Ya Zhou, Jia Lu, Hualin Xu, Liangyu Lei, Chao Chen, Juanjuan Zhao and Lin Xu

    Citation: Cancer Cell International 2017 17:71

    Content type: Primary Research

    Published on:

  35. Rituximab combined with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) is used as standard frontline regimen for diffuse large B-cell lymphoma (DLBCL). The landscape of somatic mutations in D...

    Authors: Jiao Li, Ning Ding, Xiaogan Wang, Lan Mi, Lingyan Ping, Xuan Jin, Yalu Liu, Zhitao Ying, Yan Xie, Weiping Liu, Yuqin Song and Jun Zhu

    Citation: Cancer Cell International 2017 17:70

    Content type: Primary Research

    Published on:

  36. Pancreatic cancer is an extremely dismal malignance. Chemotherapy has been widely applied to treat this intractable tumor. It has exclusive tumor microenvironment (TME), characterized by dense desmoplasia and ...

    Authors: Qiaofei Liu, Quan Liao and Yupei Zhao

    Citation: Cancer Cell International 2017 17:68

    Content type: Review

    Published on:

  37. 6-Chloro-2-methoxy-N-(phenylmethyl)-9-acridinamine (BA), a novel sponge-derived compound, has been reported to elicit a cytotoxic effect by inhibiting cell proliferation.

    Authors: Yun Huang, Guohua Liu, Feng Yang, Xiaowei Xing, Ying Li, Zhijun Huang and Hong Yuan

    Citation: Cancer Cell International 2017 17:66

    Content type: Primary Research

    Published on:

  38. Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can inter...

    Authors: Jing Li, Jing Wang, Yan Zhong, Ruixia Guo, Danxia Chu, Haifeng Qiu and Zhongfu Yuan

    Citation: Cancer Cell International 2017 17:65

    Content type: Review

    Published on:

  39. Recent studies have verified that long noncoding RNAs (lncRNAs) involved in many biological functions and play crucial roles in human cancers progression, the study aimed to detect the association between long...

    Authors: Jian-Hui Chen, Li-Yang Zhou, Suo Xu, Yu-Long Zheng, Yu-Feng Wan and Cheng-Ping Hu

    Citation: Cancer Cell International 2017 17:64

    Content type: Primary Research

    Published on:

  40. Recent evidence indicated that the aberrant expression of microRNA plays a crucial role in the development of cervical cancer. The overall shorter survival was strongly related to the abnormal expression of mi...

    Authors: Ai-Hua Chen, Yu-E Qin, Wen-Fan Tang, Jing Tao, Hua-mei Song and Manzhen Zuo

    Citation: Cancer Cell International 2017 17:63

    Content type: Primary Research

    Published on:

  41. To study the mechanism by which epithelial ovarian cancer (EOC)-derived exosomes restore the migration of endothelial cells that is suppressed by TAM-derived exosomes.

    Authors: Quanfeng Wu, Xiaoli Wu, Xiang Ying, Qinyi Zhu, Xinjing Wang, Lu Jiang, Xin Chen, Yueqian Wu and Xipeng Wang

    Citation: Cancer Cell International 2017 17:62

    Content type: Primary Research

    Published on:

  42. The completion of the human genome project and the accomplished milestones in the human proteome project; as well as the progress made so far in computational bioinformatics and “big data” processing have cont...

    Authors: Henry A. Adeola, Olujide O. Soyele, Anthonio O. Adefuye, Sikiru A. Jimoh and Azeez Butali

    Citation: Cancer Cell International 2017 17:61

    Content type: Review

    Published on:

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