Casalini P, Carcangiu ML, Tammi R, Auvinen P, Kosma VM, Valagussa P, Greco M, Balsari A, Menard S, Tagliabue E: Two distinct local relapse subtypes in invasive breast cancer: effect on their prognostic impact. Clin Cancer Res. 2008, 14: 25-31. 10.1158/1078-0432.CCR-07-0450.
Article
CAS
PubMed
Google Scholar
Klauber-DeMore N: Tumor biology of breast cancer in young women. Breast Dis. 2005, 23: 9-15.
PubMed
Google Scholar
Jemal A, Ward E, Thun MJ: Recent trends in breast cancer incidence rates by age and tumor characteristics among U.S. women. Breast Cancer Res. 2007, 9: R28-10.1186/bcr1672.
Article
PubMed Central
PubMed
Google Scholar
Ali MA, Akhmedkhanov A, Zeleniuch-Jaquotte A, Toniolo P, Frenkel K, Huang X: Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women. Cancer Det Prev. 2003, 27: 116-121. 10.1016/S0361-090X(03)00027-8.
Article
CAS
Google Scholar
Atwood CS, Meethal SV, Liu T, Wilson AC, Gallego M, Smith MA, Bowen RL: Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence. J Neuropathol Exp Neurol. 2005, 64: 93-103.
CAS
PubMed
Google Scholar
Chakraborty TR, Gore AC: Aging-related changes in ovarian hormones, their receptors, and neuroendocrine function. Exp Biol Med (Maywood). 2004, 229: 977-987.
CAS
Google Scholar
Zimmermann MB, Hurrell RF: Nutritional iron deficiency. Lancet. 2007, 370: 511-520. 10.1016/S0140-6736(07)61235-5.
Article
CAS
PubMed
Google Scholar
Cavill I, Auerbach M, Bailie GR, Barrett-Lee P, Beguin Y, Kaltwasser P, Littlewood T, Macdougall IC, Wilson K: Iron and the anaemia of chronic disease: a review and strategic recommendations. Curr Med Res Opin. 2006, 22: 731-737. 10.1185/030079906X100096.
Article
CAS
PubMed
Google Scholar
Hercberg S, Preziosi P, Galan P: Iron deficiency in Europe. Public Health Nutr. 2001, 4: 537-545. 10.1079/PHN2001139.
Article
CAS
PubMed
Google Scholar
Weiss G, Gordeuk VR: Benefits and risks of iron therapy for chronic anaemias. Eur J Clin Invest. 2005, 35 (Suppl 3): 36-45. 10.1111/j.1365-2362.2005.01529.x.
Article
CAS
PubMed
Google Scholar
Pantopoulos K: Iron metabolism and the IRE/IRP regulatory system: an update. Ann N Y Acad Sci. 2004, 1012: 1-13. 10.1196/annals.1306.001.
Article
CAS
PubMed
Google Scholar
Rouault TA: The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol. 2006, 2: 406-414. 10.1038/nchembio807.
Article
CAS
PubMed
Google Scholar
Muckenthaler MU, Galy B, Hentze MW: Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network. Annu Rev Nutr. 2008, 28: 197-213. 10.1146/annurev.nutr.28.061807.155521.
Article
CAS
PubMed
Google Scholar
Recalcati S, Minotti G, Cairo G: Iron regulatory proteins: from molecular mechanisms to drug development. Antioxid Redox Signal. 2010,
Google Scholar
Dongiovanni P, Valenti L, Ludovica Fracanzani A, Gatti S, Cairo G, Fargion S: Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. Am J Pathol. 2008, 172: 738-747. 10.2353/ajpath.2008.070097.
Article
PubMed Central
CAS
PubMed
Google Scholar
Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS: Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J Biol Chem. 2004, 279: 40337-40344. 10.1074/jbc.M403057200.
Article
CAS
PubMed
Google Scholar
Bertout JA, Patel SA, Simon MC: The impact of O2 availability on human cancer. Nat Rev Cancer. 2008, 8: 967-975. 10.1038/nrc2540.
Article
PubMed Central
CAS
PubMed
Google Scholar
Huang X: Does iron have a role in breast cancer?. Lancet Oncol. 2008, 9: 803-807. 10.1016/S1470-2045(08)70200-6.
Article
PubMed Central
CAS
PubMed
Google Scholar
Han W, Kim SW, Park IA, Kang D, Kim SW, Youn YK, Oh SK, Choe KJ, Noh DY: Young age: an independent risk factor for disease-free survival in women with operable breast cancer. BMC Cancer. 2004, 4: 82-10.1186/1471-2407-4-82.
Article
PubMed Central
PubMed
Google Scholar
Vaupel P, Mayer A, Briest S, Hockel M: Hypoxia in breast cancer: role of blood flow, oxygen diffusion distances, and anemia in the development of oxygen depletion. Adv Exp Med Biol. 2005, 566: 333-342. full_text.
Article
PubMed
Google Scholar
Kang GS, Li Q, Chen H, Costa M: Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells. Mutat Res. 2006, 610: 48-55.
Article
CAS
PubMed
Google Scholar
Cavalieri E, Frenkel K, Liehr JG, Rogan E, Roy D: Estrogens as endogenous genotoxic agents--DNA adducts and mutations. J Natl Cancer Inst Monogr. 2000, 75-93.
Google Scholar
Rennert G, Bisland-Naggan S, Barnett-Griness O, Bar-Joseph N, Zhang S, Rennert HS, Narod SA: Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations. N Engl J Med. 2007, 357: 115-123. 10.1056/NEJMoa070608.
Article
CAS
PubMed
Google Scholar
Russo J, Hasan Lareef M, Balogh G, Guo S, Russo IH: Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells. J Steroid Biochem Mol Biol. 2003, 87: 1-25. 10.1016/S0960-0760(03)00390-X.
Article
CAS
PubMed
Google Scholar
Gasparini G: Prognostic value of vascular endothelial growth factor in breast cancer. Oncologist. 2000, 5 (Suppl 1): 37-44. 10.1634/theoncologist.5-suppl_1-37.
Article
CAS
PubMed
Google Scholar
Huang X: Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal. Mutat Res. 2003, 533: 153-171.
Article
CAS
PubMed
Google Scholar
Hardman WE, Barnes CJ, Knight CW, Cameron IL: Effects of iron supplementation and ET-18-OCH3 on MDA-MB 231 breast carcinomas in nude mice consuming a fish oil diet. Br J Cancer. 1997, 76: 347-354.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ilsley JN, Leung SF, Belinsky GS, Guda K, Zhang Q, Huang X, Blumberg JB, Milbury PE, Roberts Ii LJ, Stevens RG, Rosenberg DW: Dietary iron promotes azoxymethane-induced colon tumors in mice. Nutr Cancer. 2004, 49: 162-169. 10.1207/s15327914nc4902_7.
Article
CAS
PubMed
Google Scholar
Thompson HJ, Kennedy K, Witt M, Juzefyk J: Effect of dietary iron deficiency or excess on the induction of mammary carcinogenesis by 1-methyl-1-nitrosourea. Carcinogenesis. 1991, 12: 111-114. 10.1093/carcin/12.1.111.
Article
CAS
PubMed
Google Scholar
Weinberg ED: Iron in neoplastic disease. Nutr Cancer. 1983, 4: 223-233. 10.1080/01635588209513761.
Article
CAS
PubMed
Google Scholar
Andrews NC, Schmidt PJ: Iron homeostasis. Annu Rev Physiol. 2007, 69: 69-85. 10.1146/annurev.physiol.69.031905.164337.
Article
CAS
PubMed
Google Scholar
Ganz T, Nemeth E: Regulation of iron acquisition and iron distribution in mammals. Biochim Biophys Acta. 2006, 1763: 690-699. 10.1016/j.bbamcr.2006.03.014.
Article
CAS
PubMed
Google Scholar
Lee GY, Kenny PA, Lee EH, Bissell MJ: Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods. 2007, 4: 359-365. 10.1038/nmeth1015.
Article
PubMed Central
CAS
PubMed
Google Scholar
Semenza GL: Hypoxia-inducible factor 1 and cancer pathogenesis. IUBMB Life. 2008, 60: 591-597. 10.1002/iub.93.
Article
CAS
PubMed
Google Scholar
Guo P, Fang Q, Tao HQ, Schafer CA, Fenton BM, Ding I, Hu B, Cheng SY: Overexpression of vascular endothelial growth factor by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo. Cancer Res. 2003, 63: 4684-4691.
CAS
PubMed
Google Scholar
Jiang XP, Elliott RL, Head JF: Manipulation of iron transporter genes results in the suppression of human and mouse mammary adenocarcinomas. Anticancer Res. 2010, 30: 759-765.
CAS
PubMed
Google Scholar
Jones DT, Trowbridge IS, Harris AL: Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate. Cancer Res. 2006, 66: 2749-2756. 10.1158/0008-5472.CAN-05-3857.
Article
CAS
PubMed
Google Scholar
Gerald D, Berra E, Frapart YM, Chan DA, Giaccia AJ, Mansuy D, Pouyssegur J, Yaniv M, Mechta-Grigoriou F: JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell. 2004, 118: 781-794. 10.1016/j.cell.2004.08.025.
Article
CAS
PubMed
Google Scholar
Semenza GL: Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE. 2007, 2007: cm8-10.1126/stke.4072007cm8.
Article
PubMed
Google Scholar
Robach P, Cairo G, Gelfi C, Bernuzzi F, Pilegaard H, Vigano A, Santambrogio P, Cerretelli P, Calbet JA, Moutereau S, Lundby C: Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle. Blood. 2007, 109: 4724-4731. 10.1182/blood-2006-08-040006.
Article
CAS
PubMed
Google Scholar
Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS: Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest. 2007, 117: 1926-1932. 10.1172/JCI31370.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sanchez M, Galy B, Muckenthaler MU, Hentze MW: Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol. 2007, 14: 420-426. 10.1038/nsmb1222.
Article
CAS
PubMed
Google Scholar
Semenza GL: Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med. 2001, 7: 345-350. 10.1016/S1471-4914(01)02090-1.
Article
CAS
PubMed
Google Scholar
Peyssonnaux C, Nizet V, Johnson RS: Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle. 2008, 7: 28-32. 10.4161/cc.7.1.5145.
Article
CAS
PubMed
Google Scholar
Chen CL, Hsieh YT, Chen HC: Phosphorylation of adducin by protein kinase Cdelta promotes cell motility. J Cell Sci. 2007, 120: 1157-1167. 10.1242/jcs.03408.
Article
CAS
PubMed
Google Scholar
Rothenberger S, Mullner EW, Kuhn LC: The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution. Nucleic Acids Res. 1990, 18: 1175-1179. 10.1093/nar/18.5.1175.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wu J, Eckard J, Chen H, Costa M, Frenkel K, Huang X: Altered iron homeostasis involvement in arsenite-mediated cell transformation. Free Radic Biol Med. 2006, 40: 444-452. 10.1016/j.freeradbiomed.2005.08.035.
Article
PubMed Central
PubMed
Google Scholar
Ali A, Zhang Q, Dai J, Huang X: Calcein as a fluorescent iron chemosensor for the determination of low molecular weight iron in biological fluids. Biometals. 2003, 16: 285-293. 10.1023/A:1020642808437.
Article
CAS
PubMed
Google Scholar
Zhang Q, Huang X: Induction of ferritin and lipid peroxidation by coal samples with different prevalence of coal workers' pneumoconiosis: role of iron in the coals. Am J Ind Med. 2002, 42: 171-179. 10.1002/ajim.10101.
Article
CAS
PubMed
Google Scholar