Krieg AM. Development of TLR9 agonists for cancer therapy. J Clin Invest. 2007;117:1184–94.
Article
PubMed Central
CAS
PubMed
Google Scholar
Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature. 2007;449:819–26.
Article
CAS
PubMed
Google Scholar
Takeshita F, Ishii KJ. Intracellular DNA sensors in immunity. Curr Opin Immunol. 2008;20:383–8.
Article
CAS
PubMed
Google Scholar
Xiao T. Innate immune recognition of nucleic acids. Immunol Res. 2009;43:98–108.
Article
PubMed Central
CAS
PubMed
Google Scholar
Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science. 2010;327:291–5.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kumagai Y, Akira S. Identification and functions of pattern-recognition receptors. J Allergy Clin Immunol. 2010;125:985–92.
Article
CAS
PubMed
Google Scholar
Barbalat R, Ewald SE, Mouchess ML, Barton GM. Nucleic acid recognition by the innate immune system. Annu Rev Immunol. 2011;29:185–214.
Article
CAS
PubMed
Google Scholar
Bode C, Zhao G, Steinhagen F, Kinjo T, Klinman DM. CpG DNA as a vaccine adjuvant. Expert Rev Vaccines. 2011;10:499–511.
Article
PubMed Central
CAS
PubMed
Google Scholar
Anker P, Mulcahy H, Chen XQ, Stroun M. Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients. Cancer Metastasis Rev. 1999;18(1):65–73.
Article
CAS
PubMed
Google Scholar
Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, Hesch RD, et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 2001;61(4):1659–65.
CAS
PubMed
Google Scholar
Laktionov PP, Tamkovich SN, Rykova EY, Bryzgunova OE, Starikov AV, Kuznetsova NP, et al. Extracellular circulating nucleic acids in human plasma in health and disease. Nucleosides Nucleotides Nucleic Acids. 2004;23(6–7):879–83.
Article
CAS
PubMed
Google Scholar
Tuaeva NO, Sofronov VV, Emikeeva VA, Abramova ZI, Winter VG, Mustafina DM, et al. Relationship between levels of extracellular DNA and antibodies against double-stranded DNA in new borns with pneumopathy. Kazansky Med J. 2006;87:254–7 [In Russian].
Google Scholar
Guiducci C, Tripodo C, Gong M, Sangaletti S, Colombo MP, Coffman RL, et al. Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9. J Exp Med. 2010;207(13):2931–42.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pisetsky DS, Ullal AJ. The blood nucleome in the pathogenesis of SLE. Autoimmun Rev. 2010;10(1):35–7.
Article
PubMed Central
CAS
PubMed
Google Scholar
Almqvist N, Winkler TH, Mårtensson IL. Autoantibodies: focus on anti-DNA antibodies. Self Nonself. 2011;2(1):11–8.
Article
PubMed Central
PubMed
Google Scholar
Agrawal A, Sridharan A, Prakash S, Agrawal H. Dendritic cells and aging: consequences for autoimmunity. Expert Rev Clin Immunol. 2012;8(1):73–80.
Article
PubMed Central
CAS
PubMed
Google Scholar
Choubey D. DNA-responsive inflammasomes and their regulators in autoimmunity. Clin Immunol. 2012;142(3):223–31.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kaczorowski DJ, Scott MJ, Pibris JP, Afrazi A, Nakao A, Edmonds RD, et al. Mammalian DNA is an endogenous danger signal that stimulates local synthesis and release of complement factor B. Mol Med. 2012;18:851–60.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ermakov AV, Konkova MS, Kostyuk SV, Egolina NA, Efremova LV, Veiko NN. Oxidative stress as a significant factor for development of an adaptive response in irradiated and nonirradiated human lymphocytes after inducing the bystander effect by low-dose X-radiation. Mutat Res. 2009;669(1–2):155–61.
Article
CAS
PubMed
Google Scholar
Rhodes A, Wort SJ, Thomas H, Collinson P, Bennett ED. Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. Crit Care. 2006;10(2):R60.
Article
PubMed Central
PubMed
Google Scholar
Saukkonen K, Lakkisto P, Varpula M, Varpula T, Voipio-Pulkki LM, Pettilä V, et al. Association of cell-free plasma DNA with hospital mortality and organ dysfunction in intensive care unit patients. Intensive Care Med. 2007;33(9):1624–7.
Article
CAS
PubMed
Google Scholar
Castellheim A, Brekke OL, Espevik T, Harboe M, Mollnes TE. Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis. Scand J Immunol. 2009;69(6):479–91.
Article
CAS
PubMed
Google Scholar
Arnalich F, Maldifassi MC, Ciria E, Quesada A, Codoceo R, Herruzo R, et al. Association of cell-free plasma DNA with perioperative mortality in patients with suspected acute mesenteric ischemia. Clin Chim Acta. 2010;411(17–18):1269–74.
Article
CAS
PubMed
Google Scholar
Kung CT, Hsiao SY, Tsai TC, Su CM, Chang WN, Huang CR, et al. Plasma nuclear and mitochondrial DNA levels as predictors of outcome in severe sepsis patients in the emergency room. J Transl Med. 2012;10:130.
Article
PubMed Central
CAS
PubMed
Google Scholar
Huang LC, Clarkin KC, Wahl GM. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. Proc Natl Acad Sci U S A. 1996;93:4827–32.
Article
PubMed Central
CAS
PubMed
Google Scholar
MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA. The structural determinants of checkpoint activation. Genes Dev. 2007;21:898–903.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zou L. Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response. Genes Dev. 2007;21:879–85.
Article
CAS
PubMed
Google Scholar
Dolgova EV, Proskurina AS, Nikolin VP, Popova NA, Alyamkina EA, Orishchenko KE, et al. “Delayed death” phenomenon: a synergistic action of cyclophosphamide and exogenous DNA. Gene. 2012;495:134–45.
Article
CAS
PubMed
Google Scholar
Dolgova EV, Efremov YR, Orishchenko KE, Andrushkevich OM, Alyamkina EA, Proskurina AS, et al. Delivery and processing of exogenous double-stranded DNA in mouse CD34+ hematopoietic progenitor cells and their cell cycle changes upon combined treatment with cyclophosphamide and double-stranded DNA. Gene. 2013;528(2):74–83.
Article
CAS
PubMed
Google Scholar
Dolgova EV, Alyamkina EA, Efremov YR, Nikolin VP, Popova NA, Tyrinova TV, et al. Identification of cancer stem cells and a strategy for their elimination. Cancer Biol Ther. 2014;15(10):1378–94.
Article
CAS
PubMed
Google Scholar
Barber GN. Cytoplasmic DNA innate immune pathways. Immunol Rev. 2011;243:99–108.
Article
CAS
PubMed
Google Scholar
Barber GN. Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr Opin Immunol. 2011;23:10–20.
Article
PubMed Central
CAS
PubMed
Google Scholar
Patel SJ, Jindal R, King KR, Tilles AW, Yarmush ML. The inflammatory response to double stranded DNA in endothelial cells is mediated by NFκB and TNFα. PLoS One. 2011;6(5):e19910.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sharma S, Fitzgerald KA. Innate immune sensing of DNA. PLoS Pathog. 2011;7:e1001310.
Article
PubMed Central
CAS
PubMed
Google Scholar
Alyamkina EA, Dolgova EV, Proskurina AS, Rogachev VA, Ostanin AA, Chernykh ER, et al. Intracellular systems for detection of exogenous nucleic acids and triggering mechanisms of immune response to DNA internalization. Med Immunol. 2013;15:413–30 [In Russian].
Google Scholar
Yakubov LA, Rogachev VA, Likhacheva AC, Bogachev SS, Sebeleva TE, Shilov AG, et al. Natural human gene correction by small extracellular genomic DNA fragments. Cell Cycle. 2007;6(18):2293–301.
Article
CAS
PubMed
Google Scholar
García-Olmo D, García-Olmo DC, Domínguez-Berzosa C, Guadalajara H, Vega L, García-Arranz M. Oncogenic transformation induced by cell-free nucleic acids circulating in plasma (genometastasis) remains after the surgical resection of the primary tumor: a pilot study. Expert Opin Biol Ther. 2012;12 Suppl 1:S61–8.
Article
PubMed
Google Scholar
Ledoux L. Uptake of DNA by living cells. Prog Nucleic Acid Res Mol Biol. 1965;4:231–67.
Article
CAS
PubMed
Google Scholar
Ratajczak J, Wysoczynski M, Hayek F, Janowska-Wieczorek A, Ratajczak MZ. Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia. 2006;20(9):1487–95.
Article
CAS
PubMed
Google Scholar
Cocucci E, Racchetti G, Meldolesi J. Shedding microvesicles: artefacts no more. Trends Cell Biol. 2009;19(2):43–51.
Article
CAS
PubMed
Google Scholar
Pap E, Pállinger E, Pásztói M, Falus A. Highlights of a new type of intercellular communication: microvesicle-based information transfer. Inflamm Res. 2009;58(1):1–8.
Article
CAS
PubMed
Google Scholar
Simons M, Raposo G. Exosomes–vesicular carriers for intercellular communication. Curr Opin Cell Biol. 2009;21(4):575–81.
Article
CAS
PubMed
Google Scholar
Balaj L, Lessard R, Dai L, Cho YJ, Pomeroy SL, Breakefield XO, et al. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat Commun. 2011;2:180.
Article
PubMed Central
PubMed
Google Scholar
Camussi G, Deregibus MC, Bruno S, Grange C, Fonsato V, Tetta C. Exosome/microvesicle-mediated epigenetic reprogramming of cells. Am J Cancer Res. 2011;1(1):98–110.
PubMed Central
PubMed
Google Scholar
Record M, Subra C, Silvente-Poirot S, Poirot M. Exosomes as intercellular signalosomes and pharmacological effectors. Biochem Pharmacol. 2011;81(10):1171–82.
Article
CAS
PubMed
Google Scholar
Tetta C, Bruno S, Fonsato V, Deregibus MC, Camussi G. The role of microvesicles in tissue repair. Organogenesis. 2011;7(2):105–15.
Article
PubMed Central
PubMed
Google Scholar
Ludwig AK, Giebel B. Exosomes: small vesicles participating in intercellular communication. Int J Biochem Cell Biol. 2012;44(1):11–5.
Article
CAS
PubMed
Google Scholar
Ronquist GK, Larsson A, Stavreus-Evers A, Ronquist G. Prostasomes are heterogeneous regarding size and appearance but affiliated to one DNA-containing exosome family. Prostate. 2012;72(16):1736–45.
Article
CAS
PubMed
Google Scholar
Alyamkina EA, Dolgova EV, Likhacheva AS, Rogachev VA, Sebeleva TE, Nikolin VP, et al. Combined therapy with cyclophosphamide and DNA preparation inhibits the tumor growth in mice. Genet Vaccines Ther. 2009;7(1):12.
Article
PubMed Central
PubMed
Google Scholar
Alyamkina EA, Likhacheva AS, Nikolin VP, Popova NA, Dolgova EV, Rogachev VA, et al. The effect of the exogenous DNA associated with protamine on the growth of experimental mouse tumors. Vopr Oncol. 2009;55:765–8 [In Russian].
CAS
Google Scholar
Alyamkina EA, Dolgova EV, Likhacheva AS, Rogachev VA, Sebeleva TE, Nikolin VP, et al. Exogenous allogenic fragmented double-stranded DNA is internalized into human dendritic cells and enhances their allostimulatory activity. Cell Immunol. 2010;262:120–6.
Article
CAS
PubMed
Google Scholar
Alyamkina EA, Leplina OY, Sakhno LV, Chernykh ER, Ostanin AA, Efremov YR, et al. Effect of double-stranded DNA on maturation of dendritic cells in vitro. Cell Immunol. 2010;266:46–51.
Article
CAS
PubMed
Google Scholar
Alyamkina EA, Nikolin VP, Popova NA, Dolgova EV, Proskurina AS, Orishchenko KE, et al. A strategy of tumor treatment in mice with doxorubicin-cyclophosphamide combination based on dendritic cell activation by human double-stranded DNA preparation. Genet Vaccines Ther. 2010;8(1):7.
Article
PubMed Central
PubMed
Google Scholar
Alyamkina EA, Leplina OY, Ostanin AA, Chernykh ER, Nikolin VP, Popova NA, et al. Effects of human exogenous DNA on production of perforin-containing CD8+ cytotoxic lymphocytes in laboratory setting and clinical practice. Cell Immunol. 2012;276:59–66.
Article
CAS
PubMed
Google Scholar
Ermakov AV, Konkova MS, Kostyuk SV, Smirnova TD, Malinovskaya EM, Efremova LV, et al. An extracellular DNA mediated bystander effect produced from low dose irradiated endothelial cells. Mutat Res. 2011;712(1–2):1–10.
Article
CAS
PubMed
Google Scholar
Parsons DF, Marko M, Braun SJ, Wansor KJ. Ascites tumor invasion of mouse peritoneum studied by high-voltage electron microscope stereoscopy. Cancer Res. 1982;42(11):4574–83.
CAS
PubMed
Google Scholar
Becker R, Ritter A, Eichhorn U, Lips J, Bertram B, Wiessler M, et al. Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug beta-D-glucosyl-ifosfamide mustard. Br J Cancer. 2002;86(1):130–5.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kim DJ, Kim EJ, Lee TY, Won JN, Sung MH, Poo H. Combination of poly-gamma-glutamate and cyclophosphamide enhanced antitumor efficacy against tumor growth and metastasis in a murine melanoma model. J Microbiol Biotechnol. 2013;23(9):1339–46.
Article
CAS
PubMed
Google Scholar
Sokolov MV, Dickey JS, Bonner WM, Sedelnikova OA. gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication. Cell Cycle. 2007;6(18):2210–2.
Article
CAS
PubMed
Google Scholar
Ilnytskyy Y, Kovalchuk O. Non-targeted radiation effects-an epigenetic connection. Mutat Res. 2011;714(1–2):113–25.
Article
CAS
PubMed
Google Scholar
Waters C. RBI Neurotransmissions, Newsletter Neuroscientist. 1999;XIII(2):2–7.
Google Scholar
Rosen A, Casciola-Rosen L. Autoantigenes as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. Cell Death Differ. 1999;6(1):6–12.
Article
CAS
PubMed
Google Scholar
Yamanova MV, Salmina AB, Svetlakov AV, Pozhilenkova EA, Mihutkina SV. Granulosis cell apoptosis and oocytes fertilization data in woman with endocrine sterility and endometriosis in ECF program. Problemy Reprodukcii. 2004;5:31–6.
Google Scholar
Paterson RL, Webster NR. Sepsis and the systemic inflammatory response syndrome. J R Coll Surg Edinb. 2000;45(3):178–82.
CAS
PubMed
Google Scholar
Cinel I, Opal SM. Molecular biology of inflammation and sepsis: a primer. Crit Care Med. 2009;37(1):291–304.
Article
CAS
PubMed
Google Scholar
Rivers-Auty J, Bhatia M. Hydrogen sulphide, systemic inflammatory response syndrome and compensatory anti-inflammatory response syndrome following sepsis. OA Inflammation. 2013;1(1):2.
Article
Google Scholar
Decker P, Wolburg H, Rammensee HG. Nucleosomes induce lymphocyte necrosis. Eur J Immunol. 2003;33(7):1978–87.
Article
PubMed
Google Scholar
Orishchenko KE, Ryzhikova SL, Druzhinina YG, Ryabicheva TG, Varaksin NA, Alyamkina EA, et al. Effect of human double-stranded DNA preparation on the production of cytokines by dendritic cells and peripheral blood cells from relatively healthy donors. Cancer Therapy. 2013;8:191–205.
Google Scholar
Tyrinova TV, Leplina OY, Mishinov SV, Tikhonova MA, Shevela EY, Stupak VV, et al. Cytotoxic activity of ex-vivo generated IFNα-induced monocyte-derived dendritic cells in brain glioma patients. Cell Immunol. 2013;284(1–2):146–53.
Article
CAS
PubMed
Google Scholar
Ojwang JO, Grueneberg DA, Loechler EL. Synthesis of a duplex oligonucleotide containing a nitrogen mustard interstrand DNA-DNA cross-link. Cancer Res. 1989;49(23):6529–37.
CAS
PubMed
Google Scholar
McHugh PJ, Gill RD, Waters R, Hartley JA. Excision repair of nitrogen mustard-DNA adducts in Saccharomyces cerevisiae. Nucleic Asids Res. 1999;27:3259–66.
Article
CAS
Google Scholar