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  2. The critical role of thioredoxin-interacting protein (TXNIP) in cellular sulfhydryl redox homeostasis and inflammasome activation is already widely known, however, no pan-cancer analysis is currently available.

    Authors: Xuxue Guo, Mei Huang, Haonan Zhang, Qianhui Chen, Ying Hu, Yan Meng, Changjie Wu, Chenge Tu, Yongfeng Liu, Aimin Li, Qingyuan Li, Peirong Zhou and Side Liu
    Citation: Cancer Cell International 2022 22:230
    Content type: Research Published on:

  3. Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the tr...

    Authors: Weiming Mou, Lingxuan Zhu, Tao Yang, Anqi Lin, Qiong Lyu, Linlang Guo, Zaoqu Liu, Quan Cheng, Jian Zhang and Peng Luo
    Citation: Cancer Cell International 2022 22:229
    Content type: Research Published on:

  4. Prostate cancer (PCa) is one of the most common malignant tumors in the male urinary system. In recent years, the morbidity and mortality of PCa have been increasing due to the limited effects of existing trea...

    Authors: Chuigong Yu, Yu Fan, Yu Zhang, Lupeng Liu and Gang Guo
    Citation: Cancer Cell International 2022 22:228
    Content type: Primary research Published on:

  6. A growing body of evidence has suggested the involvement of metabolism in the occurrence and development of tumors. But the link between metabolism and laryngeal squamous cell carcinoma (LSCC) has rarely been ...

    Authors: Yujie Shen, Qiang Huang, Yifan Zhang, Chi-Yao Hsueh and Liang Zhou
    Citation: Cancer Cell International 2022 22:226
    Content type: Research Published on:

  7. Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 (MCM3AP-AS1) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumor...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Mohammad Samadian
    Citation: Cancer Cell International 2022 22:225
    Content type: Review Published on:

  9. Glioma is the most common malignant tumor of the central nervous system and is associated with a poor prognosis. This study aimed to explore the function of growth factor receptor-bound protein 10(GRB 10) in g...

    Authors: Yuanbing Chen, Miao Tang, Jianbing Xiong, Qiongjue Gao, Wuyang Cao and Jun Huang
    Citation: Cancer Cell International 2022 22:223
    Content type: Research Published on:

  10. Intravenous daratumumab (DARA IV) has been increasingly used in the treatment of amyloid light-chain (AL) amyloidosis. However, the outcomes for patients administered with DARA IV have not been aggregated. The...

    Authors: Chunyan Sun, Xiaohong Wang, Renyi Zhang, Lingjie Xu, Bin Wang and Jian Li
    Citation: Cancer Cell International 2022 22:222
    Content type: Review Published on:

  11. Unlike other members of the VEGF family, the function of VEGF-B in tumor progression remains to be elucidated. Thus, the present study aimed to determine the function of VEGF-B in human choriocarcinoma cells b...

    Authors: Qianxia Tan, Jingting Cai, Jingping Peng, Cui Hu, ChenChun Wu and Huining Liu
    Citation: Cancer Cell International 2022 22:221
    Content type: Research Published on:

  12. Pancreatic cancer is the most lethal type of malignancy and is characterized by high invasiveness without severe symptoms. It is difficult to detect PC at an early stage because of the low diagnostic accuracy ...

    Authors: Haotian Wu, Suwen Ou, Hongli Zhang, Rui Huang, Shan Yu, Ming Zhao and Sheng Tai
    Citation: Cancer Cell International 2022 22:220
    Content type: Review Published on:

  13. Dysregulation of circular RNAs (circRNAs) has recently been found to play an important role in the progression and development of cancers such as non-small cell lung cancer (NSCLC). Yet the functions of many c...

    Authors: Mingming Jin, Xiyu Liu, Yue Wu, Yuqing Lou, Xue Li and Gang Huang
    Citation: Cancer Cell International 2022 22:219
    Content type: Primary research Published on:

  14. Protein disulphide isomerases (PDIs) play an important role in cancer progression. However, the relative contribution of the various isoforms of PDI in tumorigenesis is not clear.

    Authors: Anna Kurpińska, Joanna Suraj-Prażmowska, Marta Stojak, Joanna Jarosz, Łukasz Mateuszuk, Ewa Niedzielska-Andres, Magdalena Smolik, Joanna Wietrzyk, Ivars Kalvins, Maria Walczak and Stefan Chłopicki
    Citation: Cancer Cell International 2022 22:218
    Content type: Research Published on:

  15. The oncogenic role of doublecortin-like kinase 1 (DCLK1) as a putative cancer stem cell (CSC) marker has been clarified in colorectal cancer (CRC). Isoform-specific functions of DCLK1 have shed new light on di...

    Authors: Elham Kalantari, Mahdieh Razmi, Fatemeh Tajik, Mohsen Asadi-Lari, Roya Ghods and Zahra Madjd
    Citation: Cancer Cell International 2022 22:217
    Content type: Review Published on:

  16. Colorectal cancer (CRC) with pulmonary metastasis usually indicates a poor prognosis, whereas patients may benefit from adoptive cell therapy. Tumor-specific cytotoxic T lymphocytes (CTLs) have been reported a...

    Authors: Juan Zhang, Lei Wang, Shuyi Li, Xuefeng Gao and Zhong Liu
    Citation: Cancer Cell International 2022 22:216
    Content type: Primary research Published on:

  17. MIR4435-2HG (LINC00978) is a long non-coding RNA (lncRNA) that acts as an oncogene in almost all cancers. This lncRNA participates in the molecular cascades involved in other disorders such as coronary artery dis...

    Authors: Majid Ghasemian, Masoumeh Rajabibazl, Unes Sahebi, Samira Sadeghi, Reza Maleki, Veys Hashemnia and Reza Mirfakhraie
    Citation: Cancer Cell International 2022 22:215
    Content type: Review Published on:

  18. Esophageal squamous cell carcinoma (ESCC) is the leading cause of cancer-related death worldwide with a poor prognosis. Given that DEPDC1B plays a key role in multiple cancers, the role of this molecule in ESC...

    Authors: Yunfeng Yuan, Wei Ping, Ruijie Zhang, Zhipeng Hao and Ni Zhang
    Citation: Cancer Cell International 2022 22:214
    Content type: Primary research Published on:

  19. Thrombospondin-2 (THBS2) is a versatile glycoprotein that regulates numerous biological functions, including the apoptosis-proliferation balance in endothelial cells, and it has been linked to tumor angiogenes...

    Authors: Xingchen Liao, Wei Wang, Baoping Yu and Shiyun Tan
    Citation: Cancer Cell International 2022 22:213
    Content type: Research Published on:

  20. Nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4), a transcription factor of NFAT family, which is activated by Ca2+/calcineurin signaling. Recently, it is reported that aberrantly activated NFATc4 part...

    Authors: Qiu-Hua Zhong, Si-Wei Zha, Andy T. Y. Lau and Yan-Ming Xu
    Citation: Cancer Cell International 2022 22:212
    Content type: Review Published on:

  21. Studies over the past decade have shown that competitive endogenous RNA (ceRNA) plays an essential role in the tumorigenesis and progression of clear cell renal cell carcinoma (ccRCC). Meanwhile, immune checkp...

    Authors: Yankang Cui, Tianyi Shen, Feng Xu, Jing Zhang, Yuhao Wang, Jiajin Wu, Hengtao Bu, Dian Fu, Bo Fang, Huichen Lv, Suchun Wang, Changjie Shi, Bianjiang Liu, Haowei He, Hao Tang and Jingping Ge
    Citation: Cancer Cell International 2022 22:211
    Content type: Research Published on:

  23. Colorectal cancer (CRC) is the third cause of cancer death in the world that arises from the glandular and epithelial cells of the large intestine, during a series of genetic or epigenetic alternations. Recent...

    Authors: Shirin Azizidoost, Farhoodeh Ghaedrahmati, Omid Anbiyaee, Riyadh Ahmad Ali, Maryam Cheraghzadeh and Maryam Farzaneh
    Citation: Cancer Cell International 2022 22:209
    Content type: Review Published on:

  24. Radiotherapy is a powerful and widely used technique for the treatment of solid tumors. Beyond its ability to destroy tumor cells, it has been demonstrated that radiotherapy can stimulate the anti-tumor immune...

    Authors: Audrey Darmon, Ping Zhang, Julie Marill, Naeemunnisa Mohamed Anesary, Jordan Da silva and Sébastien Paris
    Citation: Cancer Cell International 2022 22:208
    Content type: Research Published on:

  25. PTENP1 is a long non-coding RNA which has been regarded as a pseudogene of the PTEN tumor suppressor gene. However, it has been shown to be a biologically active transcript that can function as a competing endoge...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Nader Akbari Dilmaghani
    Citation: Cancer Cell International 2022 22:207
    Content type: Review Published on:

  26. Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not o...

    Authors: Praveen Dhyani, Cristina Quispe, Eshita Sharma, Amit Bahukhandi, Priyanka Sati, Dharam Chand Attri, Agnieszka Szopa, Javad Sharifi-Rad, Anca Oana Docea, Ileana Mardare, Daniela Calina and William C. Cho
    Citation: Cancer Cell International 2022 22:206
    Content type: Review Published on:

  27. Colorectal cancer (CRC) is one of the three major cancers in the world and is the cancer with the most liver metastasis. The present study aimed to investigate the role of metallothionein 2A (MT2A) in the modu...

    Authors: Xi Liu, Jun Quan, Zhaolong Shen, Zequn Zhang, Zhijian Chen, Liang Li, Xiaorong Li, Gui Hu and Xiaofeng Deng
    Citation: Cancer Cell International 2022 22:205
    Content type: Research Published on:

  28. Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the lack of estrogen receptor, progesterone receptor, and HER2. Our lab previously characterized miR-3189-3p as a...

    Authors: Cecilia Vittori, Duane Jeansonne, Hassan Yousefi, Celeste Faia, Zhen Lin, Krzysztof Reiss and Francesca Peruzzi
    Citation: Cancer Cell International 2022 22:204
    Content type: Research Published on:

  29. Ubiquitination is a basic post-translational modification of intracellular proteins and can be reversed enzymatically by DUBs (deubiquitinating enzymes). More than 90 DUBs have been identified. Among them, the...

    Authors: Zhishuo Zhang, Wenxia Zhao, Yiming Li, Yang Li, Hanzeng Cheng, Liyun Zheng, Xiaoyu Sun, Hao Liu and Rongguang Shao
    Citation: Cancer Cell International 2022 22:203
    Content type: Primary research Published on:

  30. Breast cancer is the most common malignancy affecting women, yet effective targets and related candidate compounds for breast cancer treatment are still lacking. The lipogenic enzyme, stearoyl-CoA desaturase-1...

    Authors: Chen Yang, Yi-Yuan Jin, Jie Mei, Die Hu, Xiaoyu Jiao, Hui-Lian Che, Chun-Lei Tang, Yan Zhang and Guo-Sheng Wu
    Citation: Cancer Cell International 2022 22:202
    Content type: Research Published on:

  31. Phosphoglucomutase 1 (PGM1) is known for its involvement in cancer pathogenesis. However, its biological role in colorectal cancer (CRC) has remained unknown. Here, we studied the functions and mechanisms of P...

    Authors: Zhewen Zheng, Xue Zhang, Jian Bai, Long Long, Di Liu and Yunfeng Zhou
    Citation: Cancer Cell International 2022 22:201
    Content type: Primary research Published on:

  32. Cancer can be induced by a variety of possible causes, including tumor suppressor gene failure and proto-oncogene hyperactivation. Tumor-associated extrachromosomal circular DNA has been proposed to endanger h...

    Authors: Mohsen Karami Fath, Nastaran Karimfar, Andarz Fazlollahpour Naghibi, Shahriyar Shafa, Melika Ghasemi Shiran, Mehran Ataei, Hossein Dehghanzadeh, Mohsen Nabi Afjadi, Tahereh Ghadiri, Zahra Payandeh and Vahideh Tarhriz
    Citation: Cancer Cell International 2022 22:200
    Content type: Review Published on:

  33. Several studies have revealed that N6-methyladenosine (m6A) regulation is involved in various biological processes and cancer progression. Nevertheless, the potential effects of m6A modifications in the tumor ...

    Authors: Hao Xu, Lu Yin, Qianhui Xu, Jingjing Xiang and Rujun Xu
    Citation: Cancer Cell International 2022 22:199
    Content type: Research Published on:

  34. Non-small cell lung cancer (NSCLC), the most primary lung cancer subtype, threatens human health globally. Long non-coding RNAs (lncRNAs) have been uncovered to affect multiple cancers progression. Nevertheles...

    Authors: Shangxiao Huang, Shixiong Liang, Jianfeng Huang, Penghui Luo, Dunchang Mo and Hanlei Wang
    Citation: Cancer Cell International 2022 22:198
    Content type: Primary research Published on:

  35. This study aims to clarify the mechanistic action of long non-coding RNA (lncRNA) SNHG12 in the development of renal cell carcinoma (RCC), which may be associated with promoter methylation modification by KMT2...

    Authors: Jia-fu Feng, Jun Wang, Gang Xie, Yao-dong Wang, Xiao-han Li, Wen-yu Yang, Yu-wei Yang and Bin Zhang
    Citation: Cancer Cell International 2022 22:197
    Content type: Primary research Published on:

  36. Colorectal cancer (CRC) is one of the deadliest cancers in the world, the incidences and morality rate are rising and poses an important threat to the public health. It is known that multiple drug resistance (...

    Authors: Masoumeh Sharifi-Azad, Marziyeh Fathi, William C. Cho, Abolfazl Barzegari, Hamed Dadashi, Mehdi Dadashpour and Rana Jahanban-Esfahlan
    Citation: Cancer Cell International 2022 22:196
    Content type: Review Published on:

  37. Arsenic trioxide (ATO) is highly effective in acute promyelocytic leukemia (APL) patients, but it fails to show satisfactory efficacy in other acute myeloid leukemia (AML) patients with non-APL subtypes. Diffe...

    Authors: Wanbin Fu, Gelan Zhu, Lan Xu, Jia Liu, Xiaofeng Han, Junying Wang, Xinpeng Wang, Jian Hou, Huanbin Zhao and Hua Zhong
    Citation: Cancer Cell International 2022 22:195
    Content type: Research Published on:

  38. DANCR is an RNA gene located on chr4. This gene has several splice variants. Up-regulation of DANCR has been reported in many types of cancers. This lncRNA is mainly located in the cytoplasm and regulates genes e...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Aria Baniahmad, Mohammad Taheri and Mohammad Samadian
    Citation: Cancer Cell International 2022 22:194
    Content type: Review Published on:

  39. To screen and verify differential genes affecting the prognosis of breast cancer.

    Authors: Yu Xiao, Zhiqin Deng, Yongshen Li, Baoting Wei, Xiaoqiang Chen, Zhe Zhao, Yingjie Xiu, Meifang Hu, Murad Alahdal, Zhenhan Deng, Daping Wang, Jianquan Liu and Wencui Li
    Citation: Cancer Cell International 2022 22:193
    Content type: Primary research Published on:

  40. In hepatocellular carcinoma (HCC), histone deacetylases (HDACs) are frequently overexpressed. This results in chromatin compaction and silencing of tumor-relevant genes and microRNAs. Modulation of microRNA ex...

    Authors: Nicole Huge, Thea Reinkens, Reena Buurman, Maria Sandbothe, Anke Bergmann, Hannah Wallaschek, Beate Vajen, Amelie Stalke, Melanie Decker, Marlies Eilers, Vera Schäffer, Oliver Dittrich-Breiholz, Engin Gürlevik, Florian Kühnel, Brigitte Schlegelberger, Thomas Illig…
    Citation: Cancer Cell International 2022 22:192
    Content type: Primary research Published on:

  41. Deacetylation of histones by histone deacetylase 3 (HDAC3) acts importantly in modulating apoptosis, DNA damage and cellular progression. Herein, we aimed to unravel the functional role of HDAC3 in a lethal di...

    Authors: Yang Yang, Yuan Zhang, Zongxiang Lin, Kai Wu, Zhanfeng He, Dengyan Zhu, Jia Zhao, Chunyang Zhang and Yuxia Fan
    Citation: Cancer Cell International 2022 22:191
    Content type: Primary research Published on:

  42. Extracellular vesicles secreted by tumor microenvironment (TME) cells are vital players in tumor progression through transferring nucleic acids and proteins. Macrophages are the main immune cells in TME and tu...

    Authors: Wen-Xiu Xu, Dan-Dan Wang, Zhi-Qiang Zhao, He-Da Zhang, Su-Jin Yang, Qian Zhang, Lei Li and Jian Zhang
    Citation: Cancer Cell International 2022 22:190
    Content type: Review Published on:

  43. Inositol Polyphosphate-5-Phosphatase B (INPP5B), a inositol 5-phosphatase, plays an important role in many biological processes through phosphorylating PI(4,5)P2 and/or PI(3,4,5)P3 at the 5-position. Nevertheless...

    Authors: Jun Deng, Xu Lin, Qi Li, Xiao-yu Cai, Lin-wen Wu, Wei Wang, Bo Zhang, Yang-ling Li, Jian Hu and Neng-ming Lin
    Citation: Cancer Cell International 2022 22:189
    Content type: Research Published on:

  44. Anillin (ANLN) is an actin-binding protein that is essential for cell division and contributes to cell growth and migration. Although previous studies have shown that ANLN is related to carcinogenesis, no pan-...

    Authors: Yanlong Shi, Xinyu Ma, Menglu Wang, Sheng Lan, Haokun Jian, Yue Wang, Qian Wei and Fei Zhong
    Citation: Cancer Cell International 2022 22:188
    Content type: Research Published on:

  45. The interaction between tumor cells and tumor microenvironment (TME) has an important impact on progression and prognosis of multiple myeloma (MM), and has been proven to be promising therapeutic targets. This...

    Authors: Huizhong Wang, Ruonan Shao, Wenjian Liu, Shumei Peng, Shenrui Bai, Bibo Fu, Congling Zhao and Yue Lu
    Citation: Cancer Cell International 2022 22:187
    Content type: Research Published on:

  46. Immune checkpoint inhibitors (ICIs) have made important breakthrough in anti-tumor therapy, however, no single biomarker can accurately predict their efficacy. Studies have found that tumor microenvironment is...

    Authors: Wenqin Feng, Anqi Lin, Le Sun, Ting Wei, Haoxuan Ying, Jian Zhang, Peng Luo and Weiliang Zhu
    Citation: Cancer Cell International 2022 22:186
    Content type: Research Published on:

  47. Papillary thyroid carcinoma (PTC), the most common endocrine cancer, accounts for 80–85% of all malignant thyroid tumors. This study focused on identifying targets that affect the multifocality of PTC. In a pr...

    Authors: Ga Hyun Kim, Hye Jin Heo, Ji Wan Kang, Eun-Kyung Kim, Seung Eun Baek, Keunyoung Kim, In Joo Kim, Sunghwan Suh, Byung-Joo Lee, Yun Hak Kim and Kyoungjune Pak
    Citation: Cancer Cell International 2022 22:185
    Content type: Primary research Published on:

  48. Breast cancer (BC) is one of the most prevalent malignancies among women globally. Emerging evidence indicates that long non-coding RNAs (lncRNAs) are associated with BC carcinogenesis. In the current study, w...

    Authors: Congjing An, Zhigang Hu, Yuehong Li, Pengxin Zhao, Runtian Liu, Qing Zhang, Peiling Zhu, Yanting Li and Ying Wang
    Citation: Cancer Cell International 2022 22:184
    Content type: Primary research Published on:

  49. Tetraspanins are members of the 4-transmembrane protein superfamily (TM4SF) that function by recruiting many cell surface receptors and signaling proteins into tetraspanin-enriched microdomains (TEMs) that pla...

    Authors: Shijie Shao, Lianhua Piao, Liwei Guo, Jiangsong Wang, Luhui Wang, Jiawen Wang, Lei Tong, Xiaofeng Yuan, Junke Zhu, Sheng Fang and Yimin Wang
    Citation: Cancer Cell International 2022 22:183
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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