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  1. Increasing studies focused on the regulatory roles of circular RNAs (circRNAs) in diverse cancers. This study was to evaluate the function and mechanism of circRNA Scm-like with four malignant brain tumor doma...

    Authors: Zhiwei Chang, Yang Fu, Yongxu Jia, Ming Gao, Lijie Song, Weijie Zhang, Ruihua Zhao and Yanru Qin
    Citation: Cancer Cell International 2021 21:495
    Content type: Primary research Published on:

  2. Papillary thyroid carcinoma (PTC), with a rapidly increasing incidence, is the most prevalent malignant cancer of the thyroid. However, its pathogenesis is unclear and its specific clinical indicators have not...

    Authors: Yonglian Huang, Hengwei Zhang, Lidong Wang, Chenxi Liu, Mingyue Guo, Hao Tan and Zhen Liu
    Citation: Cancer Cell International 2021 21:494
    Content type: Primary research Published on:

  3. T-cell lymphoma (TCL) is highly aggressive and has a poor prognosis; thus, it is worth exploring biomarkers that may predict clinical outcomes and investigate their potential role in developing targeted therap...

    Authors: Cunte Chen, Zheng Chen, Ling Huang, Lingling Zhou, Lihua Zhu, Sichu Liu, Gengxin Luo, Wenyu Li, Chengwu Zeng and Yangqiu Li
    Citation: Cancer Cell International 2021 21:490
    Content type: Primary research Published on:

  6. As an efficient drug carrier, exosome has been widely used in the delivery of genetic drugs, chemotherapeutic drugs, and anti-inflammatory drugs. As a genetic drug carrier, exosomes are beneficial to improve t...

    Authors: Wen Zhou, Mingming Xu, Zhipeng Wang and Mingjun Yang
    Citation: Cancer Cell International 2021 21:485
    Content type: Primary research Published on:

  8. Colorectal cancer (CRC) is one of the most malignant cancer types, characterized by elevated mortality rate and treatment resistance. Despite the progress achieved in the explanation of the molecular basis of ...

    Authors: Faezeh Vakhshiteh, Shokoufeh Hassani, Navid Momenifar and Fatemeh Pakdaman
    Citation: Cancer Cell International 2021 21:483
    Content type: Minireview Published on:

  9. DNA Polymerase Theta (POLQ) is a DNA polymerase involved in error-prone translesion DNA synthesis (TLS) and error-prone repair of DNA double-strand breaks (DSBs), whose function in hepatocellular carcinoma has...

    Authors: Qi Pan, Lu Wang, Yu Liu, Min Li, Yao Zhang, Wei Peng, Tan Deng, Mei-Ling Peng, Jin-Qiong Jiang, Jiao Tang, Jingjing Wang, Hua-Xin Duan and Sha-Sha Fan
    Citation: Cancer Cell International 2021 21:482
    Content type: Primary research Published on:

  10. Phosphoglucomutase 1 (PGM1) acts as an important regulator in glucose metabolism. However, the role of PGM1 in gastric cancer (GC) remains unclear. This study aims to investigate the role of PGM1 and develop n...

    Authors: Bo Cao, Huan Deng, Hao Cui, Ruiyang Zhao, Hanghang Li, Bo Wei and Lin Chen
    Citation: Cancer Cell International 2021 21:481
    Content type: Primary research Published on:

  12. Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, play an indispensable role in cancer initiation, progression, metastasis, and metabolism. The limitations of traditi...

    Authors: Xiao Li, Hongming Zhu, Weixuan Sun, Xingru Yang, Qing Nie and Xuedong Fang
    Citation: Cancer Cell International 2021 21:479
    Content type: Review Published on:

  13. The long noncoding RNA gastric cancer associated transcript 3 (GACAT3) has been demonstrated to be implicated in the carcinogenesis and progression of many malignancies. However, GACAT3’s levels and role in es...

    Authors: Min Su, Jinming Tang, Baihua Zhang, Desong Yang, Zhining Wu, Jie Wu, Yong Zhou, Qianjin Liao, Hui Wang, Wenxiang Wang and Yuhang Xiao
    Citation: Cancer Cell International 2021 21:478
    Content type: Primary research Published on:

  14. Long noncoding RNAs (lncRNAs) have been elucidated to participate in the development and progression of various cancers. In this study, we aimed to explore the underlying functions and mechanisms of LINC00958 ...

    Authors: Hong Liang, Qiuyan Zhao, Zhonglin Zhu, Chao Zhang and Hui Zhang
    Citation: Cancer Cell International 2021 21:477
    Content type: Primary research Published on:

  15. Muscle-invasive bladder cancer (MIBC) is one of the most important type of bladder cancer, with a high morbidity and mortality rate. Studies have found that long non-coding RNA (lncRNA) plays a key role in mai...

    Authors: Yingchun Liang, Fangdie Ye, Zhang Cheng, Yuxi Ou, Lujia Zou, Yun Hu, Jimeng Hu and Haowen Jiang
    Citation: Cancer Cell International 2021 21:476
    Content type: Primary research Published on:

  16. Xanthine dehydrogenase (XDH) is a critical enzyme involved in the oxidative metabolism of purines, pterin and aldehydes and a central component of the innate immune system. However, the prognostic value of XDH...

    Authors: Zhen Lin, Yi-Zhao Xie, Ming-Chun Zhao, Pin-Pin Hou, Juan Tang and Guang-Liang Chen
    Citation: Cancer Cell International 2021 21:475
    Content type: Primary research Published on:

  17. Breast cancer is the most common cancer in women, and its high mortality has become one of the biggest health problems globally. Several studies have reported an association between breast cancer and ATM gene ...

    Authors: Masoumeh Moslemi, Maryam Vafaei, Pouria Khani, Marzieh Soheili, Reza Nedaeinia, Mostafa Manian, Yousef Moradi and Ehsan Sohrabi
    Citation: Cancer Cell International 2021 21:474
    Content type: Review Published on:

  18. Dendritic cell (DC)-based immunotherapy is capable of activating the immune system and in particular tumor-specific cytotoxic T lymphocytes (CTLs) to eradicate the tumor. However, major limitations are the ava...

    Authors: Hemavathi Dhandapani, Hascitha Jayakumar, Abirami Seetharaman, Shirley Sunder Singh, Selvaluxmy Ganeshrajah, Nirmala Jagadish, Anil Suri, Rajkumar Thangarajan and Priya Ramanathan
    Citation: Cancer Cell International 2021 21:473
    Content type: Primary research Published on:

  19. CD9 is implicated in cancer progression and metastasis by its role in suppressing cancer cell proliferation and survival. However, the prognostic and clinicopathological significance of CD9 expression is contr...

    Authors: Hyun Min Koh, Bo Gun Jang, Dong Hui Lee and Chang Lim Hyun
    Citation: Cancer Cell International 2021 21:472
    Content type: Review Published on:

  20. Hepatocellular carcinoma (HCC) is an aggressive cancer with a high rate of death globally. The use of bioinformatics may help to identify immune cell-related genes both as targets for potential immunotherapies...

    Authors: Chen Xue, Xinyu Gu and Lanjuan Li
    Citation: Cancer Cell International 2021 21:471
    Content type: Primary research Published on:

  21. Understanding the molecular mechanisms of cancer biology introduces targeted therapy as a complementary method along with other conventional therapies. Recombinant immunotoxins are tumor specific antibodies th...

    Authors: Reza Mahmoudi, Hassan Dianat-Moghadam, Mansour Poorebrahim, Samaneh Siapoush, Vahdat Poortahmasebi, Reza Salahlou and Mohammad Rahmati
    Citation: Cancer Cell International 2021 21:470
    Content type: Review Published on:

  23. Signal transducer and activator of transcription 3 (STAT3) induces breast cancer malignancy. Recent clinical and preclinical studies have demonstrated an association between overexpressed and activated STAT3 a...

    Authors: Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Ali Mohammad Pourbagher-Shahri and Saeed Samarghandian
    Citation: Cancer Cell International 2021 21:468
    Content type: Review Published on:

  24. Prostate cancer (PCa) is still a serious male malignant disease across the world. However, no exact pathogenesis had been explained. Although adenylosuccinate lyase (ADSL) gene was identified to be important i...

    Authors: Jinling Liao, Qiong Song, Jie Li, Kechen Du, Yang Chen, Chunlin Zou and Zengnan Mo
    Citation: Cancer Cell International 2021 21:467
    Content type: Primary research Published on:

  25. Definitive chemoradiotherapy (dCRT) is one of the standard treatments for esophageal squamous cell carcinoma (ESCC), but local recurrence is the main cause of treatment failure. The changes in apoptosis and au...

    Authors: Hu Qiu, Haixia Song, Man Luo, Shaobo Ke, Wei Shi, Jiamei Chen, Wensi Zhao, Hesheng Luo and Yongshun Chen
    Citation: Cancer Cell International 2021 21:466
    Content type: Primary research Published on:

  26. To evaluate the clinical effectiveness of a novel CellDetect staining technique, compared with fluorescent in situ hybridization (FISH), and urine cytology, in the diagnosis of urothelial carcinoma (UC).

    Authors: Donghao Shang, Yuting Liu, Xiuhong Xu, Zhenghao Chen and Daye Wang
    Citation: Cancer Cell International 2021 21:465
    Content type: Primary research Published on:

  27. Interferon-alpha (IFN-α) is a general therapeutic regimen to be utilized in hepatocellular carcinoma (HCC). However, regulatory mechanisms of IFN-α on competing endogenous RNAs (ceRNAs) level in anti-HCC relap...

    Authors: Yibin Wu, Longrong Wang, Xiaoshuang Wang, Yiming Zhao, Anrong Mao, Ning Zhang, Jiamin Zhou, Qi Pan, Weiping Zhu and Lu Wang
    Citation: Cancer Cell International 2021 21:464
    Content type: Primary research Published on:

  28. LYRM4 is necessary to maintain the stability and activity of the human cysteine desulfurase complex NFS1-LYRM4-ACP. The existing experimental results indicate that cancer cells rely on the high expression of N...

    Authors: Yilin Pang, Guoqiang Tan, Xunjun Yang, Yuanshan Lin, Yao Chen, Jinping Zhang, Ting Xie, Huaibin Zhou, Jun Fang, Qiongya Zhao, Xiaojun Ren, Jianghui Li, Jianxin Lyu and Zheng Wang
    Citation: Cancer Cell International 2021 21:463
    Content type: Primary research Published on:

  29. Accumulating evidence indicates that dysregulation of miR-182-5p can serve as diagnostic and prognostic biomarkers for some cancers, whereas the role of miR-182-5p has not been explored in nasopharyngeal carci...

    Authors: Gang Wang, Fangzheng Zhou, Tong Ou, Haiyan Sun, Zhirui Shan, Yingshen Lu, Gui Chen, Simin Yuan, Xiaowen Zhang and Song Wu
    Citation: Cancer Cell International 2021 21:462
    Content type: Primary research Published on:

  30. New effective drugs for prostate cancer (PCa) treatment are urgently needed. Avasimibe was recently identified as a promising drug for anticancer therapies. The main purpose of this study was to explore the ef...

    Authors: Kangping Xiong, Gang Wang, Tianchen Peng, Fenfang Zhou, Siming Chen, Wei Liu, Lingao Ju, Yu Xiao, Kaiyu Qian and Xinghuan Wang
    Citation: Cancer Cell International 2021 21:461
    Content type: Primary research Published on:

  31. Autophagy is believed to participate in embryonic development, but whether the expression of autophagy-associated genes undergoes changes during the development of human embryonic kidneys remains unknown.

    Authors: Chen Wen-jin, Pan Xiu-wu, Chu Jian, Xu Da, Chen Jia-xin, Chen Wei-jie, Wang Lin-hui and Cui Xin-gang
    Citation: Cancer Cell International 2021 21:460
    Content type: Primary research Published on:

  32. Antisense long non-coding RNAs (antisense lncRNAs), transcribed from the opposite strand of genes with either protein coding or non-coding function, were reported recently to play a crucial role in the process...

    Authors: Biao Liu, Wei Xiang, Jiahao Liu, Jin Tang, Jinrong Wang, Bin Liu, Zhi Long, Long Wang, Guangming Yin and Jianye Liu
    Citation: Cancer Cell International 2021 21:459
    Content type: Review Published on:

  33. Immunotherapy has shown promising efficacy in patients with nasopharyngeal carcinoma (NPC). Lymphocyte activating 3 gene (LAG-3) represents a significant immune target, however, its relationship with NPC remai...

    Authors: Fan Luo, Jiaxin Cao, Feiteng Lu, Kangmei Zeng, Wenjuan Ma, Yan Huang, Li Zhang and Hongyun Zhao
    Citation: Cancer Cell International 2021 21:458
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2022 22:46

  34. In recent years, there have been many studies on the relationship between DLGAP5 and different types of cancers, yet there is no pan-cancer analysis of DLGAP5. Therefore, this study aims to analyze the roles o...

    Authors: Neng Tang, Xiaolin Dou, Xing You, Qiman Shi, Mujing Ke and Guodong Liu
    Citation: Cancer Cell International 2021 21:457
    Content type: Primary research Published on:

  35. The regulatory roles of long non-coding RNA (lncRNA) CRNDE in temozolomide (TMZ) chemoresistance to glioblastoma multiforme (GBM) are still poorly understood. Therefore, the function, characteristics, and poss...

    Authors: Zijin Zhao, Miaomiao Liu, Wenyong Long, Jian Yuan, Haoyu Li, Chi Zhang, Guodong Tang, Weixi Jiang, Xianrui Yuan, Minghua Wu and Qing Liu
    Citation: Cancer Cell International 2021 21:456
    Content type: Primary research Published on:

  37. Comprehensive analysis of omics data, such as genome, transcriptome, proteome, metabolome, and interactome, is a crucial technique for elucidating the complex mechanism of cancer onset and progression. Recentl...

    Authors: Ichidai Tanaka, Taiki Furukawa and Masahiro Morise
    Citation: Cancer Cell International 2021 21:454
    Content type: Review Published on:

  38. Melanoma is an extremely aggressive type of skin cancer and experiencing a expeditiously rising mortality in a current year. Exploring new potential prognostic biomarkers and therapeutic targets of melanoma ar...

    Authors: Jinfang Liu, Zijian Zhou, Ling Ma, Chujun Li, Yu Lin, Ting Yu, Ji-Fu Wei, Lingjun Zhu and Gang Yao
    Citation: Cancer Cell International 2021 21:453
    Content type: Primary research Published on:

  40. Lung adenocarcinoma (LUAD) remains one of the world’s most known aggressive malignancies with a high mortality rate. Molecular biological analysis and bioinformatics are of great importance as they have recent...

    Authors: Aisha Al-Dherasi, Yuwei Liao, Sultan Al-Mosaib, Rulin Hua, Yichen Wang, Ying Yu, Yu Zhang, Xuehong Zhang, Raeda Jalayta, Haithm Mousa, Abdullah Al-Danakh, Fawze Alnadari, Marwan Almoiliqy, Salem Baldi, Leming Shi, Dekang Lv…
    Citation: Cancer Cell International 2021 21:451
    Content type: Primary research Published on:

  41. Taking advantage of nanobodies (Nbs) in immunotherapy, we investigated the cytotoxicity of Nb-based chimeric antigen receptor T cells (Nb CAR-T) against lymphoma cells.

    Authors: Hongxia Wang, Liyan Wang, Yanning Li, Guangqi Li, Xiaochun Zhang, Dan Jiang, Yanting Zhang, Liyuan Liu, Yuankui Chu and Guangxian Xu
    Citation: Cancer Cell International 2021 21:450
    Content type: Primary research Published on:

  44. An increasing number of studies have reported a significant association between long non-coding RNAs (lncRNAs) dysregulation and pancreatic cancers. In the present study, we aimed to gather articles to evaluat...

    Authors: Elahe Seyed Hosseini, Ali Nikkhah, Amir Sotudeh, Marziyeh Alizadeh Zarei, Fatemeh Izadpanah, Hossein Nikzad and Hamed Haddad Kashani
    Citation: Cancer Cell International 2021 21:447
    Content type: Review Published on:

  45. Processed extracts from toad skin and parotoid gland have long been used to treat various illnesses including cancer in many Asian countries. Recent studies have uncovered a family of bufadienolides as the res...

    Authors: Jiajing Niu, Jiamei Wang, Qi Zhang, Zhihua Zou and Yushuang Ding
    Citation: Cancer Cell International 2021 21:446
    Content type: Primary research Published on:

  46. Glioma is the most common malignant primary brain tumour in adults. Despite improvements in neurosurgery and radiotherapy, the prognosis of glioma patients remains poor. One of the main limitations is that the...

    Authors: Zheng Bian, Wei Ji, Bin Xu, Zhengyuan Huo, Hui Huang, Jin Huang, Jiantong Jiao, Junfei Shao and Xiaolu Zhang
    Citation: Cancer Cell International 2021 21:445
    Content type: Review Published on:

  47. Previous studies have revealed the key functions of N6-methyladenosine (m6A) modification in breast cancer (BC). MALAT1 as a highly m6A modified lncRNA associated with cancer development and metastasis, but th...

    Authors: Chengpeng Zhao, Xiaoling Ling, Yunxia Xia, Bingxue Yan and Quanlin Guan
    Citation: Cancer Cell International 2021 21:441
    Content type: Primary research Published on:

  48. Endometrial carcinoma (EC) is one common gynecological tumor, threatening physical and psychological health of females. Huge amount of essays indicated that long non-coding RNAs (lncRNAs) were widely reported ...

    Authors: Minglin Liang, Hongbo Wang, Cong Liu, Tao Lei and Jie Min
    Citation: Cancer Cell International 2021 21:440
    Content type: Primary research Published on:

  49. Cancer as one of the leading causes of human deaths has always been one of the main health challenges in the world. Despite recent advances in therapeutic and diagnostic methods, there is still a high mortalit...

    Authors: Meysam Moghbeli, Amir Sadra Zangouei, Zahra Nasrpour Navaii and Negin Taghehchian
    Citation: Cancer Cell International 2021 21:439
    Content type: Review Published on:
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Cancer Cell International

ISSN: 1475-2867

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