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  1. High RSPH14 expression appears to be related to poor prognosis of hepatocellular carcinoma (HCC). This study aimed to investigate the possible roles of RSPH14 in the proliferation, apoptosis, and invasion of H...

    Authors: Dawei Yuan, Rulan Ma, Tuanhe Sun, Kun Zhu, Chengxue Dang, Haixia Ye and Kang Li
    Citation: Cancer Cell International 2022 22:129
    Content type: Primary research Published on:

  2. While the correlation between PD-L1 expression and KRAS mutation has been previously reported in other solid tumors such as non-small cell lung cancer (NSCLC), whether PD-L1 can be modulated by ERK signaling down...

    Authors: Zheng Gao, Jia-Feng Chen, Xiao-Gang Li, Ying-Hong Shi, Zheng Tang, Wei-Ren Liu, Xin Zhang, Ao Huang, Xuan-Ming Luo, Qiang Gao, Guo-Ming Shi, Ai-Wu Ke, Jian Zhou, Jia Fan, Xiu-Tao Fu and Zhen-Bin Ding
    Citation: Cancer Cell International 2022 22:128
    Content type: Primary research Published on:

  3. Prostate cancer (PCa) is the second leading cause of cancer-related male deaths worldwide. The purpose of this study was to investigate the effects of homo sapiens solute carrier family 4 member 4 (SLC4A4), wh...

    Authors: Zelin Liu, Qinghua Wang, Guanzhong Zhai, Shuai Ke, Xi Yu and Jia Guo
    Citation: Cancer Cell International 2022 22:127
    Content type: Primary research Published on:

  4. Colorectal cancer (CRC) is one of the most lethal and prevalent solid malignancies worldwide. There is a great need of accelerating the development and diagnosis of CRC. Long noncoding RNAs (lncRNA) as transcr...

    Authors: Wen-Wen Xu, Jin Jin, Xiao-yu Wu, Qing-Ling Ren and Maryam Farzaneh
    Citation: Cancer Cell International 2022 22:126
    Content type: Review Published on:

  5. This meta-analysis aimed to determine the pooled association between polycystic ovary syndrome (PCOS), hypothyroidism, and fibrocystic breast changes. We searched important databases, including PubMed (Medline...

    Authors: Parisa Kohnepoushi, Hojat Dehghanbanadaki, Pardis Mohammadzedeh, Maziar Nikouei and Yousef Moradi
    Citation: Cancer Cell International 2022 22:125
    Content type: Review Published on:

  6. Stomach adenocarcinoma (STAD) is associated with high morbidity and mortality rates. Ferroptosis is an iron-dependent form of cell death, which plays an important role in the development of many cancers. Tumor...

    Authors: Dandan Zhu, Sifan Wu, Yafang Li, Yu Zhang, Jierong Chen, Jianhong Ma, Lixue Cao, Zejian Lyu and Tieying Hou
    Citation: Cancer Cell International 2022 22:124
    Content type: Research Published on:

  7. Breast cancer (BC) is the most frequently diagnosed cancer in women. Altering glucose metabolism and its effects on cancer progression and treatment resistance is an emerging interest in BC research. For insta...

    Authors: Rita Aoun, Christopher El Hadi, Roula Tahtouh, Rita El Habre and George Hilal
    Citation: Cancer Cell International 2022 22:123
    Content type: Primary research Published on:

  8. Cancer stem cells (CSCs) play crucial role in tumor progression, drug resistance and relapse in various cancers. CSC niche is comprised of various stromal cell types including Tumor-associated macrophages (TAM...

    Authors: N. N. V. Radharani, Amit S. Yadav, Ramakrishna Nimma, T. V. Santosh Kumar, Anuradha Bulbule, Venkatesh Chanukuppa, Dhiraj Kumar, Srinivas Patnaik, Srikanth Rapole and Gopal C. Kundu
    Citation: Cancer Cell International 2022 22:122
    Content type: Primary research Published on:

  9. NLRP3 inflammasome responses and gut microbiota have been shown an important role in lung cancer, however, the relationship between gut microbiota and NLRP3 inflammasome responses in lung cancer with Qi-yin de...

    Authors: Rui-yuan Jiang, Ting Wang, Qiao-yu Lan, Yan-chun Qin, Ting-ting Man, Hua Sun, Zhu-long Li, Xiao-ting Zhong, Chun-mei Mo and Zhen Rong
    Citation: Cancer Cell International 2022 22:121
    Content type: Primary research Published on:

  10. Autophagy has been found to be involved in the multidrug resistance (MDR) of cancers, but whether it is associated with resistance of small cell lung cancer (SCLC) has not been studied. Here, we hypothesized t...

    Authors: Tiezhi Li, Helin Zhang, Zhichao Wang, Shaolin Gao, Xu Zhang, Haiyong Zhu, Na Wang and Honglin Li
    Citation: Cancer Cell International 2022 22:120
    Content type: Primary research Published on:

  11. The condensation complex gene non-SMC condensin I complex subunit G(NCAPG), a cell cycle-associated condensin, is over-expressed in various cancers. However, its biological function in colorectal cancer (CRC) ...

    Authors: Yanlong Shi, Chang Ge, Debao Fang, Wei Wei, Li Li, Qian Wei and Hongzhu Yu
    Citation: Cancer Cell International 2022 22:119
    Content type: Primary research Published on:

  12. Ovarian cancer (OC) is an invasive gynaecologic cancer with a high cancer-related death rate. The purpose of this study was to establish an invasion-related multigene signature to predict the prognostic risk o...

    Authors: Leilei Liang, Jian Li, Jing Yu, Jing Liu, Lin Xiu, Jia Zeng, Tiantian Wang, Ning Li and Lingying Wu
    Citation: Cancer Cell International 2022 22:118
    Content type: Primary research Published on:

  13. Neoadjuvant chemoradiotherapy (nCRT) prior to surgery is the standard treatment for patients with locally advanced rectal cancer (LARC), while parts of them show poor therapeutic response accompanied by therap...

    Authors: Jianan Wang, Jiayu Liu, Jinyang Wang, Shijian Wang, Feifei Li, Ruibing Li, Peng Liu, Mianyang Li and Chengbin Wang
    Citation: Cancer Cell International 2022 22:117
    Content type: Primary research Published on:

  14. Breast cancer is the most commonly diagnosed cancer in women. Triple negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat due to the deficiency in drug-targetable receptors. LR...

    Authors: Peng Li, Yu Zeng, Yudan Chen, Peng Huang, Xinchun Chen and Weidong Zheng
    Citation: Cancer Cell International 2022 22:116
    Content type: Primary research Published on:

  15. Adaptive resistance and side effects of sorafenib treatment result in unsatisfied survival of patients with hepatocellular carcinoma (HCC). Palmitoyl-protein thioesterase 1 (PPT1) plays a critical role in prog...

    Authors: Jianjun Xu, Zhe Su, Xiang Cheng, Shaobo Hu, Wenjie Wang, Tianhao Zou, Xing Zhou, Zifang Song, Yun Xia, Yang Gao and Qichang Zheng
    Citation: Cancer Cell International 2022 22:115
    Content type: Primary research Published on:

  16. RNA 3’-terminal phosphate cyclase-like protein (Rcl1) is involved in pre-rRNA processing, but its implication in cancers remains unclear.

    Authors: Yu Jiaze, Hou Sinan, Yang Minjie, Zhou Yongjie, Du Nan, Wang Liangwen, Zhang Wen, Luo Jianjun and Yan Zhiping
    Citation: Cancer Cell International 2022 22:114
    Content type: Primary research Published on:

  17. Testicular germ cell tumours (TGCTs) are the most commonly diagnosed malignancy in young men. Although cisplatin has been shown to be effective to treat TGCT patients, long-term follow-up has shown that TGCT s...

    Authors: Kancheng He, Zitaiyu Li, Kun Ye, Yihong Zhou, Minbo Yan, Hao Qi, Huating Hu, Yingbo Dai and Yuxin Tang
    Citation: Cancer Cell International 2022 22:113
    Content type: Primary research Published on:

  18. Abnormal DNA methylation of tumor suppressor gene promoter has been found in breast cancer. Therefore, the current study set out to explore how DNA methyltransferase 1 (DNMT1) affects breast cancer through med...

    Authors: Yaobang Liu, Zhengyang Bai, Dahai Chai, Yali Gao, Ting Li, Yinling Ma and Jinping Li
    Citation: Cancer Cell International 2022 22:112
    Content type: Primary research Published on:

  19. Adhesion molecule interacting with CXADR antigen 1 (AMICA1), also known as Junction Adhesion Molecule Like (JAML), a recently identified member of the JAMs family, plays a critical role in mediating cancer dev...

    Authors: Ziyang Feng, Yan Zhang, Min He, Ying Han, Changjing Cai, Shanshan Liu, Ping Liu, Yihong Chen, Hong Shen and Shan Zeng
    Citation: Cancer Cell International 2022 22:111
    Content type: Primary research Published on:

  20. Although resistance is its major obstacle in cancer therapy, trastuzumab is the most successful agent in treating epidermal growth factor receptor 2 positive (HER2 +) breast cancer (BC). Some patients show res...

    Authors: Aysooda Hosseinzadeh, Parnaz Merikhian, Nazanin Naseri, Mohammad Reza Eisavand and Leila Farahmand
    Citation: Cancer Cell International 2022 22:110
    Content type: Review Published on:

  21. Abnormal expression of splicing factor 3A subunit 3 (SF3A3), a component of the spliceosome, has been confirmed to be related to the occurrence and development of various cancers. However, the expression and f...

    Authors: Kai-Long Liu, Yue-Wei Yin, Bao-Sai Lu, Ya-Lin Niu, Dan-Dan Wang, Bei Shi, Hong Zhang, Ping-Ying Guo, Zhan Yang and Wei Li
    Citation: Cancer Cell International 2022 22:109
    Content type: Primary research Published on:

  22. Breast cancer is a severe problem worldwide due to an increase in mortality and prevalence among women. Despite early diagnostic procedures as well as advanced therapies, more investigation is required to find...

    Authors: Vahid Karpisheh, Majid Ahmadi, Kazem Abbaszadeh-Goudarzi, Mehran Mohammadpour Saray, Asal Barshidi, Hamed Mohammadi, Mehdi Yousefi and Farhad Jadidi-Niaragh
    Citation: Cancer Cell International 2022 22:108
    Content type: Review Published on:

  23. DFNA5 (GSDME) belongs to Gasdermin familily that is involved in a variety of cancers and triggers cell pyroptosis after chemical treatment. However, the relationship in DFNA5 between prognosis and immune cells...

    Authors: Jian Hu, Wenceng Pei, Minren Jiang, Ying Huang, Fuyun Dong, Zhenyou Jiang, Ying Xu and Zihuang Li
    Citation: Cancer Cell International 2022 22:107
    Content type: Primary research Published on:

  24. Disabled homolog 2 interacting protein (DAB2IP) plays a tumor-suppressive role in several types of human cancers. However, the molecular status and function of the DAB2IP gene in esophageal squamous cell carci...

    Authors: Zhuting Tong, Weiyang Fang, Meng Xu, YeYe Xia, Rui Wang, Yue Li, Tianqi Zha, Liang Xiao, Shuhao Pan, Huiping Chai, Lei Zhao, Hao Wang, Huaguang Pan and Xiangcun Chen
    Citation: Cancer Cell International 2022 22:106
    Content type: Primary research Published on:

  26. Many studies in recent years have found that dysregulation of long non-coding RNAs (lncRNAs) can contribute to disease. Small nucleolar RNA host gene 17 (SNHG17) is a novel cancer-related lncRNA of the SNHG fa...

    Authors: Li Ma, Jin Gao, Niu Zhang, Jiawei Wang, Tianwei Xu, Tianyao Lei, Xiaoteng Zou, Chenchen Wei and Zhaoxia Wang
    Citation: Cancer Cell International 2022 22:104
    Content type: Review Published on:

  27. A hydatidiform mole is a condition caused by abnormal proliferation of trophoblastic cells. MicroRNA miR-30a acts as a tumor suppressor gene in most tumors and participates in the development of various cancer...

    Authors: Zhenzhen Guo, Chenyu Zhu, Youhui Wang, Zhen Li, Lu Wang, Jianhui Fan, Yuefei Xu, Na Zou, Ying Kong, Dong Li and Linlin Sui
    Citation: Cancer Cell International 2022 22:103
    Content type: Primary research Published on:

  28. The role of CARM1 in tumors is inconsistent. It acts as an oncogene in most cancers but it inhibits the progression of liver and pancreatic cancers. CARM1 has recently been reported to regulate autophagy, but ...

    Authors: Suzhen Yang, Jing Zhang, Di Chen, Jiayi Cao, Ying Zheng, Yuying Han, Yirong Jin, Shuhui Wang, Ting Wang, Lin Ma, Tingting Luo, Yan Wang, Wen Qin and Lei Dong
    Citation: Cancer Cell International 2022 22:102
    Content type: Primary research Published on:

  29. Emerging evidence suggests that LMNB1 is involved in the development of multiple cancer types. However, there is no study reporting the potential role of LMNB1 in a systematic pan-cancer manner.

    Authors: Haixiang Qin, Yingqiang Lu, Lin Du, Jingyan Shi, Haoli Yin, Bo Jiang, Wei Chen, Wenli Diao, Meng Ding, Wenmin Cao, Xuefeng Qiu, Xiaozhi Zhao and Hongqian Guo
    Citation: Cancer Cell International 2022 22:101
    Content type: Primary research Published on:

  30. Programmed Cell Death 2 Like (PDCD2L) correlates with cell proliferation, apoptosis and mouse embryonic development. However, the role of PDCD2L in human cancers is unclear.

    Authors: Huabin Gao, Cheng Xu, Jiangtao Liang, Songhan Ge, Fenfen Zhang, Ying Tuo, Huijuan Shi and Anjia Han
    Citation: Cancer Cell International 2022 22:100
    Content type: Primary research Published on:

  32. The current study aims to find the linker between esophageal epithelial carcinogenesis and chronic inflammation and the origin of hyperproliferative cells in precancerous lesions of esophageal squamous cell ca...

    Authors: Hao Ye, Xiang Li, Jing Lin, Peng Yang and Min Su
    Citation: Cancer Cell International 2022 22:98
    Content type: Primary Research Published on:

  33. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Costimulatory molecules have been proven to be the foundation of immunotherapy. However, the potential roles of costimulatory mo...

    Authors: Yinan Hu, Jingyi Liu, Jiahao Yu, Fangfang Yang, Miao Zhang, Yansheng Liu, Shuoyi Ma, Xia Zhou, Jingbo Wang and Ying Han
    Citation: Cancer Cell International 2022 22:97
    Content type: Primary research Published on:

  35. Prognostic assessment is imperative for clinical management of patients with hepatocellular carcinoma (HCC). Most reported prognostic signatures are based on risk scores summarized from quantitative expression...

    Authors: Xiaoyun Bu, Luyao Ma, Shuang Liu, Dongsheng Wen, Anna Kan, Yujie Xu, Xuanjia Lin and Ming Shi
    Citation: Cancer Cell International 2022 22:95
    Content type: Primary research Published on:

  36. To investigate the genotype distribution of human papillomavirus (HPV) in infected Uygur and Han women in Xinjiang, China; analyze the HPV16 E6 gene polymorphism site and relationship with the development of c...

    Authors: Huizhen Xin, Zhenzhen Pan, Xiangyi Zhe, Chunhe Zhang, Hongtao Li, Weinan Zheng, Haichen Long, Renfu Shao, Dongmei Li and Zemin Pan
    Citation: Cancer Cell International 2022 22:94
    Content type: Primary research Published on:

  37. Long non-coding RNAs (lncRNAs) regulate tumor development and metastasis in several types of cancers through various molecular mechanisms. However, the biological role of most lncRNAs in pancreatic cancer (PC)...

    Authors: Min Zhong, Zhi Fang, Bin Ruan, Jianping Xiong, Junhe Li and Zhiwang Song
    Citation: Cancer Cell International 2022 22:93
    Content type: Primary research Published on:

  38. DHX15 is one of the RNA helicase family members involving in several biological processes. Studies have reported that overexpression of DHX15 is related to cancer progression. However, the role of DHX15 in Bur...

    Authors: Yuan Chen, Xianglei Chen, Lili Pan, Yuanmao Huang, Yuanhua Cai, Jinggang Li, Yang Li and Shaoyuan Wang
    Citation: Cancer Cell International 2022 22:92
    Content type: Primary research Published on:

  39. Long non-coding RNAs and microRNAs have recently attained much attention regarding their role in the development of B cell lineage as well as participation in the lymphomagenesis. These transcripts have a high...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Elena Jamali
    Citation: Cancer Cell International 2022 22:91
    Content type: Review Published on:

  40. Esophageal squamous cell carcinoma (ESCC) is a severe disease with high mortality, and is associated with poor prognosis and frequent lymphatic metastasis. Therefore, prognostic indicators for ESCC are urgentl...

    Authors: Qiu-yun Luo, Tian Di, Miao-Zhen Qiu, Zeng-fei Xia, Yong Du, Run-duan Lin, Li-qiong Yang, Yu-ting Sun, Da-Jun Yang, Jian Sun and Lin Zhang
    Citation: Cancer Cell International 2022 22:90
    Content type: Primary research Published on:

  41. To evaluate the efficacy and safety of P-ALG (porcine anti-lymphocyte globulin) and R-ATG (rabbit anti-thymocyte globulin) in the conditioning regime for patients with acquired aplastic anemia who underwent HL...

    Authors: Juan Chen, Yuanfeng Zhang, Xin Chen, Aiming Pang, Yuanqi Zhao, Li Liu, Runzhi Ma, Jialin Wei, Yi He, Donglin Yang, Rongli Zhang, Weihua Zhai, Qiaoling Ma, Erlie Jiang, Mingzhe Han, Jiaxi Zhou…
    Citation: Cancer Cell International 2022 22:89
    Content type: Primary research Published on:

  42. KRAS mutation accounts for 30–50% of human colorectal cancer (CRC) cases. Due to the scarcity of effective treatment options, KRAS mutant CRC is difficult to treat in the clinic. Metastasis is still the major ...

    Authors: Yunzhi Dang, Jiao Yu, Shuhong Zhao, Ximing Cao and Qing Wang
    Citation: Cancer Cell International 2022 22:88
    Content type: Primary research Published on:

  43. Despite of a multimodal approach, recurrences can hardly be prevented in glioblastoma. This may be in part due to so called glioma stem cells. However, there is no established marker to identify these stem cells.

    Authors: Bülent Polat, Gisela Wohlleben, Rebekka Kosmala, Dominik Lisowski, Frederick Mantel, Victor Lewitzki, Mario Löhr, Robert Blum, Petra Herud, Michael Flentje and Camelia-Maria Monoranu
    Citation: Cancer Cell International 2022 22:87
    Content type: Primary research Published on:

  44. Increasing evidence suggests that aberrant methylation is involved in 5-fluorouracil (5-FU) resistance in gastric cancer (GC). Our previous work has identified that Methyl-CpG binding protein 2 (MeCP2) promote...

    Authors: Yannan Qin, Xiaoping Ma, Chen Guo, Shuang Cai, Hailin Ma and Lingyu Zhao
    Citation: Cancer Cell International 2022 22:86
    Content type: Primary research Published on:

  45. The role of hydrogen sulfide (H2S) in cancer biology is controversial, including colorectal cancer. The bell-shaped effect of H2S refers to pro-cancer action at lower doses and anti-cancer effect at higher concen...

    Authors: Yuyang Zhang, Shanwen Chen, Jing Zhu, Shihao Guo, Taohua Yue, Hao Xu, Jianwen Hu, Zhihao Huang, Zeyang Chen, Pengyuan Wang and Yucun Liu
    Citation: Cancer Cell International 2022 22:85
    Content type: Primary research Published on:

  46. In addition to its role in cellular progression and cancer, SIRT6, a member of nicotinamide adenine dinucleotide (NAD+)-dependent class III deacylase sirtuin family, serves a variety of roles in the body's immune...

    Authors: Xiaojing Wu, Shuyuan Wang, Xuanzhu Zhao, Sizhen Lai, Zhen Yuan, Yixiang Zhan, Kemin Ni, Zhaoce Liu, Lina Liu, Ran Xin, Xingyu Zhou, Xin Yin, Xinyu Liu, Xipeng Zhang, Wei Cui and Chunze Zhang
    Citation: Cancer Cell International 2022 22:84
    Content type: Review Published on:

  47. Osimertinib resistance limits the treatment of epidermal growth factor receptor-(EGFR)-mutated non-small-cell lung carcinoma (NSCLC). The mechanisms of osimertinib resistance need to be elucidated to determine...

    Authors: Xiaoying Wan, Boxiong Xie, Hui Sun, Weiqing Gu, Chunyan Wang, Qinfang Deng and Songwen Zhou
    Citation: Cancer Cell International 2022 22:83
    Content type: Primary research Published on:

  48. Approximately 50%–60% of secondary resistance to primary EGFR- tyrosine kinase inhibitors (TKI) therapy is caused by acquired p.Thr790Met (T790M) mutation; however, highly fragmented, low-quantity circulating tum...

    Authors: Boyeon Kim, Yoonjung Kim, Saeam Shin, Seung-Tae Lee, Jae Yong Cho and Kyung-A. Lee
    Citation: Cancer Cell International 2022 22:82
    Content type: Primary research Published on:

  49. Breast cancer (BC) threatens the health of women around the world. Researchers have proved that hsa_circ_0005505 (circ_IRAK3) facilitates BC cell invasion and migration, but the regulatory mechanisms of circ_I...

    Authors: Fang Wang, Jingruo Li, Lin Li, Zhuo Chen, Nan Wang, Mingzhi Zhu, Hailong Mi, Youyi Xiong, Guangcheng Guo and Yuanting Gu
    Citation: Cancer Cell International 2022 22:81
    Content type: Primary research Published on:

  50. The gasdermins (GSDMs) family is proposed to be pore-forming effector proteins that cause cell membrane permeabilization and pyroptosis. Despite our increasing knowledge of GSDMD, GSDME and GSDMB, the biologic...

    Authors: Mingchao Mu, Qiaoling Yu, Qin Zhang, Jing Guo, Xingjie Wang, Xuejun Sun and Junhui Yu
    Citation: Cancer Cell International 2022 22:80
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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