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  1. Compared with the proneural (PN) subtype of glioblastoma (GBM), the mesenchymal (MES) subtype is more invasive and immune evasive and is closely related to poor prognosis. Here, we used transcriptome data and ...

    Authors: Zhiying Lin, Zhu Zhang, Haojie Zheng, Haiyan Xu, Yajuan Wang, Chao Chen, Junlu Liu, Guozhong Yi, Zhiyong Li, Xiaoyan Wang and Guanglong Huang
    Citation: Cancer Cell International 2022 22:151
  2. B7-H4 is overexpressed in colorectal cancer (CRC) and plays an important role in tumor growth and immunosuppression. However, the exact mechanism that regulates B7-H4 expression remains largely unknown. Here, ...

    Authors: Bin Zhou, Youwei Lu, Zhiming Zhao, Tongguo Shi, Hongya Wu, Weichang Chen, Liang Zhang and Xueguang Zhang
    Citation: Cancer Cell International 2022 22:147
  3. Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods. Ulcerative colitis and Crohn’s disease are two major forms of the disease. IBD imposes a lot of sufferings...

    Authors: Mostafa Vaghari-Tabari, Niloufar Targhazeh, Soheila Moein, Durdi Qujeq, Forough Alemi, Maryam Majidina, Simin Younesi, Zatollah Asemi and Bahman Yousefi
    Citation: Cancer Cell International 2022 22:146
  4. This study aimed to observe the effect of transient receptor potential canonical channel 6 (TRPC6) antagonist 1-(β-[3-(4-method-phenyl) propoxy]-4-methoxyphenethyl)-1H-imidazole hydrate (SKF-96365) and its ago...

    Authors: Li-ping Bai, Ya-li Chen and Ai Zheng
    Citation: Cancer Cell International 2022 22:145
  5. Prostate cancer (PCa) is one of the most lethal cancers in male individuals. The synaptosome associated protein 25 (SNAP25) gene is a key mediator of multiple biological functions in tumors. However, its signific...

    Authors: Longjiang Di, Maoli Gu, Yan Wu, Guoqiang Liu, Lishuo Zhang, Yifei Li and Wenjing Zhang
    Citation: Cancer Cell International 2022 22:144
  6. Pancreatic adenocarcinoma (PAAD) is a severe malignant with a 5-year survival rate of approximately 9%. Oleanolic acid is a well-known natural triterpenoid which exhibits pharmacological activities. We previou...

    Authors: Shijia Wu, Yong Ai, Huimin Huang, Guangyu Wu, Shipeng Zhou, Weilong Hong, Percy David Papa Akuetteh, Guihua Jin, Xingling Zhao, Yihua Zhang, Xiaolong Zhang and Linhua Lan
    Citation: Cancer Cell International 2022 22:143
  7. 5-fluorouracil (5-FU), an effective chemotherapy drug, is commonly applied for colorectal cancer treatment. Nevertheless, its toxicity to normal tissues and the development of tumor resistance are the main obs...

    Authors: Hossein Moutabian, Mehrsa Majdaeen, Ruhollah Ghahramani-Asl, Masoumeh Yadollahi, Esmaeil Gharepapagh, Gholamreza Ataei, Zahra Falahatpour, Hamed Bagheri and Bagher Farhood
    Citation: Cancer Cell International 2022 22:142
  8. Circular RNA (circRNA), a new type of endogenous non-coding RNA, is abundantly present in eukaryotic cells, and characterized as stable high conservation and tissue specific expression. It has been generated i...

    Authors: Panpan Wang, Yunhuan Zhang, Lugang Deng, Zhi Qu, Peisen Guo, Limin Liu, Zengli Yu, Peixi Wang and Nan Liu
    Citation: Cancer Cell International 2022 22:141
  9. Esophageal squamous cell carcinoma (ESCC) has unfavorable outcomes with the highest incidence seen in China. Accordingly, exploring effective molecular biomarkers is of great value. MicroRNAs (miRNAs) are post...

    Authors: Yu Men, Yirui Zhai, Lihong Wu, Lipin Liu, Wenjue Zhang, Wei Jiang, Nan Bi, Yongmei Song, Zhouguang Hui and Luhua Wang
    Citation: Cancer Cell International 2022 22:140
  10. Although PD-L1 expression is a crucial predictive biomarker for immunotherapy, it can be influenced by many factors.

    Authors: Kang Li, Jun Liu, Lin Wu, Yajie Xiao, Jia Li, Haijian Du, Zhikun Zhao, Chao Sun, Yongtian Zhao, Jie Yang, Dongfang Wu, Zhuxiang Zhao and Bolin Chen
    Citation: Cancer Cell International 2022 22:138
  11. Circulating fibrinogen to pre-albumin ratio (FPR) and albumin to fibrinogen ratio (AFR) are effective factors for predicting the prognosis of colorectal cancer (CRC). However, the role of these two ratios in d...

    Authors: Hou-Qun Ying, Wei Chen, Cui-Fen Xiong, Yuanyuan Wang, Xiao-Juan Li and Xue-Xin Cheng
    Citation: Cancer Cell International 2022 22:137
  12. Osteosarcoma (OS) is the most common malignant tumor of bone, and the clinical efficacy of current treatments and associated survival rates need to be further improved by employing novel therapeutic strategies...

    Authors: Qiang Wang, Yinghui Wu, Meng Lin, Gaigai Wang, Jinyan Liu, Min Xie, Bo Zheng, Cong Shen and Jun Shen
    Citation: Cancer Cell International 2022 22:136
  13. Microbiome has been shown to substantially contribute to some cancers. However, the diagnostic implications of microbiome in head and neck squamous cell carcinoma (HNSCC) remain unknown.

    Authors: Yun Kyeong Kim, Eun Jung Kwon, Yeuni Yu, Jayoung Kim, Soo-Yeon Woo, Hee-Sun Choi, Munju Kwon, Keehoon Jung, Hyung-Sik Kim, Hae Ryoun Park, Dongjun Lee and Yun Hak Kim
    Citation: Cancer Cell International 2022 22:135
  14. Authors: Maryam Ranjbar, Rasoul Salehi, Shaghayegh Haghjooy Javanmard, Laleh Rafiee, Habibollah Faraji, Sima Jafarpour, Gordon A. Ferns, Majid Ghayour‑Mobarhan, Mostafa Manian and Reza Nedaeinia
    Citation: Cancer Cell International 2022 22:134

    The original article was published in Cancer Cell International 2021 21:194

  15. Lung cancer remains one of the major causes of cancer-related death globally. Recent studies have shown that aberrant m6A levels caused by METTL3 are involved in the malignant progression of various tumors, inclu...

    Authors: Chao Ma, Rui-Jie Ma, Kang Hu, Qi-Ming Zheng, Ye-Peng Wang, Nan Zhang and Zhi-Gang Sun
    Citation: Cancer Cell International 2022 22:133
  16. MicroRNAs (miRNAs) are one type of noncoding RNAs that interfere with mRNA translation to downregulate gene expression, which results in posttranscriptional gene silencing. Over the past two decades, miRNAs ha...

    Authors: Yuanshuai Su, Qiuxian Zheng, Lingxiao Zhu, Xinyu Gu, Juan Lu and Lanjuan Li
    Citation: Cancer Cell International 2022 22:132
  17. Cancer cells must rewire cellular metabolism to satisfy the unbridled proliferation, and metabolic reprogramming provides not only the advantage for cancer cell proliferation but also new targets for cancer tr...

    Authors: Rongfu Tu, Junpeng Ma, Peng Zhang, Ye Kang, Xiaofan Xiong, Junsheng Zhu, Miao Li and Chengsheng Zhang
    Citation: Cancer Cell International 2022 22:130
  18. High RSPH14 expression appears to be related to poor prognosis of hepatocellular carcinoma (HCC). This study aimed to investigate the possible roles of RSPH14 in the proliferation, apoptosis, and invasion of H...

    Authors: Dawei Yuan, Rulan Ma, Tuanhe Sun, Kun Zhu, Chengxue Dang, Haixia Ye and Kang Li
    Citation: Cancer Cell International 2022 22:129
  19. While the correlation between PD-L1 expression and KRAS mutation has been previously reported in other solid tumors such as non-small cell lung cancer (NSCLC), whether PD-L1 can be modulated by ERK signaling down...

    Authors: Zheng Gao, Jia-Feng Chen, Xiao-Gang Li, Ying-Hong Shi, Zheng Tang, Wei-Ren Liu, Xin Zhang, Ao Huang, Xuan-Ming Luo, Qiang Gao, Guo-Ming Shi, Ai-Wu Ke, Jian Zhou, Jia Fan, Xiu-Tao Fu and Zhen-Bin Ding
    Citation: Cancer Cell International 2022 22:128
  20. Prostate cancer (PCa) is the second leading cause of cancer-related male deaths worldwide. The purpose of this study was to investigate the effects of homo sapiens solute carrier family 4 member 4 (SLC4A4), wh...

    Authors: Zelin Liu, Qinghua Wang, Guanzhong Zhai, Shuai Ke, Xi Yu and Jia Guo
    Citation: Cancer Cell International 2022 22:127
  21. Colorectal cancer (CRC) is one of the most lethal and prevalent solid malignancies worldwide. There is a great need of accelerating the development and diagnosis of CRC. Long noncoding RNAs (lncRNA) as transcr...

    Authors: Wen-Wen Xu, Jin Jin, Xiao-yu Wu, Qing-Ling Ren and Maryam Farzaneh
    Citation: Cancer Cell International 2022 22:126
  22. This meta-analysis aimed to determine the pooled association between polycystic ovary syndrome (PCOS), hypothyroidism, and fibrocystic breast changes. We searched important databases, including PubMed (Medline...

    Authors: Parisa Kohnepoushi, Hojat Dehghanbanadaki, Pardis Mohammadzedeh, Maziar Nikouei and Yousef Moradi
    Citation: Cancer Cell International 2022 22:125
  23. Stomach adenocarcinoma (STAD) is associated with high morbidity and mortality rates. Ferroptosis is an iron-dependent form of cell death, which plays an important role in the development of many cancers. Tumor...

    Authors: Dandan Zhu, Sifan Wu, Yafang Li, Yu Zhang, Jierong Chen, Jianhong Ma, Lixue Cao, Zejian Lyu and Tieying Hou
    Citation: Cancer Cell International 2022 22:124
  24. Breast cancer (BC) is the most frequently diagnosed cancer in women. Altering glucose metabolism and its effects on cancer progression and treatment resistance is an emerging interest in BC research. For insta...

    Authors: Rita Aoun, Christopher El Hadi, Roula Tahtouh, Rita El Habre and George Hilal
    Citation: Cancer Cell International 2022 22:123
  25. Cancer stem cells (CSCs) play crucial role in tumor progression, drug resistance and relapse in various cancers. CSC niche is comprised of various stromal cell types including Tumor-associated macrophages (TAM...

    Authors: N. N. V. Radharani, Amit S. Yadav, Ramakrishna Nimma, T. V. Santosh Kumar, Anuradha Bulbule, Venkatesh Chanukuppa, Dhiraj Kumar, Srinivas Patnaik, Srikanth Rapole and Gopal C. Kundu
    Citation: Cancer Cell International 2022 22:122
  26. NLRP3 inflammasome responses and gut microbiota have been shown an important role in lung cancer, however, the relationship between gut microbiota and NLRP3 inflammasome responses in lung cancer with Qi-yin de...

    Authors: Rui-yuan Jiang, Ting Wang, Qiao-yu Lan, Yan-chun Qin, Ting-ting Man, Hua Sun, Zhu-long Li, Xiao-ting Zhong, Chun-mei Mo and Zhen Rong
    Citation: Cancer Cell International 2022 22:121
  27. Autophagy has been found to be involved in the multidrug resistance (MDR) of cancers, but whether it is associated with resistance of small cell lung cancer (SCLC) has not been studied. Here, we hypothesized t...

    Authors: Tiezhi Li, Helin Zhang, Zhichao Wang, Shaolin Gao, Xu Zhang, Haiyong Zhu, Na Wang and Honglin Li
    Citation: Cancer Cell International 2022 22:120
  28. The condensation complex gene non-SMC condensin I complex subunit G(NCAPG), a cell cycle-associated condensin, is over-expressed in various cancers. However, its biological function in colorectal cancer (CRC) ...

    Authors: Yanlong Shi, Chang Ge, Debao Fang, Wei Wei, Li Li, Qian Wei and Hongzhu Yu
    Citation: Cancer Cell International 2022 22:119
  29. Ovarian cancer (OC) is an invasive gynaecologic cancer with a high cancer-related death rate. The purpose of this study was to establish an invasion-related multigene signature to predict the prognostic risk o...

    Authors: Leilei Liang, Jian Li, Jing Yu, Jing Liu, Lin Xiu, Jia Zeng, Tiantian Wang, Ning Li and Lingying Wu
    Citation: Cancer Cell International 2022 22:118
  30. Neoadjuvant chemoradiotherapy (nCRT) prior to surgery is the standard treatment for patients with locally advanced rectal cancer (LARC), while parts of them show poor therapeutic response accompanied by therap...

    Authors: Jianan Wang, Jiayu Liu, Jinyang Wang, Shijian Wang, Feifei Li, Ruibing Li, Peng Liu, Mianyang Li and Chengbin Wang
    Citation: Cancer Cell International 2022 22:117
  31. Breast cancer is the most commonly diagnosed cancer in women. Triple negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat due to the deficiency in drug-targetable receptors. LR...

    Authors: Peng Li, Yu Zeng, Yudan Chen, Peng Huang, Xinchun Chen and Weidong Zheng
    Citation: Cancer Cell International 2022 22:116
  32. Adaptive resistance and side effects of sorafenib treatment result in unsatisfied survival of patients with hepatocellular carcinoma (HCC). Palmitoyl-protein thioesterase 1 (PPT1) plays a critical role in prog...

    Authors: Jianjun Xu, Zhe Su, Xiang Cheng, Shaobo Hu, Wenjie Wang, Tianhao Zou, Xing Zhou, Zifang Song, Yun Xia, Yang Gao and Qichang Zheng
    Citation: Cancer Cell International 2022 22:115
  33. RNA 3’-terminal phosphate cyclase-like protein (Rcl1) is involved in pre-rRNA processing, but its implication in cancers remains unclear.

    Authors: Yu Jiaze, Hou Sinan, Yang Minjie, Zhou Yongjie, Du Nan, Wang Liangwen, Zhang Wen, Luo Jianjun and Yan Zhiping
    Citation: Cancer Cell International 2022 22:114
  34. Testicular germ cell tumours (TGCTs) are the most commonly diagnosed malignancy in young men. Although cisplatin has been shown to be effective to treat TGCT patients, long-term follow-up has shown that TGCT s...

    Authors: Kancheng He, Zitaiyu Li, Kun Ye, Yihong Zhou, Minbo Yan, Hao Qi, Huating Hu, Yingbo Dai and Yuxin Tang
    Citation: Cancer Cell International 2022 22:113
  35. Abnormal DNA methylation of tumor suppressor gene promoter has been found in breast cancer. Therefore, the current study set out to explore how DNA methyltransferase 1 (DNMT1) affects breast cancer through med...

    Authors: Yaobang Liu, Zhengyang Bai, Dahai Chai, Yali Gao, Ting Li, Yinling Ma and Jinping Li
    Citation: Cancer Cell International 2022 22:112
  36. Adhesion molecule interacting with CXADR antigen 1 (AMICA1), also known as Junction Adhesion Molecule Like (JAML), a recently identified member of the JAMs family, plays a critical role in mediating cancer dev...

    Authors: Ziyang Feng, Yan Zhang, Min He, Ying Han, Changjing Cai, Shanshan Liu, Ping Liu, Yihong Chen, Hong Shen and Shan Zeng
    Citation: Cancer Cell International 2022 22:111
  37. Although resistance is its major obstacle in cancer therapy, trastuzumab is the most successful agent in treating epidermal growth factor receptor 2 positive (HER2 +) breast cancer (BC). Some patients show res...

    Authors: Aysooda Hosseinzadeh, Parnaz Merikhian, Nazanin Naseri, Mohammad Reza Eisavand and Leila Farahmand
    Citation: Cancer Cell International 2022 22:110
  38. Abnormal expression of splicing factor 3A subunit 3 (SF3A3), a component of the spliceosome, has been confirmed to be related to the occurrence and development of various cancers. However, the expression and f...

    Authors: Kai-Long Liu, Yue-Wei Yin, Bao-Sai Lu, Ya-Lin Niu, Dan-Dan Wang, Bei Shi, Hong Zhang, Ping-Ying Guo, Zhan Yang and Wei Li
    Citation: Cancer Cell International 2022 22:109
  39. Breast cancer is a severe problem worldwide due to an increase in mortality and prevalence among women. Despite early diagnostic procedures as well as advanced therapies, more investigation is required to find...

    Authors: Vahid Karpisheh, Majid Ahmadi, Kazem Abbaszadeh-Goudarzi, Mehran Mohammadpour Saray, Asal Barshidi, Hamed Mohammadi, Mehdi Yousefi and Farhad Jadidi-Niaragh
    Citation: Cancer Cell International 2022 22:108
  40. DFNA5 (GSDME) belongs to Gasdermin familily that is involved in a variety of cancers and triggers cell pyroptosis after chemical treatment. However, the relationship in DFNA5 between prognosis and immune cells...

    Authors: Jian Hu, Wenceng Pei, Minren Jiang, Ying Huang, Fuyun Dong, Zhenyou Jiang, Ying Xu and Zihuang Li
    Citation: Cancer Cell International 2022 22:107
  41. Disabled homolog 2 interacting protein (DAB2IP) plays a tumor-suppressive role in several types of human cancers. However, the molecular status and function of the DAB2IP gene in esophageal squamous cell carci...

    Authors: Zhuting Tong, Weiyang Fang, Meng Xu, YeYe Xia, Rui Wang, Yue Li, Tianqi Zha, Liang Xiao, Shuhao Pan, Huiping Chai, Lei Zhao, Hao Wang, Huaguang Pan and Xiangcun Chen
    Citation: Cancer Cell International 2022 22:106
  42. Many studies in recent years have found that dysregulation of long non-coding RNAs (lncRNAs) can contribute to disease. Small nucleolar RNA host gene 17 (SNHG17) is a novel cancer-related lncRNA of the SNHG fa...

    Authors: Li Ma, Jin Gao, Niu Zhang, Jiawei Wang, Tianwei Xu, Tianyao Lei, Xiaoteng Zou, Chenchen Wei and Zhaoxia Wang
    Citation: Cancer Cell International 2022 22:104
  43. A hydatidiform mole is a condition caused by abnormal proliferation of trophoblastic cells. MicroRNA miR-30a acts as a tumor suppressor gene in most tumors and participates in the development of various cancer...

    Authors: Zhenzhen Guo, Chenyu Zhu, Youhui Wang, Zhen Li, Lu Wang, Jianhui Fan, Yuefei Xu, Na Zou, Ying Kong, Dong Li and Linlin Sui
    Citation: Cancer Cell International 2022 22:103
  44. The role of CARM1 in tumors is inconsistent. It acts as an oncogene in most cancers but it inhibits the progression of liver and pancreatic cancers. CARM1 has recently been reported to regulate autophagy, but ...

    Authors: Suzhen Yang, Jing Zhang, Di Chen, Jiayi Cao, Ying Zheng, Yuying Han, Yirong Jin, Shuhui Wang, Ting Wang, Lin Ma, Tingting Luo, Yan Wang, Wen Qin and Lei Dong
    Citation: Cancer Cell International 2022 22:102
  45. Emerging evidence suggests that LMNB1 is involved in the development of multiple cancer types. However, there is no study reporting the potential role of LMNB1 in a systematic pan-cancer manner.

    Authors: Haixiang Qin, Yingqiang Lu, Lin Du, Jingyan Shi, Haoli Yin, Bo Jiang, Wei Chen, Wenli Diao, Meng Ding, Wenmin Cao, Xuefeng Qiu, Xiaozhi Zhao and Hongqian Guo
    Citation: Cancer Cell International 2022 22:101
  46. Programmed Cell Death 2 Like (PDCD2L) correlates with cell proliferation, apoptosis and mouse embryonic development. However, the role of PDCD2L in human cancers is unclear.

    Authors: Huabin Gao, Cheng Xu, Jiangtao Liang, Songhan Ge, Fenfen Zhang, Ying Tuo, Huijuan Shi and Anjia Han
    Citation: Cancer Cell International 2022 22:100

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