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  1. Content type: Primary research

    Caveolin-1 (Cav-1) plays an important role in the development of various human cancers. We investigated the relationship between Cav-1 expression and non-small cell lung cancer (NSCLC) progression in the conte...

    Authors: Yeong-Jin Kim, Ju-Hwi Kim, Ok Kim, Eun-Jung Ahn, Se-Jeong Oh, Md Rashedunnabi Akanda, In-Jae Oh, Shin Jung, Kyung-Keun Kim, Jae-Hyuk Lee, Hyung-Seok Kim, Hangun Kim, Kyung-Hwa Lee and Kyung-Sub Moon

    Citation: Cancer Cell International 2019 19:171

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  2. Content type: Primary research

    The Warburg effect demonstrates the importance of glycolysis in the development of primary and metastatic cancers. We aimed to explore the role of monocarboxylate transporter 1 (MCT1) and MCT4, two essential t...

    Authors: Chen Guo, Tao Huang, Qing-Hai Wang, Hong Li, Aashish Khanal, En-Hao Kang, Wei Zhang, Hai-Tao Niu, Zhen Dong and Yan-Wei Cao

    Citation: Cancer Cell International 2019 19:170

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  3. Content type: Primary research

    DKK1 has been reported to act as a tumor suppressor in breast cancer. However, the mechanism of DKK1 inhibits breast cancer migration and invasion was still unclear.

    Authors: Jie Niu, Xiao-Meng Li, Xiao Wang, Chao Liang, Yi-Dan Zhang, Hai-Ying Li, Fan-Ye Liu, Hua Sun, Song-Qiang Xie and Dong Fang

    Citation: Cancer Cell International 2019 19:168

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  4. Content type: Primary research

    Studies have shown that miR-146a-5p was differentially expressed in diverse cancers, but the associations between miR-146a-5p expression and prognosis across multiple types of cancer as well its potential targ...

    Authors: Mei-wei Li, Li Gao, Yi-wu Dang, Ping Li, Zu-yun Li, Gang Chen and Dian-zhong Luo

    Citation: Cancer Cell International 2019 19:167

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  5. Content type: Primary research

    New therapeutic drug for breast cancer (BRCA), especially triple negative BRCA (TNBC), is urgently needed. Even though 2-(4-morpholinoanilino)-6-cyclohexylaminopurine (reversine) is an aurora kinase inhibitor,...

    Authors: Di Huang, Yu Huang, Zisheng Huang, Jiefeng Weng, Shuai Zhang and Weili Gu

    Citation: Cancer Cell International 2019 19:166

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  6. Content type: Primary research

    Enhanced glycolysis in tumors, known as the Warburg effect, provides the metabolic basis of enhanced cancer cell proliferation and metastasis. The Warburg pathway enzyme 6-phosphofructo-2-kinase/fructose-2,6-b...

    Authors: Ling Yao, Lei Wang, Zhi-Gang Cao, Xin Hu and Zhi-Ming Shao

    Citation: Cancer Cell International 2019 19:165

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  7. Content type: Primary research

    Abnormal expression of microRNAs (miRNAs) is related to human carcinogenesis. Although previous studies have shown that miR-503 expression in gastric cancer (GC) is downregulated, however, the underlying molec...

    Authors: Wenjing Li, Jun Li, Hong Mu, Meiqi Guo and Haixia Deng

    Citation: Cancer Cell International 2019 19:164

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  8. Content type: Primary research

    The IQ-motif-containing GTPase-activating protein (IQGAP) family comprises three members, IQGAP1, IQGAP2 and IQGAP3. IQGAP3 is the latest addition to the family. This study mainly investigated the novel marker...

    Authors: Huihua Cao, Qing Wang, Zhenyan Gao, Xiang Xu, Qicheng Lu and Yugang Wu

    Citation: Cancer Cell International 2019 19:163

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  9. Content type: Primary research

    AT-rich interactive domain-containing protein 1A (ARID1A) is a subunit of the mammary SWI/SNF chromatin remodeling complex and a tumor suppressor protein. The loss of ARID1A been observed in several types of h...

    Authors: Zhou-hua Jiang, Tao Peng, Hai-long Qian, Cai-de Lu, Feng Qiu and Su-zhan Zhang

    Citation: Cancer Cell International 2019 19:162

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  10. Content type: Primary research

    The interaction between human epididymis protein 4 (HE4) and annexin A2 (Annexin A2) has been found in ovarian cancer. However, it is dimness whether the interaction exists in other malignant tumors.

    Authors: Jing Wang, Lu Deng, Huiyu Zhuang, Juanjuan Liu, Dawo Liu, Xiao Li, Shan Jin, Liancheng Zhu, Huimin Wang and Bei Lin

    Citation: Cancer Cell International 2019 19:161

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  11. Content type: Primary research

    Our previous studies revealed that Jagged 2 (JAG2) is involved in the regulation of migration and invasion of colon cancer cells without affecting cell proliferation. This study further explored the specific m...

    Authors: Wan He, Jun Tang, Wenwen Li, Yong Li, Yi Mei, Lisheng He, Keli Zhong and Ruilian Xu

    Citation: Cancer Cell International 2019 19:160

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  12. Content type: Primary research

    Mutationally activated Ras proteins are closely linked to a wide variety of human cancers. Hence, there has been an intensive search for anti-Ras therapies for cancer treatment. The sole Ras gene, which encode...

    Authors: Jiaojiao Ji, Jiang Yuan, Xiaoyu Guo, Ruifang Ji, Qinghua Quan, Mei Ding, Xia Li and Yonggang Liu

    Citation: Cancer Cell International 2019 19:159

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  13. Content type: Review

    As a pivotal regulator, cyclin D3 gives play to a crucial value in conversion from the G1 stage to the S stage of cell cycle, which is implicated in tumor progression, especially proliferation and migration. ...

    Authors: Bo Wang, Zijian Wang, Lizhi Han, Song Gong, Yanxue Wang, Zhiwen He, Yong Feng and Zhaohui Yang

    Citation: Cancer Cell International 2019 19:158

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  14. Content type: Review

    Fibromodulin (FMOD) is known as one of very important extracellular matrix small leucine-rich proteoglycans. This small leucine-rich proteoglycan has critical roles in the extracellular matrix organization and...

    Authors: Mohammad Hossein Pourhanifeh, Rezvan Mohammadi, Somaye Noruzi, Seyede Atefe Hosseini, Sahar Fanoudi, Yousef Mohamadi, Milad Hashemzehi, Zatollah Asemi, Hamid Reza Mirzaei, Reza Salarinia and Hamed Mirzaei

    Citation: Cancer Cell International 2019 19:157

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  15. Content type: Primary research

    Emerging evidence demonstrates that long non-coding RNA (lncRNA) is an important regulator in tumorigenesis and development. Tubulin Alpha 4B (TUBA4B), a novel lncRNA, was recently proposed as a tumor suppress...

    Authors: Jianbo Guo, Yan Li, He Duan and Lu Yuan

    Citation: Cancer Cell International 2019 19:156

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  16. Content type: Primary research

    Abnormal expression of the eukaryotic initiation factor 3 (eIF3) subunits plays critical roles in tumorigenesis and progression, and also has potential prognostic value in cancers. However, the expression and ...

    Authors: Rui-Chao Chai, Ning Wang, Yu-Zhou Chang, Ke-Nan Zhang, Jing-Jun Li, Jun-Jie Niu, Fan Wu, Yu-Qing Liu and Yong-Zhi Wang

    Citation: Cancer Cell International 2019 19:155

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  17. Content type: Primary research

    Lymphoma is one of the most common hematologic malignancy. Drug resistance is the main obstacle faced in lymphoma treatment. Cancer stem cells are considered as the source of tumor recurrence, metastasis and d...

    Authors: Li-Na Lv, Xiao-Chao Wang, Li-Ju Tao, Hong-Wen Li, Shu-You Li and Fei-Meng Zheng

    Citation: Cancer Cell International 2019 19:153

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  18. Content type: Primary research

    Recently, lncRNA-Testis developmental related gene 1 (TDRG1) was proved to be a key modulator in reproductive organ-related cancers. The biological role of TDRG1 in cervical cancer (CC) progression remains lar...

    Authors: Hui Jiang, Min liang, Yanqiong Jiang, Ting Zhang, Kexin Mo, Suwen Su, Aiping Wang, Yongyi Zhu, Guanqun Huang and Rujian Zhou

    Citation: Cancer Cell International 2019 19:152

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  19. Content type: Primary research

    One of the most important metabolic hallmarks of breast cancer cells is enhanced lipogenesis. Increasing evidences suggest that fatty acid synthase (FAS) plays an important role in human breast cancer. Previou...

    Authors: Wenyuan Huang, Yan Liang and Xiaofeng Ma

    Citation: Cancer Cell International 2019 19:151

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  20. Content type: Primary research

    NPL4 is an important cofactor of the valosin-containing protein (VCP)–NPL4–UFD1 complex. The VCP–NPL4–UFD1 has been considered as a ubiquitin proteasome system (UPS) regulator and response to protein degradati...

    Authors: Bao-Sai Lu, Yue-Wei Yin, Yan-Ping Zhang, Ping-Ying Guo, Wei Li and Kai-Long Liu

    Citation: Cancer Cell International 2019 19:149

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  21. Content type: Primary research

    It is becoming increasingly clear that cancers can rarely be ascribed to just one or a few genomic variations. Genes generally do not function alone, but in groups that function as “networks”. This study aimed...

    Authors: Min-Er Zhong, Yanyu Chen, Guannan Zhang, Lai Xu, Wei Ge and Bin Wu

    Citation: Cancer Cell International 2019 19:148

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  22. Content type: Primary research

    Accumulating evidence has highlighted the tumor suppressive roles of microRNA (miRNAs) in cervical cancer (CC). In the present study, we aim to delineate the functional relevance of microRNA-137 (miR-137) in i...

    Authors: Hui Miao, Nuan Wang, Lin-Xin Shi, Zheng Wang and Wen-Bo Song

    Citation: Cancer Cell International 2019 19:147

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  23. Content type: Primary research

    Programmed cell death ligand 1 (PD-L1) expression has been shown to associate with poor prognosis in a variety of solid tumors. However, the prognostic value of PD-L1 expression in cervical cancer is still con...

    Authors: Xiaobin Gu, Meilian Dong, Zheyan Liu, Yin Mi, Jing Yang, Zhigang Zhang, Ke Liu, Li Jiang, Yue Zhang, Shiliang Dong and Yonggang Shi

    Citation: Cancer Cell International 2019 19:146

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  24. Content type: Primary research

    Pancreatic cancer stem cells (CSCs), a special population of cells, renew themselves infinitely and resist to various treatment. Gramicidin A (GrA), an ionophore antibiotic derived from microorganism, can form...

    Authors: Rui-Qi Wang, Jing Geng, Wei-Jin Sheng, Xiu-Jun Liu, Min Jiang and Yong-Su Zhen

    Citation: Cancer Cell International 2019 19:145

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  25. Content type: Primary research

    Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is an H3K27me3 demethylase, a permissive mark associated with active gene transcription. UTX has been linked to various human cancers. Colo...

    Authors: Xin Tang, Wenwei Cai, Jing Cheng, Ping Lu, Shaojun Ma, Chaoting Chen, Yi Chen, Yun Sun, Caofeng Wang, Ping Hu, Xiaomin Lv, G. Sun, Yu Wang and Jing Sheng

    Citation: Cancer Cell International 2019 19:144

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  26. Content type: Primary research

    Cancer cell viability is strongly modulated by the Hippo pathway, which includes mammalian STE20-like protein kinase 1 (Mst1) and yes-associated protein (Yap). Although the roles of Mst1 and Yap in thyroid car...

    Authors: Xiaoli Zhang, Fei Li, Yeqing Cui, Shuang Liu and Haichen Sun

    Citation: Cancer Cell International 2019 19:143

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  27. Content type: Primary research

    Esophageal squamous cell carcinoma (ESCC) is one of leading malignant cancers of gastrointestinal tract worldwide. Until now, the involved mechanisms during the development of ESCC are largely unknown. This st...

    Authors: Wanli Yang, Xinhui Zhao, Yu Han, Lili Duan, Xin Lu, Xiaoqian Wang, Yujie Zhang, Wei Zhou, Jinqiang Liu, Hongwei Zhang, Qingchuan Zhao, Liu Hong and Daiming Fan

    Citation: Cancer Cell International 2019 19:142

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  28. Content type: Primary research

    Whether PD-L1/PD-1 expression plays a significant role in the prognosis of NPC is still controversial. The present study mainly aimed to investigate the prognostic significance of PD-L1/PD-1 expression in pati...

    Authors: Zi-Lu Huang, Shan Liu, Guan-Nan Wang, Shuo-Han Zheng, Shi-Rong Ding, Ya-lan Tao, Chen Chen, Song-Ran Liu, Xin Yang, Hui Chang, Xiao-Hui Wang and Yun-Fei Xia

    Citation: Cancer Cell International 2019 19:141

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  29. Content type: Primary research

    Long non-coding RNAs (lncRNAs) are promising therapeutic molecules of cancer. Here we aim to study the therapeutic effect and mechanism of a lncRNA, HOXA11-AS, in oral squamous cell carcinoma (OSCC).

    Authors: Baojun Li, Wei Wang, Susheng Miao, Guofu Li, Yuanjing Lv, Cheng Xiang and Rong Pei

    Citation: Cancer Cell International 2019 19:140

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  30. Content type: Primary research

    Hepatocellular carcinoma (HCC) remains a major challenge for public health worldwide. Considering the great heterogeneity of HCC, more accurate prognostic models are urgently needed. To identify a robust progn...

    Authors: Gao-Min Liu, Hua-Dong Zeng, Cai-Yun Zhang and Ji-Wei Xu

    Citation: Cancer Cell International 2019 19:138

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  31. Content type: Primary research

    The aim of the present study was to clarify the correlations between SPARC expression in gastric cancer-associated fibroblasts (GCAFs) and the prognosis of patients with gastric cancer and to elucidate the rol...

    Authors: Yongchen Ma, Jing Zhu, Shanwen Chen, Ju Ma, Xiaoqian Zhang, Sixia Huang, Jianwen Hu, Taohua Yue, Junling Zhang, Pengyuan Wang, Xin Wang, Long Rong, Hongjie Guo, Guowei Chen and Yucun Liu

    Citation: Cancer Cell International 2019 19:137

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  32. Content type: Primary research

    Endometrial cancer (EC) is one of the female malignant tumors. Endometrial cancer predominately affects post-menopausal women. Bioinformatics analysis has been widely applied to screen and analyze genes in lin...

    Authors: JinHui Liu, ShuLin Zhou, SiYue Li, Yi Jiang, YiCong Wan, XiaoLing Ma and WenJun Cheng

    Citation: Cancer Cell International 2019 19:136

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  33. Content type: Primary research

    Acute myeloid leukemia (AML) is a typically fatal malignancy and new drug and treatment need to be developed for a better survival outcome. Cold atmospheric plasma (CAP) is a novel technology, which has been w...

    Authors: Dehui Xu, Ning Ning, Yujing Xu, Bingchuan Wang, Qingjie Cui, Zhijie Liu, Xiaohua Wang, Dingxin Liu, Hailan Chen and Michael G. Kong

    Citation: Cancer Cell International 2019 19:135

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  34. Content type: Primary research

    Cancer stem cells (CSCs), drug-resistant cancer cell subsets, are known to be responsible for tumor metastasis and relapse. The JAK/STAT pathway, activated by SH2 domain, is known to regulate the tumor growth ...

    Authors: Xiao-Feng Xu, Feng Gao, Jian-Jiang Wang, Cong Long, Xing Chen, Lan Tao, Liu Yang, Li Ding and Yong Ji

    Citation: Cancer Cell International 2019 19:133

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  35. Content type: Primary research

    CHIP is an E3 ubiquitin ligase that plays contrast roles in diverse human malignancies, depending on its targets. To date, the mechanisms underlying the function of CHIP in gastric cancer remains unclear. Here...

    Authors: Hanjue Dai, Hao Chen, Jingjing Xu, Jun Zhou, Zhili Shan, Hengying Yang, Xiaojun Zhou and Feng Guo

    Citation: Cancer Cell International 2019 19:132

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  36. Content type: Review

    Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of ...

    Authors: Mohammad Hossein Pourhanifeh, Mehran Sharifi, Russel J. Reiter, Abdoulhossein Davoodabadi and Zatollah Asemi

    Citation: Cancer Cell International 2019 19:131

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  37. Content type: Primary research

    Bursopentin (BP5) is a multifunctional pentapeptide found in the chicken bursa of Fabricius. Recent study indicated that BP5 significantly stimulates expression of p53 protein in colon cancer HCT116 cells. How...

    Authors: Jing Li, Tian-xiang Li, Yao Ma, Yong Zhang, De-yuan Li and Hai-rong Xu

    Citation: Cancer Cell International 2019 19:130

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  38. Content type: Primary research

    Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated in multiple human malignancies. However, whether PKM2 regulates the radiosensitivity of human...

    Authors: Yanzhu Lin, Hui Zhai, Yi Ouyang, Zhiyuan Lu, Chengbiao Chu, Qianting He and Xinping Cao

    Citation: Cancer Cell International 2019 19:129

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  39. Content type: Primary research

    Cumulative evidences demonstrated the aberrant overexpression of Small Nucleolar RNA Host Gene 12 (SNHG12) in diverse human cancer. However, the expression status and involvement of SNHG12 in renal cell carcin...

    Authors: Qiguang Chen, Wei Zhou, Shu-qi Du, Da-xin Gong, Jun Li, Jian-bin Bi, Zhen-hua Li, Zhe Zhang, Ze-liang Li, Xian-kui Liu and Chui-ze Kong

    Citation: Cancer Cell International 2019 19:128

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  40. Content type: Primary research

    It is recommended postoperative adjuvant chemotherapy for all rectal cancers undergoing neo-chemoradiotherapy regardless of the final yield pathology. However, the role of adjuvant chemotherapy in pathological...

    Authors: Xiang Hu, Ya-Qi Li, Xiao-ji Ma, Long Zhang, San-Jun Cai and Jun-Jie Peng

    Citation: Cancer Cell International 2019 19:127

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  41. Content type: Primary research

    Ubinuclein-2 (UBN2) is a nuclear protein that interacts with many transcription factors. The molecular role and mechanism of UBN2 in the development and progression of cancers, including colorectal cancer (CRC...

    Authors: Ya-li Zhao, Shen-Rong Zhong, Shi-Hong Zhang, Jia-Xin Bi, Zhi-Yuan Xiao, Shu-Yang Wang, Hong-Li Jiao, Dan Zhang, Jun-Feng Qiu, Ling-Jie Zhang, Cheng-Mei Huang, Xiao-Ling Chen, Yan-Qing Ding, Ya-Ping Ye, Li Liang and Wen-ting Liao

    Citation: Cancer Cell International 2019 19:126

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  42. Content type: Primary research

    Breast cancer (BC) is the most frequent malignancy occurring in women worldwide. Emerging evidence indicates that small nucleolar RNAs (snoRNAs) play a role in tumor development. In the current study, we evalu...

    Authors: Yihan Sun, Endong Chen, Yuefeng Li, Danrong Ye, Yefeng Cai, Qingxuan Wang, Quan Li and Xiaohua Zhang

    Citation: Cancer Cell International 2019 19:125

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  43. Content type: Primary research

    Colon cancer is one of the three common malignant tumors, with lower 5 years survival rate. Akt is an important therapeutic target, while SC66 is a novel allosteric AKT inhibitor, which enhances the therapeuti...

    Authors: Yeying Liu, Yuan Huang, Jie Ding, Nannan Liu, Shuang Peng, Jiangang Wang, Feng Wang and Yingjie Zhang

    Citation: Cancer Cell International 2019 19:124

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  44. Content type: Primary research

    Increasing evidences supported the association between long non-coding RNA (lncRNA) and disease free survival in gastric cancer (GC) patients. The purpose of the current study was to construct and verify a non...

    Authors: Canchang Cheng, Qicai Wang, Minggu Zhu, Kelong Liu and Zhiqiao Zhang

    Citation: Cancer Cell International 2019 19:123

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  45. Content type: Primary research

    Acute myeloid leukemia (AML) pertains to a hematologic malignancy with heterogeneous therapeutic responses. Improvements in risk stratification in AML patients are warranted. MicroRNAs have been associated wit...

    Authors: Mingshan Niu, Yuan Feng, Ninghan Zhang, Tingting Shao, Huihui Zhang, Rong Wang, Yao Yao, Ruosi Yao, Qingyun Wu, Jiang Cao, Xuejiao Liu, Yubo Liu and Kailin Xu

    Citation: Cancer Cell International 2019 19:122

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  46. Content type: Primary research

    Further analysis of phase I trial of the KEYNOTE-001 has shown that previous radiotherapy improves the outcomes of patients with advanced non-small cell lung cancer (NSCLC) who received pembrolizumab treatment...

    Authors: Chao Liu, Qinyong Hu, Bin Xu, Xiaoyu Hu, Huichao Su, Qian Li, Xiaoling Zhang, Jinbo Yue and Jinming Yu

    Citation: Cancer Cell International 2019 19:121

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