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  1. Colorectal cancer (CRC) is one of the most general malignant tumors. Accumulating evidence implied that long non-coding RNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) participated in the t...

    Authors: Changru Fan, Qiulan Yuan, Guifeng Liu, Yuliang Zhang, Maojun Yan, Qingxu Sun and Chaoyu Zhu

    Citation: Cancer Cell International 2020 20:473

    Content type: Primary research

    Published on:

  2. Dysfunction of microRNAs (miRNAs) is a major cause of aberrant expression of inflammatory cytokines and contributes to macrophage polarization. Proinflammatory M1 macrophages promote T helper (Th) 1 responses ...

    Authors: Jiping Rong, Lu Xu, Yinying Hu, Fan Liu, Yanrong Yu, Hongyan Guo, Xudong Ni, Yanqin Huang, Lin Zhao and Zhigang Wang

    Citation: Cancer Cell International 2020 20:470

    Content type: Primary research

    Published on:

  3. Increasing evidence has shown that the transcription factor SOX4 is closely associated with the development and progression of many malignant tumors. However, the effect of SOX4 on breast cancer is unclear. In...

    Authors: Jing Zhang, Chunhua Xiao, Zhenbo Feng, Yun Gong, Baohua Sun, Zhongqi Li, Yimin Lu, Xiaojie Fei, Weizhu Wu, Xiaoping Sun and Lisong Teng

    Citation: Cancer Cell International 2020 20:468

    Content type: Primary research

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  4. Mounting evidence implicates circular RNAs (circRNAs) in various biological processes during cancer progression. Gastric cancer is a main cause of cancer-related deaths worldwide. Herein, we aimed at investiga...

    Authors: Nan Zhou, Hui Qiao, Miaomiao Zeng, Lei Yang, Yongning Zhou and Quanlin Guan

    Citation: Cancer Cell International 2020 20:465

    Content type: Primary research

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  5. N6-methyladenosine (m6A) modification might be closely associated with the genesis and development of gastric cancer (GC). Currently, the evidence established by high-throughput assay for GC-related m6A patterns ...

    Authors: Zhi Lv, Liping Sun, Qian Xu, Chengzhong Xing and Yuan Yuan

    Citation: Cancer Cell International 2020 20:464

    Content type: Primary research

    Published on:

  6. Emerging studies have disclosed long non-coding RNAs (lncRNAs) as pivotal modulators in the progression of prostate cancer (PCa). Current research planned to figure out the involvement of lncRNA nicotinamide n...

    Authors: Changlei Yao, Xianghua Cheng, Xiuquan Guo, Xulou Lu, Fan Bu and Yanfen Xu

    Citation: Cancer Cell International 2020 20:463

    Content type: Primary research

    Published on:

  7. Several studies were conducted to explore the prognostic value of modified Glasgow Prognostic Score (mGPS) in pancreatic cancer, which reported contradictory results. The purpose of this meta-analysis was to s...

    Authors: Huan Zhang, Dianyun Ren, Xin Jin and Heshui Wu

    Citation: Cancer Cell International 2020 20:462

    Content type: Primary research

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  8. Large-scale initiatives like The Cancer Genome Atlas (TCGA) performed genomics studies on predominantly Caucasian kidney cancer. In this study, we aimed to investigate genomics of Chinese clear cell renal cell...

    Authors: Qiang Zhao, Jia Xue, Baoan Hong, Wubin Qian, Tiezhu Liu, Bin Fan, Jie Cai, Yongpeng Ji, Jia Liu, Yong Yang, Qixiang Li, Sheng Guo and Ning Zhang

    Citation: Cancer Cell International 2020 20:461

    Content type: Primary research

    Published on:

  9. LncRNAs act as functional regulators in tumor progression through interacting with various signaling pathways in multiple types of cancer. However, the effect of LINC02418 on colorectal cancer (CRC) progressio...

    Authors: Jun Tian, Peng Cui, Yifei Li, Xuequan Yao, Xiaoyu Wu, Zhirong Wang and Chunsheng Li

    Citation: Cancer Cell International 2020 20:460

    Content type: Primary research

    Published on:

  10. Centromere protein F (CENPF) is a key component of the kinetochore complex involved in mitosis, cell differentiation and cellular response to stresses. However, the alteration of CENPF in response to endoplasm...

    Authors: Tao Shen, Yan Li, Shuang Liang and Zhiguang Chen

    Citation: Cancer Cell International 2020 20:459

    Content type: Primary research

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  11. Radiotherapy is one of the main treatments for pancreatic cancer, but radiation resistance limits its clinical application. As a result, novel therapeutic agents to improve radiosensitivity are urgently needed...

    Authors: Biqin Tan, Rong Dong, Bo Zhang, Youyou Yan, Qingyu Li, Fei Wang and Nengming Lin

    Citation: Cancer Cell International 2020 20:458

    Content type: Primary research

    Published on:

  12. Pancreatic cancer is one of the main causes of tumor-related deaths worldwide because of its low morbidity but extremely high mortality, and is therefore colloquially known as the “king of cancer.” Sudden onse...

    Authors: Yizhi Wang, Li Zhou, Jun Lu, Bolun Jiang, Chengxi Liu, Junchao Guo and Gary Guishan Xiao

    Citation: Cancer Cell International 2020 20:457

    Content type: Review

    Published on:

  13. Cancer immunotherapy has been emerged as a promising strategy for treatment of a broad spectrum of malignancies ranging from hematological to solid tumors. One of the principal approaches of cancer immunothera...

    Authors: Seyed Mohammad Miri, Elham Tafsiri, William Chi Shing Cho and Amir Ghaemi

    Citation: Cancer Cell International 2020 20:456

    Content type: Review

    Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:521

  14. Some studies have investigated the prognostic value exhibited by the Prognostic Nutritional Index (PNI) in patients suffering diffuse large B-cell lymphoma (DLBCL), but varying results were obtained. In order ...

    Authors: Chunyan Luan, Fei Wang, Ning Wei and Baoan Chen

    Citation: Cancer Cell International 2020 20:455

    Content type: Research Article

    Published on:

  15. Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of breast cancer with a bad prognosis. Chemotherapy is still the standard of care for TNBC treatment. Circular RNAs (CircRNAs) have been ...

    Authors: Dongwei Dou, Xiaoyang Ren, Mingli Han, Xiaodong Xu, Xin Ge, Yuanting Gu, Xinxing Wang and Song Zhao

    Citation: Cancer Cell International 2020 20:454

    Content type: Primary research

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  16. It has been well documented that long non-coding RNAs (lncRNAs) regulate numerous characteristics of cancer, including proliferation, migration, metastasis, apoptosis, and even metabolism. LncRNA BCYRN1 (BCYRN...

    Authors: Liu Yang, Yinan Zhang, Jun Bao and Ji-Feng Feng

    Citation: Cancer Cell International 2020 20:453

    Content type: Primary research

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  17. Drug resistance to 5-fluorouracil (5-FU) and recurrence after chemotherapy in colorectal cancer remain a challenge to be resolved for the improvement of patient outcomes. It is recognized that a variety of sec...

    Authors: Siyuan Chang, Jing Huang, Huan Niu, Jing Wang, Yang Si, Zhigang Bai, Shan Cheng and Wei Ding

    Citation: Cancer Cell International 2020 20:452

    Content type: Primary research

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  18. Kejinyan decoction, as an experienced formula of Zhou Zhongying (the Master of Traditional Chinese Medicine) has been widely used in clinic for lung cancer treatment in China, while the anti-lung cancer mechan...

    Authors: Meijuan Chen, Cheng Hu, Qian Gao, Liqiu Li, Ziyu Cheng, Qirui Li, Zhihui Li, Zhaohui Wang, Zejia Mao, Weiqian Tian and Xu Zhang

    Citation: Cancer Cell International 2020 20:451

    Content type: Primary research

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  19. Hexokinase domain component 1 (HKDC1) plays an oncogenic role in certain types of cancer, such as lymphoma, liver cancer, and breast cancer. Previous bioinformatics study revealed that HKDC1 was significantly ...

    Authors: Xinyu Wang, Bowen Shi, Yue Zhao, Qijue Lu, Xiang Fei, Chaojing Lu, Chunguang Li and Hezhong Chen

    Citation: Cancer Cell International 2020 20:450

    Content type: Primary research

    Published on:

  20. Epithelial ovarian cancer (EOC), a subclass of ovarian cancer (OC), is usually diagnosed at advanced stages due to the lack of effective screening means. Mounting reports have disclosed the vitally important r...

    Authors: Deying Wang, Yulan Cui, Aili Xu, Lin Zhao and Peiling Li

    Citation: Cancer Cell International 2020 20:447

    Content type: Primary research

    Published on:

  21. To analyze the clinical efficacy of intraoperative radiotherapy (IORT) after breast-conserving surgery (BCS) in patients with early-stage breast cancer (BC), and to investigate the relationship between its inf...

    Authors: Lin Wang, Minmin Zhu, Yuelong Cui, Xudong Zhang and Guowen Li

    Citation: Cancer Cell International 2020 20:446

    Content type: Primary research

    Published on:

  22. Runt related transcription factor3 (RUNX3) is considered as a tumor suppressor gene (TSG) that functions through the TGF-β dependent apoptosis. Promoter methylation of the CpG islands of RUNX3 and overexpressi...

    Authors: Asad Ur Rehman, Mohammad Askandar Iqbal, Real Sumayya Abdul Sattar, Snigdha Saikia, Mohammad Kashif, Wasif Mohammad Ali, Subhash Medhi, Sundeep Singh Saluja and Syed Akhtar Husain

    Citation: Cancer Cell International 2020 20:445

    Content type: Primary research

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  23. Urological cancers are responsible for thousands of cancer-related deaths around the world. Despite all developments in therapeutic approaches for cancer therapy, the absence of efficient treatments is a criti...

    Authors: Mohammad Hossein Pourhanifeh, Azam Hosseinzadeh, Kobra Bahrampour Juybari and Saeed Mehrzadi

    Citation: Cancer Cell International 2020 20:444

    Content type: Review

    Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:466

  24. The microRNA miR-221-3p has previously been found to be an underlying biomarker of pancreatic cancer. However, the mechanisms of miR-221-3p underlying its role in pancreatic cancer pathogenesis, proliferation ...

    Authors: Xuejiao Wu, Jia Huang, Zilin Yang, Ying Zhu, Yongping Zhang, Jiancheng Wang and Weiyan Yao

    Citation: Cancer Cell International 2020 20:443

    Content type: Primary research

    Published on:

  25. Acute lymphoblastic leukemia (ALL) is an aggressive hematopoietic malignancy that is most commonly observed in children. Alantolactone (ALT) has been reported to exhibit anti-tumor activity in different types ...

    Authors: Ce Shi, Wenjia Lan, Zhenkun Wang, Dongguang Yang, Jia Wei, Zhiyu Liu, Yueqiu Teng, Mengmeng Gu, Tian Yuan, Fenglin Cao, Jin Zhou and Yang Li

    Citation: Cancer Cell International 2020 20:442

    Content type: Primary research

    Published on:

  26. It has reported that long non-coding RNAs (lncRNAs) exerted regulatory functions by targeting specific genes through a competing endogenous RNA (ceRNA) pathway. LncRNA OIP5-AS1 has been identified as a tumor-e...

    Authors: Yu Wang, Lei Dou, Yun Qin, Huiyuan Yang and Peng Yan

    Citation: Cancer Cell International 2020 20:440

    Content type: Primary research

    Published on:

  27. KLF5 is a member of the Kruppel-like factor, subfamily of zinc finger proteins that are involved in cancers. KLF5 functions as a transcription factor and regulates the diverse protein-coding genes (PCGs) in color...

    Authors: Qi Liao, Linbo Chen, Ning Zhang, Yang Xi, Shiyun Hu, Derry Minyao Ng, Fatma Yislam Hadi Ahmed, Guofang Zhao, Xiaoxiang Fan, Yangyang Xie, Xiaoyu Dai, Yanping Jin, Jiaxin Ge, Changzheng Dong, Xinjun Zhang and Junming Guo

    Citation: Cancer Cell International 2020 20:439

    Content type: Primary research

    Published on:

  28. Non-small cell lung cancer (NSCLC) is a deadly human malignancy, and previous studies support the contribution of microRNAs (miRNAs) to cancer assessment. It has been reported that miR-1231 can be used as a bi...

    Authors: Jing Li, Jialiang Xu, Zhijun Cao, Shouzuo Du and Luyu Zhang

    Citation: Cancer Cell International 2020 20:438

    Content type: Primary research

    Published on:

  29. Cholangiocarcinoma (CCA) is a rare tumor that arises from cholangiocytes, the epithelial cells of the bile duct. The tumor is characterized by insidious onset, high degree of malignancy, poor prognosis and hig...

    Authors: Mingzhen Bai, Wenkang Fu, Gang Su, Jie Cao, Long Gao, Chongfei Huang, Haidong Ma, Jinduo Zhang, Ping Yue, Bing Bai, Yanyan Lin, Wenbo Meng and Xun Li

    Citation: Cancer Cell International 2020 20:435

    Content type: Review

    Published on:

  30. The genetic variants of the ARID5B gene have recently been reported to be associated with disease susceptibility and treatment outcome in childhood acute lymphoblastic leukemia (ALL). However, few studies have ex...

    Authors: Minori Tamai, Meixian Huang, Keiko Kagami, Masako Abe, Shinpei Somazu, Tamao Shinohara, Daisuke Harama, Atsushi Watanabe, Koshi Akahane, Kumiko Goi, Kanji Sugita, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto and Takeshi Inukai

    Citation: Cancer Cell International 2020 20:434

    Content type: Primary research

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  31. Gastric cancer (GC) is one of the high-risk cancers that lacks effective methods for prognosis prediction. Therefore, we searched for immune cells related to the prognosis of GC and studied the role of related...

    Authors: Gang Hu, Ningjie Sun, Jiansong Jiang and Xiansheng Chen

    Citation: Cancer Cell International 2020 20:433

    Content type: Primary research

    Published on:

  32. Lung adenocarcinoma is metastatic cancer with a high mortality rate. Circular RNAs (circRNAs) are a type of noncoding RNA and play a vital role in cancer progression. However, the expression and function of ci...

    Authors: Yongyong Yan, Jiantian Yang, Janak L. Pathak, Haiyan Wang, Jun Zha, Yongxiang Wei, Haibo Tang and Linhu Ge

    Citation: Cancer Cell International 2020 20:432

    Content type: Primary research

    Published on:

  33. Circular RNA (circRNA), an novel type of non-coding RNA, could interact with miRNA and protein molecules to regulate the occurrence and progression of hepatocellular carcinoma (HCC). However, little is known a...

    Authors: Yabin Yu, Suyang Han, Meng Li, Yan Song and Fuzhen Qi

    Citation: Cancer Cell International 2020 20:431

    Content type: Primary research

    Published on:

  34. Growing evidence has revealed the involvement of circular RNAs (circRNAs) in numerous carcinogenesis. However, the role of circRNAs in the cancer biology of colorectal cancer (CRC) remains vague.

    Authors: Jiabin Du, Jianhua Xu, Junxing Chen, Weinan Liu, Pengcheng Wang and Kai Ye

    Citation: Cancer Cell International 2020 20:430

    Content type: Primary research

    Published on:

  35. Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 receptor (TLR/ILR) superfamily. The...

    Authors: Jiaoduan Li, Nian Liu, Ling Tang, Bei Yan, Xiang Chen, Jianglin Zhang and Cong Peng

    Citation: Cancer Cell International 2020 20:429

    Content type: Review

    Published on:

  36. Glioma is one prevalent malignant tumor originates from the central nervous system. Dysregulation of long non-coding RNAs (lncRNAs) has been found to be a molecular signature behind the pathology of a variety ...

    Authors: Jianguo Qi, Zhengrui Wang, Zhensheng Zhao and Lijun Liu

    Citation: Cancer Cell International 2020 20:428

    Content type: Primary research

    Published on:

  37. Circular RNAs (circRNAs) are a novel class of noncoding RNAs. Increasing evidence indicates that circRNAs play an important role in the occurrence and development of tumors. However, the role of circRNA hsa_ci...

    Authors: Liang Jing, Junhui Wu, Xiaocheng Tang, Min Ma, Fei Long, Buning Tian and Changwei Lin

    Citation: Cancer Cell International 2020 20:427

    Content type: Primary research

    Published on:

  38. The methylation of the CpG islands of the LINE-1 promoter is a tight control mechanism on the function of mobile elements. However, simultaneous quantification of promoter methylation and transcription of LINE...

    Authors: Milad Shademan, Khadijeh Zare, Morteza Zahedi, Hooman Mosannen Mozaffari, Hadi Bagheri Hosseini, Kamran Ghaffarzadegan, Ladan Goshayeshi and Hesam Dehghani

    Citation: Cancer Cell International 2020 20:426

    Content type: Primary research

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  39. Dysregulation of fatty acid (FA) metabolism is involved in hepatocellular carcinoma (HCC) development. Non-POU domain-containing octamer binding protein (NONO), known as the component of nuclear paraspeckles, ...

    Authors: Hongda Ding, Junpeng Liu, Caibin Wang and Yang Su

    Citation: Cancer Cell International 2020 20:425

    Content type: Primary research

    Published on:

  40. Cervical cancer (CC) is the one of most common malignant gynecological tumors, which is characterized with the high mortality and recurrence rate. Previous studies have elucidated the oncogenic role of small n...

    Authors: Jin Liu, Xiaojiao Liu and Rong Li

    Citation: Cancer Cell International 2020 20:424

    Content type: Primary research

    Published on:

  41. Krüppel-like factor 8 (KLF8), a cancer-promoting factor that regulates critical gene transcription and cellular cancer-related events, has been implicated in tumor development and progression. However, the fun...

    Authors: Ming-Da Wang, Hao Xing, Chao Li, Lei Liang, Han Wu, Xin-Fei Xu, Li-Yang Sun, Meng-Chao Wu, Feng Shen and Tian Yang

    Citation: Cancer Cell International 2020 20:422

    Content type: Primary research

    Published on:

  42. Glioblastoma (GBM) is a common and aggressive primary brain tumor, and the prognosis for GBM patients remains poor. This study aimed to identify the key genes associated with the development of GBM and provide...

    Authors: Wei-cheng Lu, Hui Xie, Ce Yuan, Jin-jiang Li, Zhao-yang Li and An-hua Wu

    Citation: Cancer Cell International 2020 20:419

    Content type: Primary research

    Published on:

  43. Immunocompetent animal models are required to study tumor-host interactions, immunotherapy, and immunotherapeutic combinations, however the currently available immunocompetent lung cancer models have substanti...

    Authors: Kyle Nolan, Gregory Verzosa, Tim Cleaver, Darinee Tippimanchai, Lisa N. DePledge, Xiao-Jing Wang, Christian Young, Anh Le, Robert Doebele, Howard Li and Stephen P. Malkoski

    Citation: Cancer Cell International 2020 20:417

    Content type: Primary research

    Published on:

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