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  1. Content type: Primary research

    Previous studies have demonstrated that the expression of homeobox8 (HOXB8) is higher in colorectal cancer (CRC) tissues than in normal tissues; however, the precise role of HOXB8 in human CRC cells remains to...

    Authors: Tingting Wang, Feiyan Lin, Xuecheng Sun, Lei Jiang, Ruibo Mao, Shenyue Zhou, Wenjing Shang, Ruichun Bi, Fengying Lu and Shaotang Li

    Citation: Cancer Cell International 2019 19:3

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  2. Content type: Primary research

    The estrogen metabolite 2-methoxyestradiol (2ME2) and a number of synthesised derivatives have been shown to bind to microtubules thereby arresting cancer cells in mitosis which leads to apoptosis. In interpha...

    Authors: Rustelle Janse van Vuuren, Mandie Botes, Tamarin Jurgens, Anna Margaretha Joubert and Iman van den Bout

    Citation: Cancer Cell International 2019 19:1

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  3. Content type: Primary research

    ESPN (Espin), an actin filament-binding protein, plays an important role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializati...

    Authors: Shau-Hsuan Li, Hung-I Lu, Wan-Ting Huang, Yen-Hao Chen, Chien-Ming Lo, Ya-Chun Lan, Wei-Che Lin, Hsin-Ting Tsai and Chang-Han Chen

    Citation: Cancer Cell International 2018 18:219

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  4. Content type: Primary research

    Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it’s essential to...

    Authors: Jun Shang, Qian Song, Zuyi Yang, Xiaoyan Sun, Meijuan Xue, Wenjie Chen, Jingcheng Yang and Sihua Wang

    Citation: Cancer Cell International 2018 18:218

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  5. Content type: Review

    Many studies have investigated the prognostic role of biomarkers in colorectal liver metastases (CRLM). However, no biomarker has been established in routine clinical practice. The aim of this study was to scr...

    Authors: William Torén, Daniel Ansari and Roland Andersson

    Citation: Cancer Cell International 2018 18:217

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  6. Content type: Primary research

    Metastatic cancer to bone is well-known to produce extreme pain. It has been suggested that the magnitude of this perceived pain is associated with disease progression and poor prognosis. These data suggest a ...

    Authors: Silvia Gutierrez and M. Danilo Boada

    Citation: Cancer Cell International 2018 18:216

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  7. Content type: Primary research

    Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecula...

    Authors: Xin-xin Cao, Hao Cai, Yue-ying Mao, Qi Wu, Lu Zhang, Dao-bin Zhou and Jian Li

    Citation: Cancer Cell International 2018 18:215

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    The Correction to this article has been published in Cancer Cell International 2019 19:14

  8. Content type: Primary research

    Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors. The rapid progression of PDAC results in an advanced stage of patients when diagnosed. However, the dynamic molecular mechanism und...

    Authors: Zongfu Pan, Lu Li, Qilu Fang, Yiwen Zhang, Xiaoping Hu, Yangyang Qian and Ping Huang

    Citation: Cancer Cell International 2018 18:214

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  9. Content type: Primary research

    Tumor suppressor epigenetic silencing plays an important role in non-small cell lung cancer (NSCLC) development and progression. Previously, the expression of speckle-type POZ protein (SPOP) has been found to ...

    Authors: Sumei Yao, Xinming Chen, Jinliang Chen, Yangbo Guan, Yifei Liu, Jianrong Chen and Xuedong Lv

    Citation: Cancer Cell International 2018 18:213

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  10. Content type: Primary research

    CXC chemokine receptor 7 (CXCR7) is frequently overexpressed in a variety of tumors. Nevertheless, whether CXCR7 can be used as a tumor prognosis marker has not been systematically assessed. The current meta-a...

    Authors: Huiqian Fan, Weijun Wang, Jingjing Yan, Li Xiao and Ling Yang

    Citation: Cancer Cell International 2018 18:212

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  11. Content type: Primary research

    Glioma is the most common highly aggressive, primary adult brain tumour. Clinical data show that therapeutic approaches cannot reach the expectations in patients, thus gliomas are mainly incurable diseases. Tu...

    Authors: Gábor Petővári, Zoltán Hujber, Ildikó Krencz, Titanilla Dankó, Noémi Nagy, Fanni Tóth, Regina Raffay, Katalin Mészáros, Hajnalka Rajnai, Enikő Vetlényi, Krisztina Takács-Vellai, András Jeney and Anna Sebestyén

    Citation: Cancer Cell International 2018 18:211

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  12. Content type: Primary research

    It has been demonstrated that bufadienolides exert potent anti-cancer activity in various tumor types. However, the mechanisms that underlie their anti-cancer properties remain unclear. Yes-associated protein,...

    Authors: Li-Juan Deng, Ming Qi, Qun-Long Peng, Min-Feng Chen, Qi Qi, Jia-Yan Zhang, Nan Yao, Mao-Hua Huang, Xiao-Bo Li, Yin-Hui Peng, Jun-Shan Liu, Deng-Rui Fu, Jia-Xu Chen, Wen-Cai Ye and Dong-Mei Zhang

    Citation: Cancer Cell International 2018 18:209

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  13. Content type: Primary research

    TRIP13 is highly expressed in several cancers and is closely connected with cancer progression. However, its roles on the growth and metastasis of hepatocellular carcinoma (HCC), and the underlying mechanism a...

    Authors: Jianning Yao, Xuexiu Zhang, Jiaheng Li, Dongyao Zhao, Bing Gao, Haining Zhou, Shilin Gao and Lianfeng Zhang

    Citation: Cancer Cell International 2018 18:208

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  14. Content type: Primary research

    To investigate the potential prognostic role of pre-treatment prognostic nutritional index (PNI) in urinary cancers.

    Authors: Feng Qi, Xiang Zhou, Yi Wang, Yamin Wang, Yichun Wang, Qijie Zhang, Rong Cong, Jie Yang and Ninghong Song

    Citation: Cancer Cell International 2018 18:207

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  15. Content type: Primary research

    Chromophobe renal cell carcinoma (ChRCC) is the second common subtype of non-clear cell renal cell carcinoma (nccRCC), which accounting for 4–5% of renal cell carcinoma (RCC). However, there is no effective bi...

    Authors: Xiaomao Yin, Jianfeng Wang and Jin Zhang

    Citation: Cancer Cell International 2018 18:206

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  16. Content type: Hypothesis

    The origin of cancer cells is the most fundamental yet unresolved problem in cancer research. Cancer cells are thought to be transformed from the normal cells. However, recent studies reveal that the primary c...

    Authors: Qing-lin Dong and Xiang-ying Xing

    Citation: Cancer Cell International 2018 18:205

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  17. Content type: Primary research

    Homeobox C6 (HOXC6) plays a part in malignant progression of some tumors. However, the expression of HOXC6 and its clinical significance remains unclear in cervical carcinoma (CC). The purpose of this study is...

    Authors: Feng Zhang, Chen-Chen Ren, Ling Liu, Yan-Nan Chen, Li Yang and Xiao-An Zhang

    Citation: Cancer Cell International 2018 18:204

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  18. Content type: Primary research

    Colorectal cancer (CRC) is one of the most lethal malignancies. Tripartite Motif Containing 14 (TRIM14) is a member of TRIM family proteins, which are involved in the pathogenesis of various cancers. This stud...

    Authors: Zhonghai Jin, Hongguang Li, Xiaofei Hong, Guangrong Ying, Xiaofeng Lu, Lilei Zhuang and Shenbao Wu

    Citation: Cancer Cell International 2018 18:202

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  19. Content type: Review

    There is increasing evidence that inflammation-based biomarkers are associated with tumor microenvironment which plays important roles in cancer progression. A high lymphocyte-to-monocyte ratio (LMR), has been...

    Authors: Yiming Mao, Donglai Chen, Shanzhou Duan, Yuhuan Zhao, Changjiang Wu, Feng Zhu, Chang Chen and Yongbing Chen

    Citation: Cancer Cell International 2018 18:201

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  20. Content type: Primary research

    Apoptosis and autophagy are known to play important roles in cancer development. It has been reported that HVJ-E induces apoptosis in cancer cells, thereby inhibiting the development of tumors. To define the m...

    Authors: Tao Wang, Ning Yu, Miao Qian, Jie Feng, Shuyang Cao, Jun Yin and Quan Zhang

    Citation: Cancer Cell International 2018 18:200

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  21. Content type: Primary research

    To get insight into the molecular mechanisms underlying the anti-tumor activity of S-adenosyl-l-methionine (AdoMet), we analyzed AdoMet-induced modulation of microRNAs (miRNAs) expression profile in MCF-7 breast ...

    Authors: Concetta Paola Ilisso, Donatella Delle Cave, Laura Mosca, Martina Pagano, Alessandra Coppola, Luigi Mele, Michele Caraglia, Giovanna Cacciapuoti and Marina Porcelli

    Citation: Cancer Cell International 2018 18:197

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  22. Content type: Primary research

    RNA editing by adenosine deaminases acting on RNA (ADARs) converts adenosines to inosines (A-to-I) in RNA, that alters gene expression and generates protein diversity. Dysregulation of A-to-I editing has been ...

    Authors: Ying Zhang, Kuanyu Wang, Zheng Zhao, Si Sun, Kenan Zhang, Ruoyu Huang, Fan Zeng and Huimin Hu

    Citation: Cancer Cell International 2018 18:196

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  23. Content type: Primary research

    MicroRNAs play crucial roles in tumorigenesis and tumor progression. miR-770 has been reported to be downregulated in several cancers and affects cancer cell proliferation, apoptosis, metastasis and drug resis...

    Authors: Jun-feng Zhang, Jian-shui Zhang, Zhao-hua Zhao, Peng-bo Yang, Sheng-feng Ji, Nan Li, Qin-dong Shi, Jing Tan, Xi Xu, Cang-bao Xu and Ling-yu Zhao

    Citation: Cancer Cell International 2018 18:195

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  24. Content type: Primary research

    As one of the most common malignant tumors in humans, lung cancer has experienced a gradual increase in morbidity and mortality. This study examined prognosis-related methylation-driven genes specific to lung ...

    Authors: Chundi Gao, Jing Zhuang, Huayao Li, Cun Liu, Chao Zhou, Lijuan Liu and Changgang Sun

    Citation: Cancer Cell International 2018 18:194

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  25. Content type: Primary research

    Anoikis resistance has been demonstrated to facilitate distant metastases of cancers. MicroRNA-133b (miR-133b) is found to be down-regulated in various tumors, including esophageal squamous cell carcinoma (ESC...

    Authors: Jin-Feng Zhu, Yi Liu, He Huang, Li Shan, Zhi-Gang Han, Jun-Yuan Liu, Ying-Long Li, Xiang Dong and Wei Zeng

    Citation: Cancer Cell International 2018 18:193

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  26. Content type: Primary research

    The response of soft tissue sarcomas to cytotoxic chemotherapy is inconsistent. Biomarkers of chemoresistance or chemosensitivity are needed in order to identify appropriate patients for treatment. Given that ...

    Authors: Yike Bing, Zacharie Wund, Tina Abratte, Lucia Borlle, Susie Kang, Teresa Southard and Kelly R. Hume

    Citation: Cancer Cell International 2018 18:192

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  27. Content type: Primary research

    Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune respons...

    Authors: Bangshun He, Tao Xu, Bei Pan, Yuqin Pan, Xuhong Wang, Jingwu Dong, Huiling Sun, Xueni Xu, Xiangxiang Liu and Shukui Wang

    Citation: Cancer Cell International 2018 18:191

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  28. Content type: Primary research

    Rhabdoid tumors (RTs) are aggressive tumors that occur most frequently in children under 2 years old, which often invade kidney (KRTs) and Center Nervous System, named Atypical teratoid/rhabdoid tumors (AT/RTs...

    Authors: Yanming Ren, Chuanyuan Tao, Xiliang Wang and Yan Ju

    Citation: Cancer Cell International 2018 18:190

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  29. Content type: Primary research

    2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical applicatio...

    Authors: Mandie Botes, Tamarin Jurgens, Zohreh Riahi, Michelle Visagie, Rustelle Janse van Vuuren, Anna Margaretha Joubert and Iman van den Bout

    Citation: Cancer Cell International 2018 18:188

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  30. Content type: Primary research

    Accumulating evidence have indicated that regulatory T cells (Tregs) play an essential role in T cell-mediated immune response and development of multiple myeloma (MM). CD4+FoxP3+ T cells are composed of three ph...

    Authors: Ji-nuo Wang, Xin-xin Cao, Ai-lin Zhao, Hao Cai, Xuan Wang and Jian Li

    Citation: Cancer Cell International 2018 18:187

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  31. Content type: Primary research

    MiRNAs was recognized as vital regulators involved in cancer development. Radioresistance remains a major obstacle for effective treatment of cancers. The mechanisms on the miRNA-mediated radioresistance of ca...

    Authors: Chunbao Zang, Fangfang Zhao, Lei Hua and Youguang Pu

    Citation: Cancer Cell International 2018 18:186

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  32. Content type: Primary research

    Lung cancer is the leading cause of cancer deaths in the world. The major histopathological subtype of lung cancer is non-small cell lung cancer (NSCLC). Platinum-based therapy is the standard of care for pati...

    Authors: Heather E. Kapperman, Alicia A. Goyeneche and Carlos M. Telleria

    Citation: Cancer Cell International 2018 18:185

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  33. Content type: Primary research

    miRNA clusters are widely expressed across species, accumulating evidence has illustrated that miRNA cluster functioned more efficiently than single miRNA in cancer oncogenesis. It is likely that miRNA cluster...

    Authors: Zhikui Gao, Peng Zhang, Ming Xie, Han Gao, Lihong Yin and Ran Liu

    Citation: Cancer Cell International 2018 18:184

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  34. Content type: Primary research

    Cervical cancer (CC) is one of the most common cancers among females worldwide. Spindle and kinetochore-associated complex subunit 3 (SKA3), located on chromosome 13q, was identified as a novel gene involved i...

    Authors: Rong Hu, Ming-qing Wang, Wen-bo Niu, Yan-jing Wang, Yang-yang Liu, Ling-yu Liu, Ming Wang, Juan Zhong, Hai-yan You, Xiao-hui Wu, Ning Deng, Lu Lu and Lian-bo Wei

    Citation: Cancer Cell International 2018 18:183

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  35. Content type: Primary research

    Nuclear transcription factor kappa B (NF-κB) subunits exhibit crucial roles in tumorigenesis and chemo-sensitivity. Recent studies suggest that RelB, the key subunit of the alternative NF-κB pathway, plays a c...

    Authors: Xiaojun Zhou, Zhili Shan, Hengying Yang, Jingjing Xu, Wenjing Li and Feng Guo

    Citation: Cancer Cell International 2018 18:181

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  36. Content type: Primary research

    With the increasing popularity of water-pipe smoking (WPS), it is critical to comprehend how WPS may affect women’s health. The main goal of this study is to identify the potential outcome of WPS on human brea...

    Authors: Khaled W. Sadek, Mahmoud Y. Haik, Anas A. Ashour, Tahira Baloch, Tahar Aboulkassim, Amber Yasmeen, Semir Vranic, Asad Zeidan and Ala-Eddin Al Moustafa

    Citation: Cancer Cell International 2018 18:180

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  37. Content type: Review

    Some progresses have been made in research of long non-coding RNA (hereunder referred to as LncRNA) related to breast cancer. Lots of data about LncRNA transcription concerning breast cancer have been obtained...

    Authors: Xu Bin, Yang Hongjian, Zhang Xiping, Chen Bo, Yang Shifeng and Tang Binbin

    Citation: Cancer Cell International 2018 18:179

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  38. Content type: Primary research

    Deregulated Hippo signaling has been uncovered to be intricately involved in tumorigenesis. Transcriptional factor TEADs serve as key mediators of Hippo signaling and have been increasingly appreciated as puta...

    Authors: Wei Zhang, Jin Li, Yaping Wu, Han Ge, Yue Song, Dongmiao Wang, Hua Yuan, Hongbing Jiang, Yanling Wang and Jie Cheng

    Citation: Cancer Cell International 2018 18:178

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  39. Content type: Primary research

    Sorafenib is the standard targeted drug used to treat hepatocellular carcinoma (HCC), but the therapeutic response between individuals varies markedly. Recently, cytokine-based immunotherapy has been a topic o...

    Authors: Xiaoyan Ding, Wei Sun and Jinglong Chen

    Citation: Cancer Cell International 2018 18:176

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  40. Content type: Commentary

    Gao-Min Liu and Yao-Ming Zhang recently published a review entitled «Targeting FBPase is an emerging novel approach for cancer therapy» (Liu and Zhang in Cancer Cell Int 18:36, 2018). In this paper, the authors h...

    Authors: Philippe Icard, Ludovic Fournel, Antoine Coquerel, Joseph Gligorov, Marco Alifano and Hubert Lincet

    Citation: Cancer Cell International 2018 18:175

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  41. Content type: Primary research

    Pancreatic cancer is characterized by its unsatisfying early detection rate, rapid disease progression and poor prognosis. Further studies on molecular mechanism and novel predictive biomarkers for pancreatic ...

    Authors: Defeng Sun, Haoyi Jin, Jun Zhang and Xiaodong Tan

    Citation: Cancer Cell International 2018 18:174

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  42. Content type: Primary research

    Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis. Unfortunately, the mechanisms underlying these pr...

    Authors: Yujie Feng, Xiao Hu, Guangwei Liu, Lianfang Lu, Wei Zhao, Fangzhen Shen, Kai Ma, Chuandong Sun, Chengzhan Zhu and Bingyuan Zhang

    Citation: Cancer Cell International 2018 18:173

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