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  1. Hepatocellular carcinoma (HCC) is an aggressive cancer with a high rate of death globally. The use of bioinformatics may help to identify immune cell-related genes both as targets for potential immunotherapies...

    Authors: Chen Xue, Xinyu Gu and Lanjuan Li

    Citation: Cancer Cell International 2021 21:471

    Content type: Primary research

    Published on:

  2. Understanding the molecular mechanisms of cancer biology introduces targeted therapy as a complementary method along with other conventional therapies. Recombinant immunotoxins are tumor specific antibodies th...

    Authors: Reza Mahmoudi, Hassan Dianat-Moghadam, Mansour Poorebrahim, Samaneh Siapoush, Vahdat Poortahmasebi, Reza Salahlou and Mohammad Rahmati

    Citation: Cancer Cell International 2021 21:470

    Content type: Review

    Published on:

  3. Signal transducer and activator of transcription 3 (STAT3) induces breast cancer malignancy. Recent clinical and preclinical studies have demonstrated an association between overexpressed and activated STAT3 a...

    Authors: Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Ali Mohammad Pourbagher-Shahri and Saeed Samarghandian

    Citation: Cancer Cell International 2021 21:468

    Content type: Review

    Published on:

  4. Definitive chemoradiotherapy (dCRT) is one of the standard treatments for esophageal squamous cell carcinoma (ESCC), but local recurrence is the main cause of treatment failure. The changes in apoptosis and au...

    Authors: Hu Qiu, Haixia Song, Man Luo, Shaobo Ke, Wei Shi, Jiamei Chen, Wensi Zhao, Hesheng Luo and Yongshun Chen

    Citation: Cancer Cell International 2021 21:466

    Content type: Primary research

    Published on:

  5. Interferon-alpha (IFN-α) is a general therapeutic regimen to be utilized in hepatocellular carcinoma (HCC). However, regulatory mechanisms of IFN-α on competing endogenous RNAs (ceRNAs) level in anti-HCC relap...

    Authors: Yibin Wu, Longrong Wang, Xiaoshuang Wang, Yiming Zhao, Anrong Mao, Ning Zhang, Jiamin Zhou, Qi Pan, Weiping Zhu and Lu Wang

    Citation: Cancer Cell International 2021 21:464

    Content type: Primary research

    Published on:

  6. LYRM4 is necessary to maintain the stability and activity of the human cysteine desulfurase complex NFS1-LYRM4-ACP. The existing experimental results indicate that cancer cells rely on the high expression of N...

    Authors: Yilin Pang, Guoqiang Tan, Xunjun Yang, Yuanshan Lin, Yao Chen, Jinping Zhang, Ting Xie, Huaibin Zhou, Jun Fang, Qiongya Zhao, Xiaojun Ren, Jianghui Li, Jianxin Lyu and Zheng Wang

    Citation: Cancer Cell International 2021 21:463

    Content type: Primary research

    Published on:

  7. Accumulating evidence indicates that dysregulation of miR-182-5p can serve as diagnostic and prognostic biomarkers for some cancers, whereas the role of miR-182-5p has not been explored in nasopharyngeal carci...

    Authors: Gang Wang, Fangzheng Zhou, Tong Ou, Haiyan Sun, Zhirui Shan, Yingshen Lu, Gui Chen, Simin Yuan, Xiaowen Zhang and Song Wu

    Citation: Cancer Cell International 2021 21:462

    Content type: Primary research

    Published on:

  8. New effective drugs for prostate cancer (PCa) treatment are urgently needed. Avasimibe was recently identified as a promising drug for anticancer therapies. The main purpose of this study was to explore the ef...

    Authors: Kangping Xiong, Gang Wang, Tianchen Peng, Fenfang Zhou, Siming Chen, Wei Liu, Lingao Ju, Yu Xiao, Kaiyu Qian and Xinghuan Wang

    Citation: Cancer Cell International 2021 21:461

    Content type: Primary research

    Published on:

  9. Autophagy is believed to participate in embryonic development, but whether the expression of autophagy-associated genes undergoes changes during the development of human embryonic kidneys remains unknown.

    Authors: Chen Wen-jin, Pan Xiu-wu, Chu Jian, Xu Da, Chen Jia-xin, Chen Wei-jie, Wang Lin-hui and Cui Xin-gang

    Citation: Cancer Cell International 2021 21:460

    Content type: Primary research

    Published on:

  10. Antisense long non-coding RNAs (antisense lncRNAs), transcribed from the opposite strand of genes with either protein coding or non-coding function, were reported recently to play a crucial role in the process...

    Authors: Biao Liu, Wei Xiang, Jiahao Liu, Jin Tang, Jinrong Wang, Bin Liu, Zhi Long, Long Wang, Guangming Yin and Jianye Liu

    Citation: Cancer Cell International 2021 21:459

    Content type: Review

    Published on:

  11. Immunotherapy has shown promising efficacy in patients with nasopharyngeal carcinoma (NPC). Lymphocyte activating 3 gene (LAG-3) represents a significant immune target, however, its relationship with NPC remai...

    Authors: Fan Luo, Jiaxin Cao, Feiteng Lu, Kangmei Zeng, Wenjuan Ma, Yan Huang, Li Zhang and Hongyun Zhao

    Citation: Cancer Cell International 2021 21:458

    Content type: Primary research

    Published on:

  12. In recent years, there have been many studies on the relationship between DLGAP5 and different types of cancers, yet there is no pan-cancer analysis of DLGAP5. Therefore, this study aims to analyze the roles o...

    Authors: Neng Tang, Xiaolin Dou, Xing You, Qiman Shi, Mujing Ke and Guodong Liu

    Citation: Cancer Cell International 2021 21:457

    Content type: Primary research

    Published on:

  13. The regulatory roles of long non-coding RNA (lncRNA) CRNDE in temozolomide (TMZ) chemoresistance to glioblastoma multiforme (GBM) are still poorly understood. Therefore, the function, characteristics, and poss...

    Authors: Zijin Zhao, Miaomiao Liu, Wenyong Long, Jian Yuan, Haoyu Li, Chi Zhang, Guodong Tang, Weixi Jiang, Xianrui Yuan, Minghua Wu and Qing Liu

    Citation: Cancer Cell International 2021 21:456

    Content type: Primary research

    Published on:

  14. Comprehensive analysis of omics data, such as genome, transcriptome, proteome, metabolome, and interactome, is a crucial technique for elucidating the complex mechanism of cancer onset and progression. Recentl...

    Authors: Ichidai Tanaka, Taiki Furukawa and Masahiro Morise

    Citation: Cancer Cell International 2021 21:454

    Content type: Review

    Published on:

  15. Melanoma is an extremely aggressive type of skin cancer and experiencing a expeditiously rising mortality in a current year. Exploring new potential prognostic biomarkers and therapeutic targets of melanoma ar...

    Authors: Jinfang Liu, Zijian Zhou, Ling Ma, Chujun Li, Yu Lin, Ting Yu, Ji-Fu Wei, Lingjun Zhu and Gang Yao

    Citation: Cancer Cell International 2021 21:453

    Content type: Primary research

    Published on:

  16. Lung adenocarcinoma (LUAD) remains one of the world’s most known aggressive malignancies with a high mortality rate. Molecular biological analysis and bioinformatics are of great importance as they have recent...

    Authors: Aisha Al-Dherasi, Yuwei Liao, Sultan Al-Mosaib, Rulin Hua, Yichen Wang, Ying Yu, Yu Zhang, Xuehong Zhang, Raeda Jalayta, Haithm Mousa, Abdullah Al-Danakh, Fawze Alnadari, Marwan Almoiliqy, Salem Baldi, Leming Shi, Dekang Lv…

    Citation: Cancer Cell International 2021 21:451

    Content type: Primary research

    Published on:

  17. Taking advantage of nanobodies (Nbs) in immunotherapy, we investigated the cytotoxicity of Nb-based chimeric antigen receptor T cells (Nb CAR-T) against lymphoma cells.

    Authors: Hongxia Wang, Liyan Wang, Yanning Li, Guangqi Li, Xiaochun Zhang, Dan Jiang, Yanting Zhang, Liyuan Liu, Yuankui Chu and Guangxian Xu

    Citation: Cancer Cell International 2021 21:450

    Content type: Primary research

    Published on:

  18. An increasing number of studies have reported a significant association between long non-coding RNAs (lncRNAs) dysregulation and pancreatic cancers. In the present study, we aimed to gather articles to evaluat...

    Authors: Elahe Seyed Hosseini, Ali Nikkhah, Amir Sotudeh, Marziyeh Alizadeh Zarei, Fatemeh Izadpanah, Hossein Nikzad and Hamed Haddad Kashani

    Citation: Cancer Cell International 2021 21:447

    Content type: Review

    Published on:

  19. Processed extracts from toad skin and parotoid gland have long been used to treat various illnesses including cancer in many Asian countries. Recent studies have uncovered a family of bufadienolides as the res...

    Authors: Jiajing Niu, Jiamei Wang, Qi Zhang, Zhihua Zou and Yushuang Ding

    Citation: Cancer Cell International 2021 21:446

    Content type: Primary research

    Published on:

  20. Glioma is the most common malignant primary brain tumour in adults. Despite improvements in neurosurgery and radiotherapy, the prognosis of glioma patients remains poor. One of the main limitations is that the...

    Authors: Zheng Bian, Wei Ji, Bin Xu, Zhengyuan Huo, Hui Huang, Jin Huang, Jiantong Jiao, Junfei Shao and Xiaolu Zhang

    Citation: Cancer Cell International 2021 21:445

    Content type: Review

    Published on:

  21. H. pylori infection is the main risk factor for gastric cancer. In this study, we investigated H. pylori-mediated activation of STAT3 and NF-κB in gastric cancer, using in vitro and in vivo models.

    Authors: Mohammed Soutto, Nadeem Bhat, Shayan Khalafi, Shoumin Zhu, Julio Poveda, Monica Garcia-Buitrago, Alexander Zaika and Wael El-Rifai

    Citation: Cancer Cell International 2021 21:444

    Content type: Primary research

    Published on:

  22. Lung cancer has the highest case fatality rate among cancers because of uncontrolled proliferation and early metastasis of cancer cells in the lung tissue. This study aimed to clarify the role of the non-SMC c...

    Authors: Yun Wu, Ying Lin, Junfan Pan, Xunwei Tu, Yiquan Xu, Hongru Li and Yusheng Chen

    Citation: Cancer Cell International 2021 21:443

    Content type: Primary research

    Published on:

  23. Hepatocellular carcinoma (HCC) remains one of the most common malignant neoplasms. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) plays a key role in the lipid remodelling and is correlated with various neopl...

    Authors: Rong-Quan He, Jian-Di Li, Xiu-Fang Du, Yi-Wu Dang, Lin-Jie Yang, Zhi-Guang Huang, Li-Min Liu, Liu-Feng Liao, Hong Yang and Gang Chen

    Citation: Cancer Cell International 2021 21:442

    Content type: Primary research

    Published on:

  24. Previous studies have revealed the key functions of N6-methyladenosine (m6A) modification in breast cancer (BC). MALAT1 as a highly m6A modified lncRNA associated with cancer development and metastasis, but th...

    Authors: Chengpeng Zhao, Xiaoling Ling, Yunxia Xia, Bingxue Yan and Quanlin Guan

    Citation: Cancer Cell International 2021 21:441

    Content type: Primary research

    Published on:

  25. Endometrial carcinoma (EC) is one common gynecological tumor, threatening physical and psychological health of females. Huge amount of essays indicated that long non-coding RNAs (lncRNAs) were widely reported ...

    Authors: Minglin Liang, Hongbo Wang, Cong Liu, Tao Lei and Jie Min

    Citation: Cancer Cell International 2021 21:440

    Content type: Primary research

    Published on:

  26. Cancer as one of the leading causes of human deaths has always been one of the main health challenges in the world. Despite recent advances in therapeutic and diagnostic methods, there is still a high mortalit...

    Authors: Meysam Moghbeli, Amir Sadra Zangouei, Zahra Nasrpour Navaii and Negin Taghehchian

    Citation: Cancer Cell International 2021 21:439

    Content type: Review

    Published on:

  27. Growing evidence indicates a significant role of long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) in ovarian cancer, a frequently occurring malignant tumor in women; however, the pos...

    Authors: Lili Yin and Yu Wang

    Citation: Cancer Cell International 2021 21:437

    Content type: Primary research

    Published on:

  28. We previously demonstrated that nuclear BCL10 translocation participates in the instigation of NF-κB in breast cancer and lymphoma cell lines. In this study, we assessed whether nuclear BCL10 translocation is ...

    Authors: Sung-Hsin Kuo, Shih-Hung Yang, Ming-Feng Wei, Hsiao-Wei Lee, Yu-Wen Tien, Ann-Lii Cheng and Kun-Huei Yeh

    Citation: Cancer Cell International 2021 21:436

    Content type: Primary research

    Published on:

  29. Ovarian cancer (OC) is one of the most common malignant tumors in women. OC is associated with the activation of oncogenes, the inactivation of tumor suppressor genes, and the activation of abnormal cell signa...

    Authors: Weiwei Xie, Huizhen Sun, Xiaoduan Li, Feikai Lin, Ziliang Wang and Xipeng Wang

    Citation: Cancer Cell International 2021 21:434

    Content type: Review

    Published on:

  30. Encouraged by the goal of developing an effective treatment strategy for prostate cancer, this study explored the mechanism involved in metformin-mediated inhibition of AR-negative prostate cancer.

    Authors: Chunyang Chen, He Wang, Xinyu Geng, Dongze Zhang, Zhengyu Zhu, Guangbo Zhang and Jianquan Hou

    Citation: Cancer Cell International 2021 21:404

    Content type: Primary research

    Published on:

  31. Pancreatic cancer (PC) is one of the most lethal cancer types with high degree of malignancy and poor prognosis. Recent studies have shown that long non-coding RNAs (lncRNAs) were associated with the initiatio...

    Authors: Xin Yin, Jingyan Yang, Jintian Chen, Ruiqi Ni, Yanhao Zhou, Hao Song, Liang Jin, Tingting Tang and Yi Pan

    Citation: Cancer Cell International 2021 21:433

    Content type: Primary research

    Published on:

  32. Gastric cancer (GC) is a globally prevalent cancer, ranking fifth for incidence and fourth for mortality worldwide. The N6-methyladenosine (m6A) related long noncoding RNAs (lncRNAs) were widely investigated in r...

    Authors: Tenghui Han, Dong Xu, Jun Zhu, Jipeng Li, Lei Liu and Yanchun Deng

    Citation: Cancer Cell International 2021 21:432

    Content type: Primary research

    Published on:

  33. Recent studies on the pathophysiology of COVID-19 are indicating that the Angiotensin convertase enzyme 2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) can act as a major component in the fusion of SAR...

    Authors: Sepehr Shafiee, Luca Cegolon, Mostafa Khafaei, Nasrin Gholami, Shi Zhao, Nasrin Khalesi, Hamidreza Moosavian, Saeid Fathi, Morteza Izadi, Alireza Ghadian, Mohammad Javanbakht, Amin Javanbakht and Reza Akhavan-Sigari

    Citation: Cancer Cell International 2021 21:431

    Content type: Review

    Published on:

  34. DDX52 is a type of DEAD/H box RNA helicase that was identified as a novel prostate cancer (PCa) genetic locus and possible causal gene in a European large-scale transcriptome-wide association study. However, t...

    Authors: Wandong Yu, Hangbin Ma, Junhong Li, Jinchao Ge, Pengyu Wang, Yinghao Zhou, Jun Zhang and Guowei Shi

    Citation: Cancer Cell International 2021 21:430

    Content type: Primary research

    Published on:

  35. Several previous studies have implied the significance of lncRNA1410 (LINC01410) in gastric cancer, rectal cancer, and cervical cancer. Nevertheless, the potential of LINC01410 in bladder cancer (BC) developme...

    Authors: Wei Guo, Qimei Gai, Yue Ma, Zhengfei Shan and Jitao Wu

    Citation: Cancer Cell International 2021 21:429

    Content type: Primary research

    Published on:

  36. Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations will inevitably develop drug resistance after being treated with the third-generation EGFR-tyrosine kinase inh...

    Authors: Xinying Li, Cen Chen, Zimu Wang, Jiaxin Liu, Wei Sun, Kaikai Shen, Yanling Lv, Suhua Zhu, Ping Zhan, Tangfeng Lv and Yong Song

    Citation: Cancer Cell International 2021 21:428

    Content type: Primary research

    Published on:

  37. Pseudolarix kaempferi is a traditional Chinese natural product that possesses the potential cytotoxic effects against cancer. However, the precise molecular mechanism underlying its cytotoxic effects has not yet ...

    Authors: Su-Jung Choi, Chi-Hyun Ahn, Kyoung-Ok Hong, Ji-Hoon Kim, Seong-Doo Hong, Ji-Ae Shin and Sung-Dae Cho

    Citation: Cancer Cell International 2021 21:427

    Content type: Primary research

    Published on:

  38. The high incidence and mortality of lung cancer have seriously affected human life and health. Nivolumab is a monoclonal antibody that can inhibit programmed death 1 (PD-1) and Ipilimumab is a monoclonal antib...

    Authors: Huihui Jiang, Aiqun Xu, Wanli Xia, Xingyuan Xia, Pulin Li, Binbin Zhang, Ke Zhu, Sijing Zhou and Ran Wang

    Citation: Cancer Cell International 2021 21:426

    Content type: Review

    Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:520

  39. Long noncoding RNAs (lncRNAs) OGFRP1 is up-regulated in endometrial cancer and cervical carcinoma, and OGFRP1 suppression inhibits the malignant behavior of cancer cells. Here, we evaluated the expression patt...

    Authors: Xiaojing Liu, Na Niu, Pibao Li, Liping Zhai, Ke Xiao, Wendan Chen and Xuewei Zhuang

    Citation: Cancer Cell International 2021 21:425

    Content type: Primary research

    Published on:

  40. Glioma is a common primary central nervous system tumour, and therapeutic drugs that can effectively improve the survival rate of patients in the clinic are lacking. Bufalin is effective in treating various tu...

    Authors: Yao Li, Yan Zhang, Xufang Wang, Qian Yang, Xuanxuan Zhou, Junsheng Wu, Xu Yang, Yani Zhao, Rui Lin, Yanhua Xie, Jiani Yuan, Xiaohui Zheng and Siwang Wang

    Citation: Cancer Cell International 2021 21:424

    Content type: Primary research

    Published on:

  41. In recent years, with the development of RNA sequencing technology and bioinformatics methods, the epigenetic modification of RNA based on N6-methyladenosine (m6A) has gradually become a research hotspot in the f...

    Authors: Xiaoqing Zhang, Ning Lu, Li Wang, Yixuan Wang, Minna Li, Ying Zhou, Manli Cui, Mingxin Zhang and Lingmin Zhang

    Citation: Cancer Cell International 2021 21:421

    Content type: Review

    Published on:

  42. The underlying mechanism behind the tumorigenesis and progression of pancreatic cancer is not clear, and treatment failure is generally caused by early metastasis, recurrence, drug resistance and vascular inva...

    Authors: Xueyi Jiang, Jie Wang, Peng Chen, Zhiwei He, Jian Xu, Yankun Chen, Xinyuan Liu and Jianxin Jiang

    Citation: Cancer Cell International 2021 21:420

    Content type: Primary research

    Published on:

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