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  1. CTLA-4 is a well-studied immune checkpoint protein that negatively regulates T cell-mediated immune responses. However, the expression of CTLA-4 in glioma and the effects of CTLA-4 on prognosis in patients wit...

    Authors: Fangkun Liu, Jing Huang, Xuming Liu, Quan Cheng, Chengke Luo and Zhixiong Liu

    Citation: Cancer Cell International 2020 20:7

    Content type: Primary research

    Published on:

  2. The issue of drug resistance in gastric cancer has attracted global attention. TSPAN9, a 4-transmembrane protein that plays an important role in tumor progression and signal transduction, has been found to be ...

    Authors: Yaoyue Qi, Weiwei Qi, Shihai Liu, Libin Sun, Aiping Ding, Guohong Yu, Hui Li, Yixuan Wang, Wensheng Qiu and Jing Lv

    Citation: Cancer Cell International 2020 20:4

    Content type: Primary research

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  3. Ubiquilin-4 (UBQLN4) is a member of the ubiquitin–proteasome system that is usually upregulated in many tumor cells. Its overexpression has been associated with poor disease outcomes in various cancer diseases...

    Authors: Yan Yu, Penglin Xu, Guangying Cui, Xiaodong Xu, Kongfei Li, Xiaolong Chen and Jie Bao

    Citation: Cancer Cell International 2020 20:3

    Content type: Primary research

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  4. Lung adenocarcinoma (LUAD), a widespread histopathological subtype of lung cancer, is deemed as a malignant tumor with a peak risk of mortality. Emerged as RNA with a loop structure that depleted protein codin...

    Authors: Nan Gao and Baoguo Ye

    Citation: Cancer Cell International 2020 20:2

    Content type: Primary research

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  5. Gliomas account for the major part of primary brain tumors. Based on their histology and molecular alternations, adult gliomas have been classified into four grades, each with distinct biology and outcome. Pre...

    Authors: Wenxin Zeng, Zhaohua Tang, Yongguo Li, Guangnian Yin, Zili Liu, Jie Gao, Yan Chen and Feilan Chen

    Citation: Cancer Cell International 2020 20:1

    Content type: Primary research

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  6. Increasing studies have suggested that aberrant expression of microRNAs might play essential roles in the progression of cancers. In this study, we sought to construct a high-specific and superior microRNAs si...

    Authors: Rong Ma, Yanyun Zhao, Miao He, Hongliang Zhao, Yifan Zhang, Shuqi Zhou, Mengcong Gao, Di Di, Jue Wang, Jian Ding and Minjie Wei

    Citation: Cancer Cell International 2019 19:360

    Content type: Primary research

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  7. The editor has retracted this article [1] because Fig. 2f has been duplicated from Fig. 6j in a previously published article [2]. In addition, the article contains sections that substantially overlap with a pr...

    Authors: Jie Song, Wei Zhao, Chang Lu and Xue Shao

    Citation: Cancer Cell International 2019 19:359

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2019 19:60

  8. The editor has retracted this article [1] because Figures 2 and 4 contain duplicated and modified figures from [2–4]. The data reported in this article are therefore unreliable.

    Authors: Xiaoyan Ding, Wei Sun and Jinglong Chen

    Citation: Cancer Cell International 2019 19:358

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2018 18:176

  9. Neuroblastoma (NB) is one of most common childhood tumors with high mortality among children worldwide. microRNAs (miRNAs) have been reported to play essential roles in the pathogenesis and therapeutics of NB....

    Authors: Fengxia Mao, Ju Zhang, Xinru Cheng and Qianya Xu

    Citation: Cancer Cell International 2019 19:357

    Content type: Primary research

    Published on:

  10. The DNA damage and repair pathway is considered a promising target for developing strategies against cancer. RAD51, also known as RECA, is a recombinase that performs the critical step in homologous recombinat...

    Authors: Xiaomeng Zhang, Ningyi Ma, Weiqiang Yao, Shuo Li and Zhigang Ren

    Citation: Cancer Cell International 2019 19:356

    Content type: Primary research

    Published on:

  11. The purpose of this study was to build functional nomograms based on significant clinicopathological features to predict cause-specific survival (CSS) and overall survival (OS) in patients with stage I–III col...

    Authors: Zheng Zhou, Shaobo Mo, Weixing Dai, Wenqiang Xiang, Lingyu Han, Qingguo Li, Renjie Wang, Lu Liu, Long Zhang, Sanjun Cai and Guoxiang Cai

    Citation: Cancer Cell International 2019 19:355

    Content type: Primary research

    Published on:

  12. miR-100 has been reported to closely associate with gastric cancer (GC) initiation and progression. However, the underlying mechanism of miR-100-3p in GC is still largely unclear. In this study, we intend to s...

    Authors: Chun-Wei Peng, Ling-Xiao Yue, Yuan-Qin Zhou, Sai Tang, Chen Kan, Lei-Ming Xia, Fan Yang and Si-Ying Wang

    Citation: Cancer Cell International 2019 19:354

    Content type: Primary research

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  13. Gastric cancer (GC) is a common-sighted cancer which is hard to cure over the world. Substantial researches revealed that long non-coding RNAs (lncRNAs) were fundamental regulators in the process of cancers. N...

    Authors: Zhaosheng Chen, Honglei Wu, Zhen Zhang, Guangchun Li and Bin Liu

    Citation: Cancer Cell International 2019 19:351

    Content type: Primary research

    Published on:

  14. Gastric cancer (GC) is one common cancer which occurs in the stomach leading to high mortality around the world. Long non-coding RNAs (lncRNAs) were found overexpressed or silenced in the occurrence and progre...

    Authors: Hua Zhang, Haitao Huang, Xiaomei Xu, Haiying Wang, Jianxiang Wang, Zuoyi Yao, Xiaoyan Xu, Qian Wu and Fenlan Xu

    Citation: Cancer Cell International 2019 19:350

    Content type: Primary research

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  15. Over the years, long non-coding RNAs (lncRNAs) have been clarified in malignancies, this research was focused on the role of lncRNA cartilage injury-related (lncRNA-CIR) in osteosarcoma cells.

    Authors: Shiwei Liu, Jingchao Li, Liang Kang, Yueyang Tian and Yuan Xue

    Citation: Cancer Cell International 2019 19:349

    Content type: Primary research

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  16. Casticin, an isoflavone compound extracted from the herb Fructus Viticis, has demonstrated anti-inflammatory and anticancer activities and properties. The aim of this study was to investigate the effects and m...

    Authors: Jingxian Liu, Jinghong Yang, Yuhe Hou, Zhenwei Zhu, Jie He, Hao Zhao, Xidong Ye, Dengke Li, Zhaohui Wu, Zhongxi Huang, Bingtao Hao and Kaitai Yao

    Citation: Cancer Cell International 2019 19:348

    Content type: Primary research

    Published on:

  17. Ovarian cancer (OC) is a gynecological malignancy with a high mortality. Cisplatin-based treatment is the typical treatment regimen for OC patients; however, it may cause unfavorable resistance. The current st...

    Authors: Hua Guo, Chunfang Ha, Hui Dong, Zhijuan Yang, Yuan Ma and Yonghui Ding

    Citation: Cancer Cell International 2019 19:347

    Content type: Primary research

    Published on:

  18. Treatments that generate T cell-mediated immunity to a patient’s unique neoantigens are the current holy grail of cancer immunotherapy. In particular, treatments that do not require cumbersome and individualiz...

    Authors: Stephen M. Shaw, Jenny Middleton, Kim Wigglesworth, Amber Charlemagne, Oliver Schulz, Melanie S. Glossop, Giles F. Whalen, Robert Old, Mike Westby, Chris Pickford, Rinat Tabakman, Irit Carmi-Levy, Abi Vainstein, Ella Sorani, Arik A. Zur and Sascha A. Kristian

    Citation: Cancer Cell International 2019 19:346

    Content type: Primary research

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  19. Glioblastoma has been seen as the most common malignancy of brain tumor. Emerging reports has claimed that SNHG29 (LRRC75A-AS1) was involved in several biological processes via modulation of signaling pathway,...

    Authors: Lizhang Han, Zhonggang Li, Yuquan Jiang, Zheng Jiang and Ling Tang

    Citation: Cancer Cell International 2019 19:345

    Content type: Primary research

    Published on:

  20. Gastric cancer (GC) is one of the most common gastrointestinal malignancies worldwide. Emerging evidence indicates that hyperglycemia promotes tumor progression, especially the processes of migration, invasion...

    Authors: Xin Xu, Bang Chen, Shaopu Zhu, Jiawei Zhang, Xiaobo He, Guodong Cao and Bo Chen

    Citation: Cancer Cell International 2019 19:344

    Content type: Primary research

    Published on:

  21. The progression of ductal carcinoma in situ (DCIS) into invasive ductal carcinoma (IDC) is prevented by normal breast myoepithelial cells. Studies have suggested that EMT-associated genes were enriched in IDC ...

    Authors: Li Wang, Cong Xu, Xia Liu, Yang Yang, Lu Cao, Guomin Xiang, Fang Liu, Shuling Wang, Jing Liu, Qingxiang Meng, Jiao Jiao and Yun Niu

    Citation: Cancer Cell International 2019 19:343

    Content type: Primary research

    Published on:

  22. As a novel type of isothiocyanate derived from radish seeds from cruciferous vegetables, sulforaphene (SFE, 4-methylsufinyl-3-butenyl isothiocyanate) has various important biological effects, such as anti-oxid...

    Authors: Chengjuan Zhang, Junxia Zhang, Qiong Wu, Benling Xu, Guoguo Jin, Yan Qiao, Simin Zhao, Yang Yang, Jinwen Shang, Xiaofang Li and Kangdong Liu

    Citation: Cancer Cell International 2019 19:342

    Content type: Primary research

    Published on:

  23. Circulating tumor cells (CTCs) are a rare subset of cells found in the blood of patients with solid tumors, which function as a seed for metastases. Cancer cells metastasize through the bloodstream either as s...

    Authors: Chang Yang, Bai-Rong Xia, Wei-Lin Jin and Ge Lou

    Citation: Cancer Cell International 2019 19:341

    Content type: Review

    Published on:

  24. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, especially in China, with high metastasis and poor prognosis. Recently, as the core component of the polycomb repressive complex...

    Authors: Xiaonian Zhu, Wei Luo, Chunhua Bei, Juan Kong, Shidong Zhang, Yuanyuan Fu, Di Li and Shengkui Tan

    Citation: Cancer Cell International 2019 19:340

    Content type: Primary research

    Published on:

  25. Ovarian cancer is one of the leading causes of female death worldwide, with a poor prognosis of advanced patients. Sevoflurane, a volatile anesthetic commonly used in clinical operations, has been reported to ...

    Authors: Chuanfeng Zhang, Baosheng Wang, Xiuqin Wang, Xiugui Sheng and Yongchun Cui

    Citation: Cancer Cell International 2019 19:339

    Content type: Primary research

    Published on:

  26. The dysregulation of circABCB10 may play an critical role in tumor progression. However, its function in liver cancer (HCC) is still unclear. Therefore, this experimental design is based on circABCB10 to explo...

    Authors: Yu Fu, Limin Cai, Xuexue Lei and Dunwei Wang

    Citation: Cancer Cell International 2019 19:338

    Content type: Primary research

    Published on:

  27. Muscle-invasive bladder cancer (MIBC) is originated in the muscle wall of the bladder, and is the ninth most common malignancy worldwide. However, there are no reliable, accurate and robust gene signatures for...

    Authors: Ping-Bao Zhang, Zi-Li Huang, Yong-Hua Xu, Jin Huang, Xin-Yu Huang and Xiu-Yan Huang

    Citation: Cancer Cell International 2019 19:337

    Content type: Primary research

    Published on:

  28. Autophagy is an evolutionarily conserved process through which cells degrade and recycle cytoplasm. The relation among autophagy, apoptosis and tumor is highly controversial until now and the molecular mechani...

    Authors: Jing Liu, Shuaiyu Long, Huanan Wang, Nannan Liu, Chuchu Zhang, Lingling Zhang and Yingjie Zhang

    Citation: Cancer Cell International 2019 19:336

    Content type: Primary research

    Published on:

  29. The high prevalence of alternative splicing among genes implies the importance of genomic complexity in regulating normal physiological processes and diseases such as gastric cancer (GC). The standard form of ...

    Authors: Wei-zhao Peng, Ji-xi Liu, Chao-feng Li, Ren Ma and Jian-zheng Jie

    Citation: Cancer Cell International 2019 19:335

    Content type: Primary research

    Published on:

  30. Endometrial carcinoma (EC) accounts for 5.8% of all cancers in Saudi females. Although most ECs are sporadic, 2–5% tend to be familial, being associated with Lynch syndrome and Cowden syndrome. In this study, ...

    Authors: Abdul K. Siraj, Sandeep Kumar Parvathareddy, Rong Bu, Kaleem Iqbal, Sarah Siraj, Tariq Masoodi, Rica Micaela Concepcion, Laila Omar Ghazwani, Ismail AlBadawi, Fouad Al-Dayel and Khawla S. Al-Kuraya

    Citation: Cancer Cell International 2019 19:334

    Content type: Primary research

    Published on:

  31. Abiraterone and MDV3100 are two effective anticancer agents for prostate cancer, however, the mechanism of their downstream action remains undefined.

    Authors: Jingli Han, Junhua Zhang, Wei Zhang, Dalei Zhang, Ying Li, Jinsong Zhang, Yaqun Zhang, Tongxiang Diao, Luwei Cui, Wenqing Li, Fei Xiao, Ming Liu and Lihui Zou

    Citation: Cancer Cell International 2019 19:332

    Content type: Primary research

    Published on:

  32. Abnormal activation of the classic Wnt signaling pathway is closely related to the occurrence of epithelial cancers. B-cell lymphoma 9 (BCL9), a transcription factor, is a novel oncogene discovered in the clas...

    Authors: Jing Wang, Mingjun Zheng, Liancheng Zhu, Lu Deng, Xiao Li, Linging Gao, Caixia Wang, Huimin Wang, Juanjuan Liu and Bei Lin

    Citation: Cancer Cell International 2019 19:330

    Content type: Primary research

    Published on:

  33. Hepatocellular carcinoma (HCC) is the most prevalent type of malignant liver disease worldwide. Molecular changes in HCC collectively contribute to Wnt/β-catenin, as a tumor proliferative signaling pathway, to...

    Authors: Jafar Ai, Neda Ketabchi, Javad Verdi, Nematollah Gheibi, Hossein Khadem Haghighian and Maria Kavianpour

    Citation: Cancer Cell International 2019 19:329

    Content type: Review

    Published on:

  34. Circular RNA Itchy E3 ubiquitin protein ligase (Circ-ITCH) is significantly down-regulated in various kinds of tumors, however, the mechanisms of action and functions of circITCH gene in prostate cancer (PC) a...

    Authors: Xuegang Wang, Rong Wang, Zhun Wu and Peide Bai

    Citation: Cancer Cell International 2019 19:328

    Content type: Primary research

    Published on:

  35. The aim of this study was to investigate the regulatory network of lncRNAs as competing endogenous RNAs (ceRNA) in bladder urothelial carcinoma (BUC) based on gene expression data derived from The Cancer Genom...

    Authors: Jiawu Wang, Chengyao Zhang, Yan Wu, Weiyang He and Xin Gou

    Citation: Cancer Cell International 2019 19:327

    Content type: Primary research

    Published on:

  36. Osteosarcoma (OS) is still a disease with high mortality from malignant tumors in children and adolescents. Due to its poor treatment, this study explored the involvement of lncRNA ZFAS1/microRNA-135a (miR-135...

    Authors: Zilong Zhao, Xiafei Lin, Yunhui Tong and Wenxia Li

    Citation: Cancer Cell International 2019 19:326

    Content type: Primary research

    Published on:

  37. The large involvement of long non-coding RNAs (LncRNAs) in the biological progression of numerous cancers has been reported. The function of lncRNA KCNQ1OT1 in bladder cancer (BC) remains largely unknown. This...

    Authors: Jingyu Wang, Hao Zhang, Jie Situ, Mingzhao Li and Hua Sun

    Citation: Cancer Cell International 2019 19:325

    Content type: Primary research

    Published on:

  38. Spindle and kinetochore associated protein 1 (SKA1) is a protein involved in chromosome congression and mitosis. It has been found to be upregulated and oncogenic in several human cancers. Herein, we investiga...

    Authors: Xizhao Wang, Yu Zeng, Mingfeng Zhou, Xian Zhang, Anqi Xu, Jie Lin, Zhiyong Wu, Cheng Xie, Jie Luo, Shengfeng Ding, Zhengming Zhan, Hao Long and Ye Song

    Citation: Cancer Cell International 2019 19:324

    Content type: Primary research

    Published on:

  39. There is growing evidence of the role of long non-coding RNAs (lncRNAs) in cervical cancer (CC). The objective was to discuss whether exosomal lncRNA HNF1A-AS1 impacted drug resistance in CC via binding to mic...

    Authors: Xiaoqiong Luo, Jingxi Wei, Feng-lian Yang, Xiao-xia Pang, Feng Shi, Yu-xia Wei, Bi-yun Liao and Jun-li Wang

    Citation: Cancer Cell International 2019 19:323

    Content type: Primary research

    Published on:

  40. Autologous tumor-infiltrating lymphocytes (Tils) immunotherapy is a promising treatment in patients with advanced hepatocellular cancer. Although Tils treatment has shown great promise, their persistence and t...

    Authors: Benling Xu, Long Yuan, Guangyu Chen, Tiepeng Li, Jinxue Zhou, Chengjuan Zhang, Peng Qin, Musleh M. Muthana, Shengdian Wang, Xuexiang Du and Quanli Gao

    Citation: Cancer Cell International 2019 19:322

    Content type: Primary research

    Published on:

  41. Since FTO was recognized as the first m6A demethylase, the understanding of its biological function has been widely expanded. However, the role of FTO in cervical cancer tumorigenesis remains unclear.

    Authors: Dongling Zou, Lei Dong, Chenying Li, Zhe Yin, Shuan Rao and Qi Zhou

    Citation: Cancer Cell International 2019 19:321

    Content type: Primary research

    Published on:

  42. Pancreatic cancer (PC) is one of the deadliest cancers about the digestive system. Recent researches have validated that long non-coding RNAs (lncRNAs) play vital roles in various cancers, while the function o...

    Authors: Luyang Zhang, Yunjian Wang, Ling Zhang, Guohua You, Congyu Li, Bo Meng, Minghe Zhou and Min Zhang

    Citation: Cancer Cell International 2019 19:320

    Content type: Primary research

    Published on:

  43. Osteosarcoma is the most common bone tumors which consisted of malignant mesenchymal cells generating osteoid and immature bone. It has been showed that osteosarcoma is common in children and adolescents and s...

    Authors: Hadis Fathizadeh, Hamed Mirzaei and Zatollah Asemi

    Citation: Cancer Cell International 2019 19:319

    Content type: Review

    Published on:

  44. This study aimed to investigate the prognostic value of the potential biomarker collagen triple helix repeat containing 1 (CTHRC1) in lung adenocarcinoma (LUAD) patients.

    Authors: Yangshan Chen, Yu Sun, Yongmei Cui, Yiyan Lei, Neng Jiang, Wenting Jiang, Han Wang, Lili Chen, Jiping Luo, Yanyang Chen, Kejing Tang, Chengzhi Zhou and Zunfu Ke

    Citation: Cancer Cell International 2019 19:318

    Content type: Primary research

    Published on:

  45. Cisplatin plus pemetrexed combination therapy is considered the standard treatment for patients with advanced, non-squamous, non-small-cell lung cancer (NSCLC). However, advanced NSCLC has a 5-year survival ra...

    Authors: Yanyun Gao, Patrick Dorn, Shengchen Liu, Haibin Deng, Sean R. R. Hall, Ren-Wang Peng, Ralph A. Schmid and Thomas M. Marti

    Citation: Cancer Cell International 2019 19:317

    Content type: Primary research

    Published on:

  46. Glioma is a lethal malignant brain tumor, which affects the brain functions and is life-threatening. LncRNA UCA1 was identified as a pivotal regulator for tumorigenesis of glioma. MiR-206 was discovered to pro...

    Authors: Zhi Huang, Xuya Zhao, Xiaowen Wu, Lei Xiang, Yingnan Yuan, Shi Zhou and Wenfeng Yu

    Citation: Cancer Cell International 2019 19:316

    Content type: Primary research

    Published on:

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