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  1. Tumor-infiltrating immune cells (TIICs) are highly relevant to clinical outcome of glioma. However, previous studies cannot account for the diverse functions that make up the immune response in malignant trans...

    Authors: Jiacheng Lu, Hailin Li, Zhengxin Chen, Ligang Fan, Shuang Feng, Xiaomin Cai and Huibo Wang

    Citation: Cancer Cell International 2019 19:265

    Content type: Primary research

    Published on:

  2. Centromere Protein F (CENPF) associates with the centromere–kinetochore complex and influences cell proliferation and metastasis in several cancers. The role of CENPF in breast cancer (BC) bone metastasis rema...

    Authors: Jingbo Sun, Jingzhan Huang, Jin Lan, Kun Zhou, Yuan Gao, Zhigao Song, Yunyao Deng, Lixin Liu, Ying Dong and Xiaolong Liu

    Citation: Cancer Cell International 2019 19:264

    Content type: Primary research

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  3. Triple-negative breast carcinoma (TNBC) patients do not benefit from hormone- or human epidermal growth factor receptor 2- (HER2-) targeted therapies. Accurate testing is pivotal for these patients.

    Authors: Jose De Jesus and Marilin Rosa

    Citation: Cancer Cell International 2019 19:263

    Content type: Primary research

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  4. Pancreatic cancer is a malignancy with a very poor prognosis. The emergence of liquid biopsy is expected to achieve accurate early diagnosis through detection of tumor-derived secreted proteins in the blood. E...

    Authors: Peng Liu, Lingming Kong, Haoyi Jin, Yunhao Wu, Xiaodong Tan and Bing Song

    Citation: Cancer Cell International 2019 19:262

    Content type: Primary research

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  5. Cancer has been a worldwide health problem with a high risk of morbidity and mortality, however ideal biomarkers for effective screening and diagnosis of cancer patients are still lacking. Small nucleolar RNA ...

    Authors: Chenghao Zhang, Xiaolei Ren, Jieyu He, Wanchun Wang, Chao Tu and Zhihong Li

    Citation: Cancer Cell International 2019 19:261

    Content type: Primary research

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  6. The glial cells of the primary olfactory nervous system, olfactory ensheathing cells (OECs), are unusual in that they rarely form tumors. Only 11 cases, all of which were benign, have been reported to date. In...

    Authors: Mariyam Murtaza, Anu Chacko, Ali Delbaz, Ronak Reshamwala, Andrew Rayfield, Brent McMonagle, James A. St John and Jenny A. K. Ekberg

    Citation: Cancer Cell International 2019 19:260

    Content type: Review

    Published on:

  7. Serum/plasma YKL-40 can be a useful index that is associated with tumor development. However, the prognostic value of serum/plasma YKL-40 in patients with solid tumors is still unclear. We aimed to utilize the...

    Authors: Bingxian Bian, Li Li, Junyao Yang, Yi Liu, Guohua Xie, Yingxia Zheng, Liang Zeng, Junxiang Zeng and Lisong Shen

    Citation: Cancer Cell International 2019 19:259

    Content type: Primary research

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  8. This study is conducted to investigate the effect of lncRNA PIK3CD-AS1 on the growth and metastasis of hepatocellular carcinoma (HCC) and its potential mechanism.

    Authors: Wei Song, Jingjing Zhang, Jianbo Zhang, Miaomiao Sun and Qingxin Xia

    Citation: Cancer Cell International 2019 19:150

    Content type: Primary research

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  9. Non-small-cell lung cancer (lung cancer) has become one of the leading causes worldwide and the underlying mechanism is not fully understood. The transcriptional factor Kruppel like factor 8 (KLF8) is involved...

    Authors: Dongjie Ma, Hongsheng Liu, Yingzhi Qin, Zhenhuan Tian, Shanqing Li and Naixin Liang

    Citation: Cancer Cell International 2019 19:258

    Content type: Primary research

    Published on:

  10. miRNAs, a major class of small noncoding RNAs approximately 18–25 nucleotides in length, function by repressing the expression of target genes through binding to complementary sequences in the 3′-UTRs of targe...

    Authors: Yue Yu and Xu-Chen Cao

    Citation: Cancer Cell International 2019 19:257

    Content type: Review

    Published on:

  11. A hallmark of acute promyelocytic leukemia (APL) is the expression of PML/RARα fusion protein. Treatment with all-trans retinoic acid (ATRA) results in the terminal differentiation of neutrophil granulocytes. ...

    Authors: Xinrui Wang, Huiyong Fan, Congling Xu, Guojuan Jiang, Haiwei Wang and Ji Zhang

    Citation: Cancer Cell International 2019 19:256

    Content type: Primary research

    Published on:

  12. Hepatocellular carcinoma (HCC), the most common primary cancer of the liver, is one of the most common malignancies and the leading cause of cancer-related death worldwide. Leucine-rich repeat and sterile alph...

    Authors: Lili Pian, Xiaofeng Huang, Min Zhao, Yaolin Zhang, Cheng Qin, Jiyan Zhang, Jun Zhang and Qingyang Wang

    Citation: Cancer Cell International 2019 19:255

    Content type: Primary research

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  13. Extracellular ATP (eATP) was shown to induce epithelial–mesenchymal transition (EMT), a very important early process in metastasis, in cancer cells via purinergic receptor signaling. However, the exact inducti...

    Authors: Yanyang Cao, Xuan Wang, Yunsheng Li, Maria Evers, Haiyun Zhang and Xiaozhuo Chen

    Citation: Cancer Cell International 2019 19:254

    Content type: Primary research

    Published on:

  14. Phosphoglucomutase (PGM), a key enzyme in the metabolism of glucose-1-phosphate and glucose-6-phosphate, has been found to be associated with proliferation, invasion, and metastasis of cancer. However, the exp...

    Authors: Yifan Sun, Haihua Long, Lin Sun, Xiujuan Sun, Liping Pang, Jianlin Chen, Qingqun Yi, Tianwei Liang and Yongqi Shen

    Citation: Cancer Cell International 2019 19:253

    Content type: Primary research

    Published on:

  15. Circular RNA (circRNA) CDR1as plays an important role in the occurrence and development of human tumors. The purpose of this study is to investigate the molecular mechanism of circRNA CDR1as in the development...

    Authors: Qiong Zhong, Juncong Huang, Jiawang Wei and Renrui Wu

    Citation: Cancer Cell International 2019 19:252

    Content type: Primary research

    Published on:

  16. Exosomal nucleic acid (exoNA) is a feasible target to improve the sensitivity of EGFR mutation testing in non-small cell lung cancer patients with limited cell-free DNA (cfDNA) mutant copies. However, the type an...

    Authors: Yoonjung Kim, Saeam Shin, Boyeon Kim and Kyung-A Lee

    Citation: Cancer Cell International 2019 19:251

    Content type: Primary research

    Published on:

  17. Esophageal squamous cell carcinoma (ESCC) is the eighth most common cancer worldwide and is one of the most lethal malignancies. Cisplatin (DDP) is a key drug for ESCC treatment, but the presence of chemothera...

    Authors: Tian-Liang Zheng, De-Ping Li, Zhan-Feng He and Song Zhao

    Citation: Cancer Cell International 2019 19:250

    Content type: Primary research

    Published on:

  18. Hepatocellular carcinoma (HCC) is the second-most lethal cancer worldwide with a complex pathogenesis. RuvB-like 2 (RUVBL2) was previously found to contribute to hepatocarcinogenesis. However, its expression, ...

    Authors: Tao Yan, Fang Liu, Jiajia Gao, Haizhen Lu, Jianqiang Cai, Xiaohang Zhao and Yulin Sun

    Citation: Cancer Cell International 2019 19:249

    Content type: Primary research

    Published on:

  19. Neuropilin-1 (NRP-1) is a non-tyrosine kinase receptor interacting with multiple signaling pathways that underpin the biological behavior and fate of cancer cells. However, in pancreatic cancer, the mechanisms...

    Authors: Lixin Ma, Bo Zhai, Huaqiang Zhu, Weidong Li, Wenjing Jiang, Liwang Lei, Shujun Zhang, Haiquan Qiao, Xian Jiang and Xueying Sun

    Citation: Cancer Cell International 2019 19:248

    Content type: Primary research

    Published on:

  20. CD146 alternatively called melanoma cell adhesion molecule (MCAM), is a biomarker and therapeutic target of clinical significance. It is found on different cells including the endothelial cells and lymphocytes...

    Authors: Ayobami Matthew Olajuyin, Adefunke Kafayat Olajuyin, Ziqi Wang, Xingru Zhao and Xiaoju Zhang

    Citation: Cancer Cell International 2019 19:247

    Content type: Review

    Published on:

  21. Recently, some studies reported the prognostic value of platelet-to-lymphocyte ratio (PLR) in patients with diffuse large B-cell lymphoma (DLBCL), however, the results varied from different studies. Therefore,...

    Authors: Ying Chen, Zongxin Zhang, Qiu Fang and Huiqin Jian

    Citation: Cancer Cell International 2019 19:245

    Content type: Primary research

    Published on:

  22. Following publication of the original article [1], it has been brought to our attention that an incorrect Sequenom MassArray trace and an incorrect nomenclature were used to represent the PIK3CA p.E545A mutati...

    Authors: Matteo Fassan, Luca Vianello, Diana Sacchi, Giuseppe N. Fanelli, Giada Munari, Marco Scarpa, Rocco Cappellesso, Fotios Loupakis, Cristiano Lanza, Roberta Salmaso, Claudia Mescoli, Nicola Valeri, Marco Agostini, Edoardo D’Angelo, Sara Lonardi, Salvatore Pucciarelli…

    Citation: Cancer Cell International 2019 19:244

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2018 18:131

  23. The hypoxic tumor microenvironment accelerates the invasion and migration of colorectal cancer (CRC) cells. The aim of this study was to develop and validate a hypoxia gene signature for predicting the outcome...

    Authors: Yi-feng Zou, Yu-ming Rong, Ying-xin Tan, Jian Xiao, Zhao-liang Yu, Yu-feng Chen, Jia Ke, Cheng-hang Li, Xi Chen, Xiao-jian Wu, Ping Lan, Xu-tao Lin and Feng Gao

    Citation: Cancer Cell International 2019 19:243

    Content type: Primary research

    Published on:

  24. Triple negative breast cancer (TNBC) is a breast cancer (BC) subtype that is characterized by its strong invasion and a high risk of metastasis. However, the specific mechanisms underlying these phenotypes are...

    Authors: Weiguang Liu, Jianjun Han, Sufang Shi, Yuna Dai and Jianchao He

    Citation: Cancer Cell International 2019 19:242

    Content type: Primary research

    Published on:

  25. Persistent infection with high-risk human papillomavirus (hrHPV) is associated with cervical cancer development. This process involves the virus-encoded E6 and E7 oncoproteins, which are maintained and express...

    Authors: Chao Li, Yanfei Li, Lanxia Sui, Jian Wang and Fang Li

    Citation: Cancer Cell International 2019 19:241

    Content type: Primary research

    Published on:

  26. Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs, which have the ability to influence the chemo-resistance of lung adenocarcinoma (LAC). In this study, we explored the mechanism by which ...

    Authors: Wei Zuo, Wei Zhang, Fei Xu, Jing Zhou and Wei Bai

    Citation: Cancer Cell International 2019 19:240

    Content type: Primary research

    Published on:

  27. Lung cancer has been a common malignant tumor with a leading cause of morbidity and mortality, current molecular targets are woefully lacking comparing to the highly progressive cancer. The study is designed t...

    Authors: Wenxia Ma, Bin Wang, Yaping Zhang, Ziyue Wang, Dan Niu, Siyu Chen, Zhirong Zhang, Ningning Shen, Weixia Han, Xiaoqin Zhang, Rong Wei and Chen Wang

    Citation: Cancer Cell International 2019 19:239

    Content type: Primary research

    Published on:

  28. Avoiding the phagocytosis by tumor-associated macrophages (TAMs) is necessary for the growth and metastasis of solid tumors. CD47 binds to the receptor signal-regulatory protein-α (SIRP-α) on the macrophages t...

    Authors: Jingping Yuan, Huihua He, Chuang Chen, Juan Wu, Jie Rao and Honglin Yan

    Citation: Cancer Cell International 2019 19:238

    Content type: Primary research

    Published on:

  29. The basal transcription/repair factor TFIIH is a ten sub-unit complex essential for RNA polymerase II (RNAP2) transcription initiation and DNA repair. In both these processes TFIIH acts as a DNA helix opener, ...

    Authors: Lise-Marie Donnio, Catherine Miquel, Wim Vermeulen, Giuseppina Giglia-Mari and Pierre-Olivier Mari

    Citation: Cancer Cell International 2019 19:237

    Content type: Primary research

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  30. Hyperoside (Hy) is a plant-derived quercetin 3-d-galactoside that exhibits inhibitory activities on various tumor types. The objective of the current study was to explore Hy effects on cervical cancer cell prolif...

    Authors: Weikang Guo, Hui Yu, Lu Zhang, Xiuwei Chen, Yunduo Liu, Yaoxian Wang and Yunyan Zhang

    Citation: Cancer Cell International 2019 19:235

    Content type: Primary research

    Published on:

  31. Chemotherapy resistance is one of the main causes of recurrence in colorectal cancer (CRC) patients and leads to poor prognosis. Long noncoding RNAs (lncRNAs) have been reported to regulate chemoresistance. We...

    Authors: Xinke Wang, Zhixian Lan, Juan He, Qiuhua Lai, Xiang Yao, Qingyuan Li, Yongfeng Liu, Huasheng Lai, Chuncai Gu, Qun Yan, Yuxin Fang, Yue Zhang, Aimin Li and Side Liu

    Citation: Cancer Cell International 2019 19:234

    Content type: Primary research

    Published on:

  32. Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibod...

    Authors: Cui Jiang, SunRun Cao, Na Li, Lei Jiang and Tao Sun

    Citation: Cancer Cell International 2019 19:233

    Content type: Primary research

    Published on:

  33. Methyl-CpG binding domain protein 1 (MBD1), which couples DNA methylation to transcriptional repression, has been implicated in transcriptional regulation, heterochromatin formation, genomic stability, cell cy...

    Authors: Liu Wensheng, Zhang Bo, Hu Qiangsheng, Xu Wenyan, Ji Shunrong, Xu Jin, Ni Quanxing, Yu Xianjun and Xu Xiaowu

    Citation: Cancer Cell International 2019 19:232

    Content type: Primary research

    Published on:

  34. MicroRNA-200c-3p (miR-200c-3p) has been revealed to be related to renal cell carcinoma (RCC) progression, while the inner mechanisms remain unknown. In our study, we intend to unearth the capability of miR-200...

    Authors: Shuai Li, Ziyu Feng, Xuechong Zhang, Dongyang Lan and Yudong Wu

    Citation: Cancer Cell International 2019 19:231

    Content type: Primary research

    Published on:

  35. Despite several reports describing the dual role of miR-145 as an oncogene and a tumor suppressor in cancer, not much has been resolved and understood.

    Authors: Siddharth Manvati, Kailash Chandra Mangalhara, Ponnuswamy Kalaiarasan, Rupali Chopra, Gaurav Agarwal, Rakesh Kumar, Sunil Kumar Saini, Monika Kaushik, Ankita Arora, Usha Kumari, Rameshwar Nath Koul Bamezai and Pawan Kumar Dhar

    Citation: Cancer Cell International 2019 19:230

    Content type: Primary research

    Published on:

  36. The fatality and recurrence rates of bladder cancer (BC) have progressively increased. DNA methylation is an influential regulator associated with gene transcription in the pathogenesis of BC. We describe a co...

    Authors: Liwei Wang, Jiazhong Shi, Yaqin Huang, Sha Liu, Jingqi Zhang, Hua Ding, Jin Yang and Zhiwen Chen

    Citation: Cancer Cell International 2019 19:229

    Content type: Primary research

    Published on:

  37. Hepatocellular carcinoma (HCC) is one of the most fatal cancers, and its molecular basis needs to be delineated to identify biomarkers for its potential treatment. The purpose of this study was to identify a n...

    Authors: Yong Le, Anna Kan, Qi-Jiong Li, Min-Ke He, Hai-Long Chen and Ming Shi

    Citation: Cancer Cell International 2019 19:228

    Content type: Primary research

    Published on:

  38. Cervical cancer (CC) is the second most common cancer in less developed countries and the second leading cause of death by cancer in women worldwide. The 99% of CC patients are infected with the Human Papillom...

    Authors: Inocencia Guadalupe Ramírez-López, Adrián Ramírez de Arellano, Luis Felipe Jave-Suárez, Christian David Hernández-Silva, Mariel García-Chagollan, Jorge Hernández-Bello, Edgar I. Lopez-Pulido, José Macias-Barragan, Margarita Montoya-Buelna, José Francisco Muñoz-Valle and Ana Laura Pereira-Suárez

    Citation: Cancer Cell International 2019 19:227

    Content type: Primary research

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  39. Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-M...

    Authors: Xiangyu Zhang, Jiali Wang, Yunlong Jia, Tianxu Liu, Mengjie Wang, Wei Lv, Rong Zhang, Juan Shi and Lihua Liu

    Citation: Cancer Cell International 2019 19:226

    Content type: Primary research

    Published on:

  40. Gastric cancer (GC) is the third-leading cause of cancer-related deaths. We established a prospective database of patients with GC who underwent surgical treatment. In this study, we explored the prognostic si...

    Authors: Jingyue Sun, Yao Long, Xin Peng, Desheng Xiao, Jianhua Zhou, Yongguang Tao and Shuang Liu

    Citation: Cancer Cell International 2019 19:225

    Content type: Primary research

    Published on:

  41. Cap-dependent mRNA translation is essential for the translation of key oncogenic proteins at optimal levels and is highly regulated by the rate limiting, initiation step in protein synthesis. Eukaryotic Transl...

    Authors: Praveen Kumar Jaiswal, Sweaty Koul, Nallasivam Palanisamy and Hari K. Koul

    Citation: Cancer Cell International 2019 19:224

    Content type: Primary research

    Published on:

  42. Neoplastic cells promote a hypercoagulable state by the expression of cell surface proteins, such as tissue factor. In BRAFv600 mutated melanoma patients upon BRAF inhibitors, a hypercoagulable state correlates w...

    Authors: Cristian Scatena, Sara Franceschi, Maria Franzini, Chiara Sanguinetti, Nadia Romiti, Laura Caponi, Mario Mandalà, Chiara Maria Mazzanti and Antonio Giuseppe Naccarato

    Citation: Cancer Cell International 2019 19:223

    Content type: Primary research

    Published on:

  43. Myeloid cell leukaemia 1 (MCL1) is a pro-survival Bcl-2 family protein that plays important roles in cell survival, proliferation, differentiation and tumourigenesis. MCL1 is a fast-turnover protein that is de...

    Authors: Lanqin Wu, Yingying Lin, Jinan Feng, Yuanlin Qi, Xinrui Wang, Qiaofa Lin, Wanyan Shi, Enrun Zheng, Wei Wang, Zhenzhu Hou, Hanbin Lin, Cheng Yu, Yan He, Yan Xu, Hong Yang, Ling Lin…

    Citation: Cancer Cell International 2019 19:222

    Content type: Primary research

    Published on:

  44. Renal cell carcinoma (RCC) is not sensitive to conventional radio- and chemotherapies and is at least partially resistant to impairments in cell death-related signaling pathways. The hallmarks of RCC formation...

    Authors: Yongchang Lai, Tao Zeng, Xiongfa Liang, Weizou Wu, Fangling Zhong and Wenqi Wu

    Citation: Cancer Cell International 2019 19:221

    Content type: Review

    Published on:

  45. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and human papillomavirus (HPV) has been increasingly recognized as a pathogenic factor for the initiation and development...

    Authors: Yu Jin, Yuexiu Li, Xin Wang and Ya Yang

    Citation: Cancer Cell International 2019 19:220

    Content type: Primary research

    Published on:

  46. Lung cancer is one of the most common malignant tumors worldwide. CD36 is a receptor for fatty acids and plays an important role in regulating fatty acid metabolism, which is closely related to tumorigenesis a...

    Authors: Kewei Ni, Dimin Wang, Heyun Xu, Fuyang Mei, Changhao Wu, Zhifang Liu and Bing Zhou

    Citation: Cancer Cell International 2019 19:219

    Content type: Primary research

    Published on:

  47. Relapse represents the leading cause of death in both child and adult patients with acute lymphoblastic leukemia (ALL). Development of chemo-resistance is ultimately responsible for treatment failure and relap...

    Authors: Haowen Xiao, Yingying Ding, Yang Gao, Li-Mengmeng Wang, Huafang Wang, Lijuan Ding, Xiaoqing Li, Xiaohong Yu and He Huang

    Citation: Cancer Cell International 2019 19:218

    Content type: Primary research

    Published on:

  48. Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a no...

    Authors: Fei Ding, Jindong Lai, Yang Gao, Genhui Wang, Jingwen Shang, Daojun Zhang and Shumao Zheng

    Citation: Cancer Cell International 2019 19:217

    Content type: Primary research

    Published on:

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