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  1. Multiple Myeloma (MM) is a hematologic malignant disease whose underlying molecular mechanism has not yet fully understood. Generally, cell adhesion plays an important role in MM progression. In our work, we i...

    Authors: Yue Peng, Dong Wu, Fangmei Li, Peihua Zhang, Yuandong Feng and Aili He

    Citation: Cancer Cell International 2020 20:262

    Content type: Primary research

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  2. Circular RNA downstream neighbor of SON (circDONSON) has been revealed to promote gastric cancer (GC) growth and invasion, while the role and molecular mechanism underlying circDONSON in GC cisplatin (DDP) res...

    Authors: Yong Liu, Jianzhong Xu, Min Jiang, Lingna Ni and Yang Ling

    Citation: Cancer Cell International 2020 20:261

    Content type: Primary research

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  3. Recent studies have demonstrated that the kallikrein and kallikrein-related peptidases (KLKs) exhibit aberrant expression in patients with colorectal cancer (CRC) and might be considered as potential prognosti...

    Authors: Qiliang Peng, Yi Shen, Peifeng Zhao, Ming Cheng, Yongyou Wu and Yaqun Zhu

    Citation: Cancer Cell International 2020 20:260

    Content type: Primary research

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  4. Osteosarcoma (OS) is a common malignant bone tumor originating in the interstitial tissues and occurring mostly in adolescents and young adults. Energy metabolism is a prerequisite for cancer cell growth, prol...

    Authors: Naiqiang Zhu, Jingyi Hou, Guiyun Ma, Shuai Guo, Chengliang Zhao and Bin Chen

    Citation: Cancer Cell International 2020 20:259

    Content type: Primary research

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  5. Cisplatin is widely used as a first-line treatment for non-small cell lung cancer (NSCLC), but chemoresistance remains a major clinical obstacle for efficient use. As a microRNA, miR-223 was reported to promot...

    Authors: Hui Wang, Jiabin Chen, Shufen Zhang, Xiaoxiao Zheng, Shangzhi Xie, Jiayan Mao, Ying Cai, Xuemei Lu, Liqiang Hu, Jian Shen, Kequn Chai and Wei Chen

    Citation: Cancer Cell International 2020 20:258

    Content type: Primary research

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  6. Deregulation of integrins signaling had been documented to participate in multiple fundamental biological processes, and the aberrant expression of integrin family members were linked to the prognosis of vario...

    Authors: Tingting Zhu, Ruifang Chen, Jieyu Wang, Huiran Yue, Xin Lu and Jun Li

    Citation: Cancer Cell International 2020 20:257

    Content type: Primary research

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  7. Fyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies on the function role of Fyn and its specific inhibitors in melanoma.

    Authors: Ling Tang, Jing Long, Keke Li, Xu Zhang, Xiang Chen and Cong Peng

    Citation: Cancer Cell International 2020 20:256

    Content type: Primary research

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  8. Bladder cancer (BCA) is the most common urinary tumor, but its pathogenesis is unclear, and the associated treatment strategy has rarely been updated. In recent years, a deeper understanding of tumor epigeneti...

    Authors: Zijian Tian, Lingfeng Meng, Xingbo Long, Tongxiang Diao, Maolin Hu, Miao Wang, Ming Liu and Jianye Wang

    Citation: Cancer Cell International 2020 20:255

    Content type: Primary research

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  9. MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH...

    Authors: Babak Otoukesh, Mehdi Abbasi, Habib-o-Lah Gorgani, Hossein Farahini, Mehdi Moghtadaei, Bahram Boddouhi, Peyman Kaghazian, Shayan Hosseinzadeh and Atefe Alaee

    Citation: Cancer Cell International 2020 20:254

    Content type: Review

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  10. CDK4/6 inhibitors such as ribociclib are becoming widely used targeted therapies in hormone-receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2−) breast cancer. However, cancers can...

    Authors: Vince Kornél Grolmusz, Jinfeng Chen, Rena Emond, Patrick A. Cosgrove, Lance Pflieger, Aritro Nath, Philip J. Moos and Andrea H. Bild

    Citation: Cancer Cell International 2020 20:253

    Content type: Primary research

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  11. Increasing evidence has indicated the important role of long non-coding RNAs (lncRNAs) in regulating the development and progression of cancers, including triple-negative breast cancer (TNBC). Small nucleolar ...

    Authors: Xuan Fang, Jin Zhang, Chunyan Li, Jinjin Liu, Zhendong Shi and Peng Zhou

    Citation: Cancer Cell International 2020 20:252

    Content type: Primary research

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  12. Hepatocellular carcinoma (HCC) one of the most common digestive system tumors, threatens the tens of thousands of people with high morbidity and mortality world widely. The purpose of our study was to investig...

    Authors: Lingyun Guo, Zhenjiang Wang, Yuanyuan Du, Jie Mao, Junqiang Zhang, Zeyuan Yu, Jiwu Guo, Jun Zhao, Huinian Zhou, Haitao Wang, Yanmei Gu and Yumin Li

    Citation: Cancer Cell International 2020 20:251

    Content type: Primary research

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  13. Acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) have a high relapse rate and poor prognosis. This study aims to explore the underlying mechanism of ...

    Authors: Xiaoli Hu, Jiayi Cai, Jianyi Zhu, Wenjing Lang, Jihua Zhong, Hua Zhong and Fangyuan Chen

    Citation: Cancer Cell International 2020 20:250

    Content type: Primary research

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  14. Circular RNAs (circRNAs), a subgroup of non-coding RNAs, are recognized as pivotal mediators in various types of cancers. CircRNA_0000284 (circ_0000284) was manifested to participate in the development of non-...

    Authors: Li Li, Qiaohua Zhang and Ke Lian

    Citation: Cancer Cell International 2020 20:247

    Content type: Primary research

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  15. Matrine has been reported to exert anti-tumor effects in multiple types of cancers containing hepatocellular carcinoma (HCC). However, the anti-tumor molecular mechanisms of matrine in HCC is still not fully r...

    Authors: Shaobing Lin, Jie Zhuang, Liping Zhu and Zongsheng Jiang

    Citation: Cancer Cell International 2020 20:246

    Content type: Primary research

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  16. Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents, and hyperproliferation of cells is a major problem of OS. FBXO2 belongs to the family of F-box proteins, and is a subst...

    Authors: Xunming Zhao, Weichun Guo, Lixue Zou and Biao Hu

    Citation: Cancer Cell International 2020 20:245

    Content type: Primary research

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  17. Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bac...

    Authors: Yuedi Ding, Jun Fan, Lili Deng, Biao Huang and Bin Zhou

    Citation: Cancer Cell International 2020 20:243

    Content type: Primary research

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  18. Emerging studies have demonstrated that circular RNAs (circRNAs) are key regulators for tumorigenesis in cancers, including papillary thyroid carcinoma (PTC). In this study, we aimed to explore the effects of ...

    Authors: Xiaolong Gui, Yan Li, Xiaobin Zhang, Ka Su and Wenlong Cao

    Citation: Cancer Cell International 2020 20:241

    Content type: Primary research

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  19. Endometrial cancer was the commonest gynecological malignancy in developed countries. Despite striking advances in multimodality management, however, for patients in advanced stage, targeted therapy still rema...

    Authors: Hongyu Zhou, Chufan Zhang, Haoran Li, Lihua Chen and Xi Cheng

    Citation: Cancer Cell International 2020 20:240

    Content type: Primary research

    Published on:

  20. The incidence and mortality of melanoma is increasing around the world. To deeply explain the mechanism insight into it, we conducted a systematic analysis to examine the levels of regulatory genes of the comm...

    Authors: Tengda Li, Mingli Gu, Anmei Deng and Cheng Qian

    Citation: Cancer Cell International 2020 20:239

    Content type: Primary research

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  21. Non-receptor protein tyrosine phosphatases (PTPNs) are a set of enzymes involved in the tyrosyl phosphorylation. The present study intended to clarify the associations between the expression patterns of PTPN f...

    Authors: Jing Chen, Xu Zhao, Yuan Yuan and Jing-Jing Jing

    Citation: Cancer Cell International 2020 20:238

    Content type: Primary research

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  22. The aberrant expression of microRNA-454 (miR-454) has been confirmed to be involved in the development of cancers. However, the functional role of miR-454 in the progression of ovarian cancer remains unclear.

    Authors: Yunhe An, Jun Zhang, Xiaoyan Cheng, Baoming Li, Yanjie Tian, Xiaoli Zhang and Fangqi Zhao

    Citation: Cancer Cell International 2020 20:237

    Content type: Primary research

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  23. Long noncoding RNA small nucleolar RNA host gene 16 (lncRNA SNHG16) has been revealed to be involved in the tumorigenesis of neuroblastoma. However, the role of SNHG16 in regulating cisplatin sensitivity in ne...

    Authors: Zhaoying Xu, Yongfa Sun, Danfeng Wang, Huifang Sun and Xiaojun Liu

    Citation: Cancer Cell International 2020 20:236

    Content type: Primary research

    Published on:

  24. Aberrant DNA methylation patterns are involved in the pathogenesis of papillary renal cell carcinoma (pRCC). This study aimed to investigate the potential of methylation-driven genes as biomarkers in determini...

    Authors: Zeyu Liu, Yuxiang Wan, Ming Yang, Xuewei Qi, Zhenzhen Dong, Jinchang Huang and Jingnan Xu

    Citation: Cancer Cell International 2020 20:235

    Content type: Primary research

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  25. Kinesin superfamily proteins (KIFs) serve as microtubule-dependent molecular motors, and are involved in the progression of many malignant tumors. In this study, we aimed to investigate the expression pattern ...

    Authors: Zhi-Gang Sun, Feng Pan, Jing-Bo Shao, Qian-Qian Yan, Lu Lu and Nan Zhang

    Citation: Cancer Cell International 2020 20:233

    Content type: Primary research

    Published on:

  26. Dysregulation of long non-coding RNAs (lncRNAs) results in development of human diseases including hepatocellular carcinoma (HCC). Although several HCC related lncRNAs have been reported, the biological functi...

    Authors: Qiang Fei, Feihong Song, Xinwei Jiang, Han Hong, Xiaoyong Xu, Zhengkang Jin, Xiang Zhu, Binghua Dai, Jiamei Yang, Chengjun Sui and Minhui Xu

    Citation: Cancer Cell International 2020 20:232

    Content type: Primary research

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  27. Emerging evidence suggests that competing endogenous RNAs plays a crucial role in the development and progress of pancreatic adenocarcinoma (PAAD). The objective was to identify a new lncRNA-miRNA-mRNA network...

    Authors: Wanqing Weng, Zhongjing Zhang, Weiguo Huang, Xiangxiang Xu, Boda Wu, Tingbo Ye, Yunfeng Shan, Keqing Shi and Zhuo Lin

    Citation: Cancer Cell International 2020 20:231

    Content type: Research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:282

  28. We aimed to identify differentially expressed pseudogenes and explore their potential functions in four types of common gynecological malignancies (e.g., cervical squamous cell carcinoma, ovarian serous cystad...

    Authors: Shitong Lin, Yifan Meng, Canhui Cao, Ping Wu, Peipei Gao, Wenhua Zhi, Ting Peng and Peng Wu

    Citation: Cancer Cell International 2020 20:229

    Content type: Primary research

    Published on:

  29. Lung adenocarcinoma has surpassed lung squamous cell carcinoma as the most common type of non-small cell lung cancer. In this study, we had tested the biological role of TRIM2 in lung adenocarcinoma.

    Authors: Zhaoxian Lin, Xing Lin, Lihuan Zhu, Jianyuan Huang and Yangyun Huang

    Citation: Cancer Cell International 2020 20:228

    Content type: Primary research

    Published on:

  30. MicroRNAs (miRNAs) serve as important regulators of the tumorigenesis and progression of many human cancers. Therefore, we evaluated the biological function and underlying mechanism of miR-363 in clear cell re...

    Authors: Yongpeng Xie, Luyao Chen, Yu Gao, Xin Ma, Weiyang He, Yu Zhang, Fan Zhang, Yang Fan, Liangyou Gu, Pin Li, Xu Zhang and Xin Gou

    Citation: Cancer Cell International 2020 20:227

    Content type: Primary research

    Published on:

  31. Hepatocellular carcinoma (HCC) is a common tumor characterized by high morbidity and mortality rates. The importance of circRNA in cancer diagnosis has been established. The study aimed to identify differentia...

    Authors: Xiang-Hong Sun, Yu-Tong Wang, Guo-Fu Li, Nan Zhang and Ling Fan

    Citation: Cancer Cell International 2020 20:226

    Content type: Primary research

    Published on:

  32. Pancreatic cancer is a highly malignant gastrointestinal cancer that can widely metastasize during the early stage of disease, and it is associated with one of the worst prognoses among cancers. In this study,...

    Authors: Yongping Zhou, Zhiyuan Hua, Ye Zhu, Liying Wang, Fangming Chen, Ting Shan, Yunhai Zhou and Tu Dai

    Citation: Cancer Cell International 2020 20:225

    Content type: Primary research

    Published on:

  33. Osteosarcoma (OS) is a common malignant bone cancer and is still a growing threat to young people. Circular RNAs (CircRNAs) are reported to be involved in the development of diverse human cancers. However, the...

    Authors: Haojie Wu, Weihua Li, Shutao Zhu, Dengfeng Zhang and Minghui Zhang

    Citation: Cancer Cell International 2020 20:223

    Content type: Primary research

    Published on:

  34. A novel systemic immune-inflammation index (SII), based on the neutrophils, lymphocytes and platelet counts, is associated with the prognosis of several cancers. The present study evaluates the prognostic sign...

    Authors: Xu Hu, Yan-Xiang Shao, Zhi-Qiang Yang, Wei-Chao Dou, San-Chao Xiong and Xiang Li

    Citation: Cancer Cell International 2020 20:222

    Content type: Primary research

    Published on:

  35. Because cell movement is primarily driven by the connection between F-actin and integrin through a physical linkage, cellular elasticity and adhesion strength have been considered as biomarkers of cell motilit...

    Authors: Sangwoo Kwon, Woochul Yang, Donggerami Moon and Kyung Sook Kim

    Citation: Cancer Cell International 2020 20:217

    Content type: Primary research

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  36. ZKSCAN3, a zinc-finger transcription factor containing KRAB and SCAN domains, has been reported to be regulated in several human cancers. However, its expression and function in hepatocellular carcinoma (HCC) ...

    Authors: Jieqiong Li, Nan Hao, Juan Han, Mi Zhang, Xiaomei Li and Nan Yang

    Citation: Cancer Cell International 2020 20:216

    Content type: Primary research

    Published on:

  37. Understanding the molecular mechanism of long non-coding RNAs (lncRNAs) in carcinogenesis is conducive for providing potential target for cancers. The role of FLVCR1-AS1 in breast cancer (BC) has not been prob...

    Authors: Zhiyu Pan, Junbin Ding, Zhen Yang, Huaqing Li, Hongjian Ding and Qian Chen

    Citation: Cancer Cell International 2020 20:214

    Content type: Primary research

    Published on:

  38. Dietary fiber is effective for colorectal cancer (CRC) treatment. Interleukin-6 (IL-6) and its adaptors are potential targets for CRC therapy. Butyrate, a metabolite of dietary fiber, is a new, highly safe typ...

    Authors: Yin Yuan, Bo Li, Yanbin Kuang, Shuo Ni, Aoxiang Zhuge, Jing Yang, Longxian Lv, Silan Gu, Ren Yan, Yating Li, Kaicen Wang, Liya Yang, Xueling Zhu, Jingjing Wu, Xiaoyuan Bian and Lanjuan Li

    Citation: Cancer Cell International 2020 20:212

    Content type: Primary research

    Published on:

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