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  1. The aim of this study was to determine the underlying potential mechanisms and function of DIO3OS, a lincRNA in osteosarcoma and clarify that DIO3OS can be used as a potential diagnostic biomarker and immunoth...

    Authors: Jinghong Yuan, Jingyu Jia, Tianlong Wu, Zhi Du, Qi Chen, Jian Zhang, Zhiwen Wu, Zhao Yuan, Xiaokun Zhao, Jiahao Liu, Jia Guo and Xigao Cheng
    Citation: Cancer Cell International 2023 23:215
  2. Immunoblockade therapy based on the PD-1 checkpoint has greatly improved the survival rate of patients with skin cutaneous melanoma (SKCM). However, existing anti-PD-1 therapeutic efficacy prediction markers o...

    Authors: Shaolong Leng, Gang Nie, Changhong Yi, Yunsheng Xu, Lvya Zhang and Linyu Zhu
    Citation: Cancer Cell International 2023 23:214
  3. Luteolin is an active ingredient in various traditional Chinese medicines for the treatment of multiple tumors. However, the mechanisms of its inhibitory effect on osteosarcoma proliferation and metastasis rem...

    Authors: Renxuan Huang, Mingxian Xu, Weitang Guo, Mingzhe Cheng, Rui Dong, Jian Tu, Shao Xu and Changye Zou
    Citation: Cancer Cell International 2023 23:213
  4. Research studies have demonstrated that Midkine (MDK) can influence the expression and activity of Renin-angiotensin system (RAS) components. Angiotensin II is involved in tumor growth and angiogenesis in diff...

    Authors: Tai-Jan Chiu, Chang-Han Chen, Yi-Ju Chen, Yinshen Wee, Ching-Shuen Wang and Sheng‑Dean Luo
    Citation: Cancer Cell International 2023 23:212
  5. Pancreatic cancer is one of the leading causes of cancer death in Western societies. Its late diagnosis and resistance to chemotherapies result in a high mortality rate; thus, the development of more effective...

    Authors: Mariola Gimła, Agnieszka Pyrczak-Felczykowska, Marcelina Malinowska, Aleksandra Hać, Magdalena Narajczyk, Irena Bylińska, Tristan A. Reekie and Anna Herman-Antosiewicz
    Citation: Cancer Cell International 2023 23:210
  6. Lung cancer is a leading cause of cancer-related deaths, and the most common type is lung adenocarcinoma (LUAD). LUAD is frequently diagnosed in people who never smoked, patients are always diagnosed at advanc...

    Authors: Xu Lin, Ye-han Liu, Huan-qi Zhang, Lin-wen Wu, Qi Li, Jun Deng, Qingyi Zhang, Yuhong Yang, Chong Zhang, Yang-ling Li and Jian Hu
    Citation: Cancer Cell International 2023 23:208
  7. Lung cancer has the highest mortality rate in the world, and mounting evidence suggests that cancer stem cells (CSCs) are associated with poor prognosis, recurrence, and metastasis of lung cancer. It is urgent...

    Authors: Chia-Hao Tung, Jia-En Wu, Meng-Fan Huang, Wen-Lung Wang, Yi-Ying Wu, Yao-Tsung Tsai, Xiu-Rui Hsu, Sheng-Hsiang Lin, Yuh-Ling Chen and Tse-Ming Hong
    Citation: Cancer Cell International 2023 23:207
  8. Lymphangiogenesis has been reported to play crucial roles in the metastasis of thyroid cancer (THCA), but despite the significant research on lymphangiogenesis in THCA, the precise regulatory mechanism remains...

    Authors: Liyun Yang, Runyu Zhao, Peipei Qiao, Jiaxin Cui, Xiaoping Chen, Jinping Fan, An Hu and Shuixian Huang
    Citation: Cancer Cell International 2023 23:206
  9. Hepatocellular Carcinoma (HCC) possesses the high mortality in cancers worldwide. Nevertheless, the concrete mechanism underlying HCC proliferation remains obscure. In this study, we show that high expression ...

    Authors: Yabing Hu, Yongchu Huang, Xiaohang Xie, Longshan Li, Yong Zhang and Xiaochao Zhang
    Citation: Cancer Cell International 2023 23:205
  10. Triple negative breast cancer (TNBC) represents a significant clinical challenge. Chemotherapy remains the mainstay for a large part of TNBC patients, whereas drug resistance and tumor recurrence frequently oc...

    Authors: Hui Lyu, Fei Shen, Sanbao Ruan, Congcong Tan, Jundong Zhou, Ann D. Thor and Bolin Liu
    Citation: Cancer Cell International 2023 23:204
  11. Outcomes for patients with relapsed acute lymphoblastic leukemia (ALL) are poor and there is a need for novel therapies to improve outcomes. Targeted inhibition of WEE1 with small-molecule inhibitor adavoserti...

    Authors: Hayden L. Bell, Helen J. Blair, Mankaran Singh, Anthony V. Moorman, Olaf Heidenreich, Frederik W. van Delft, John Lunec and Julie A. E. Irving
    Citation: Cancer Cell International 2023 23:202
  12. A growing body of evidence indicates that the anticancer effect of the immune system can be activated by the immunogenic modulation of dying cancer cells. Cancer cell death, as a result of the activation of an...

    Authors: Mina Amiri, Ommoleila Molavi, Shahnaz Sabetkam, Sevda Jafari and Soheila Montazersaheb
    Citation: Cancer Cell International 2023 23:200
  13. Hepatitis B virus (HBV)-encoded X antigen, HBx, assists in the development of hepatocellular carcinoma (HCC) through complex mechanisms. Our results provide new insights into the EZH2 epigenetic repression of ...

    Authors: Chen-Shiou Wu, Yi-Chung Chien, Chia‐Jui Yen, Jia-Yan Wu, Li-Yuan Bai and Yung-Luen Yu
    Citation: Cancer Cell International 2023 23:199
  14. Small nucleolar RNA host gene 1 (SNHG1) is an important member of the SNHG family. This family is composed of a group of host genes that can be processed into small nucleolar RNAs and play important biological...

    Authors: Huang Zeng, Shouang Zhou, Weiqiang Cai, Mingqiang Kang and Peipei Zhang
    Citation: Cancer Cell International 2023 23:198
  15. Telomerase can overcome replicative senescence by elongation of telomeres but is also a specific element in most cancer cells. It is expressed more vastly than any other tumor marker. Telomerase as a tumor tar...

    Authors: Jaber Haj Ali and Michael Walter
    Citation: Cancer Cell International 2023 23:197
  16. The prognosis of tumor patients can be assessed by measuring the levels of lncRNAs (long non-coding RNAs), which play a role in controlling the methylation of the RNA. Prognosis in individuals with colorectal ...

    Authors: Ziyang Di, Gaoran Xu, Zheyu Ding, Chengxin Li, Jialin Song, Guoquan Huang, Jinsen Zheng, Xinyao Zhang and Bin Xiong
    Citation: Cancer Cell International 2023 23:196
  17. Polypyrimidine tract binding protein 1 (PTBP1) has been found to play an important role in the occurrence and development of various tumors. At present, the role of PTBP1 in gastric cancer (GC) is still unknow...

    Authors: Zewen Chu, Miao Zhu, Yuanyuan Luo, Yaqi Hu, Xinyi Feng, Haibo Wang, Masataka Sunagawa and Yanqing Liu
    Citation: Cancer Cell International 2023 23:195
  18. Lung adenocarcinoma (LUAD) exhibits a higher fatality rate among all cancer types worldwide, yet the precise mechanisms underlying its initiation and progression remain unknown. Mounting evidence suggests that...

    Authors: Liyao Dong, Lin Zhang, Xinyun Zhao, Hongling Zou, Sisi Lin, Xinping Zhu, Jili Cao, Chun Zhou, Zhihong Yu, Yongqiang Zhu, Kequn Chai, Mingqian Li and Qun Li
    Citation: Cancer Cell International 2023 23:194
  19. In recent years, several bispecific antibodies (BsAbs) have been introduced that revolutionized the treatment approach for patients with multiple myeloma (MM). In the present study, we sought for conducting a ...

    Authors: Maryam Noori, Niloufar Yazdanpanah and Nima Rezaei
    Citation: Cancer Cell International 2023 23:193
  20. Approximately 50% of patients with primary colorectal carcinoma develop liver metastases. This study investigates the possible molecular discrepancies between primary colorectal cancer (pCRC) and their respect...

    Authors: Hersh Ham-Karim, Ola Negm, Narmeen Ahmad and Mohammad Ilyas
    Citation: Cancer Cell International 2023 23:192
  21. Progranulin (PGRN), a glycoprotein secreted by a wide range of epithelial cells and plays an important role in inflammatory mechanisms and tumor progression. In this study, the expression, and functions of PGR...

    Authors: Yanxu Dong, Hao Tan, Lidong Wang and Zhen Liu
    Citation: Cancer Cell International 2023 23:191
  22. Docetaxel (DTX) resistance reduces therapeutic efficacy in prostate cancer (PCa). Accumulating reports support the role of phytochemicals in the reversal of DTX resistance. This study aimed to determine whether E...

    Authors: Wenjing Xu, Jin Ding, Shida Kuang, Bonan Li, Tiansong Sun, Congxu Zhu, Juan Liu, Lemei Zhu, Yingqiu Li and Wen Sheng
    Citation: Cancer Cell International 2023 23:190
  23. The tumor vasculature was different from the normal vasculature in both function and morphology, which caused hypoxia in the tumor microenvironment (TME). Previous anti-angiogenesis therapy had led to a modest...

    Authors: Yang Li, Lei Fu, Baokang Wu, Xingqi Guo, Yu Shi, Chao Lv, Yang Yu, Yizhou Zhang, Zhiyun Liang, Chongli Zhong, Shukun Han, Feng Xu and Yu Tian
    Citation: Cancer Cell International 2023 23:189
  24. The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been reported to play a vital role in the occurrence and development of various tumors. However, the underlying mecha...

    Authors: Guang-Zhen Li, Guang-Xiao Meng, Guo-Qiang Pan, Xiao Zhang, Lun-Jie Yan, Rui-Zhe Li, Zi-Niu Ding, Si-Yu Tan, Dong-Xu Wang, Bao-wen Tian, Yu-Chuan Yan, Zhao-Ru Dong, Jian-Guo Hong and Tao Li
    Citation: Cancer Cell International 2023 23:188
  25. To date, data on the efficacy of targeted therapies for mucosal melanoma (MM) are limited. In this study, we analyzed genetic alterations according to the primary site of origin, which could provide clues for ...

    Authors: Hai-Yun Wang, Ye Liu, Ling Deng, Kuntai Jiang, Xin-Hua Yang, Xiao-Yan Wu, Kai-Hua Guo and Fang Wang
    Citation: Cancer Cell International 2023 23:187
  26. Renal cell carcinoma (RCC) is a hypermetabolic disease. Abnormal up-regulation of glycolytic signaling promotes tumor growth, and glycolytic metabolism is closely related to immunotherapy of renal cancer. The ...

    Authors: Sichen Di, Min Gong, Jianmin Lv, Qiwei Yang, Ye Sun, Yijun Tian, Cheng Qian, Wenjin Chen, Wang Zhou, Keqin Dong, Xiaokai Shi, Yuning Wang, Hongru Wang, Jian Chu, Sishun Gan, Xiuwu Pan…
    Citation: Cancer Cell International 2023 23:186
  27. The transferrin receptor (TfR) encoded by TFRC gene is the main cellular iron importer. TfR is highly expressed in many cancers and is expected to be a promising new target for cancer therapy; however, its role i...

    Authors: Guofei Feng, Yasushi Arima, Kaoru Midorikawa, Hatasu Kobayashi, Shinji Oikawa, Weilin Zhao, Zhe Zhang, Kazuhiko Takeuchi and Mariko Murata
    Citation: Cancer Cell International 2023 23:185
  28. Across the world, oral cancer is a prevalent tumor. Over the years, both its mortality and incidence have grown. Oral cancer metastasis is a complex process involving cell invasion, migration, proliferation, a...

    Authors: Meghdad Eslami, Saba Khazeni, Xaniar Mohammadi Khanaghah, Mohammad Hossein Asadi, Mohamad Amin Ansari, Javad Hayati Garjan, Mohammad Hassan Lotfalizadeh, Mobina Bayat, Mohammad Taghizadieh, Seyed Pouya Taghavi, Michael R Hamblin and Javid Sadri Nahand
    Citation: Cancer Cell International 2023 23:182
  29. Dietary compounds in cancer prevention have gained significant consideration as a viable method. Indole-3-carbinol (I3C) and 3,3′-diindolylmethane (DIM) are heterocyclic and bioactive chemicals found in crucif...

    Authors: Octavio Daniel Reyes-Hernández, Gabriela Figueroa-González, Laura Itzel Quintas-Granados, Stephany Celeste Gutiérrez-Ruíz, Hector Hernández-Parra, Alejandra Romero-Montero, María Luisa Del Prado-Audelo, Sergio Alberto Bernal-Chavez, Hernán Cortés, Sheila I. Peña-Corona, Lashyn Kiyekbayeva, Dilek Arslan Ateşşahin, Tamar Goloshvili, Gerardo Leyva-Gómez and Javad Sharifi-Rad
    Citation: Cancer Cell International 2023 23:180
  30. Unlike improved treatment response in multiple myeloma (MM), the mortality rate in MM is still high. The study’s aim is to investigate the potential role of circRNAs as a new biomarker for diagnosis, prognosis...

    Authors: Yasin Mirazimi, Amir Hossein Aghayan, Abbasali Keshtkar, Mahsa Mottaghizadeh Jazi, Atefeh Davoudian and Mohammad Rafiee
    Citation: Cancer Cell International 2023 23:178
  31. Metabolic reprogramming refers to tumor-associated metabolic alterations during tumorigenesis and has been regarded as one of the most important features of cancer. Profiling the altered metabolites and lipids...

    Authors: Bangzhen Ma, Yang Zhang, Jiwei Ma, Xinguo Chen, Chenglong Sun and Chengkun Qin
    Citation: Cancer Cell International 2023 23:177
  32. Skin cancer is one of the most widespread cancers, with a significant global health effect. UV-induced DNA damage in skin cells triggers them to grow and proliferate out of control, resulting in cancer develop...

    Authors: Mahsa Khayyati Kohnehshahri, Aila Sarkesh, Leila Mohamed Khosroshahi, Zanyar HajiEsmailPoor, Ali Aghebati-Maleki, Mehdi Yousefi and Leili Aghebati-Maleki
    Citation: Cancer Cell International 2023 23:174
  33. The B7-H3 protein, encoded by the CD276 gene, is a member of the B7 family of proteins and a transmembrane glycoprotein. It is highly expressed in various solid tumors, such as lung and breast cancer, and has ...

    Authors: Seol Hwa Shin, Eun Jin Ju, Jin Park, Eun Jung Ko, Mi Ri Kwon, Hye Won Lee, Ga Won Son, Yun-Yong Park, Yeon Joo Kim, Si Yeol Song, Sangkwang Lee, Beom Seok Seo, Jin-A Song, Sangbin Lim, Doohwan Jung, Sunyoung Kim…
    Citation: Cancer Cell International 2023 23:172
  34. The development of nonapoptotic programmed cell death inducers as anticancer agents has emerged as a cancer therapy field. Ferroptosis, ferrous ion-driven programmed cell death that is induced by redox imbalan...

    Authors: Yung-Ding Bow, Ching-Chung Ko, Wen-Tsan Chang, Sih-Yan Chou, Chun-Tzu Hung, Jau-Ling Huang, Chih-Hua Tseng, Yeh-Long Chen, Ruei-Nian Li and Chien-Chih Chiu
    Citation: Cancer Cell International 2023 23:171
  35. Although, there is a high rate of good prognosis in early stage head and neck tumors, about half of these tumors are detected in advanced stages with poor prognosis. A combination of chemotherapy, radiotherapy...

    Authors: Faezeh Tolue Ghasaban, Amirhosein Maharati, Amir Sadra Zangouei, Alireza Zangooie and Meysam Moghbeli
    Citation: Cancer Cell International 2023 23:170
  36. About 10% of hematologic malignancies are multiple myeloma (MM), an untreatable cancer. Although lactate and branched-chain amino acids (BCAA) are involved in supporting various tumor growth, it is unknown whe...

    Authors: Zhengyu Yu, Bingquan Qiu, Hui Zhou, Linfeng Li and Ting Niu
    Citation: Cancer Cell International 2023 23:169
  37. Chemotherapy is widely used as one of the first line therapeutic methods in cancer patients. However, chemotherapeutic resistance is one of the most common problems in cancer patients, which leads to the thera...

    Authors: Amirhosein Maharati, Yalda Samsami, Hanieh Latifi, Faezeh Tolue Ghasaban and Meysam Moghbeli
    Citation: Cancer Cell International 2023 23:168
  38. Immune checkpoint inhibitor (ICI) therapy has been used in various tumors. The biomarkers predictive of a response to ICI treatment remain unclear, and additional and combined biomarkers are urgently needed. S...

    Authors: Xueping Wang, Hao Huang, Lin Zhang, Yaxian Wu, Yingsheng Wen, Xuezi Weng, Qi Chen and Wanli Liu
    Citation: Cancer Cell International 2023 23:167

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