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  1. Programmed death- ligand 1 (PD-L1) seems to be associated with the immune escape of tumors, and immunotherapy may be a favorable treatment for PD-L1-positive patients. We evaluated intrahepatic cholangiocarcin...

    Authors: Min Deng, Shao-Hua Li, Xu Fu, Xiao-Peng Yan, Jun Chen, Yu-Dong Qiu and Rong-Ping Guo

    Citation: Cancer Cell International 2021 21:371

    Content type: Primary research

    Published on:

  2. LncRNA prostate cancer-associated transcript 6 (PCAT6) has been reported to be dysregulated in several cancers and is associated with tumor progression. Here, we have performed a meta-analysis to assess the ge...

    Authors: Song-bo Shi, Qing-hao Cheng, Shi-yi Gong, Ting-ting Lu, Shi-fang Guo, Shao-ming Song, Yu-ping Yang, Qi Cui, Ke-hu Yang and Yao-wen Qian

    Citation: Cancer Cell International 2021 21:370

    Content type: Review

    Published on:

  3. Epstein-Barr virus-associated gastric cancer (EBVaGC) is the most common EBV-related malignancy. A comprehensive research for the protein expression patterns in EBVaGC established by high-throughput assay rema...

    Authors: Zeyang Wang, Zhi Lv, Qian Xu, Liping Sun and Yuan Yuan

    Citation: Cancer Cell International 2021 21:368

    Content type: Primary research

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  4. Peroxiredoxins (PRDXs) are an antioxidant enzymes protein family involved in several biological functions such as differentiation, cell growth. In addition, previous studies report that PRDXs play critical rol...

    Authors: Lei Gao, Jialin Meng, Chuang Yue, Xingyu Wu, Quanxin Su, Hao Wu, Ze Zhang, Qinzhou Yu, Shenglin Gao, Song Fan and Li Zuo

    Citation: Cancer Cell International 2021 21:366

    Content type: Primary research

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  5. Uterus corpus endometrial cancer (UCEC) is the main malignant tumor in gynecology, with a high degree of heterogeneity, especially in terms of prognosis and immunotherapy efficacy. DNA methylation is one of th...

    Authors: JinHui Liu, ChengJian Ji, Yichun Wang, Cheng Zhang and HongJun Zhu

    Citation: Cancer Cell International 2021 21:365

    Content type: Primary research

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  6. Exosomes are single-membrane, secreted organelles with a diameter of 30–200 nm, containing diverse bioactive constituents, including DNAs, RNAs, proteins, and lipids, with prominent molecular heterogeneity. Ex...

    Authors: Zheng Zhao, Guiping Zhao, Shuyue Yang, Shengtao Zhu, Shutian Zhang and Peng Li

    Citation: Cancer Cell International 2021 21:364

    Content type: Review

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  7. Both N6-methyladenosine (m6A) modification and lncRNAs play an important role in the carcinogenesis and cancer inhibition of ovarian cancer (OC). However, lncRNAs involved in m6A regulation (LI-m6As) have neve...

    Authors: Jianfeng Zheng, Jialu Guo, Benben Cao, Ying Zhou and Jinyi Tong

    Citation: Cancer Cell International 2021 21:363

    Content type: Primary research

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  8. Growing evidence has shown that long noncoding RNA: microRNA: mRNA is implicated in tumor initiation, development, and progression. Long noncoding RNA HAND2-AS1 exhibits anti-cancer effects in diverse cancers....

    Authors: Liping Shan, Wei Liu and Yunhong Zhan

    Citation: Cancer Cell International 2021 21:361

    Content type: Primary research

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  9. Long non-coding RNAs (lncRNAs) and microRNAs (miRs) are differentially expressed in ovarian cancer (OC) cells and influence OC progression. This study intended to explore the underlying roles of LINC00115 and ...

    Authors: Rui Hou and Luo Jiang

    Citation: Cancer Cell International 2021 21:360

    Content type: Primary research

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  10. A large number of patients with stage II/III colorectal cancer (CRC) have a high recurrence rate after radical resection. We aimed to develop a novel tool to stratify patients with different recurrence-risk fo...

    Authors: Zaoqu Liu, Taoyuan Lu, Jing Li, Libo Wang, Kaihao Xu, Qin Dang, Chunguang Guo, Long Liu, Dechao Jiao, Zhenqiang Sun and Xinwei Han

    Citation: Cancer Cell International 2021 21:359

    Content type: Primary research

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  11. Because its metastasis to the lymph nodes are closely related to poor prognosis, miRNAs and mRNAs can serve as biomarkers for the diagnosis, prognosis, and therapy of colorectal cancer (CRC). This study aimed ...

    Authors: Xi Wang, Guangyu Gao, Zhengrong Chen, Zhihao Chen, Mingxiao Han, Xiaolu Xie, Qiyuan Jin, Hong Du, Zhifei Cao and Haifang Zhang

    Citation: Cancer Cell International 2021 21:358

    Content type: Primary research

    Published on:

  12. In view of the fact that peripheral blood parameters have been reported as predictors of immunotherapy to various cancers, this study aimed to determine the predictors of response to anti-programmed death-1 (a...

    Authors: Xianbin Wu, Runkun Han, Yanping Zhong, Nuoqing Weng and Ao Zhang

    Citation: Cancer Cell International 2021 21:356

    Content type: Primary research

    Published on:

  13. Clear cell renal cell carcinoma (ccRCC) occupied most of renal cell carcinoma (RCC), which associated with poor prognosis. The purpose of this study is to screen novel and prognostic biomarkers for patients wi...

    Authors: Hua-Hui Wu, Xin Yan, Zhao Chen, Guo-Wei Du, Xiao-Jie Bai, Kurerban Tuoheti and Tong-Zu Liu

    Citation: Cancer Cell International 2021 21:354

    Content type: Primary research

    Published on:

  14. Ovarian cancer (OC) is the most lethal gynaecological tumor. Changes in glycolysis have been proven to play an important role in OC progression. We aimed to identify a novel glycolysis-related gene signature t...

    Authors: Jing Yu, Ting-Ting Liu, Lei-Lei Liang, Jing Liu, Hong-Qing Cai, Jia Zeng, Tian-Tian Wang, Jian Li, Lin Xiu, Ning Li and Ling-Ying Wu

    Citation: Cancer Cell International 2021 21:353

    Content type: Primary research

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  15. Long non-coding RNAs (lncRNAs), acting as competing endogenous RNA (ceRNA) have been reported to regulate the expression of targeted genes by sponging miRNA in colon adenocarcinoma (COAD).

    Authors: Yinling Mao, Jiachen Lv, Li Jiang and Yihui Wang

    Citation: Cancer Cell International 2021 21:352

    Content type: Primary research

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  16. Type 2 diabetes mellitus and breast cancer are complex, chronic, heterogeneous, and multi-factorial diseases; with common risk factors including but not limited to diet, obesity, and age. They also share mutua...

    Authors: Ilhaam Ayaz Durrani, Attya Bhatti and Peter John

    Citation: Cancer Cell International 2021 21:351

    Content type: Review

    Published on:

  17. The mitochondrion is an organelle that plays a vital role in energy production, cytoplasmic protein degradation and cell death. Mitophagy is an autophagic procedure that specifically clears damaged mitochondri...

    Authors: Yanjie Guan, Yifei Wang, Bo Li, Kai Shen, Quanfu Li, Yingyin Ni and Lei Huang

    Citation: Cancer Cell International 2021 21:350

    Content type: Review

    Published on:

  18. Osteosarcoma is a primary bone tumor. Although it is a rare disease in general, it is the most common primary bone tumor among children. Despite the significant advances made in the field of osteosarcoma treat...

    Authors: Parisa Maleki Dana, Fatemeh Sadoughi, Zatollah Asemi and Bahman Yousefi

    Citation: Cancer Cell International 2021 21:349

    Content type: Review

    Published on:

  19. Mature T-cell lymphomas (MTCLs), a group of diseases with high aggressiveness and vulnerable prognosis, lack for the accurate prognostic stratification systems at present. Novel prognostic markers and models a...

    Authors: Tiange Lu, Lei Shi, Guanggang Shi, Yiqing Cai, Shunfeng Hu, Jiarui Liu, Shuai Ren, Xiangxiang Zhou and Xin Wang

    Citation: Cancer Cell International 2021 21:348

    Content type: Primary research

    Published on:

  20. Glioblastoma remains one of the most lethal brain cancers. T-cell immunoglobulin and mucin domain 1 (Tim-1) is associated with various immune diseases. The molecular mechanism of Tim-1 in regulating glioblasto...

    Authors: Li Wei, Ya Peng, Naiyuan Shao and Peng Zhou

    Citation: Cancer Cell International 2021 21:347

    Content type: Primary research

    Published on:

  21. Methylation plays an important role in colorectal cancer (CRC) pathogenesis. The goal of this study was to identify aberrantly differentially methylated genes (DMGs) and pathways through bioinformatics analysi...

    Authors: Mahla Ghorbani, Marjan Azghandi and Mohammad Amin Kerachian

    Citation: Cancer Cell International 2021 21:346

    Content type: Primary research

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  22. Hypoxia, which affects the development, metastasis and prognosis of cancer, represents a key feature of cancer. This study describe a hypoxia risk factor model, with predicting the prognosis of cervical cancer.

    Authors: Yang Yang, Yaling Li, Ruiqun Qi and Lan Zhang

    Citation: Cancer Cell International 2021 21:345

    Content type: Primary research

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  23. Although immunotherapy for colon cancer has made promising progress, only a few patients currently benefit from it. A recent study revealed that infiltrating immune cells are highly relevant to tumor prognosis...

    Authors: Hao Xu, Qianhui Xu and Lu Yin

    Citation: Cancer Cell International 2021 21:344

    Content type: Primary research

    Published on:

  24. Clear cell renal cell carcinoma (ccRCC), derived from renal tubular epithelial cells, is the most common malignant tumor of the kidney. The study of key genes related to the pathogenesis of ccRCC has become im...

    Authors: Chunxiu Yang, Jingjing Pang, Jian Xu, He Pan, Yueying Li, Huainian Zhang, Huan Liu and Shu-Yuan Xiao

    Citation: Cancer Cell International 2021 21:343

    Content type: Primary research

    Published on:

  25. Hepatocellular carcinoma (HCC) was the sixth common malignancies characteristic with highly aggressive in the world. It was well established that tumor mutation burden (TMB) act as indicator of immunotherapeut...

    Authors: Qianhui Xu, Hao Xu, Rongshan Deng, Zijie Wang, Nanjun Li, Zhixuan Qi, Jiaxin Zhao and Wen Huang

    Citation: Cancer Cell International 2021 21:342

    Content type: Primary research

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  26. Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2) is a member of the PAS superfamily. Previous studies explored the carcinogenic roles of transcription factor ARNTL2 in human malignancies. However...

    Authors: Song Wang, Xueyou Ma, Yufan Ying, Jiazhu Sun, Zitong Yang, Jiangfeng Li, Ke Jin, Xiao Wang, Bo Xie, Xiangyi Zheng, Ben Liu and Liping Xie

    Citation: Cancer Cell International 2021 21:341

    Content type: Primary research

    Published on:

  27. Long non-coding RNAs (lncRNAs) are increasingly recognized as the crucial mediators in the regulation of ferroptosis and iron metabolism. A systematic understanding of ferroptosis and iron-metabolism related l...

    Authors: Jie Yao, Xiao Chen, Xiao Liu, Rui Li, Xijia Zhou and Yiqing Qu

    Citation: Cancer Cell International 2021 21:340

    Content type: Primary research

    Published on:

  28. Fatty acid oxidation (FAO) is the emerging hallmark of cancer metabolism because certain tumor cells preferentially utilize fatty acids for energy. Lymph node metastasis, the most common way of tumor metastasi...

    Authors: Mao Li, Hong-chun Xian, Ya-Jie Tang, Xin-hua Liang and Ya-ling Tang

    Citation: Cancer Cell International 2021 21:339

    Content type: Review

    Published on:

  29. Some driver oncogenes are still unknown in non-small-cell lung cancer (NSCLC). DNAJC19, a major component of the translocation machinery of mitochondrial membranes, is a disease-associated protein. Herein, we ...

    Authors: Ji Zhou, Yang Peng, Ying-chun Gao, Tai-yu Chen, Peng-cheng Li, Ke Xu, Tao Liu and Tao Ren

    Citation: Cancer Cell International 2021 21:338

    Content type: Primary research

    Published on:

  30. Additional epidermal growth factor receptor (EGFR) mutations confer the drug resistance to generations of EGFR targeted tyrosine kinase inhibitor (EGFR-TKI), posing a major challenge to developing effective tr...

    Authors: Leiming Xia, Fan Yang, Xiao Wu, Suzhi Li, Chen Kan, Hong Zheng and Siying Wang

    Citation: Cancer Cell International 2021 21:337

    Content type: Primary research

    Published on:

  31. Osteosarcoma (OS) is a common type of bone malignancy that often occurs in children and adolescents. Chemoresistance is a huge barrier to cancer therapy. This study aimed to investigate the role and potential ...

    Authors: Huapeng Guan, Hao Xu, Jinshui Chen, Weishan Wu, Dongfeng Chen, Yungang Chen and Jianzhong Sun

    Citation: Cancer Cell International 2021 21:336

    Content type: Primary research

    Published on:

  32. Gastric cancer (GC) is one of the most common cancer worldwide. It is essential to identify non-invasive diagnostic and prognostic biomarkers of GC. The aim of the present study was to screen candidate biomark...

    Authors: Lei Liu, Honglin Pang, Qiao He, Biran Pan, Xiaobin Sun, Jing Shan, Liping Wu, Kaiwen Wu, Xue Yao and Yuanbiao Guo

    Citation: Cancer Cell International 2021 21:335

    Content type: Primary research

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  33. Lung cancer is one of the most common malignant tumours worldwide. however, emerging immunotherapy and targeted therapies continue to show limited efficacy. In the search for new targets for lung cancer treatm...

    Authors: Runzhi Qi, Yuwei Zhao, Qiujun Guo, Xue Mi, Mengqi Cheng, Wei Hou, Honggang Zheng and Baojin Hua

    Citation: Cancer Cell International 2021 21:333

    Content type: Review

    Published on:

  34. BCL2L13 belongs to the BCL2 super family, with its protein product exhibits capacity of apoptosis-mediating in diversified cell lines. Previous studies have shown that BCL2L13 has functional consequence in severa...

    Authors: Fei Meng, Luojin Zhang, Mingjun Zhang, Kaiqin Ye, Wei Guo, Yu Liu, Wulin Yang, Zhimin Zhai, Hongzhi Wang, Jun Xiao and Haiming Dai

    Citation: Cancer Cell International 2021 21:332

    Content type: Primary research

    Published on:

  35. Emerging evidence shows that abnormal expression of long non-coding RNA is involved in the occurrence and development of various tumors. LncRNA MONC is abnormally expressed in head and neck squamous cell carci...

    Authors: Yibing Li, Jianing Huo, Junjian He and Xiaoxin Ma

    Citation: Cancer Cell International 2021 21:331

    Content type: Primary research

    Published on:

  36. Hepatocellular carcinoma (HCC) has a poor prognosis and has become the sixth most common malignancy worldwide due to its high incidence. Advanced approaches to therapy, including immunotherapeutic strategies, ...

    Authors: Qiuxian Zheng, Qin Yang, Jiaming Zhou, Xinyu Gu, Haibo Zhou, Xuejun Dong, Haihong Zhu and Zhi Chen

    Citation: Cancer Cell International 2021 21:330

    Content type: Primary research

    Published on:

  37. Patients with nasopharyngeal cancer (NPC) differ in prognosis, even at the same stage; therefore, new biomarkers are urgently required to identify early-stage NPC patients at high risk of poor prognosis. Altho...

    Authors: Tianhao Liang, Weixing Liu, Junyang Xie, Yiyan Wang, Gui Chen, Wenjing Liao, Lijuan Song and Xiaowen Zhang

    Citation: Cancer Cell International 2021 21:329

    Content type: Review

    Published on:

  38. Small non‐coding RNAs (sncRNAs) are a subgroup of non‐coding RNAs, with less than 200 nucleotides length and no potential for coding proteins. PiRNAs, a member of sncRNAs, were first discovered more than a dec...

    Authors: Fatemeh Sadoughi, Seyyed Mehdi Mirhashemi and Zatollah Asemi

    Citation: Cancer Cell International 2021 21:328

    Content type: Review

    Published on:

  39. CD58 has been demonstrated to be abnormally expressed in multiple hematopoietic malignancies and solid tumors and plays an essential role in tumorigenesis and progression; however, its clinical significance an...

    Authors: Yalu Zhang, Qiaofei Liu, Jingkai Liu and Quan Liao

    Citation: Cancer Cell International 2021 21:327

    Content type: Primary research

    Published on:

  40. RNA binding protein (RBP) is an active factor involved in the occurrence and development of colorectal cancer (CRC). Therefore, the potential mechanism of RBP in CRC needs to be clarified by dry-lab analyses o...

    Authors: Qinglian He, Ziqi Li, Xue Lei, Qian Zou, Haibing Yu, Yuanlin Ding, Guangxian Xu and Wei Zhu

    Citation: Cancer Cell International 2021 21:325

    Content type: Primary research

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  41. Circular RNAs (circRNAs) have been reported to be important regulators of the development and progression of various carcinomas. However, the role of circRNA_100290 in gastric cancer (GC) is still unclear. Thi...

    Authors: Gang Wang, Dan Sun, Wenhui Li and Yan Xin

    Citation: Cancer Cell International 2021 21:324

    Content type: Primary research

    Published on:

  42. The dysfunction of myc-related zinc finger protein (MAZ) has been proven to contribute to tumorigenesis and development of multiple cancer types. However, the biological roles and clinical significance of MAZ ...

    Authors: Li-Xin Ren, Jin-Chun Qi, An-Ning Zhao, Bei Shi, Hong Zhang, Dan-Dan Wang and Zhan Yang

    Citation: Cancer Cell International 2021 21:323

    Content type: Primary research

    Published on:

  43. It have been proven that long non-coding RNAs (lncRNAs) serve as regulators in carcinogenesis. Interleukin enhancer binding factor 3 antisense RNA 1 (ILF3-AS1) has been illuminated as a prognostic factor in so...

    Authors: Zhaohui Zeng, Qiangfeng Teng and Jinhong Xiao

    Citation: Cancer Cell International 2021 21:322

    Content type: Primary research

    Published on:

  44. Long non-coding RNAs (lncRNAs), a class of non-coding RNAs (ncRNAs) associated with diverse biological processes of cells. Over the past decades, cumulating research evidences revealed that abnormal expression...

    Authors: Md Zahirul Islam Khan and Helen Ka Wai Law

    Citation: Cancer Cell International 2021 21:321

    Content type: Primary research

    Published on:

  45. Rho GTPase activating protein 10 (ARHGAP10) has been implicated as an essential element in multiple cellular process, including cell migration, adhesion and actin cytoskeleton dynamic reorganization. However, ...

    Authors: Lan-Lan Lin, Fan Yang, Dong-Huan Zhang, Cong Hu, Sheng Yang and Xiang-Qi Chen

    Citation: Cancer Cell International 2021 21:320

    Content type: Primary research

    Published on:

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