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  1. p27(Kip1) is a cyclin-dependent kinase inhibitor. When up-regulated, p27 inhibits G1-to-S phase transition of the cell cycle. This report addresses the question of whether various nutritional and chemopreventi...

    Authors: Isao Eto
    Citation: Cancer Cell International 2006 6:20
  2. Human papillomavirus type 16 (HPV-16) E5 protein co-operates with epidermal growth factor to stimulate mitogenesis of murine fibroblasts. Currently, little is known about which viral amino acids are involved i...

    Authors: Rahul Nath, Christine A Mant, Barbara Kell, John Cason and Jon M Bible
    Citation: Cancer Cell International 2006 6:19
  3. Hepatitis C (HCV) viral infection is a serious medical problem in Egypt and it has a devastating impact on the Egyptian economy. It is estimated that over 15% of Egyptians are infected by the virus and thus fi...

    Authors: Mostafa K El Awady, Noha G Badr El Din, Wael T El Garf, Samar S Youssef, Moataza H Omran, Jasmin El Abd and Said A Goueli
    Citation: Cancer Cell International 2006 6:18
  4. Cationic (positively charged) liposomes have been tested in various gene therapy clinical trials for neoplastic and other diseases. They have demonstrated selectivity for tumour vascular endothelial cells rais...

    Authors: Crispin R Dass and Peter FM Choong
    Citation: Cancer Cell International 2006 6:17
  5. Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of extracellular matrix proteins and promoting cell motility. ...

    Authors: Britny J Candia, William C Hines, Christopher M Heaphy, Jeffrey K Griffith and Robert A Orlando
    Citation: Cancer Cell International 2006 6:16
  6. Immortalization is a key step in malignant transformation, but immortalization alone is insufficient for transformation. Human mammary epithelial cell (HMEC) transformation is a complex process that requires a...

    Authors: Krishna Rao, Özge Alper, Kent E Opheim, George Bonnet, Kristine Wolfe, Eileen Bryant, Siobhan O'Hara Larivee, Peggy Porter and James K McDougall
    Citation: Cancer Cell International 2006 6:15
  7. Human papillomavirus has been implicated in virtually all cervical cancers and is believed to be the primary etiological factor that transforms cervical epithelia. The presence of HPV in oral cancers suggests ...

    Authors: Karl Kingsley, Devin Johnson and Susan O'Malley
    Citation: Cancer Cell International 2006 6:14
  8. Integrin-linked kinase (ILK) is a ubiquitously expressed protein kinase that has emerged as one of the points of convergence between integrin- and growth factor-signalling pathways.

    Authors: Glenn A Driver and Robin B Veale
    Citation: Cancer Cell International 2006 6:12
  9. We have demonstrated that in some human cancer cells both chronic mild heat and ionizing radiation exposures induce a transient block in S and G2 phases of the cell cycle. During this delay, cyclin B1 protein ...

    Authors: Fiorenza Ianzini, Alessandro Bertoldo, Elizabeth A Kosmacek, Stacia L Phillips and Michael A Mackey
    Citation: Cancer Cell International 2006 6:11
  10. Zinc plays important roles in maintaining normal function of the prostate and in development of prostate malignancy. It has been demonstrated that prostate malignant epithelial cells contain much less cellular...

    Authors: Liping Huang, Catherine P Kirschke and Yunfan Zhang
    Citation: Cancer Cell International 2006 6:10
  11. Lovastatin and other statins may reduce the development of melanomas. The effects on melanoma cells and their ability to enhance angiogenesis in a co-culture system presented an opportunity to assess whether L...

    Authors: Ivan Depasquale and Denys N Wheatley
    Citation: Cancer Cell International 2006 6:9
  12. Plasminogen activators are known to play a key role in the remodeling of bone matrix which occurs during tumor progression, bone metastasis and bone growth. Dysfunctional remodeling of bone matrix gives rise t...

    Authors: Daniel Vial, Elizabeth Monaghan-Benson and Paula J McKeown-Longo
    Citation: Cancer Cell International 2006 6:8
  13. Chlorogenic acid (CHL), the most potent functional inhibitor of the microsomal glucose-6-phosphate translocase (G6PT), is thought to possess cancer chemopreventive properties. It is not known, however, whether...

    Authors: Anissa Belkaid, Jean-Christophe Currie, Julie Desgagnés and Borhane Annabi
    Citation: Cancer Cell International 2006 6:7
  14. In order to explore a pre-clinical method to evaluate if [18F]FDG is valid for monitoring early response, we investigated the uptake of FDG in Multicellular tumour spheroids (MTS) without and with treatment with ...

    Authors: Azita Monazzam, Pasha Razifar, Martin Simonsson, Fredrik Qvarnström, Raymond Josephsson, Carl Blomqvist, Bengt Långström and Mats Bergström
    Citation: Cancer Cell International 2006 6:6
  15. Cancer is one of the most complex dynamic human disease. Despite rapid advances in the fields of molecular and cell biology, it is still widely debated as to how neoplastic cells progress through carcinogenesi...

    Authors: Fabio Grizzi and Maurizio Chiriva-Internati
    Citation: Cancer Cell International 2006 6:4
  16. The product of the retinoblastoma-susceptibility gene (pRb) is a substrate for Protein Phosphatase 1 (PP1). At mitotic exit, all three PP1 isoforms, α, γ1 and δ, bind to pRb and dephosphorylate its Ser/Thr sit...

    Authors: Michele Vietri, Mariarita Bianchi, John W Ludlow, Sibylle Mittnacht and Emma Villa-Moruzzi
    Citation: Cancer Cell International 2006 6:3
  17. Among the epigenetic alterations occurring in cancer, DNA hypermethylation and histone hypoacetylation are the focus of intense research because their pharmacological inhibition has shown to produce antineopla...

    Authors: Alma Chavez-Blanco, Carlos Perez-Plasencia, Enrique Perez-Cardenas, Claudia Carrasco-Legleu, Edgar Rangel-Lopez, Blanca Segura-Pacheco, Lucia Taja-Chayeb, Catalina Trejo-Becerril, Aurora Gonzalez-Fierro, Myrna Candelaria, Gustavo Cabrera and Alfonso Duenas-Gonzalez
    Citation: Cancer Cell International 2006 6:2
  18. Pluripotent mouse embryonic stem (ES) cells can be induced in vitro to become neural progenitors. Upon transplantation, neural progenitors migrate toward areas of damage and inflammation in the CNS. We tested whe...

    Authors: Peter Serfozo, Maggie S Schlarman, Chris Pierret, Bernard L Maria and Mark D Kirk
    Citation: Cancer Cell International 2006 6:1
  19. Mitochondrial DNA (mtDNA) is known for high mutation rates caused by lack of protective histones, inefficient DNA repair systems, and continuous exposure to mutagenic effects of oxygen radicals. Alterations in...

    Authors: Himani Sharma, Archna Singh, Chandresh Sharma, Sunesh Kumar Jain and Neeta Singh
    Citation: Cancer Cell International 2005 5:34
  20. Clinicians will argue that cancer can only really receive the treatment that is needed through thorough understanding of medicine. However, even empirical approaches to therapy result in experimental analysis ...

    Authors: Denys N Wheatley Editor-in-Chief, Cancer Cell International
    Citation: Cancer Cell International 2005 5:33
  21. Considering the width and importance of using Multicellular Tumor Spheroids (MTS) in oncology research, size determination of MTSs by an accurate and fast method is essential. In the present study an effective...

    Authors: Azita Monazzam, Pasha Razifar, Örjan Lindhe, Raymond Josephsson, Bengt Långström and Mats Bergström
    Citation: Cancer Cell International 2005 5:32
  22. It is known that aurora B, a chromosomal passenger protein responsible for the proper progression of mitosis and cytokinesis, is overexpressed throughout the cell cycle in cancer cells. Overexpression of auror...

    Authors: Ash-shafie Abdullah, Charlene Foong and Maki Murata-Hori
    Citation: Cancer Cell International 2005 5:31
  23. The p23.2 region of human chromosome 8 is frequently deleted in several types of epithelial cancer and those deletions appear to be associated with poor prognosis. Cub and Sushi Multiple Domains 1 (CSMD1) was pos...

    Authors: Toni M Richter, Benton D Tong and Steven B Scholnick
    Citation: Cancer Cell International 2005 5:29
  24. Many anticancer agents and carcinogens are DNA damaging chemicals and exposure to such chemicals results in the deregulation of cell cycle progression. The molecular mechanisms of DNA damage-induced cell cycle...

    Authors: Huijun Zhu, Catherine Smith, Charles Ansah and Nigel J Gooderham
    Citation: Cancer Cell International 2005 5:28
  25. p53 is important in the development of hepatocellular carcinoma (HCC) and in therapeutic approaches, but the mechanism whereby it inhibits HCC growth is still unclear. The aim of the present study was to estab...

    Authors: Tian-Yi Chi, George G Chen, Lok-Kee Ho and Paul BS Lai
    Citation: Cancer Cell International 2005 5:27
  26. Sodium weighted images can indicate sodium signal intensities from different features in the tumor before and 24 hours following administration of Taxotere.

    Authors: Rakesh Sharma, Richard P Kline, Ed X Wu and Jose K Katz
    Citation: Cancer Cell International 2005 5:26
  27. This study was undertaken to examine the relationship between the tumor suppressor gene p53 and the nuclear signaling protein beta-catenin during bone differentiation. Cross talk between p53 and beta-catenin p...

    Authors: Nalini Chandar, Rasleen Saluja, Peter C Lamar, Kevin Kolman and Walter C Prozialeck
    Citation: Cancer Cell International 2005 5:24
  28. The effects of a rectified semi-sinewave signal (15 mT amplitude, 120 pulses per second, EMF Therapeutics, Inc.) (TEMF) alone and in combination with gamma irradiation (IR) therapy in nude mice bearing a human...

    Authors: Ivan L Cameron, Lu-Zhe Sun, Nicholas Short, W Elaine Hardman and C Douglas Williams
    Citation: Cancer Cell International 2005 5:23
  29. Multidrug resistance mediated by the multidrug resistance-associated protein 1 (MRP1) decreases cellular drug accumulation. The exact mechanism of MRP1 involved multidrug resistance has not been clarified yet,...

    Authors: Ilhan Akan, Selma Akan, Hakan Akca, Burhan Savas and Tomris Ozben
    Citation: Cancer Cell International 2005 5:22
  30. A secreted peptide Pep27 initiates the cell death program in S. pneumoniae through signal transduction. This study was undertaken to evaluate the relation between the structure and cytotoxic activity of Pep27 and...

    Authors: Dong Gun Lee, Kyung-Soo Hahm, Yoonkyung Park, Hai-Young Kim, Weontae Lee, Sung-Chul Lim, Youn-Kyung Seo and Cheol-Hee Choi
    Citation: Cancer Cell International 2005 5:21
  31. Expression of P-glycoprotein (P-gp), the multidrug resistance (MDR) 1 gene product, can lead to multidrug resistance in tumours. However, the physiological role of P-gp in tumours growing as multicellular sphe...

    Authors: Ponce de León Valeria and Barrera-Rodríguez Raúl
    Citation: Cancer Cell International 2005 5:20
  32. Insensitivity of advanced-stage prostate cancer to androgen ablation therapy is a serious problem in clinical practice because it is associated with aggressive progression and poor prognosis. Targeted therapeu...

    Authors: Ekwere T Ifon, Alan LY Pang, Warren Johnson, Kathleen Cashman, Sharon Zimmerman, Sumitra Muralidhar, Wai-Yee Chan, John Casey and Leonard Jason Rosenthal
    Citation: Cancer Cell International 2005 5:19
  33. A neoplastic tumor cannot grow beyond a millimeter or so in diameter without recruitment of endothelial cells and new blood vessels to supply nutrition and oxygen for tumor cell survival. This study was design...

    Authors: Ivan L Cameron, Nicholas Short, LuZhe Sun and W Elaine Hardman
    Citation: Cancer Cell International 2005 5:17
  34. Combined effect of vanadium and beta-carotene on rat liver DNA-chain break and Proton induced X-ray emission (PIXE) analysis was studied during a necrogenic dose (200 mg/kg of body weight) of Diethyl Nitrosami...

    Authors: Mitali Basu Chattopadhyay, Sutapa Mukherjee, Indira Kulkarni, V Vijayan, Manika Doloi, NB Kanjilal and Malay Chatterjee
    Citation: Cancer Cell International 2005 5:16
  35. Multidrug resistance (MDR) phenotype of malignant cells is the major problem in the chemotherapy of neoplasia. The treatment of leukemia with retinoids is aimed on the induction of leukemic cells differentiati...

    Authors: Tatjana P Stromskaya, Ekaterina Y Rybalkina, Tatjana N Zabotina, Alexander A Shishkin and Alla A Stavrovskaya
    Citation: Cancer Cell International 2005 5:15
  36. A human malignant continuous cell line, named NG97, was recently established in our laboratory. This cell line has been serially subcultured over 100 times in standard culture media presenting no sign of cell ...

    Authors: Camila ML Machado, André Schenka, José Vassallo, Wirla MSC Tamashiro, Estela M Gonçalves, Selma C Genari and Liana Verinaud
    Citation: Cancer Cell International 2005 5:13
  37. The effects of an omega-3 (n-3) fatty acid enriched diet alone and in combination with gamma irradiation (IR) therapy in nude mice bearing a human MDA-MB231 breast cancer xenograft were tested. The cancer cell...

    Authors: W Elaine Hardman, LuZhe Sun, Nicholas Short and Ivan L Cameron
    Citation: Cancer Cell International 2005 5:12
  38. Inflammatory breast cancer (IBC) is the most lethal form of locally invasive breast cancer known. However, very little information is available on the cellular mechanisms responsible for manifestation of the I...

    Authors: Michaela R Hoffmeyer, Kristin M Wall and Suranganie F Dharmawardhane
    Citation: Cancer Cell International 2005 5:11
  39. The almost universal belief that cancer is caused by mutation may gradually be giving way to the belief that cancer begins as a cellular adaptation that involves the local epigenetic silencing of various genes...

    Authors: Richmond T Prehn
    Citation: Cancer Cell International 2005 5:9
  40. Androgens and androgen receptors (AR) regulate normal prostate development and growth. They also are involved in pathological development of prostatic diseases, including benign prostatic hyperplasia (BPH) and...

    Authors: Qing Yang, Kar-Ming Fung, Wanda V Day, Bradley P Kropp and Hsueh-Kung Lin
    Citation: Cancer Cell International 2005 5:8
  41. Calcineurin (CaN) is an important serine-threonine phosphatase (PP2B), which plays a crucial role in calcium-calmodulin mediated signal transduction events. Calcineurin has been implicated in pathogenesis of v...

    Authors: S Padma, A Pavani Sowjanya, Usha Rani Poli, Meenakshi Jain, BN Rao and Gayatri Ramakrishna
    Citation: Cancer Cell International 2005 5:7
  42. A full-term pregnancy has been associated with reduced risk for developing breast cancer. In rodent models, the protective effect of pregnancy can be mimicked with a defined regimen of estrogen and progesteron...

    Authors: Jiahui Zhang, Yifan Tu and Sallie Smith-Schneider
    Citation: Cancer Cell International 2005 5:6
  43. The necessary and sufficient capabilities of cancer cell have been identified. Strikingly, this list does not include one that would seem to be a key property, namely the ability of cancer cells to kill their ...

    Authors: Anatoly V Lichtenstein
    Citation: Cancer Cell International 2005 5:5

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