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  1. Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysre...

    Authors: Shyam Nyati, Brian D Ross, Alnawaz Rehemtulla and Mahaveer S Bhojani
    Citation: Cancer Cell International 2010 10:23
  2. The association between the wnt signaling pathway and apoptosis has become more firmly established in the recent scientific literature. Many reports indicate that the wnt signaling pathway regulates apoptosis ...

    Authors: Nives Pećina-Šlaus
    Citation: Cancer Cell International 2010 10:22
  3. Intravesical immunotherapy with Mycobacterium bovis bacillus Calmette-Guérin has been established as the most effective adjuvant treatment for high risk non-muscle-invasive bladder cancer (NMIBC). We investigated...

    Authors: Katja Schwarzer, Martin Foerster, Thomas Steiner, Inge-Marie Hermann and Eberhard Straube
    Citation: Cancer Cell International 2010 10:21
  4. Blockade of the angiotensin (ANG) II type 1 receptor (AT1R) inhibits tumour growth in several cancers, including colorectal cancer (CRC) liver metastases. While AT1R blockade has been extensively studied, the ...

    Authors: Eleanor I Ager, Way W Chong, Shu-wen Wen and Christopher Christophi
    Citation: Cancer Cell International 2010 10:19

    The Erratum to this article has been published in Cancer Cell International 2010 10:37

  5. In this study the effect of myenteric denervation induced by benzalconium chloride (BAC) on distribution of fibrillar components of extracellular matrix (ECM) and inflammatory cells was investigated in gastric...

    Authors: Cássia F Estofolete, Carla Botelho-Machado, Sebastião R Taboga, Sérgio Zucoloto, Ana Cláudia Polli-Lopes and Cristiane D Gil
    Citation: Cancer Cell International 2010 10:18
  6. Ovarian cancer is one of the most significant malignancies in the western world. Studies showed that Ovarian cancers tend to grow resistance to cisplatin treatment. Therefore, new approaches are needed in ovar...

    Authors: Haitao Luo, Matthew K Daddysman, Gary O Rankin, Bing-Hua Jiang and Yi C Chen
    Citation: Cancer Cell International 2010 10:16
  7. Micro(mi)RNAs are a class of small non-coding RNAs that play critical roles in the induction of various cancers, including lymphomas induced by oncogenic viruses. While some of the miRNAs are oncogenic, miRNAs...

    Authors: Hongtao Xu, Yongxiu Yao, Lorraine P Smith and Venugopal Nair
    Citation: Cancer Cell International 2010 10:15
  8. Hydnophytum formicarium Jack is an epyphytic shrub that belongs to the family of Rubiaceae and is native to the tropical rain forests of the Asean region, which includes Malaysia. A flavanoid derivative, 7, 3', 5...

    Authors: Hasmah Abdullah, Azimahtol Hawariah Lope Pihie, Judit Hohmann and Joseph Molnár
    Citation: Cancer Cell International 2010 10:14
  9. MLL2, an epigenetic regulator in mammalian cells, mediates histone 3 lysine 4 tri-methylation (H3K4me3) through the formation of a multiprotein complex. MLL2 shares a high degree of structural similarity with ...

    Authors: Thanemozhi G Natarajan, Bhaskar V Kallakury, Christine E Sheehan, Margaret B Bartlett, Natarajan Ganesan, Anju Preet, Jeffrey S Ross and Kevin T FitzGerald
    Citation: Cancer Cell International 2010 10:13
  10. The DNA enzyme Dz13, targeted against the oncogene c-Jun, is capable of inhibiting various model tumours in mice albeit in ectopic models of neoplasia. In previous studies using orthotopic models of disease, t...

    Authors: Mei Lin Tan, Peter FM Choong and Crispin R Dass
    Citation: Cancer Cell International 2010 10:9
  11. The interaction between viral oncoproteins such as Simian virus 40 TAg, adenovirus E1A, and human papilloma virus E7, and the retinoblastoma protein (pRB) occurs through a well characterized peptide sequence, ...

    Authors: Shauna A Henley, Sarah M Francis, Jordan Demone, Peter Ainsworth and Frederick A Dick
    Citation: Cancer Cell International 2010 10:8
  12. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expression of PADI4 in various malignant tumour tissues. PADI4 is also ex...

    Authors: Xiaotian Chang and Kehua Fang
    Citation: Cancer Cell International 2010 10:7
  13. Pancratistatin, a natural compound extracted from Hymenocallis littoralis, can selectively induce apoptosis in several cancer cell lines. In this ex vivo study, we evaluated the effect of pancratistatin on periph...

    Authors: Carly Griffin, Caroline Hamm, James McNulty and Siyaram Pandey
    Citation: Cancer Cell International 2010 10:6
  14. Most cancer researchers regularly practice the responsible conduct of research (RCR) without consciously considering it. As professional scientists, we simply do what we are trained to do. However, as we train...

    Authors: Mark A Brown, Richard J Ablin and Denys N Wheatley
    Citation: Cancer Cell International 2010 10:5
  15. Simian Virus 40 (SV40) immortalization followed by treatment of cells with 3-methylcholanthrene (3-MC) has been used to elicit tumors in athymic mice. 3-MC carcinogenesis has been thoroughly studied, however g...

    Authors: Lynn M Crosby, Tanya M Moore, Michael George, Lawrence W Yoon, Marilyn J Easton, Hong Ni, Kevin T Morgan and Anthony B DeAngelo
    Citation: Cancer Cell International 2010 10:4

    The Erratum to this article has been published in Cancer Cell International 2010 10:10

  16. Lung cancers are the most common type of human malignancy and are intractable. Lung cancers are generally classified into four histopathological subtypes: adenocarcinoma (AD), squamous cell carcinoma (SQ), lar...

    Authors: Takashi Watanabe, Tomohiro Miura, Yusuke Degawa, Yuna Fujita, Masaaki Inoue, Makoto Kawaguchi and Chie Furihata
    Citation: Cancer Cell International 2010 10:2
  17. ASPM (Abnormal Spindle-like Microcephaly associated) over-expression was recently implicated in the development of malignant gliomas.

    Authors: Sandra-Nadia Ngwabyt Bikeye, Carole Colin, Yannick Marie, Raphaël Vampouille, Philippe Ravassard, Audrey Rousseau, Blandine Boisselier, Ahmed Idbaih, Charles Félix Calvo, Pascal Leuraud, Myriam Lassalle, Soufiane El Hallani, Jean-Yves Delattre and Marc Sanson
    Citation: Cancer Cell International 2010 10:1

    The Erratum to this article has been published in Cancer Cell International 2011 11:10

  18. Intravesical BCG immunotherapy is effective for preventing recurrence and progression in none muscle-invasive bladder cancer but the dosing schedule and duration of treatment remain empirical. The mechanisms b...

    Authors: Akira Kitamura, Sohkichi Mastumoto and Izumi Asahina
    Citation: Cancer Cell International 2009 9:30
  19. Cancer remains one of the most dreaded diseases causing an astonishingly high death rate, second only to cardiac arrest. The fact that conventional and newly emerging treatment procedures like chemotherapy, ca...

    Authors: Gowhar Shafi, Anjana Munshi, Tarique N Hasan, Ali A Alshatwi, A Jyothy and David KY Lei
    Citation: Cancer Cell International 2009 9:29
  20. The gene encoding integrator complex subunit 6 (INTS6), previously known as deleted in cancer cells 1 (DICE1, OMIM 604331) was found to be frequently affected by allelic deletion and promoter hypermethylation in ...

    Authors: Stephanie Filleur, Jennifer Hirsch, Aline Wille, Margarete Schön, Christian Sell, Michael H Shearer, Thomas Nelius and Ilse Wieland
    Citation: Cancer Cell International 2009 9:28
  21. Malignant glioma cells are particularly motile and can travel diffusely through the brain parenchyma, apparently without following anatomical structures to guide their migration. The neural adhesion/recognitio...

    Authors: Muhua Yang, Shalini Adla, Murali K Temburni, Vivek P Patel, Errin L Lagow, Owen A Brady, Jing Tian, Magdy I Boulos and Deni S Galileo
    Citation: Cancer Cell International 2009 9:27
  22. Osteoprotegerin (OPG), a member of the tumor necrosis factor (TNF) receptor superfamily, contributes determinatively to the bone remodeling as well as to the pathogenetic mechanism of bone malignancies and dis...

    Authors: Sofia Fili, Maria Karalaki and Bernhard Schaller
    Citation: Cancer Cell International 2009 9:26
  23. Glucosamine is known as a toxic agent for several malignant cell lines and transplanted tumors with little toxicity to normal host tissues. However, the mechanisms underlying anticancer activity of glucosamine...

    Authors: Viktor Chesnokov, Chao Sun and Keiichi Itakura
    Citation: Cancer Cell International 2009 9:25
  24. The Signal Transducer and Activator of Transcription (STAT) proteins comprise a family of latent transcription factors with diverse functions. STAT3 has well established roles in cell proliferation, growth and...

    Authors: Brian Hutzen, William Willis, Sarah Jones, Ling Cen, Stephanie Deangelis, Beng Fuh and Jiayuh Lin
    Citation: Cancer Cell International 2009 9:24
  25. Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+. Up regulation of genes which contribute to store operated channel...

    Authors: Ebru Aydar, Syn Yeo, Mustafa Djamgoz and Christopher Palmer
    Citation: Cancer Cell International 2009 9:23
  26. Gap junction intercellular communication (GJIC) is considered to play a role in the regulation of homeostasis because it regulates important processes, such as cell proliferation and cell differentiation. A re...

    Authors: Marisa Ionta, Raphael Adolpho Sant'ana Ferreira, Sandra Cristina Pfister and Gláucia Maria Machado-Santelli
    Citation: Cancer Cell International 2009 9:22
  27. The human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces apoptosis after cell cycle arrest at the G2 phase in primate cells. We have reported previously that C81, a carboxy-terminally truncat...

    Authors: Mizuho Nonaka, Yoshie Hashimoto, Shin-nosuke Takeshima and Yoko Aida
    Citation: Cancer Cell International 2009 9:20
  28. NUCKS (Nuclear, Casein Kinase and Cyclin-dependent Kinase Substrate) is a nuclear, DNA-binding and highly phosphorylated protein. A number of reports show that NUCKS is highly expressed on the level of mRNA in se...

    Authors: Yiannis Drosos, Mirsini Kouloukoussa, Anne Carine Østvold, Kirsten Grundt, Nikos Goutas, Dimitrios Vlachodimitropoulos, Sophia Havaki, Panagoula Kollia, Christos Kittas, Evangelos Marinos and Vassiliki Aleporou-Marinou
    Citation: Cancer Cell International 2009 9:19
  29. SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes ...

    Authors: Neill Patani, Wen Jiang, Robert Mansel, Robert Newbold and Kefah Mokbel
    Citation: Cancer Cell International 2009 9:18
  30. CD26 is a type II, cell surface glycoprotein known as dipeptidyl peptidase (DPP) IV. Previous studies have revealed CD26 expression in T cell leukemia/lymphoma and malignant mesothelioma, and an inhibitory eff...

    Authors: Kohji Yamada, Mutsumi Hayashi, Wenlin Du, Kei Ohnuma, Michiie Sakamoto, Chikao Morimoto and Taketo Yamada
    Citation: Cancer Cell International 2009 9:17
  31. Eurycomanone is a cytotoxic compound found in Eurycoma longifolia Jack. Previous studies had noted the cytotoxic effect against various cancer cell lines. The aim of this study is to investigate the cytotoxici...

    Authors: Yusmazura Zakaria, Asmah Rahmat, Azimahtol Hawariah Lope Pihie, Noor Rain Abdullah and Peter J Houghton
    Citation: Cancer Cell International 2009 9:16
  32. Cancer and Alzheimer's disease (AD) are two seemingly distinct diseases and rarely occur simultaneously in patients. To explore molecular determinants differentiating pathogenic routes towards AD or cancer, we...

    Authors: Hong Zhao, Jinmin Zhu, Kemi Cui, Xiaoyin Xu, Megan O'Brien, Kelvin K Wong, Santosh Kesari, Weiming Xia and Stephen TC Wong
    Citation: Cancer Cell International 2009 9:15
  33. Recent evidence suggests that several human cancers are capable of uncoupling of mitochondrial ATP generation in the presence of intact tricarboxylic acid (TCA) enzymes. The goal of the current study was to te...

    Authors: Eugene J Fine, Anna Miller, Edward V Quadros, Jeffrey M Sequeira and Richard D Feinman
    Citation: Cancer Cell International 2009 9:14
  34. Metabolic states of neoplastic cells are increasingly being relied upon for diagnostic and prognostic assessment of neoplastic conditions. The nucleic acid distribution pattern of cells in general, in terms of...

    Authors: Godwin N Isitor, Mervyn Campbell and Shivananda B Nayak
    Citation: Cancer Cell International 2009 9:13
  35. In the Western world, endometrial cancers are the most common gynaecological neoplastic disorders among women. Initial symptoms are often vague and may be confused with several other conditions or disorders. T...

    Authors: Sandra Karlsson, Björn Olsson and Karin Klinga-Levan
    Citation: Cancer Cell International 2009 9:12
  36. The Wnt family of secreted proteins is implicated in the regulation of cell fate during development, as well as in cell proliferation, morphology, and migration. Aberrant activation of the Wnt/β-catenin signal...

    Authors: Kelly J Gauger, Jeremy M Hugh, Melissa A Troester and Sallie Smith Schneider
    Citation: Cancer Cell International 2009 9:11
  37. DNA methylation is an epigenetic phenomenon known to play an important role in the development of cancers, including colorectal cancer (CRC). Aberrant methylation of promoter regions of genes is potentially re...

    Authors: Sylwia Flis, Agnieszka Gnyszka, Irena Misiewicz-Krzemińska and Jacek Spławiński
    Citation: Cancer Cell International 2009 9:10
  38. Protein used in medicine, e.g. interferon, are immunogenic and quickly broken down by the body. Pegylation is a recognized way of preserving their integrity and reducing immune reactions, and works well with e...

    Authors: Sam-Mui Tsui, Wai-Man Lam, Tin-Lun Lam, Hiu-Chi Chong, Pui-Kin So, Sui-Yi Kwok, Simon Arnold, Paul Ning-Man Cheng, Denys N Wheatley, Wai-Hung Lo and Yun-Chung Leung
    Citation: Cancer Cell International 2009 9:9
  39. MCF-10A cells are near diploid and normal human mammary epithelial cells. In three-dimensional reconstituted basement membrane culture, they undergo a well-defined program of proliferation, differentiation, an...

    Authors: Karen M Imbalzano, Iva Tatarkova, Anthony N Imbalzano and Jeffrey A Nickerson
    Citation: Cancer Cell International 2009 9:7
  40. Piper sarmentosum, locally known as kaduk is belonging to the family of Piperaceae. It is our interest to evaluate their effect on human hepatoma cell line (HepG2) for the potential of anticarcinogenic activity.

    Authors: Shahrul Hisham Zainal Ariffin, Wan Haifa Haryani Wan Omar, Zaidah Zainal Ariffin, Muhd Fauzi Safian, Sahidan Senafi and Rohaya Megat Abdul Wahab
    Citation: Cancer Cell International 2009 9:6
  41. The prototypical antiprogestin mifepristone exhibits potent growth inhibition activity towards ovarian cancer cells in vitro and in vivo. The aim of this research was to establish whether mifepristone is capable ...

    Authors: Elizabeth M Freeburg, Alicia A Goyeneche, Erin E Seidel and Carlos M Telleria
    Citation: Cancer Cell International 2009 9:4

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